Sebastian Gutsfeld

Postion: PhD student
Molecular Toxicology Group
Sebastian Gutsfeld
Photo: Sebastian Wiedling

Address:

Permoserstr. 15
04318 Leipzig
Germany

Building: 6.1
Room: 802
Phone: +49 341 6025 2869

Sebastian Gutsfeld

Research Interests

  • The main focus of my research is to understand how Per- and polyfluoroalkyl substances (PFAS), some of which are known as „forever“-chemicals because of their persistence in the environment disrupt neurodevelopment.
  • In one project, I use a combination of automated behavior tests and gene editing (CRISPR/Cas9) to study the mechanism(s) by which exposure to certain PFAS cause hyperactivity in larval zebrafish.
  • My second project focuses on understanding chemical-microbiome interactions that influence host neurodevelopment.
  • I investigate possible mechanisms by which microbial colonization (e.g. of the gut) affects neurobehavioral programming and how PFAS-microbiome interactions potentially cause developmental neurotoxicity in the host zebrafish.

Curriculum Vitae

Since 12/2020

PhD student within MibiTox PhD college at Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany

04/2019–11/2020

Research Associate at University of Applied Sciences Aschaffenburg and Martin-Luther-University Halle-Wittenberg

Development of a Human induced-pluripotent stemcell based (hiPSC) neuronal 3D-cell culture model as a functional in vitro test system

10/2018

M.Sc. Thesis at Alfred-Wegener-Institute, Helmholtz-Centre for Polar and Marine Research - AWI, Bremerhaven, Germany, Department of Integrative Ecophysiology

Title: „Validation and quantification of cardiac parameters obtained by cine MR imaging in the edible crab Cancer pagurus“

2015 - 2018

M.Sc. in Technical Biology, Technical University Darmstadt, Germany

2012 - 2015

B.Sc. in Biology, Technical University Darmstadt, Germany

B.Sc. Thesis: "Morphological adaptations to the ptychoid defensive mechanism in Euphthiracarus cribrarius (Acari, Oribatida)"

Awards/Grants/other Activities

07/2023

Best PhD Student Platform Presentation Award of the European Zebrafish Society

03/2023

First place, Carl C. Smith Graduate Student Award, Mechanisms Specialty Section, Society of Toxicology

03/2023

Toshio Narahashi Neurotoxicology Specialty Section Trainee Conference Endowment Award, Society of Toxicology

12/2019

Best Poster: Human induced-pluripotent stemcell based (hiPSC) neuronal 3D-cell culture as functional in vitro testsystems; 6th Research Day of University Medicine Halle (Saale)