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DOI 10.1038/s42003-023-05698-x
Licence creative commons licence
Title (Primary) A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
Author Li, S.; Spitz, N.; Ghantous, A.; Abrishamcar, S.; Reimann, B.; Marques, I.; Silver, M.J.; Aguilar-Lacasaña, S.; Kitaba, N.; Rezwan, F.I.; Röder, S. ORCID logo ; Sirignano, L.; Tuhkanen, J.; Mancano, G.; Sharp, G.C.; Metayer, C.; Morimoto, L.; Stein, D.J.; Zar, H.J.; Alfano, R.; Nawrot, T.; Wang, C.; Kajantie, E.; Keikkala, E.; Mustaniemi, S.; Ronkainen, J.; Sebert, S.; Silva, W.; Vääräsmäki, M.; Jaddoe, V.W.V.; Bernstein, R.M.; Prentice, A.M.; Cosin-Tomas, M.; Dwyer, T.; Håberg, S.E.; Herceg, Z.; Magnus, M.C.; Munthe-Kaas, M.C.; Page, C.M.; Völker, M.; Gilles, M.; Send, T.; Witt, S.; Zillich, L.; Gagliardi, L.; Richiardi, L.; Czamara, D.; Räikkönen, K.; Chatzi, L.; Vafeiadi, M.; Arshad, S.H.; Ewart, S,; Plusquin, M.; Felix, J.F.; Moore, S.E.; Vrijheid, M.; Holloway, J.W.; Karmaus, W.; Herberth, G. ORCID logo ; Zenclussen, A.; Streit, F.; Lahti, J.; Hüls, A.; Hoang, T.T.; London, S.J.; Wiemels, J.L.
Source Titel Communications Biology
Year 2024
Department IMMU
Volume 7
Page From art. 66
Language englisch
Topic T9 Healthy Planet
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.
Persistent UFZ Identifier
Li, S., Spitz, N., Ghantous, A., Abrishamcar, S., Reimann, B., Marques, I., Silver, M.J., Aguilar-Lacasaña, S., Kitaba, N., Rezwan, F.I., Röder, S., Sirignano, L., Tuhkanen, J., Mancano, G., Sharp, G.C., Metayer, C., Morimoto, L., Stein, D.J., Zar, H.J., Alfano, R., Nawrot, T., Wang, C., Kajantie, E., Keikkala, E., Mustaniemi, S., Ronkainen, J., Sebert, S., Silva, W., Vääräsmäki, M., Jaddoe, V.W.V., Bernstein, R.M., Prentice, A.M., Cosin-Tomas, M., Dwyer, T., Håberg, S.E., Herceg, Z., Magnus, M.C., Munthe-Kaas, M.C., Page, C.M., Völker, M., Gilles, M., Send, T., Witt, S., Zillich, L., Gagliardi, L., Richiardi, L., Czamara, D., Räikkönen, K., Chatzi, L., Vafeiadi, M., Arshad, S.H., Ewart, S,, Plusquin, M., Felix, J.F., Moore, S.E., Vrijheid, M., Holloway, J.W., Karmaus, W., Herberth, G., Zenclussen, A., Streit, F., Lahti, J., Hüls, A., Hoang, T.T., London, S.J., Wiemels, J.L. (2024):
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
Commun. Biol. 7 , art. 66 10.1038/s42003-023-05698-x