Dr. Stefan Scholz

Address:
Permoserstr. 15
04318 Leipzig
Germany
Building: 6.0
Room: 327
Phone: +49 341 6025 1080
Dr. Stefan Scholz
Research Interests
- Mechanisms of action of chemicals
- High content analysis and automatisation bioassays
- Development of bioassays, particularly as alternatives to animal testing, for effect assessment of chemicals and biomonitoring
Curriculum Vitae
Since 2024
Senior scientist & Deputy Head, Department Bioanalytical Ecotoxicology
2022 - 2023
Acting Head, Department Bioanalytical Ecotoxicology
01/2015 - 06/2015
Visting scientist, US-EPA (Environmental Protection Agency), Mid-continent ecology division Duluth, MN.
01/2004 - 03/2004
Guest scientist, Bioscience and Biotechnology Center, Laboratory of Freshwater Fish Stocks, University of Nagoya, Japan
Since 2002
PostDoc and senior scientist, Department Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research - UFZ, Leipzig
04/1995 - 06/2002
Lecturer and research scientist, Institute of Zoology, University of Dresden
11/1992 - 03/1995
Doctoral thesis, Martin-Luther University Halle Wittenberg and Section Environmental Chemistry and Ecotoxicology, Helmholtz-Centre for Environmntal Research - UFZ, Leipzig
Topic: Induction of CYP1A in liver cell cultures of the rainbow trout
1987 - 1992
Student, Ruhruniversität Bochum
Diplom thesis: Di-myo-inositol-1,1'-phosphate: A new inositol phosphate isolated from Pyrococcus woesei
Awards
2015
OECD Cooperative Research scholarship
2004
Scholarship of the University of Nagoya, Japan
Publications
Index:
You could use our publication index for further requests.
2025 (1)
- Nöth, J., Michaelis, P., Schüler, L., Scholz, S., Krüger, J., Haake, V., Busch, W. (2025):
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Arch. Toxicol. 10.1007/s00204-024-03944-7
2024 (9)
- Escher, B.I., Ahlheim, J., Böhme, A., Borchardt, D., Brack, W., Braun, G., Colbourne, J.K., Dann, J.P., Gessner, J., Jahnke, A., König, M., Klüver, N., Krauss, M., Lee, J., Li, X., Lips, S., Orsini, L., Rinke, K., Schmitt-Jansen, M., Scholz, S., Schulze, T., Spahr, S., Ulrich, N., Weitere, M., Varga, E. (2024):
Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Nat. Water 2 (9), 889 - 898 10.1038/s44221-024-00297-4 - Grasse, N., Massei, R., Seiwert, B., Scholz, S., Escher, B.I., Reemtsma, T., Fu, Q. (2024):
Impact of biotransformation on internal concentrations and specificity classification of organic chemicals in the zebrafish embryo (Danio rerio)
Environ. Sci. Technol. 58 (40), 17898 - 17907 10.1021/acs.est.4c04156 - Gutsfeld, S., Wehmas, L., Omoyeni, I.E., Schweiger, N., Leuthold, D., Michaelis, P., Howey, X.M., Gaballah, S., Herold, N., Vogs, C., Wood, C., Bertotto, L., Wu, G.-M., Klüver, N., Busch, W., Scholz, S., Schor, J., Tal, T. (2024):
Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS)
Environ. Health Perspect. 132 (7), art. 077007 10.1289/EHP13667 - Hayot, G., Marcato, D., Cramer von Clausbruch, C.A., Pace, G., Strähle, U., Colbourne, J.K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T. (2024):
Evaluating toxicity of chemicals using a zebrafish vibration startle response screening system
J. Vis. Exp. 2024 (203), e66153 10.3791/66153 - Hayot, G., Massei, R., Lloyd, G., Keith, N., Diwan, G., Martinez Lopez, R., Barnard, M., Cramer von Clausbruch, C.A., Grasse, N., Smoot, S., Escher, B., Tennessen, J., Tindall, A., Oliver, B., Shaw, J., Scholz, S., Freedman, J., Strähle, U., Colbourne, J., Weiss, C., Dickmeis, T. (2024):
Systematic acquisition of toxicity data in non- sentient models across animal phylogeny: implications for read- across and estimation of toxicity in humans
Naunyn-Schmiedebergs Arch. Pharmacol. 397 (Suppl. 1), S17 - S18-69 10.1007/s00210-024-02974-3 - Michaelis, P., Klüver, N., Aulhorn, S., Bohring, H., Bumberger, J., Haase, K., Kuhnert, T., Küster, E., Krüger, J., Luckenbach, T., Massei, R., Nerlich, L., Petruschke, S., Schnicke, T., Schnurpel, A., Scholz, S., Schweiger, N., Sielaff, D., Busch, W. (2024):
Leveraging zebrafish embryo phenotypic observations to advance data-driven analyses in toxicology
bioRxiv 10.1101/2024.10.11.617795 - Nöth, J., Busch, W., Tal, T., Lai, C., Ambekar, A., Kießling, T.R., Scholz, S. (2024):
Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Arch. Toxicol. 98 (2), 537 - 549 10.1007/s00204-023-03633-x - Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P.J., Escher, B.I., Dirven, H., Hellsten, K., Dolva, K., Hessel, E., Heusinkveld, H.J., Hadzhiev, Y., Hurem, S., Jagiello, K., Judzinska, B., Klüver, N., Knoll-Gellida, A., Kühne, B.A., Leist, M., Lislien, M., Lyche, J.L., Müller, F., Colbourne, J.K., Neuhaus, W., Pallocca, G., Seeger, B., Scharkin, I., Scholz, S., Spjuth, O., Torres-Ruiz, M., Bartmann, K. (2024):
