Publication Details

Category Text Publication
Reference Category Journals
DOI 10.3390/ijms242216091
Licence creative commons licence
Title (Primary) B cells induce early-onset maternal inflammation to protect against LPS-induced fetal rejection
Author Uehre, G.M.; Tchaikovski, S.; Ignatov, A.; Zenclussen, A.C.; Busse, M.
Source Titel International Journal of Molecular Sciences
Year 2023
Department IMMU
Volume 24
Issue 22
Page From art. 16091
Language englisch
Topic T9 Healthy Planet
Keywords preterm birth; pregnancy; lipopolysaccharide; inflammation; B cells
Abstract The maternal balance between B regulatory (Breg) cells and inflammatory B cells is of central importance for protection against preterm birth (PTB). However, the impact of B cell signaling in early maternal and fetal immune responses on inflammatory insults remains underinvestigated. To understand which role B cells and B-cell-specific signaling play in the pathogenesis of PTB, the later was induced by an injection of LPS in B cell-sufficient WT mice, CD19−/−, BMyD88−/− and µMT murine dams at gestational day 16 (gd 16). WT dams developed a strong inflammatory response in their peritoneal cavity (PC), with an increased infiltration of granulocytes and enhanced IL-6, TNF-α, IL-17 and MCP-1 levels. However, they demonstrated a reduced NOS2 expression of PC macrophages 4 h after the LPS injection. Simultaneously, LPS-challenged WT dams upregulated pregnancy-protective factors like IL-10 and TARC. The concentrations of inflammatory mediators in the placental supernatants, amniotic fluids, fetal serums and gestational tissues were lower in LPS-challenged WT dams compared to CD19−/−, BMyD88−/− and µMT dams, thereby protecting WT fetuses from being born preterm. B cell deficiency, or the loss of B-cell-specific CD19 or MyD88 expression, resulted in an early shift from immune regulation towards inflammation at the fetomaternal interface and fetuses, resulting in PTB
Persistent UFZ Identifier
Uehre, G.M., Tchaikovski, S., Ignatov, A., Zenclussen, A.C., Busse, M. (2023):
B cells induce early-onset maternal inflammation to protect against LPS-induced fetal rejection
Int. J. Mol. Sci. 24 (22), art. 16091 10.3390/ijms242216091