PD Dr. Tobias Polte
Contact
PD Dr. Tobias Polte
Scientist, Deputy Head of the Department, Theme Coordinator of
Maternal exposure and offspring health
and Platform Coordinator of
In vivo models
Helmholtz Centre for
Environmental Research – UFZ
Department of Environmental Immunology
Permoserstr. 15
04318 Leipzig, Germany
Phone: +49 341 6025-1545
Email
Research Interests
Currently we are investigating in different murine disease models the role of environmental pollutants as risk factors in the development of immune diseases like allergic asthma or rheumatoid arthritis but also possible effects on metabolism or behaviour. Thereby we are in particular looking on the impact of maternal exposure to environmental pollutants on the disease risk of the offspring. Another topic are gene-environment interactions. The long-term objective of our research is the development of new prevention and therapeutic strategies for immune diseases.
Curriculum vitae / Scientific career
Since 2020
Deputy Head of the Department Environmental Immunology, UFZ Leipzig
2018 - 2020
Acting Head of the Department Environmental Immunology, UFZ Leipzig
2016 - 2018
Deputy Head of the Department Environmental Immunology, UFZ Leipzig
Since 2012
Head of the Helmholtz University Research Group Experimental Allergy and Immunology
2012
Habilitation and Venia legendi at the Leipzig University, Faculty of Medicine
2007 - 2012
Head of a Helmholtz University Young Investigators Group at the UFZ and the University of Leipzig
2002 - 2007
Postdoc in the Junior Research Group of Prof. Gesine Hansen at the Medical School of the Martin Luther University, Halle
2002
Postdoc at the Department of Pediatrics, Stanford Medical School, Stanford University (USA)
2000 - 2002
Postdoc at the Department of Pharmacy and Pharmacology, University of Bath (UK)
1997 - 2000
PhD, Department of Pharmacology and Toxicology,
Martin Luther University, Halle
1996 - 1997
Graduand at the Department of Pharmacology and Toxicology, Martin Luther University, Halle
1991 - 1995
Study of Pharmacy at the Martin Luther University, Halle
Awards
2010
Brigitte-Gedek-Science-Award of the Society for Mycotoxin Research
2007
Wilhelm-Roux Award of the Martin Luther University, Halle
2000 - 2002
Postdoctoral fellowship of the German Research Council (DFG)
2000
Dorothea Erxleben Award of the Martin Luther University, Halle
Highlighted Publications
Buchenauer L, Haange S, Bauer M, Rolle-Kampczyk UE, Wagner M, Stucke J, Elter E, Fink B, Vass M, von Bergen M, Schulz A, Zenclussen AC, Junge KM, Stangl GI, Polte T. Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis. Sci Total Environ. 2023; 905:167034 Abstract
Leppert B, Strunz S, Seiwert B, Schlittenbauer L, Schlichting R, Pfeiffer C, Röder S, Bauer M, Borte M, Stangl GI, Schöneberg T, Schulz A, Karkossa I, Rolle-Kampczyk UE, Thürmann L, von Bergen M, Escher BI, Junge KM., Reemtsma T., Lehmann I, Polte T. Maternal paraben exposure triggers childhood overweight development. Nat Commun 2020;11 , art. 561 Abstract Press Release Research Highlight Nature Reviews Endocrinology
Jahreis S, Trump S, Bauer M, Bauer T, Thürmann L, Feltens R, Wang Q, Gu L, Grützmann K, Röder S, Averbeck M, Weichenhan D, Plass C, Sack U, Borte M, Dubourg V, Schüürmann G, Simon JC, von Bergen M, Hackermüller J, Eils R, Lehmann I, Polte T. Maternal phthalate exposure promotes allergic airway inflammation over two generations via epigenetic modifications. J Allergy Clin Immunol. 2018 Feb;141:741-753 Abstract Press Release Editorial
Polte T, Petzold S, Bertrand J, Schütze N, Hinz D, Simon JC, Lehmann I, Echtermeyer F, Pap T, Averbeck M. Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation. Nat Commun 2015 Jul 13;6:7554 Abstract Press Release
Schütze N, Lehmann I, Bönisch U, Simon JC, Polte T. Exposure to mycotoxins increases the allergic immune response in a murine asthma model. Am J Respir Crit Care Med 2010; 181: 1188-1199. Cover Press Release
Polte T, Hennig C, Hansen G. Allergy prevention starts before conception: Maternofetal transfer of tolerance protects from the development of asthma. J Allergy Clin Immunol. 2008 Nov;122(5):1022-1030.e5 Abstract
Polte T, Behrendt AK, Hansen G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006 Oct;118(4):942-8 Abstract
Polte T, Foell J, Werner C, Hoymann HG, Braun A, Burdach S, Mittler RS, Hansen G. CD137-mediated immunotherapy for allergic asthma. J Clin Invest. 2006 Apr;116(4):1025-36 Abstract