Molecular Toxicology Group
The Mechanistic Toxicology Group (mTOX) is dedicated to understanding how chemical exposure disrupts biology. Our main areas of research include the development of New Approach Methods (NAMs) for Developmental and Adult Neurotoxicity Testing (DNT and ANT), integration of multiple, zebrafish-based endpoints to predict toxicity outcomes, the use of molecular approaches to reveal causal mechanisms by which chemical exposure affects neurodevelopment, the investigation of chemical-microbiome interactions that influence host health, and NAM development to assess the effect of chemical mixtures on behavior and enteric nervous system development.
Build Developmental Neurotoxicity (DNT) and Adult Neurotoxicity (ANT) NAMs
The developing nervous system is particularly sensitive to chemical exposure and there is heightened public concern linking the rise in children’s neurodevelopmental impairments, including learning disabilities, to environmental chemicals. From an ecological perspective, ~16% of chemicals detected in multiple EU water sampling studies have neurotoxic modes of action. Despite the link between chemical exposure and adverse neurodevelopmental outcomes, from among an estimated 350.000 chemicals in commerce, data from less than 200 OECD rodent neurotoxicity tests are available. To solve the gap in testing, we need to radically change the way we assess the potential for chemicals to harm the developing nervous system. Cellular assays fail to recapitulate complex neurodevelopmental endpoints captured in OECD rodent tests including behavior, learning, and memory. mTox builds, evaluates, and validates zebrafish embryo-based NAMs for complex behavioral endpoints including non-associative habituation learning and memory retention, and build fingerprinting systems to reveal putative chemical mode of action information. Funded by the Partnership for the Assessment of Risk from Chemicals (PARC) and UFZ CITE. In the PANDORA project, funded by the European Food Safety Authority, we are modifying our behavior battery, coupled with high-content imaging of transgenic zebrafish labeling dopaminergic cells, to understand how dopaminergic cell loss is linked to behavioral manifestations observed upon exposure to reference chemicals and pesticides used in Europe.
Figure: We developed a novel zebrafish embryo behavior assay battery for the identification of neurotoxic chemicals. The battery is comprised of sequential behavior assays that quantify visual and acoustic startle responses (VSRs, ASRs), visual motor responses (VMRs), acoustic startle habituation (ASH), potentiation of habituation, and memory retention of acoustic stimuli. We use the assay to identify chemicals that disrupt complex behaviors in early life stage zebrafish.
mTox DNT and ANT NAM Team: David Leuthold, Nadia Herold, Renee Owen, Jana Raab, Julia Spath, Stefan Scholz, Tamara Tal
Discover chemical mode of action
Zebrafish embryo behavior data has yet to be used for human and ecological risk assessment. One reason is a lack of confidence that chemical-dependent changes in zebrafish behavior represent developmentally or acutely neurotoxic endpoints that are translationally relevant. One strategy that can build confidence in the use of these data is a better understanding of underlying mechanisms that drive behavior effects. mTox seeks to causally describe chemical mode of action to generate regulatory confidence that a chemical pollutant is likely to disrupt neurodevelopment across taxa, including humans. Funded by the Partnership for the Assessment of Risk from Chemicals (PARC) and UFZ CITE.
Figure: CRISPR/Cas9-based gene editing of the tyrosinase gene caused significant reductions in pigmentation (light blue=uninjected control; blue=negative control crispant; red=tyrosinase crispant). This strategy is applied to test whether genes and pathways are required for chemical-dependent effects on behavior.
mTox Mechanism Team: Sebastian Gutsfeld, Nicole Schweiger, David Leuthold, Renee Owen, Stefan Scholz, Tamara Tal
Understand chemical-microbiome interactions that affect host health
The intestinal microbiome harbors the capacity to influence the toxicokinetics and toxicodynamics of xenobiotic exposures. It is widely understood that exposure to exogenous chemicals disrupts the community structure of host-associated microbes and several reports show that chemical-selected microbiomes biotransform environmental chemicals. A major knowledge gap relates to whether xenobiotic-induced effects on microbial ecology and biotransformation causally alter the toxicity of environmental chemicals to the host organism. Until this question is answered, the microbiome will not be considered in risk assessment strategies. mTox moves the science forward to illuminate the mode of action in microbiome-mediated toxicity using the three-colonization cohort system comprised of axenic (i.e., microbe-free), conventionalized, and conventionally colonized zebrafish. Funded by Neuro-Xeno-Microbiome and UFZ CITE MibiTox Consortium.