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Front. Toxicol. 6 , art. 1359507 10.3389/ftox.2024.1359507 - Wilhelmi, P., Haake, V., Zickgraf, F.M., Giri, V., Ternes, P., Driemert, P., Nöth, J., Scholz, S., Barenys, M., Flick, B., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2024):
Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish
Arch. Toxicol. 98 (3), 943 - 956 10.1007/s00204-023-03655-5
2023 (9)
- Bajard, L., Adamovsky, O., Audouze, K., Baken, K., Barouki, R., Beltman, J.B., Beronius, A., Bonefeld-Jørgensen, E.C., Cano-Sancho, G., de Baat, M.L., Di Tillio, F., Fernández, M.F., FitzGerald, R.E., Gundacker, C., Hernández, A.F., Hilscherova, K., Karakitsios, S., Kuchovska, E., Long, M., Luijten, M., Majid, S., Marx-Stoelting, P., Mustieles, V., Negi, C.K., Sarigiannis, D., Scholz, S., Sovadinova, I., Stierum, R., Tanabe, S., Tollefsen, K.E., van den Brand, A.D., Vogs, C., Wielsøe, M., Wittwehr, C., Blaha, L. (2023):
Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
Environ. Res. 217 , art. 114650 10.1016/j.envres.2022.114650 - Bashirova, N., Poppitz, D., Klüver, N., Scholz, S., Matysik, J., Alia, A. (2023):
A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
Sci. Rep. 13 , art. 1891 10.1038/s41598-023-28712-y - Colbourne, J.K., Andrews, E., Barnard, M., Čavoški, A., Chaturvedi, A., Epps, D.J.T., Holden, L., Jones, M.R., Li, X., Mueller, F., Ormanin-Lewandowska, A., Orsini, L., Roberts, R., Weber, R.J.M., Zhou, J., Apic, G., Ignasiak, T., Jankovic, K., Krsmanovic, T., Leoni, B., Asole, G., Guigó, R., Marangio, P., Palumbo, E., Perez-Lluch, S., Wucher, V., Vlot, A.H., Anholt, R., Mackay, T., Escher, B.I., Grasse, N., Huchthausen, J., Massei, R., Reemtsma, T., Scholz, S., Schüürmann, G., Bondesson, M., Cherbas, P., et al. (2023):
The Precision Toxicology initiative
Toxicol. Lett. 383 , 33 - 42 10.1016/j.toxlet.2023.05.004 - Cramer von Clausbruch, C.A., Weiss, C., Dickmeis, T., Peravali, R., Strähle, U., Colbourne, J., Hayot, G., Scholz, S., Martinez Lopez, R. (2023):
Quantitative and qualitative assessment of cytotoxicity by automated fluorescence microscopy in human hepatocytes
Naunyn-Schmiedebergs Arch. Pharmacol. 396 (Suppl. 1), S61 - S62 10.1007/s00210-023-02397-6 - Escher, B.I., Altenburger, R., Blüher, M., Colbourne, J.K., Ebinghaus, R., Fantke, P., Hein, M., Köck, W., Kümmerer, K., Leipold, S., Li, X., Scheringer, M., Scholz, S., Schloter, M., Schweizer, P.-J., Tal, T., Tetko, I., Traidl-Hoffmann, C., Wick, L.Y., Fenner, K. (2023):
Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
Arch. Toxicol. 97 (5), 1267 - 1283 10.1007/s00204-023-03485-5 - Grasse, N., Seiwert, B., Massei, R., Scholz, S., Fu, Q., Reemtsma, T. (2023):
Uptake and biotransformation of the tire rubber-derived contaminants 6-PPD and 6-PPD quinone in the zebrafish embryo (Danio rerio)
Environ. Sci. Technol. 57 (41), 15598 - 15607 10.1021/acs.est.3c02819 - Hayot, G., von Clausbruch, C., Martinez Lopez, R., Scholz, S., Colbourne, J., Strähle, U., Weiss, C., Peravali, R., Dickmeis, T. (2023):
Phenotypic anchoring for OMICS-guided assessment of liver toxicity in zebrafish
Naunyn-Schmiedebergs Arch. Pharmacol. 396 (Suppl. 1), S61 - S61 10.1007/s00210-023-02397-6 - Scholz, S. (2023):
sscholz-UFZ/EmbryoMotion: EmbryoMotion Version 1.1. - a software to analyse spontaneous tail contraction and photomotor response of zebrafish embryos
Version: 1.1 Zenodo 10.5281/zenodo.8362019 - Wilhelmi, P., Giri, V., Zickgraf, F.M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2023):
A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil
Chem.-Biol. Interact. 382 , art. 110565 10.1016/j.cbi.2023.110565
2022 (11)
- Lee, J., Escher, B.I., Scholz, S., Schlichting, R. (2022):
Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells
Arch. Toxicol. 96 (4), 1039 - 1053 10.1007/s00204-022-03237-x - Lee, J., Huchthausen, J., Schlichting, R., Scholz, S., Henneberger, L., Escher, B.I. (2022):
Validation of an SH-SY5Y cell-based acetylcholinesterase inhibition assay for water quality assessment
Environ. Toxicol. Chem. 41 (12), 3046 - 3057 10.1002/etc.5490 - Lee, J., Schlichting, R., König, M., Scholz, S., Krauss, M., Escher, B.I. (2022):
Monitoring mixture effects of neurotoxicants in surface water and wastewater treatment plant effluents with neurite outgrowth inhibition in SH-SY5Y cells
