My research project focuses on evaluating the viability of adverse outcome pathway (AOP)-based approaches for predicting prenatal developmental toxicity using the zebrafish model. Specifically, I investigate AOPs centered around changes in retinoic acid concentration as a key event aiming to establish causal links between observed developmental effects and molecular initial events. Moreover, I am interested in the internal concentrations of chemicals in zebrafish and modeling their toxicokinetic (TK) and toxicodynamic (TD) processes. By integrating these insights, I expect to develop a novel, cutting-edge physiologically based TKTD -AOP model. This model will bridge time-course chemical concentrations with key biological events, offering a robust framework for predicting developmental toxicity and advancing mechanistic toxicology.