Figure: This image depicts an axenic zebrafish larva mono-associated with a fluorescently labeled strain of bacteria.
mTox Microbiome Team: Sebastian Gutsfeld, Nicole Schweiger, Chloe Wray, Tamara Tal
Papers
DOI: 10.1093/toxsci/kfz166
DOI: 10.1186/s42523-020-00069-x
Large scale data
mTox generates a vast amount of automated bright field and fluorescence imaging data, automated behavior datas, and underlying videos. We are working towards making our data Findable, Accessible, Interoperable, and Reusable (FAIR). We apply and integrate open source computational tools for reproducible effect assessment such as R or Python for our workflows in GALAXY KNIME or SHINY. Our imaging and effect data are archived in databases such as OMERO or INTOB. Our software tools are made available publicly via gitlab or github repositories.
mTox Data Team: Sebastian Gutsfeld, Elena Nicolay, Tamara Tal, Gilberto Mercado, Katharina Wifling
Effects of endocrine disrupting chemicals (EDCs) on intestinal inflammation and enteric nervous system development
To bridge chemical exposure and behavior effects, another interest of the group is to develop high-content imaging approaches to quantify cellular and sub-cellular effects of chemicals and mixtures. In the ENDOMIX project, a combination of transgenic zebrafish lines is used to understand how commonly co-occurring EDC chemicals might cause inflammation of the intestinal tract and/or alter enteric nervous system development. Funded by ENDOMIX.
Figure: The maximum projection shows a five-day-old double-transgenic zebrafish larva (Tg(neurod:GFP) x Tg(mpeg1:mCherry)). Neurons, including the ones located in the intestine, are labelled in yellow (neurod), and macrophages in magenta (mpeg1), modelling their interplay under environmental chemical exposure.
EDC Team: Elena Nicolay, Tamara Tal
mTOX Group Leader
Copyright: Sebastian Wiedling
Prof. Dr. Tamara Tal leads the Mechanistic Toxicology Group at the Helmholtz Centre for Environmental Research – UFZ. She also holds a Professorship in Integrated Systems Toxicology in the Medical Faculty at University Leipzig. Prior to joining the UFZ in 2019, Tamara was a Principal Investigator at the United States Environmental Protection Agency in the Office of Research and Development. Tamara completed postdoctoral fellowships in the labs of Dr. Robyn Tanguay (Oregon State University) and Dr. Stephanie Padilla (EPA) and earned a doctorate in toxicology from the University of North Carolina at Chapel Hill under the mentorship of Dr. James Samet. Tamara leads New Approach Method development for developmental and adult neurotoxicity endpoints in the European Partnership for the Assessment of Risks from Chemicals (PARC) and participates in the PANDORA and ENDOMIX consortia.
mTox Group members
Team members
Lead
Prof. Dr. Tamara Tal
Senior scientist
2019 - present
Email
Dr David Leuthold
Postdoctoral scientist
2019 - present
Email
Nicole Schweiger
Technician
2019 - present
Email
Alumni
Shiraz Kader, student researcher August 2024 - December 2025
Julia Nöth, Doctoral student 2020-2022. Next Position: Heraeus, DE.
Gabriel de Macedo, DAAD Visiting PhD Fellow, October 2022 - February 2023.
Ifeoluwa Omoyeni, Erasmus Master’s Student, February-July 2022. Next position: Associate Toxicologist, Broughton Life Sciences, UK
Dr. Luísa Becker Bertotto, US EPA ORISE Postdoctoral Fellow, 2018-2019. Next position: Postdoctoral Fellow, Scripps Research Institute.
Shaza Gaballah, US EPA ORISE Post-Baccalaureate Trainee, 2017-2019. Next position: PhD student at Duke University, Stapleton Lab.
Allison Kvasnicka, US EPA Undergraduate Research Volunteer (Summer 2017) and ORISE trainee (Summer 2018). Next position: Research Specialist, BioAgilytix.
Dr. Tara Catron, US EPA ORISE Postdoctoral Fellow. Next position: Ecotoxicologist, BASF.
Drake Phelps, US EPA ORISE Post-Baccalaureate Trainee, 2016-2017. Next position: PhD Student NCSU Neuroimmunology Program, Yoder Lab.
Publications
Index:
You could use our publication index for further requests.
