Publication Details

Reference Category Journals
DOI / URL link
Creative Commons Licence creative commons licence
Title (Primary) Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice
Author Musiol, S.; Harris, C.P.; Karlina, R.; Gostner, J.M.; Rathkolb, B.; Schnautz, B.; Schneider, E.; Mair, L.; Elorduy Vergara, E.; Flexeder, C.; Koletzko, S.; Bauer, C.-P.; Schikowski, T.; Berdel, D.; von Berg, A.; Herberth, G. ORCID logo ; Rozman, J.; Hrabe de Angelis, M.; Standl, M.; Schmidt-Weber, C.B..; Ussar, S.; Alessandrini, F.
Journal Allergy
Year 2022
Department IMMU
Language englisch
Topic T9 Healthy Planet
Supplements https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fall.15589&file=all15589-sup-0001-FigureS1-S8.pdf
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fall.15589&file=all15589-sup-0002-Supinfo.docx
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fall.15589&file=all15589-sup-0003-Supinfo.pdf
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fall.15589&file=all15589-sup-0004-Supinfo.docx
Keywords carbohydrates; nutrition; asthma; allergic airway inflammation; oxidative stress
Abstract

Background

Dietary carbohydrates and fats are intrinsically correlated within the habitual diet. We aimed to disentangle the associations of starch and sucrose from those of fat, in relation to allergic sensitization, asthma and rhinoconjuctivitis prevalence in humans, and to investigate underlying mechanisms using murine models.

Methods

Epidemiological data from participants of two German birth cohorts (age 15) were used in logistic regression analyses testing cross-sectional associations of starch and sucrose (and their main dietary sources) with aeroallergen sensitization, asthma and rhinoconjunctivitis, adjusting for correlated fats (saturated, monounsaturated, omega-6 and omega-3 polyunsaturated) and other covariates. For mechanistic insights, murine models of aeroallergen-induced allergic airway inflammation (AAI) fed with a low-fat-high-sucrose or -high-starch versus a high-fat diet were used to characterize and quantify disease development. Metabolic and physiologic parameters were used to track outcomes of dietary interventions and cellular and molecular responses to monitor the development of AAI. Oxidative stress biomarkers were measured in murine sera or lung homogenates.

Results

We demonstrate a direct association of dietary sucrose with asthma prevalence in males, while starch was associated with higher asthma prevalence in females. In mice, high-carbohydrate feeding, despite scant metabolic effects, aggravated AAI compared to high-fat in both sexes, as displayed by humoral response, mucus hypersecretion, lung inflammatory cell infiltration and TH2-TH17 profiles. Compared to high-fat, high-carbohydrate intake was associated with increased pulmonary oxidative stress, signals of metabolic switch to glycolysis and decreased systemic anti-oxidative capacity.

Conclusion

High consumption of digestible carbohydrates is associated with increased prevalence of asthma in humans and aggravated lung allergic inflammation in mice, involving oxidative stress-related mechanisms.

Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=26860
Musiol, S., Harris, C.P., Karlina, R., Gostner, J.M., Rathkolb, B., Schnautz, B., Schneider, E., Mair, L., Elorduy Vergara, E., Flexeder, C., Koletzko, S., Bauer, C.-P., Schikowski, T., Berdel, D., von Berg, A., Herberth, G., Rozman, J., Hrabe de Angelis, M., Standl, M., Schmidt-Weber, C.B.., Ussar, S., Alessandrini, F. (2022):
Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice
Allergy