Sebastian Gutsfeld

Postion: PhD student
Molecular Toxicology Group
Sebastian Gutsfeld
Photo: Sebastian Wiedling


Permoserstr. 15
04318 Leipzig

Building: 6.1
Room: 802
Phone: +49 341 6025 2869

Sebastian Gutsfeld

Research Interests

  • The main focus of my research is to understand how Per- and polyfluoroalkyl substances (PFAS), some of which are known as „forever“-chemicals because of their persistence in the environment disrupt neurodevelopment.
  • In one project, I use a combination of automated behavior tests and gene editing (CRISPR/Cas9) to study the mechanism(s) by which exposure to certain PFAS cause hyperactivity in larval zebrafish.
  • My second project focuses on understanding chemical-microbiome interactions that influence host neurodevelopment.
  • I investigate possible mechanisms by which microbial colonization (e.g. of the gut) affects neurobehavioral programming and how PFAS-microbiome interactions potentially cause developmental neurotoxicity in the host zebrafish.

Curriculum Vitae

Since 12/2020

PhD student within MibiTox PhD college at Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany


Research Associate at University of Applied Sciences Aschaffenburg and Martin-Luther-University Halle-Wittenberg

Development of a Human induced-pluripotent stemcell based (hiPSC) neuronal 3D-cell culture model as a functional in vitro test system


M.Sc. Thesis at Alfred-Wegener-Institute, Helmholtz-Centre for Polar and Marine Research - AWI, Bremerhaven, Germany, Department of Integrative Ecophysiology

Title: „Validation and quantification of cardiac parameters obtained by cine MR imaging in the edible crab Cancer pagurus“

2015 - 2018

M.Sc. in Technical Biology, Technical University Darmstadt, Germany

2012 - 2015

B.Sc. in Biology, Technical University Darmstadt, Germany

B.Sc. Thesis: "Morphological adaptations to the ptychoid defensive mechanism in Euphthiracarus cribrarius (Acari, Oribatida)"

Awards/Grants/other Activities


Best PhD Student Platform Presentation Award of the European Zebrafish Society


First place, Carl C. Smith Graduate Student Award, Mechanisms Specialty Section, Society of Toxicology


Toshio Narahashi Neurotoxicology Specialty Section Trainee Conference Endowment Award, Society of Toxicology


Best Poster: Human induced-pluripotent stemcell based (hiPSC) neuronal 3D-cell culture as functional in vitro testsystems; 6th Research Day of University Medicine Halle (Saale)