2026 (7)
- Didio, A., van Echten, A., Raps, S., Fu, Q., Tal, T., Schubert, K. (2026):
Proteomic profiling reveals selective cellular responses in macrophages exposed to PFAS
Toxicol. Lett. 423 (Suppl.), art. 112660
10.1016/j.toxlet.2026.112660 - Gutsfeld, S., Wray, C., Schweiger, N., Röhrig, A., Paschke, H., Fu, Q., Kasmanas, J.C., Abdulkadir, N., Kader, S., Rocha, U., Ebert, A., Tal, T. (2026):
N-Ethyl perfluorooctane sulfonamide (N-EtFOSA) exposure alters microbiome composition and causes microbiome-dependent behavior effects in larval zebrafish
Environ. Sci. Technol. 60 (20), 14276 - 14291
10.1021/acs.est.5c16330 - Herold, N.K., Sørensen, L., Creese, M.E., Nahrgang, J., Schweiger, N., Tal, T. (2026):
Identification of neuroactive chemicals in crude oil-derived water-accommodated fractions
Environ. Sci. Technol. 60 (1), 181 - 195
10.1021/acs.est.5c06859 - Leuthold, D., Herold, N.K., Nerlich, J., Bartmann, K., Scharkin, I., Hallermann, S.J., Schweiger, N., Fritsche, E., Tal, T. (2026):
Multibehavioral phenotyping in early-life-stage zebrafish for identifying disruptors of nonassociative learning
Environ. Health Perspect. 134 (4), 465 - 484
10.1021/EHP.6c00394 - Spath, J., Raab, J., Schor, J., Scholz, S., Gutsfeld, S., Tal, T. (2026):
The zebrafish visual and acoustic motor response (VAMR) assay has the potential to add value to the developmental neurotoxicity in vitro battery (DNT IVB)
NeuroToxicology 114 , art. 103414
10.1016/j.neuro.2026.103414 - Wray, C., Castañeda-Monsalve, V., Engelmann, B., Rolle-Kampczyk, U.E., Schweiger, N., Gutsfeld, S., Ghosh, D., Kader, S., Tyler, C.R., Jehmlich, N., Tal, T. (2026):
Dataset for Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin (v.2) [Data set]
Zenodo
10.5281/zenodo.18433571 - Wray, C., Castañeda-Monsalve, V., Engelmann, B., Rolle-Kampczyk, U.E., Schweiger, N., Gutsfeld, S., Ghosh, D., Kader, S., Tyler, C.R., Jehmlich, N., Tal, T. (2026):
Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin
Toxicol. Sci. 209 (4), kfag022
10.1093/toxsci/kfag022
2025 (22)
- Ayuk, H.S., Pierzchalski, A., Tal, T., Myhre, O., Lindeman, B., Smith, N.M., Stojanovska, V., Zenclussen, A.C. (2025):
Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees
Environ. Int. 198 , art. 109409
10.1016/j.envint.2025.109409 - Celardo, I., Aschner, M., Ashton, R.S., Carstens, K.E., Cediel-Ulloa, A., Cöllen, E., Crofton, K.M., Debad, S.J., Dreser, N., Fitzpatrick, S., Fritsche, E., Gutsfeld, S., Hardy, B., Hartung, T., Hessel, E., Heusinkveld, H., Hogberg, H.T., Hsieh, J.-H., Kanda, Y., Knight, G.T., Knudsen, T., Koch, K., Kuchovska, E., Mangas, I., Marty, M.S., Melching-Kollmuss, S., Müller, I., Müller, P., Myhre, O., Paparella, M., Pitzer, E., Bal-Price, A., Sachana, M., Schlüppmann, K., Shafer, T.J., Schäfer, J., Smirnova, L., Tal, T., Tanaskov, Y., Tangianu, S., Testa, G., Ückert, A.-K., Whelan, M., Leist, M. (2025):
Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing
ALTEX-Altern. Anim. Exp. 42 (2), 323 - 349
10.14573/altex.2503191 - Glaberman, S., Frey, H.C., Tal, T. (2025):
Dismantling EPA’s research office jeopardizes environmental safety, public health, and US competitiveness
Proc. Natl. Acad. Sci. U.S.A. 122 (24), e2508060122
10.1073/pnas.2508060122 - Gómez-Olarte, S., Kretschmer, T., Zantop, S., Tal, T., Myhre, O., Stojanovska, V., Meyer, N., Zenclussen, A.C. (2025):
PFAS mixture effects on single-cell CyTOF-based profiling of human primary immune cells: transitioning to new approach methodologies