ACS Environ. Au 2 (6), 523 - 535 10.1021/acsenvironau.2c00026 - Nöth, J., Michaelis, P., Busch, W., Scholz, S. (2022):
Analysis vascular disruptors in zebrafish embryos as an endpoint to predict developmental toxicity
Toxicol. Lett. 368 (Suppl.), S34 - S35 10.1016/j.toxlet.2022.07.111 - Ortmann, J., Altenburger, R., Scholz, S., Luckenbach, T. (2022):
Photomotor response data analysis approach to assess chemical neurotoxicity with the zebrafish embryo
ALTEX-Altern. Anim. Exp. 39 (1), 82 - 94 10.14573/altex.2004021 - Paini, A., Campia, I., Cronin, M.T.D., Asturiol, D., Ceriani, L., Exner, T.E., Gao, W., Gomes, C., Kruisselbrink, J., Martens, M., Meek, M.E.B., Pamies, D., Pletz, J., Scholz, S., Schüttler, A., Spînu, N., Villeneuve, D.L., Wittwehr, C., Worth, A., Luijten, M. (2022):
Towards a qAOP framework for predictive toxicology - Linking data to decisions
Comput. Toxicol. 21 , art. 100195 10.1016/j.comtox.2021.100195 - Scholz, S., Brack, W., Escher, B.I., Hackermüller, J., Liess, M., von Bergen, M., Wick, L.Y., Zenclussen, A.C., Altenburger, R. (2022):
The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Arch. Toxicol. 96 (8), 2381 - 2386 10.1007/s00204-022-03313-2 - Scholz, S., Nichols, J.W., Escher, B.I., Ankley, G.T., Altenburger, R., Blackwell, B., Brack, W., Burkhard, L., Collette, T.W., Doering, J.A., Ekman, D., Fay, K., Fischer, F., Hackermüller, J., Hoffman, J.C., Lai, C., Leuthold, D., Martinovic-Weigelt, D., Reemtsma, T., Pollesch, N., Schroeder, A., Schüürmann, G., von Bergen, M. (2022):
The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45 10.1002/etc.5242 - Spînu, N., Cronin, M.T.D., Lao, J., Bal-Price, A., Campia, I., Enoch, S.J., Madden, J.C., Lagares, L.M., Novič, M., Pamies, D., Scholz, S., Villeneuve, D.L., Worth, A.P. (2022):
Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
Comput. Toxicol. 21 , art. 100206 10.1016/j.comtox.2021.100206 - Teixidó, E., Kieβling, T.R., Klüver, N., Scholz, S. (2022):
Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test
Arch. Toxicol. 96 (5), 1353 - 1369 10.1007/s00204-022-03253-x - Wilhelmi, P., Giri, V., Henkes, S., Walk, T., Haake, V., Scholz, S., Busch, W., Barenys, M., Zickgraf, F., Landsiedel, R., Funk-Weyer, D., Birk, B., Flick, B. (2022):
A targeted metabolomics approach for unraveling different modes of embryotoxicity in zebrafish
Toxicol. Lett. 368 (Suppl.), S252 - S252 10.1016/j.toxlet.2022.07.671
2021 (8)
- Ambekar, A., Poschen, C., Lai, C., Scholz, S., Teixidó, E. (2021):
Analyzing morphological changes in zebrafish embryos exposed to toxic chemicals
2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Houston, TX, USA, 9-12 December 2021
Institute of Electrical and Electronics Engineers (IEEE), New York, NY, p. 1711 - 1718 10.1109/BIBM52615.2021.9669338 - Bieczynski, F., Burkhardt-Medicke, K., Luquet, C.M., Scholz, S., Luckenbach, T. (2021):
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity
FEBS Lett. 595 (6), 828 - 843 10.1002/1873-3468.14015 - Huhn, S., Escher, B.I., Krauss, M., Scholz, S., Hackermüller, J., Altenburger, R. (2021):
Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive
Environ. Sci. Eur. 33 , art. 17 10.1186/s12302-020-00444-0 - Lee, J., Braun, G., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2021):
Critical membrane concentration and mass-balance model to identify baseline cytotoxicity of hydrophobic and ionizable organic chemicals in mammalian cell lines
Chem. Res. Toxicol. 34 (9), 2100 - 2109 10.1021/acs.chemrestox.1c00182 - Ogungbemi, A.O., Massei, R., Altenburger, R., Scholz, S., Küster, E. (2021):
Assessing combined effects for mixtures of similar and dissimilar acting neuroactive substances on zebrafish embryo movement
Toxics 9 (5), art. 104 10.3390/toxics9050104 - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2021):
Automated measurement of the spontaneous tail coiling of zebrafish embryos as a sensitive behavior endpoint using a workflow in KNIME
MethodsX 8 , art. 101330 10.1016/j.mex.2021.101330 - Paparella, M., Scholz, S., Belanger, S., Braunbeck, T., Bicherel, P., Connors, K., Faßbender, C., Halder, M., Lillicrap, A., Liska, R., Schirmer, K., Stoddart, G., Thomas, P., Walter-Rohde, S. (2021):
Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods
ALTEX-Altern. Anim. Exp. 38 (1), 20 - 32 10.14573/altex.2006051 - Teixidó, E., Klüver, N., Ogungbemi, A.O., Küster, E., Scholz, S. (2021):
Evaluation of neurotoxic effects in zebrafish embryos by automatic measurement of early motor behaviors
In: Llorens, J., Barenys, M. (eds.)
