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Title (Primary) Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches
Author Teixidó, E.; Krupp, E.; Amberg, A.; Czich, A.; Scholz, S.
Journal Reproductive Toxicology
Year 2018
Department BIOTOX
Volume 76
Page From 93
Page To 102
Language englisch
Keywords Embryo-fetal developmental toxicity; Database; Alternative methods; Cross-species analysis
UFZ wide themes RU3;
Abstract For regulatory information requirements, developmental toxicity testing is often conducted in two mammalian species. In order to provide a set of reference compounds that could be used to explore alternative approaches to supersede testing in a second species, a retrospective data analysis was conducted. The aim was to identify compounds for which species sensitivity differences between rats and rabbits are not caused by maternal toxicity or toxicokinetic differences. A total of 330 compounds were analysed and classified according to their species-specific differences. A lack of concordance between rat and rabbit was observed in 24% of the compounds, of which 10% were found to be selective developmental toxicants in one of the species. In contrast to previously published analyses the presented comparison is based entirely on publically data allowing validating and comparing alternative approaches for developmental toxicity testing. Furthermore, this list could be useful to identify mechanisms leading to species differences.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19906
Teixidó, E., Krupp, E., Amberg, A., Czich, A., Scholz, S. (2018):
Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches
Reprod. Toxicol. 76 , 93 - 102