Dr. David Leuthold
Address:
Permoserstr. 15
04318 Leipzig
Germany
Building: 6.0
Room: 519
Phone: +49 341 6025 1521
Research Interests
- Understanding toxicity mechanisms of environmental chemicals and mixtures
- Development and application of novel behavior-based assays in embryo-larval stages of zebrafish (Danio rerio) and state-of-the-art genetic engineering approaches including CRISPR/Cas9 gene editing
Curriculum Vitae
Since 07/2019
Postdoctoral Researcher, Department Bioanalytical Ecotoxicology, Molecular Toxicology Group, Helmholtz-Centre for Environmental Research – UFZ, Leipzig
07/2016 - 06/2019
PhD student, Faculty of Mathematics, Computer Science and Natural Sciences, Department of Biology, RWTH Aachen University and Department Bioanalytical Ecotoxicology, Helmholtz-Centre for Environmental Research – UFZ, Leipzig
PhD thesis: “Zebrafish locomotor activity as a sensitive effect-based tool for the assessment of environmental chemicals and mixtures”
05/2016 - 06/2016
Research assistant, Szent-István-University, Gödöllő, Hungary
11/2015 - 06/2016
Research assistant, Department Bioanalytical Ecotoxicology, Helmholtz-Centre for Environmental Research – UFZ, Leipzig
10/2009 - 10/2015
Student, Applied Natural Science, focus on Environmental Science and Biotechnology, Faculty of Chemistry and Physics, Institute for Biosciences, Technical University Bergakademie Freiberg
Master thesis: “Sublethal effect profile of selected acetylcholinesterase inhibitors in the early developmental phase of zebrafish (Danio rerio)”
Bachelor thesis: „An investigation into the influence of selected electron donors on the population structure and sulfate reduction rate in fixed-bed column reactors”
Awards/Grants
03/2022
Molecular and Systems Biology Specialty Section Postdoctoral Scholar Research Award - 1st place - Society of Toxicology (SOT), USA
03/2022
Neurotoxicology Specialty Section Toshio Narahashi Best Postdoctoral Poster Presentation Award - 2nd place - Society of Toxicology (SOT), USA
03/2022
Mechanisms Specialty Section Gabriel L. Plaa Education Award - 2nd place - Society of Toxicology (SOT), USA
03/2022
Neurotoxicology Specialty Section Toshio Narahashi Best Postdoctoral Abstract Award - 1st place - Society of Toxicology (SOT), USA
03/2022
Mechanisms Specialty Section Sheldon D. Murphy Postdoctoral Endowment Award - 1st place - Society of Toxicology (SOT), USA
12/2021
UFZ Young Scientist Award for Applied Research
07/2017 - 06/2019
Full PhD scholarship; German Federal Environmental Foundation (Deutsche Bundesstiftung Umwelt DBU)
Publications
2022 (1)
- Scholz, S., Nichols, J.W., Escher, B.I., Ankley, G.T., Altenburger, R., Blackwell, B., Brack, W., Burkhard, L., Collette, T.W., Doering, J.A., Ekman, D., Fay, K., Fischer, F., Hackermüller, J., Hoffman, J.C., Lai, C., Leuthold, D., Martinovic-Weigelt, D., Reemtsma, T., Pollesch, N., Schroeder, A., Schüürmann, G., von Bergen, M. (2022):
The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45 10.1002/etc.5242
2021 (1)
- Schüttler, A., Jakobs, G., Fix, J.M., Krauss, M., Krüger, J., Leuthold, D., Altenburger, R., Busch, W. (2021):
Transcriptome-wide prediction and measurement of combined effects induced by chemical mixture exposure in zebrafish embryos
Environ. Health Perspect. 129 (4), art. 047006 10.1289/EHP7773
2020 (2)
- Leuthold, D. (2020):
Zebrafish locomotor activity as a sensitive effect-based tool for the assessment of environmental chemicals and mixtures
Dissertation, Rheinisch-Westfälische Technische Hochschule (RWTH), Fakultät für Mathematik, Informatik und Naturwissenschaften
PhD Dissertation 04/2020
Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig, xxiv, 156 pp. - Teixidó, E., Leuthold, D., de Crozé, N., Léonard, M., Scholz, S. (2020):
Comparative assessment of the sensitivity of fish early‐life stage, Daphnia and algae to the chronic ecotoxicity of xenobiotics – perspectives for alternatives to animal testing
Environ. Toxicol. Chem. 39 (1), 30 - 41 10.1002/etc.4607
2019 (2)
- Leuthold, D., Klüver, N., Altenburger, R., Busch, W. (2019):
Can environmentally relevant neuroactive chemicals specifically be detected with the locomotor response test in zebrafish embryos?
Environ. Sci. Technol. 53 (1), 482 - 493 10.1021/acs.est.8b04327 - Ogungbemi, A., Leuthold, D., Scholz, S., Küster, E. (2019):
Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
Environ. Sci. Eur. 31 , art. 88 10.1186/s12302-019-0270-5
2018 (1)
- Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
An ecotoxicological view on neurotoxicity assessment
Environ. Sci. Eur. 30 , art. 46 10.1186/s12302-018-0173-x
2017 (1)
- Teixido, E., Kießling, T., Leuthold, D., Scholz, S. (2017):
Effect signatures in zebrafish embryos exposed to compounds with potential developmental toxicity
Reprod. Toxicol. 72 , 49 10.1016/j.reprotox.2017.06.179
2016 (2)
- Teixidó, E., Leuthold, D., Amberg, A., Czich, A., Krupp, E., Scholz, S. (2016):
ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA)
Reprod. Toxicol. 64 , 22 10.1016/j.reprotox.2016.06.048 - Teixidó, E., Leuthold, D., Scholz, S., Quevedo, C., Muriana, A., Czich, A., Krupp, E. (2016):
An inter-laboratory validation of the zebrafish embryo assay for the detection of developmental toxicity
Reprod. Toxicol. 64 , 44 10.1016/j.reprotox.2016.06.096