Experimental neurotoxicology methods
Neuromethods 172
Springer Nature, p. 381 - 397 10.1007/978-1-0716-1637-6_17
2020 (5)
- Halbach, K., Ulrich, N., Goss, K.-U., Seiwert, B., Wagner, S., Scholz, S., Luckenbach, T., Bauer, C., Schweiger, N., Reemtsma, T. (2020):
Yolk sac of zebrafish embryos as backpack for chemicals?
Environ. Sci. Technol. 54 (16), 10159 - 10169 10.1021/acs.est.0c02068 - Larras, F., Billoir, E., Scholz, S., Tarkka, M., Wubet, T., Delignette-Muller, M.-L., Schmitt-Jansen, M. (2020):
A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus
J. Hazard. Mater. 397 , art. 122727 10.1016/j.jhazmat.2020.122727 - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2020):
Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®
Neurotoxicol. Teratol. 81 , art. 106918 10.1016/j.ntt.2020.106918 - Teixidó, E., Leuthold, D., de Crozé, N., Léonard, M., Scholz, S. (2020):
Comparative assessment of the sensitivity of fish early‐life stage, Daphnia and algae to the chronic ecotoxicity of xenobiotics – perspectives for alternatives to animal testing
Environ. Toxicol. Chem. 39 (1), 30 - 41 10.1002/etc.4607 - Ulrich, N., Schweiger, N., Pfennigsdorff, A., Scholz, S., Goss, K.-U. (2020):
Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio
Environ. Toxicol. Chem. 39 (8), 1506 - 1516 10.1002/etc.4744
2019 (5)
- Halbach, K., Wagner, S., Scholz, S., Luckenbach, T., Reemtsma, T. (2019):
Elemental imaging (LA-ICP-MS) of zebrafish embryos to study the toxicokinetics of the acetylcholinesterase inhibitor naled
Anal. Bioanal. Chem. 411 (3), 617 - 627 10.1007/s00216-018-1471-2 - Ogungbemi, A., Leuthold, D., Scholz, S., Küster, E. (2019):
Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
Environ. Sci. Eur. 31 , art. 88 10.1186/s12302-019-0270-5 - Perkins, E.J., Ashauer, R., Burgoon, L., Conolly, R., Landesmann, B., Mackay, C., Murphy, C.A., Pollesch, N., Wheeler, J.R., Zupanic, A., Scholz, S. (2019):
Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
Environ. Toxicol. Chem. 38 (9), 1850 - 1865 10.1002/etc.4505 - Philipp, K., Lemke, F., Scholz, S., Wallrabe, U., Wapler, M.C., Koukourakis, N., Czarske, J.W. (2019):
Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens
Sci. Rep. 9 , art. 9532 10.1038/s41598-019-45993-4 - Teixidó, E., Kießling, T.R., Krupp, E., Quevedo, C., Muriana, A., Scholz, S. (2019):
Automated morphological feature assessment for zebrafish embryo developmental toxicity screens
Toxicol. Sci. 167 (2), 438 - 449 10.1093/toxsci/kfy250
2018 (9)
- Birke, A., Scholz, S. (2018):
Zebrafish embryo and acute fish toxicity test show similar sensitivity for narcotic compounds
ALTEX-Altern. Anim. Exp. 36 (1), 131 - 135 10.14573/altex.1808101 - Fischer, F.C., Abele, C., Droge, S.T.J., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2018):
Cellular uptake kinetics of neutral and charged chemicals in in vitro assays measured by fluorescence microscopy
Chem. Res. Toxicol. 31 (8), 646 - 657 10.1021/acs.chemrestox.8b00019 - Jarque, S., Fetter, E., Veneman, W.J., Spaink, H.P., Peravali, R., Strähle, U., Scholz, S. (2018):
An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
PLOS One 13 (8), e0203087 10.1371/journal.pone.0203087 - Larras, F., Billoir, E., Baillard, V., Siberchicot, A., Scholz, S., Wubet, T., Tarkka, M., Schmitt-Jansen, M., Delignette-Muller, M.-L. (2018):
DRomics: A turnkey tool to support the use of the dose–response framework for omics data in ecological risk assessment
Environ. Sci. Technol. 52 (24), 14461 - 14468 10.1021/acs.est.8b04752 - Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
An ecotoxicological view on neurotoxicity assessment
Environ. Sci. Eur. 30 , art. 46 10.1186/s12302-018-0173-x - Scholz, S., Schreiber, R., Armitage, J., Mayer, P., Escher, B.I., Lidzba, A., Léonard, M., Altenburger, R. (2018):
Meta‐analysis of fish early life stage tests—Association of toxic ratios and acute‐to‐chronic ratios with modes of action
Environ. Toxicol. Chem. 37 (4), 955 - 969 10.1002/etc.4090 - Sobanska, M., Scholz, S., Nyman, A.-M., Cesnaitis, R., Gutierrez Alonso, S., Klüver, N., Kühne, R., Tyle, H., de Knecht, J., Dang, Z., Lundbergh, I., Carlon, C., De Coen, W. (2018):
Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)
Environ. Toxicol. Chem. 37 (3), 657 - 670 10.1002/etc.4055 - Teixido, E., Kerkhof, O., Kießling, T., Scholz, S. (2018):