Toxicol. Lett. 411 (Supplement), S184 - S185
10.1016/j.toxlet.2025.07.444 - Gutsfeld, S., Wray, C., Schweiger, N., Röhrig, A., Paschke, H., Fu, Q., Kasmanas, J.C., Kader, S., Nunes da Rocha, U., Tal, T. (2025):
The zebrafish microbiome has the capacity to bioactivate PFOS precursor compounds
Toxicol. Lett. 411 (Supplement), S176
10.1016/j.toxlet.2025.07.425 - Herold, N.K., Gutsfeld, S., Leuthold, D., Wray, C., Spath, J., Tal, T. (2025):
Multi-behavioral fingerprints can identify potential modes of action for neuroactive environmental chemicals
NeuroToxicology 108 , 377 - 399
10.1016/j.neuro.2025.05.001 - Herold, N.K., Sørensen, L., Creese, M.E., Nahrgang, J., Schweiger, N., Scholz, S., Tal, T. (2025):
Neuroactive behavioral fingerprinting of crude oil-derived water accommodated fractions in larval zebrafish using a new approach method
Toxicol. Lett. 411 (Supplement), S119
10.1016/j.toxlet.2025.07.302 - Herold, N.K., Sørensen, L., Creese, M.E., Nahrgang, J., Schweiger, N., Tal, T. (2025):
Chemical and Behavioral Fingerprinting Data for the Identification of Neuroactive Compounds in Crude Oil-Derived Water Accommodated Fractions [V3]
Mendeley Data
10.17632/8hmr85pjw7.3 - Leuthold, D., Herold, N., Nerlich, J., Bartmann, K., Scharkin, I., Hallermann, S.J., Schweiger, N., Fritsche, E., Tal, T. (2025):
Data used in Leuthold et al. "Multi-behavioral phenotyping in early-life-stage zebrafish for identifying disruptors of non-associative learning"
figshare
10.6084/m9.figshare.26819890 - Massei, R., Busch, W., Serrano-Solano, B., Bernt, M., Scholz, S., Nicolay, E.K., Bohring, H., Bumberger, J. (2025):
High-content screening (HCS) workflows for FAIR image data management with OMERO
Sci. Rep. 15 , art. 16236
10.1038/s41598-025-00720-0 - Michaelis, P., Klüver, N., Aulhorn, S., Bohring, H., Bumberger, J., Haase, K., Kuhnert, T., Küster, E., Krüger, J., Luckenbach, T., Massei, R., Nerlich, L., Petruschke, S., Schnicke, T., Schnurpel, A., Scholz, S., Schweiger, N., Sielaff, D., Busch, W. (2025):
Leveraging zebrafish embryo phenotypic observations to advance data-driven analyses in toxicology
Environ. Sci. Technol. 59 (9), 4304 - 4317
10.1021/acs.est.4c11757 - Nicolay, E.K., Massei, R., Trofimova, D., Haase, R., Isensee, F., Tal, T. (2025):
Establishing a high-content imaging workflow to investigate the effect of environmental chemicals on macrophages and enteric neurons in zebrafish larvae
Neurogastroenterol. Motil. 37 (S2), e70126 - NGS21070-82
10.1111/nmo.70126 - Nyffeler, J., Tal, T., Schildknecht, S., Viviani, B., Tanja, B., Fu, Q., Owen, R., Krishnakumar, A.E.V., Mangas, I., Terron, A. (2025):
Towards a defined approach to assess pesticides for their potential to cause Parkinsonian neurodegeneration
Toxicol. Lett. 411 (Supplement), S397 - S398
10.1016/j.toxlet.2025.07.916 - Owen, R., de Macedo, G., Nerlich, J., Scharkin, I., Bartmann, K., Döbler, J., Engelmann, B., Rolle-Kampczyk, U.E., Leuthold, D., Gutsfeld, S., Schweiger, N., Tal, T. (2025):
Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models
Toxicol. Sci. 207 (2), 449 - 466
10.1093/toxsci/kfaf101 - Owen, R., de Macedo, G., Nerlich, J., Scharkin, I., Bartmann, K., Döbler, J., Engelmann, B., Rolle-Kampczyk, U., Leuthold, D., Gutsfeld, S., Schweiger, N., Tal, T. (2025):
Dataset for PFOS antagonism of GABA receptors in vertebrate models
Zenodo
10.5281/zenodo.15394336 - Owen, R., Herzke, D., Haug, L.S., Myhre, O., Nerlich, J., Scharkin, I., Bartmann, K., Tal, T. (2025):
