Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.neuro.2019.11.008
Document accepted manuscript
Title (Primary) Exploring interactions between xenobiotics, microbiota, and neurotoxicity in zebrafish
Author Bertotto, L.B.; Catron, T.R.; Tal, T.
Source Titel NeuroToxicology
Year 2020
Department BIOTOX
Volume 76
Page From 235
Page To 244
Language englisch
Keywords Microbiome; Zebrafish; Developmental neurotoxicity
Abstract Susceptibility to xenobiotic exposures is variable. One factor that might account for this is the microbiome, which encompasses all microorganisms, their encoded genes, and associated functions that colonize a host organism. Microbiota harbor the capacity to affect the toxicokinetics and toxicodynamics of xenobiotic exposures. The neurotoxicological effects of environmental chemicals may be modified by intestinal microbes via the microbiota-gut-brain axis. This is a complex, bi-directional signaling pathway between intestinal microbes and the host nervous system. As a model organism, zebrafish are extremely well-placed to illuminate mechanisms by which microbiota modify the developmental neurotoxicity of environmental chemicals. The goal of this review article is to examine the microbiota-gut-brain axis in a toxicological context, specifically focusing on the strengths and weaknesses of the zebrafish model for the investigation of interactions between xenobiotic agents and host-associated microbes. Previous studies describing the relationship between intestinal microbes and host neurodevelopment will be discussed. From a neurotoxicological perspective, studies utilizing zebrafish to assess links between neurotoxicological outcomes and the microbiome are emphasized. Overall, there are major gaps in our understanding the mechanisms by which microbiota interact with xenobiotics to cause or modify host neurotoxicity. In this review, we demonstrate that zebrafish are an ideal model system for studying the complex relationship between chemical exposures, microorganisms, and host neurotoxicological outcomes.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=22721
Bertotto, L.B., Catron, T.R., Tal, T. (2020):
Exploring interactions between xenobiotics, microbiota, and neurotoxicity in zebrafish
NeuroToxicology 76 , 235 - 244 10.1016/j.neuro.2019.11.008