Retrieving mode of action information by automated effect pattern analysis using the zebrafish embryo toxicity test
Reprod. Toxicol. 80 , 18 - 19 10.1016/j.reprotox.2018.06.074 - Teixidó, E., Krupp, E., Amberg, A., Czich, A., Scholz, S. (2018):
Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches
Reprod. Toxicol. 76 , 93 - 102 10.1016/j.reprotox.2018.01.005
2017 (3)
- Andrade, T.S., Henriques, J.F., Almeida, A.R., Soares, A.M.V.M., Scholz, S., Dominigues, I. (2017):
Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV-light irradiation
Environ. Toxicol. Chem. 36 (3), 682 - 690 10.1002/etc.3579 - Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106 10.1016/j.envint.2016.11.029 - Teixido, E., Kießling, T., Leuthold, D., Scholz, S. (2017):
Effect signatures in zebrafish embryos exposed to compounds with potential developmental toxicity
Reprod. Toxicol. 72 , 49 10.1016/j.reprotox.2017.06.179
2016 (6)
- Klüver, N., Vogs, C., Altenburger, R., Escher, B.I., Scholz, S. (2016):
Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test
Chemosphere 164 , 164 - 173 10.1016/j.chemosphere.2016.08.079 - Scholz, S., Jarque, S., Fetter, E. (2016):
A fully automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
Reprod. Toxicol. 64 (Special Issue), 30 10.1016/j.reprotox.2016.06.064 - Scholz, S., Klüver, N., Kühne, R. (2016):
Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. Report ECHA-UFZ contract ECHA/2014/341
Helmholtz Centre for Environmental Research - UFZ, Leipzig, 104 pp. - Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016):
Zebrafish biosensor for toxicant induced muscle hyperactivity
Sci. Rep. 6 , art. 23768 10.1038/srep23768 - Teixidó, E., Leuthold, D., Amberg, A., Czich, A., Krupp, E., Scholz, S. (2016):
ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA)
Reprod. Toxicol. 64 , 22 10.1016/j.reprotox.2016.06.048 - Teixidó, E., Leuthold, D., Scholz, S., Quevedo, C., Muriana, A., Czich, A., Krupp, E. (2016):
An inter-laboratory validation of the zebrafish embryo assay for the detection of developmental toxicity
Reprod. Toxicol. 64 , 44 10.1016/j.reprotox.2016.06.096
2015 (8)
- Fetter, E., Baldauf, L., Da Fonte, D.F., Ortmann, J., Scholz, S. (2015):
Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos
Reprod. Toxicol. 57 , 10 - 20 10.1016/j.reprotox.2015.04.012 - Fetter, E., Smetanová, S., Baldauf, L., Lidzba, A., Altenburger, R., Schüttler, A., Scholz, S. (2015):
Identification and characterization of androgen-responsive genes in zebrafish embryos
Environ. Sci. Technol. 49 (19), 11789 - 11798 10.1021/acs.est.5b01034 - Hernández, R.B., Nishita, M.I., Espósito, B.P., Scholz, S., Michalke, B. (2015):
The role of chemical speciation, chemical fractionation and calcium disruption in manganese-induced developmental toxicity in zebrafish (Danio rerio) embryos
J. Trace Elem. Med. Biol. 32 , 209 - 217 10.1016/j.jtemb.2015.07.004 - Jonas, A., Scholz, S., Fetter, E., Sychrova, E., Novakova, K., Ortmann, J., Benisek, M., Adamovsky, O., Giesy, J.P., Hilscherova, K. (2015):
Endocrine, teratogenic and neurotoxic effects of cyanobacteria detected by cellular in vitro and zebrafish embryos assays
Chemosphere 120 , 321 - 327 10.1016/j.chemosphere.2014.07.074 - Klüver, N., König, M., Ortmann, J., Massei, R., Paschke, A., Kühne, R., Scholz, S. (2015):
Fish embryo toxicity test: Identification of compounds with weak toxicity and analysis of behavioral effects to improve prediction of acute toxicity for neurotoxic compounds
Environ. Sci. Technol. 49 (11), 7002 - 7011 10.1021/acs.est.5b01910 - Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
What determines chemical uptake by the zebrafish embryo model?
Toxicol. Lett. 238 (2, Suppl.), S54 10.1016/j.toxlet.2015.08.151 - Massei, R., Vogs, C., Renner, P., Altenburger, R., Scholz, S. (2015):
Differential sensitivity in embryonic stages of the zebrafish (Danio rerio): The role of toxicokinetics for stage-specific susceptibility for azinphos-methyl lethal effects
Aquat. Toxicol. 166 , 36 - 41 10.1016/j.aquatox.2015.06.011 - Scholz, S. (2015):
In response: Quantitative adverse outcome pathways for prediction of adverse effects—An academic perspective
Environ. Toxicol. Chem. 34 (9), 1935 - 1937 10.1002/etc.3043
Index:
You could use our publication index for further requests.