Exposure to a human-relevant PFAS mixture causes behavioral effects in larval zebrafish: A focus on chemical drivers, phenotypes, and underlying mechanisms
Toxicol. Lett. 411 (Supplement), S56 - S57
10.1016/j.toxlet.2025.07.165 - Raab, J., Gutsfeld, S., Tal, T. (2025):
NeuroBEAT: A comprehensive and flexible behavior analysis tool for neurotoxicity testing in larval zebrafish
Toxicol. Lett. 411 (Supplement), S109
10.1016/j.toxlet.2025.07.282 - Tal, T. (2025):
The microbiome modifies neurobehavior in zebrafish exposed to Aryl Hydrocarbon Receptor (AHR) modulators
Toxicol. Lett. 411 (Supplement), S45 - S46
10.1016/j.toxlet.2025.07.138 - Uthoff, C., Herold, N., Alkassab, A.T., Engelmann, B., Rolle-Kampczyk, U., Pistorius, J., Schweiger, N., Finckh, S., Krauss, M., Thum, A.S., Jehmlich, N., Tal, T., von Bergen, M. (2025):
Cross-taxa sublethal impacts of plant protection products on honeybee in-hive and zebrafish swimming behaviours at environmentally relevant concentrations
Environ. Int. 203 , art. 109750
10.1016/j.envint.2025.109750 - Uthoff, C., Herold, N., Alkassab, A.T., Engelmann, B., Rolle-Kampczyk, U., Pistorius, J., Schweiger, N., Finckh, S., Krauss, M., Thum, A.S., Jehmlich, N., Tal, T., von Bergen, M. (2025):
Dataset for 'Cross-taxa sublethal impacts of plant protection products on honeybee in-hive and zebrafish swimming behaviours at environmentally relevant concentrations'
Zenodo
10.5281/zenodo.16983482 - Wray, C., Kader, S., Escher, B.I., Henneberger, L., Krauss, M., Schweiger, N., Owen, R., Tyler, C.R., Tal, T. (2025):
Chemical-microbiome interactions in larval zebrafish: Unraveling the interactive effects of microbiome induced biotransformation of PAHs and host behavior
Toxicol. Lett. 411 (Supplement), S174
10.1016/j.toxlet.2025.07.421 - Zenclussen, A.C., Belmar Erilkin, V., Böhmert, L., Borilova Linhartova, P., Braeuning, A., Braun, G., Chevrier, C., Duijts, L., Escher, B.I., Felix, J., Gómez-Olarte, S., Guxens, M., Herberth, G., Hilscherova, K., Klanova, J., Kohl, Y., Krischak, K., Lagadic-Gossmann, D., Langouët, S., Llop, S., Lopez-Espinosa, M.-J., Maitre, L., Martin-Chouly, C., Meyer, N., Ouidir, M., Pham, T.A.M., Philippat, C., Pieters, R., Pinel-Marie, M.-L., Podechard, N., Polte, T., Price, E., Robinson, O., Schubert, K., Schumacher, A., Stojanovska, V., Tal, T., Vineis, P., van Vorstenbosch, R., Vermeulen, R., Warembourg, C. (2025):
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease [version 2]
Open Research Europe 4 , art. 271
10.12688/openreseurope.19088.2
2024 (4)
- Gutsfeld, S. (2024):
Analysis of Zebrafish Swimming Behavior Data using Mixed Effects Modelling
Version: v0.1 Zenodo
10.5281/zenodo.11396730 - Gutsfeld, S., Wehmas, L., Omoyeni, I.E., Schweiger, N., Leuthold, D., Michaelis, P., Howey, X.M., Gaballah, S., Herold, N., Vogs, C., Wood, C., Bertotto, L., Wu, G.-M., Klüver, N., Busch, W., Scholz, S., Schor, J., Tal, T. (2024):
Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS)
Environ. Health Perspect. 132 (7), art. 077007
10.1289/EHP13667 - Nöth, J., Busch, W., Tal, T., Lai, C., Ambekar, A., Kießling, T.R., Scholz, S. (2024):
Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Arch. Toxicol. 98 (2), 537 - 549
10.1007/s00204-023-03633-x - Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P.J., Escher, B.I., Dirven, H., Hellsten, K., Dolva, K., Hessel, E., Heusinkveld, H.J., Hadzhiev, Y., Hurem, S., Jagiello, K., Judzinska, B., Klüver, N., Knoll-Gellida, A., Kühne, B.A., Leist, M., Lislien, M., Lyche, J.L., Müller, F., Colbourne, J.K., Neuhaus, W., Pallocca, G., Seeger, B., Scharkin, I., Scholz, S., Spjuth, O., Torres-Ruiz, M., Bartmann, K. (2024):
