Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1002/etc.4744 |
Licence  |
|
| Title (Primary) | Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio |
| Author | Ulrich, N.; Schweiger, N.; Pfennigsdorff, A.; Scholz, S.
; Goss, K.-U. |
| Source Titel | Environmental Toxicology and Chemistry |
| Year | 2020 |
| Department | BIOTOX; AUC |
| Volume | 39 |
| Issue | 8 |
| Page From | 1506 |
| Page To | 1516 |
| Language | englisch |
| Supplements | Supplement 1 |
| Keywords | Zebrafish embryo; Danio rerio; Yolk‐water partitioning; Linear free energy relationships (pp‐LFER) |
| Abstract | Yolk is the most important temporary biological compartment of the early life stages of the fish embryos. The sorption strength of a chemical to yolk components may significantly influence the distribution of that chemical in the fish embryo. We determined yolk/water partition coefficients (Kyolk/water in Lwater/kgyolk, normalized to dry weight) for 70 neutral organic chemicals. The log Kyolk/water values cover a range from 0.76 to 6.56. On basis of these values we developed polyparameter linear free energy relationship (pp‐LFER) models to predict yolk/water partitioning for a broad range of neutral organic chemicals with a rmse of 0.37 and a r² of 0.919. These models can be applied for the prediction of internal concentrations at equilibrium (neglecting biotransformation and active transport) in the zebrafish embryo test system. |
| Ulrich, N., Schweiger, N., Pfennigsdorff, A., Scholz, S., Goss, K.-U. (2020): Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio Environ. Toxicol. Chem. 39 (8), 1506 - 1516 10.1002/etc.4744 |
|