2014 (7)
- Busquet, F., Strecker, R., Rawlings, J.M., Belanger, S.E., Braunbeck, T., Carr, G.J., Cenijn, P., Fochtman, P., Gourmelon, A., Hübler, N., Kleensang, A., Knöbel, M., Kussatz, C., Legler, J., Lillicrap, A., Martínez-Jerónimo, F., Polleichtner, C., Rzodeczko, H., Salinas, E., Schneider, K.E., Scholz, S., van den Brandhof, E.-J., van der Ven, L.T.M., Walter-Rohde, S., Weigt, S., Witters, H., Halder, M. (2014):
OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing
Regul. Toxicol. Pharmacol. 69 (3), 496 - 511 10.1016/j.yrtph.2014.05.018 - Escher, B.I., Allinson, M., Altenburger, R., Bain, P.A., Balaguer, P., Busch, W., Crago, J., Denslow, N.D., Dopp, E., Hilscherova, K., Humpage, A.R., Kumar, A., Grimaldi, M., Jayasinghe, B.S., Jarosova, B., Jia, A., Makarov, S., Maruya, K.A., Medvedev, A., Mehinto, A.C., Mendez, J.E., Poulsen, A., Prochazka, E., Richard, J., Schifferli, A., Schlenk, D., Scholz, S., Shiraishi, F., Snyder, S., Su, G., Tang, J.Y.M., van der Burg, B., van der Linden, S.C., Werner, I., Westerheide, S.D., Wong, C.K.C., Yang, M., Yeung, B.H.Y., Zhang, X., Leusch, F.D.L. (2014):
Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays
Environ. Sci. Technol. 48 (3), 1940 - 1956 10.1021/es403899t - Fetter, E., Krauss, M., Brion, F., Kah, O., Scholz, S., Brack, W. (2014):
Effect-directed analysis for estrogenic compounds in a fluvial sediment sample using transgenic cyp19a1b-GFP zebrafish embryos
Aquat. Toxicol. 154 , 221 - 229 10.1016/j.aquatox.2014.05.016 - Jonas, A., Buranova, V., Scholz, S., Fetter, E., Novakova, K., Kohoutek, J., Hilscherova, K. (2014):
Retinoid-like activity and teratogenic effects of cyanobacterial exudates
Aquat. Toxicol. 155 , 283 - 293 10.1016/j.aquatox.2014.06.022 - Klüver, N., Ortmann, J., Paschke, H., Renner, P., Ritter, A.P., Scholz, S. (2014):
Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos
PLOS One 9 (3), e90619 10.1371/journal.pone.0090619 - Scholz, S., Ortmann, J., Klüver, N., Léonard, M. (2014):
Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories
Regul. Toxicol. Pharmacol. 69 (3), 572 - 579 10.1016/j.yrtph.2014.06.004 - Tollefsen, K.E., Scholz, S., Cronin, M.T., Edwards, S.W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A., Patlewicz, G. (2014):
Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)
Regul. Toxicol. Pharmacol. 70 (3), 629 - 640 10.1016/j.yrtph.2014.09.009
2013 (4)
- Petersen, K., Fetter, E., Kah, O., Brion, F., Scholz, S., Tollefsen, K.E. (2013):
Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals
Aquat. Toxicol. 138-139 , 88 - 97 10.1016/j.aquatox.2013.05.001 - Scholz, S. (2013):
Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity
Arch. Toxicol. 87 (5), 767 - 769 10.1007/s00204-013-1044-2 - Scholz, S., Renner, P., Belanger, S.E., Busquet, F., Davi, R., Demeneix, B.A., Denny, J.S., Léonard, M., McMaster, M.E., Villeneuve, D.L., Embry, M.R. (2013):
Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians – screening for estrogen, androgen and thyroid hormone disruption
Crit. Rev. Toxicol. 43 (1), 45 - 70 10.3109/10408444.2012.737762 - Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013):
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Regul. Toxicol. Pharmacol. 67 (3), 506 - 530 10.1016/j.yrtph.2013.10.003
2012 (5)
- Altenburger, R., Scholz, S., Schmitt-Jansen, M., Busch, W., Escher, B.I. (2012):
Mixture toxicity revisited from a toxicogenomic perspective
Environ. Sci. Technol. 46 (5), 2508 - 2522 10.1021/es2038036 - Büttner, A., Busch, W., Klüver, N., Giannis, A., Scholz, S. (2012):
Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine
Reprod. Toxicol. 33 (2), 254 - 263 10.1016/j.reprotox.2011.12.010 - Knöbel, M., Busser, F.J.M., Rico-Rico, A., Kramer, N.I., Hermens, J.L.M., Hafner, C., Tanneberger, K., Schirmer, K., Scholz, S. (2012):
Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
Environ. Sci. Technol. 46 (17), 9690 - 9700 10.1021/es301729q - Scholz, S. (2012):
Special issue: zebrafish teratogenesis
Reprod. Toxicol. 33 (2), 127 - 127 10.1016/j.reprotox.2012.01.008 - Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., Braunbeck, T. (2012):
Zebrafish embryos as an alternative to animal experiments - a commentary on the definition of the onset of protected life stages in animal welfare regulations
Reprod. Toxicol. 33 (2), 128 - 132 10.1016/j.reprotox.2011.06.121
2011 (7)
- Busch, W., Duis, K., Fenske, M., Maack, G., Legler, J., Padilla, S., Strähle, U., Witters, H., Scholz, S. (2011):
The zebrafish embryo model in toxicology and teratology, September 2-3, 2010, Karlsruhe, Germany
Reprod. Toxicol. 31 (4), 585 - 588 10.1016/j.reprotox.2011.02.010 - dos Anjos, N.A., Schulze, T., Brack, W., Val, A.L., Schirmer, K., Scholz, S. (2011):
Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems
Aquat. Toxicol. 103 (1-2), 46 - 52 10.1016//j.aquatoc.2011.02.004 - Georgi, A., Mackenzie, K., Scholz, S., Potthoff, A., Springer, A. (2011):
Eisenbasierte Nanopartikel und Nanokompositstrukturen zur Schadstoffentfernung aus Grund- und Abwässern
WING.DE 2011 – Tagungsband : Werkstoffe gestalten Zukunft, 4.-6. Oktober 2011 Berlin
Bundesministerium für Bildung und Forschung (BMBF), Berlin, S. 86 - 88 - Klüver, N., Yang, L., Busch, W., Scheffler, K., Scheffler, P., Strähle, U., Scholz, S. (2011):
Transcriptional response of zebrafish embryos exposed to neurotoxic compounds reveals a muscle activity dependent hspb11 expression
PLoS One 6 (12), e29063 10.1371/journal.pone.0029063 - Scholz, S., Büttner, A., Klüver, N., Guinea, J. (2011):
Fish embryos as alternative models for drug safety evaluation
In: Xu, J.J., Urban, L. (eds.)