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Front. Toxicol. 6 , art. 1359507
10.3389/ftox.2024.1359507
2023 (5)
- Avila Santos, A.P., Kabiru Nata’ala, M., Kasmanas, J.C., Bartholomäus, A., Keller-Costa, T., Jurburg, S.D., Tal, T., Camarinha-Silva, A., Saraiva, J.P., de Carvalho, A.C.P.L.F., Stadler, P.F., Sipoli Sanches, D., Nunes da Rocha, U. (2023):
The AnimalAssociatedMetagenomeDB reveals a bias towards livestock and developed countries and blind spots in functional-potential studies of animal-associated microbiomes
Animal Microbiome 5 , art. 48
10.1186/s42523-023-00267-3 - Baleeiro, F.C.F., Raab, J., Kleinsteuber, S., Neumann, A., Sträuber, H. (2023):
Mixotrophic chain elongation with syngas and lactate as electron donors
Microb. Biotechnol. 16 (2), 322 - 336
10.1111/1751-7915.14163 - De Castelbajac, T., Aiello, K., Arenas, C.G., Svingen, T., Ramhøj, L., Zalko, D., Barouki, R., Vanhaecke, T., Rogiers, V., Audebert, M., Oelgeschlaeger, M., Braeuning, A., Blanc, E., Tal, T., Rüegg, J., Fritsche, E., Marx-Stoelting, P., Rivière, G. (2023):
Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment
Front. Toxicol. 5 , art. 1216369
10.3389/ftox.2023.1216369 - Escher, B.I., Altenburger, R., Blüher, M., Colbourne, J.K., Ebinghaus, R., Fantke, P., Hein, M., Köck, W., Kümmerer, K., Leipold, S., Li, X., Scheringer, M., Scholz, S., Schloter, M., Schweizer, P.-J., Tal, T., Tetko, I., Traidl-Hoffmann, C., Wick, L.Y., Fenner, K. (2023):
Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
Arch. Toxicol. 97 (5), 1267 - 1283
10.1007/s00204-023-03485-5 - Raab, J., Fink, B., Bauer, M. (2023):
Appearance of ghost bands in gel electrophoresis depending on agarose concentration
Electrophoresis 44 (15-16), 1206 - 1209
10.1002/elps.202300041
2022 (1)
- Scholz, S., Nichols, J.W., Escher, B.I., Ankley, G.T., Altenburger, R., Blackwell, B., Brack, W., Burkhard, L., Collette, T.W., Doering, J.A., Ekman, D., Fay, K., Fischer, F., Hackermüller, J., Hoffman, J.C., Lai, C., Leuthold, D., Martinovic-Weigelt, D., Reemtsma, T., Pollesch, N., Schroeder, A., Schüürmann, G., von Bergen, M. (2022):
The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45
10.1002/etc.5242
2021 (5)
- Kasmanas, J.C., Bartholomäus, A., Borim Corrêa, F., Tal, T., Jehmlich, N., Herberth, G., von Bergen, M., Stadler, P.F., de Carvalho, A.C.P.L.F., Nunes da Rocha, U. (2021):
HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes
Nucleic Acids Res. 49 (D1), D743 - D750
10.1093/nar/gkaa1031 - Schüttler, A., Jakobs, G., Fix, J.M., Krauss, M., Krüger, J., Leuthold, D., Altenburger, R., Busch, W. (2021):
Transcriptome-wide prediction and measurement of combined effects induced by chemical mixture exposure in zebrafish embryos
Environ. Health Perspect. 129 (4), art. 047006
10.1289/EHP7773 - Tal, T., Vogs, C. (2021):
Invited perspective: PFAS bioconcentration and biotransformation in early life stage zebrafish and its implications for human health protection
Environ. Health Perspect. 129 (7), art. 071304
10.1289/EHP9625 - Volz, D.C., Cannon, J., Tal, T. (2021):
Introduction to leveraging non-mammalian models for developmental neurotoxicity testing
Neurotoxicol. Teratol. 87 , art. 107001