Predictive toxicology in drug safety
Cambridge University Press, New York, p. 244 - 268 10.1017/CBO9780511779053.015 - Siegert, F., Erdmann, F., Schwan, G., Scholz, S., Briel, D., Altenburger, R., Nieber, K. (2011):
Pharmacological and cytotoxic effects of new selective PDE10A ligands
Naunyn-Schmiedebergs Arch. Pharmacol. 383 (Suppl. 1), 21 - 21 10.1007/s00210-011-0617-y - Volz, D.C., Belanger, S., Embry, M., Padilla, S., Sanderson, H., Schirmer, K., Scholz, S., Villeneuve, D. (2011):
Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies
Toxicol. Sci. 123 (3), 349 - 358 10.1093/toxsci/kfr185
2010 (2)
- Busch, W., Kühnel, D., Schirmer, K., Scholz, S. (2010):
Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
BMC Genomics 11 , art. 65 10.1186/1471-2164-11-65 - Scholz, S., Schirmer, K., Altenburger, R. (2010):
Pharmaceutical contaminants in urban water cycles - a discussion of novel concepts for environmental risk assessment
In: Fatta-Kassinos, D., Bester, K., Kümmerer, K. (eds.)
Xenobiotics in the urban water cycle: mass flows, environmental processes and mitigation strategies
Environ. Pollut. 16
Springer, Heidelberg, p. 227 - 244 10.1007/978-90-481-3509-7
2009 (8)
- Bastian, S., Busch, W., Kühnel, D., Springer, A., Meißner, T., Holke, R., Scholz, S., Iwe, M., Pompe, W., Gelinsky, M., Potthoff, A., Richter, V., Ikonomidou, H., Schirmer, K. (2009):
Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
Environ. Health Perspect. 117 (4), 530 - 536 10.1289/ehp.0800121 - Busch, W., Kühnel, D., Springer, A., Meissner, T., Gelinsky, M., Potthoff, A., Scholz, S., Richter, V., Schirmer, K. (2009):
Tungsten carbide and tungsten carbide cobalt nanoparticle toxicity: The role of cellular particle uptake, leached ions and cobalt bioavailability
Toxicol. Lett. 189 (Suppl. 1), S185 - S185 10.1016/j.toxlet.2009.06.645 - Büttner, A., Seifert, K., Cottin, T., Sarli, V., Tzagkaroulaki, L., Scholz, S., Giannis, A. (2009):
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
Bioorg. Med. Chem. 17 (14), 4943 - 4954 10.1016/j.bmc.2009.06.008 - Klüver, N., Scheffler, K., Renner, P., Scholz, S. (2009):
Toxicogenomic response of azinphos-methyl treated zebrafish embryos and implication for the development of predictive models for chronic (fish) toxicity
Toxicol. Lett. 189 (Suppl. 1), S94 - S94 10.1016/j.toxlet.2009.06.284 - Kühnel, D., Busch, W., Meissner, T., Springer, A., Potthoff, A., Richter, V., Gelinsky, M., Scholz, S., Schirmer, K. (2009):
Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line
Aquat. Toxicol. 93 (2-3), 91 - 99 10.1016/j.aquatox.2009.04.003 - Scholz, S., Klüver, N. (2009):
Effects of endocrine disrupters on sexual, gonadal development in fish
Sex. Dev. 3 (2-3), 136 - 151 10.1159/000223078 - Scholz, S., Knöbel, M., Ortmann, J., Busser, F., Kramer, N., Hermens, J., Tanneberger, K., Schirmer, K. (2009):
The fish embryo test as an alternative to acute fish toxicity testing: Optimisation for difficult compounds and role of metabolic activation
Toxicol. Lett. 189 (Suppl. 1), S205 - S205 10.1016/j.toxlet.2009.06.620 - Weil, M., Scholz, S., Zimmer, M., Sacher, F., Duis, K. (2009):
Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the early life stage test
Environ. Toxicol. Chem. 28 (9), 1970 - 1978 10.1897/08-627.1
Index:
You could use our publication index for further requests.
2008 (5)
- Richter, V., Potthoff, A., Pompe, W., Gelinsky, M., Ikonomidou, H., Bastian, S., Schirmer, K., Scholz, S., Hofinger, J. (2008):
Evaluation of health risks of nano- and microparticles
Powder Metall. 51 (1), 8 - 9 10.1179/174329008X286640 - Schirmer, K., Tanneberger, K., Kramer, N.I., Völker, D., Scholz, S., Hafner, C., Lee, L.E.J., Bols, N.C., Hermens, J.L.M. (2008):
Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
Aquat. Toxicol. 90 (2), 128 - 137 10.1016/j.aquatox.2008.08.005 - Scholz, S., Fischer, S., Gündel, U., Küster, E., Luckenbach, T., Voelker, D. (2008):
The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
Environ. Sci. Pollut. Res. 15 (5), 394 - 404 10.1007/s11356-008-0018-z - Scholz, S., Mayer, I. (2008):
Molecular biomarkers of endocrine disruption in small model fish
Mol. Cell. Endocrinol. 293 (1-2), 57 - 70 10.1016/j.mce.2008.06.008 - Voelker, D., Stetefeld, N., Schirmer, K., Scholz, S. (2008):
The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos
Aquat. Toxicol. 86 (1), 112 - 120 10.1016/j.aquatox.2007.10.007
2007 (3)
- Voelker, D., Veß, C., Tillmann, M., Nagel, R., Otto, G.W., Geisler, R., Schirmer, K., Scholz, S. (2007):
Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae
Aquat. Toxicol. 81 (4), 355 - 364 10.1016/j.aquatox.2006.12.013 - Völker, D., Veß, C., Schirmer, K., Scholz, S. (2007):
Gen-DarT- ein Vorhersagemodell für die chronische Toxizität durch Analyse veränderter Genexpression in Embryonen des Zebrabärblings (Danio rerio)?
Mitt Umweltchem Ökotox 13 (4), 91 - 94 - Watzke, J., Schirmer, K., Scholz, S. (2007):
Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio)
Fish Shellfish Immunol. 23 (4), 901 - 905 10.1016/j.fsi.2007.03.004
2005 (2)
- Scholz, S., Kurauchi, K., Kinoshita, M., Oshima, Y., Ozato, K., Schirmer, K., Wakamatsu, Y. (2005):
Analysis of estrogenic effects by quantification of green flourescent protein in juvenile fish of a transgenic medaka
Environ. Toxicol. Chem. 24 (10), 2553 - 2561 10.1897/04-525R.1 - Zierau, O., Hamann, J., Tischer, S., Schwab, P., Metz, P., Vollmer, G., Gutzeit, H.O., Scholz, S. (2005):
Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
Biochem. Biophys. Res. Commun. 326 (4), 909 - 916 10.1016/j.bbrc.2004.11.124
2004 (2)
- Scholz, S., Domaschke, H., Kanamori, A., Ostermann, K., Rödel, G., Gutzeit, H.O. (2004):
Germ cell-less expression in Medaka (Oryzias latipes)
Mol. Reprod. Dev. 67 (1), 15 - 18 10.1002/mrd.20012 - Scholz, S., Kordes, C., Hamann, J., Gutzeit, H.O. (2004):
Induction of vitellogenin in vivo and in vitro in the model teleost medaka (Oryzias latipes): comparison of gene expression and protein levels
Mar. Environ. Res. 57 (3), 235 - 244 10.1016/s0141-1136(03)00082-5
2003 (1)
- Scholz, S., Rösler, S., Schäffer, M., Hornung, U., Schartl, M., Gutzeit, H.O. (2003):
Hormonal induction and stability of monosex populations in the medaka (Oryzias latipes): expression of sex-specific marker genes
Biol. Reprod. 69 (2), 673 - 678 10.1095/biolreprod.103.016873
2000 (1)
- Scholz, S., Gutzeit, H.O. (2000):
17-α-ethinylestradiol affects reproduction, sexual differentiation and aromatase gene expression of the medaka (Oryzias latipes)
Aquat. Toxicol. 50 (4), 363 - 373 10.1016/S0166-445X(00)00090-4
1999 (1)
- Scholz, S., Segner, H. (1999):
Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: concentration-response relationships for four model substances
Ecotox. Environ. Safe. 43 (3), 252 - 260 10.1006/eesa.1999.1786
1998 (1)
- Scholz, S., Braunbeck, T., Segner, H. (1998):
Viability and differential function of rainbow trout liver cells in primary culture: Coculture with two permanent fish cells
In Vitro Cell. Dev. Biol.-Anim. 34 (10), 762 - 771 10.1007/s11626-998-0030-0
1997 (1)
- Scholz, S., Behn, I., Honeck, H., Hauck, C., Braunbeck, T., Segner, H. (1997):
Development of a monoclonal antibody for ELISA of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes
Biomarkers 2 (5), 287 - 294 10.1080/135475097231517
1996 (2)
- Braunbeck, T., Hauck, C., Scholz, S., Segner, H. (1996):
Mixed function oxygenases in cultured fish cells: contributions of in vitro studies to the understanding of MFO induction
Z. Angew. Zool. 81 (1), 55 - 72 - Scholz, S. (1996):
Induktion von CYP1A1 durch Xenobiotica in Leberzellkulturen von Regenbogenforellen
UFZ-Bericht 13/1996
UFZ Leipzig-Halle GmbH, Leipzig, 105 S.