10.1016/j.ntt.2021.107001 - Weitekamp, C.A., Kvasnicka, A., Keely, S.P., Brinkmann, N.E., Howey, X.M., Gaballah, S., Phelps, D., Catron, T., Zurlinden, T., Wheaton, E., Tal, T. (2021):
Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish
Animal Microbiome 3 , art. 12
10.1186/s42523-020-00069-x
2020 (7)
- Bertotto, L.B., Catron, T.R., Tal, T. (2020):
Exploring interactions between xenobiotics, microbiota, and neurotoxicity in zebrafish
NeuroToxicology 76 , 235 - 244
10.1016/j.neuro.2019.11.008 - Gaballah, S., Swank, A., Sobus, J.R., Howey, X.M., Schmid, J., Catron, T., McCord, J., Hines, E., Strynar, M., Tal, T. (2020):
Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS
Environ. Health Perspect. 128 (4), art. 047005
10.1289/EHP5843 - Halbach, K., Ulrich, N., Goss, K.-U., Seiwert, B., Wagner, S., Scholz, S., Luckenbach, T., Bauer, C., Schweiger, N., Reemtsma, T. (2020):
Yolk sac of zebrafish embryos as backpack for chemicals?
Environ. Sci. Technol. 54 (16), 10159 - 10169
10.1021/acs.est.0c02068 - Leuthold, D. (2020):
Zebrafish locomotor activity as a sensitive effect-based tool for the assessment of environmental chemicals and mixtures
Dissertation, Rheinisch-Westfälische Technische Hochschule (RWTH), Fakultät für Mathematik, Informatik und Naturwissenschaften
PhD Dissertation 04/2020
Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig, xxiv, 156 pp. - Tal, T., Yaghoobi, B., Lein, P.J. (2020):
Translational toxicology in zebrafish
Curr. Opin. Toxicol. 23-24 , 56 - 66
10.1016/j.cotox.2020.05.004 - Teixidó, E., Leuthold, D., de Crozé, N., Léonard, M., Scholz, S. (2020):
Comparative assessment of the sensitivity of fish early‐life stage, Daphnia and algae to the chronic ecotoxicity of xenobiotics – perspectives for alternatives to animal testing
Environ. Toxicol. Chem. 39 (1), 30 - 41
10.1002/etc.4607 - Ulrich, N., Schweiger, N., Pfennigsdorff, A., Scholz, S., Goss, K.-U. (2020):
Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio
Environ. Toxicol. Chem. 39 (8), 1506 - 1516
10.1002/etc.4744
2019 (3)
- Catron, T.R., Gaballah, S., Tal, T. (2019):
Using zebrafish to investigate interactions between xenobiotics and microbiota
Curr. Pharmacol. Rep. 5 , 468 - 480
10.1007/s40495-019-00203-7 - Leuthold, D., Klüver, N., Altenburger, R., Busch, W. (2019):
Can environmentally relevant neuroactive chemicals specifically be detected with the locomotor response test in zebrafish embryos?
Environ. Sci. Technol. 53 (1), 482 - 493
10.1021/acs.est.8b04327 - Ogungbemi, A., Leuthold, D., Scholz, S., Küster, E. (2019):
Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
Environ. Sci. Eur. 31 , art. 88
10.1186/s12302-019-0270-5
2018 (1)
- Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
An ecotoxicological view on neurotoxicity assessment
Environ. Sci. Eur. 30 , art. 46
10.1186/s12302-018-0173-x
2017 (1)
- Teixido, E., Kießling, T., Leuthold, D., Scholz, S. (2017):
Effect signatures in zebrafish embryos exposed to compounds with potential developmental toxicity
Reprod. Toxicol. 72 , 49
10.1016/j.reprotox.2017.06.179
2016 (2)
- Teixidó, E., Leuthold, D., Amberg, A., Czich, A., Krupp, E., Scholz, S. (2016):
ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA)
Reprod. Toxicol. 64 , 22
10.1016/j.reprotox.2016.06.048 - Teixidó, E., Leuthold, D., Scholz, S., Quevedo, C., Muriana, A., Czich, A., Krupp, E. (2016):
An inter-laboratory validation of the zebrafish embryo assay for the detection of developmental toxicity
Reprod. Toxicol. 64 , 44
10.1016/j.reprotox.2016.06.096