Dr. Florence Fischer
Contact
Dr. rer. nat. Florence Fischer
Guest Scientist
Helmholtz Centre for
Environmental Research – UFZ
Department of Environmental Immunology
Permoserstr. 15
04318 Leipzig, Germany
Email
Research Interests
- Relevance of environmental chemicals for intestinal homeostasis
- Influence of environmental chemicals on the maturation of the intestinal microbiota and the immune system in early development
Knowledge transfer from the laboratory to society
Curriculum vitae / Scientific career
Since 2024
Guest Scientist, Department of Environmental Immunology, Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany
Since 2023
Principal investigator, Institute of Clinical Immunology, Faculty of Medicine, Leipzig University
2020 - 2023
Scientist, Department of Environmental Immunology, Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany
2015 - 2020
PhD student, Institute of Medical Microbiology and Hospital Hygiene, Philipps University Marburg, Germany,
Thesis: Dietary cellulose attenuates intestinal inflammation by promoting microbiota maturation and gut barrier function, Degree: Dr. rer. nat. (summa cum laude)
2012 - 2015
Master of Science, nutritional science, Justus Liebig University Gießen, Germany
2009 - 2012
Bachelor of Science, ecotrophology, Justus Liebig University Gießen, Germany
Memberships
Since 2016
German Society of Immunology (DGfI)
Funding
02/2023
Empowering pregnant women through awareness about potential risks of environmental chemicals: app-based approach - Phase II, Knowledge and Technology Transfer, UFZ funding programme for innovative products, TP-23-04
Own third-party funded projects
The first 1000 days of life matter: How endocrine disrupting chemicals affect the microbial and immunological imprinting of the gut, Deutsche Forschungsgemeinschaft (DFG), 508974529
Awards
2019
Luminex Award, Spring School on Immunology Ettal, poster award
2018
German Academic Exchange Service (DAAD), travel grant
2017
German Society of Immunology (DGfI), travel grant
Publications
Index:
You could use our publication index for further requests.
2024 (6)
- Fischer, F., Ermer, M.R., Howanski, J., Yin, Z., Bauer, M., Wagner, M., Fink, B., Zenclussen, A.C., Schumacher, A. (2024):
Single and mixture effects of bisphenol A and benzophenone-3 on in vitro T helper cell differentiation
Chem.-Biol. Interact. 395 , art. 111011 10.1016/j.cbi.2024.111011 - Fischer, F., Kretschmer, T., Seifert, P., Howanski, J., Krieger, E., Rödiger, J., Fink, B., Yin, Z., Bauer, M., Zenclussen, M.L., Meyer, N., Schumacher, A., Zenclussen, A.C. (2024):
Single and combined exposures to bisphenol A and benzophenone-3 during early mouse pregnancy have differential effects on fetal and placental development
Sci. Total Environ. 922 , art. 171386 10.1016/j.scitotenv.2024.171386 - Fischer, F., Kretschmer, T., Seifert, P., Krieger, E., Rödiger, J., Howanski, J., Meyer, N., Zenclussen, M.L., Schumacher, A., Zenclussen, A.C. (2024):
Combined exposure to bisphenol A and benzophenone-3 during early mouse pregnancy affects fetal development in a sex-dependent manner
Reprod. Sci. 31 (1 Suppl.), 229A - 229A 10.1007/s43032-024-01501-2 - Fischer, F., Pierzchalski, A., Riesbeck, S., Aldehoff, A.S., Castañeda-Monsalve, V., Haange, S.-B., von Bergen, M., Rolle-Kampczyk, U.E., Jehmlich, N., Zenclussen, A.C., Herberth, G. (2024):
An in vitro model system for testing chemical effects on microbiome-immune interactions - examples with BPX and PFAS mixtures
Front. Immunol. 15 , art. 1298971 10.3389/fimmu.2024.1298971 - Krausser, K., Howanski, J., Fink, B., Bauer, M., Fischer, F., Zenclussen, A.C., Schumacher, A. (2024):
Benzophenone-3 as endocrine-disrupting chemical does not seem to affect the human decidualization process in an in vitro setting
Reprod. Sci. 31 (1 Suppl.), 264A - 264A 10.1007/s43032-024-01501-2 - Krieger, E., Kretschmer, T., Howanski, J., Fink, B., Bauer, M., Fischer, F., Schumacher, A., Zenclussen, A.C. (2024):
The combined influence of the endocrine disrupting chemicals bisphenol A and benzophenone-3 on follicular maturation and immune cell populations in the ovaries of offspring exposed in utero and during lactation
Reprod. Sci. 31 (1 Suppl.), 265A - 265A 10.1007/s43032-024-01501-2
2023 (3)
- Fischer, F., Ermer, M.R., Howanski, J., Zenclussen, A.C., Schumacher, A. (2023):
Bisphenol A and benzophenone-3, two ubiquitous endocrine disruptors, may interfere with tolerance pathways by disturbing the T cell equilibrium
Am. J. Reprod. Immunol. 89 (S1), 83 - 83 10.1111/aji.13696 - Fischer, F., Zenclussen, A.C., Meyer, N. (2023):
Gefährdung durch Alltagschemikalien: Ein Impuls für die Schwangerschaftsvorsorge. Hazards due to everyday chemicals: An impulse for prenatal care
Gynäkologie 56 (9), 633 - 640 10.1007/s00129-023-05125-6 - Kretschmer, T., Fischer, F., Seifert, P., Schumacher, A., Kass, L., Rodríguez, H.A., Zenclussen, M.L., Zenclussen, A.C. (2023):
Intrauterine exposure to bisphenol A and benzophenone-3 affects fetal growth and impacts on uterine innate immune cells supporting pregnancy
Am. J. Reprod. Immunol. 89 (S1), 82 - 83 10.1111/aji.13696
2022 (3)
- Fischer, F., Schumacher, A., Meyer, N., Fink, B., Bauer, M., Stojanovska, V., Zenclussen, A.C. (2022):
An old friend with a new face: YB-1 and its role in healthy pregnancy and pregnancy-associated complications
Front. Cell. Dev. Biol. 10 , art. 1039206 10.3389/fcell.2022.1039206 - Romero Perez, R.V., Zarzycka, A., Preussner, M., Fischer, F., Roth, K., Keber, C.U., Suryamohan, K., Raifer, H., Luu, M., Leister, H., Bertrams, W., Klein, M., Shams-Eldin, H., Jacob, R., Mollenkopf, H.-J., Rajalingam, K., Visekruna, A., Steinhoff, U. (2022):
A defined bacterial community restores immunity in germ-free mice via maturation of the intestinal vascular system
Eur. J. Immunol. 52 (S1), 49 - 50 10.1002/eji.202270100 - Romero, R., Zarzycka, A., Preussner, M., Fischer, F., Hain, T., Herrmann, J.-P., Roth, K., Keber, C.U., Suryamohan, K., Raifer, H., Luu, M., Leister, H., Bertrams, W., Klein, M., Shams-Eldin, H., Jacob, R., Mollenkopf, H.-J., Rajalingam, K., Visekruna, A., Steinhoff, U. (2022):
Selected commensals educate the intestinal vascular and immune system for immunocompetence
Microbiome 10 , art. 158 10.1186/s40168-022-01353-5
2021 (2)
- O’Shaughnessy, K.L., Fischer, F., Zenclussen, A.C. (2021):
Perinatal exposure to endocrine disrupting chemicals and neurodevelopment: How articles of daily use influence the development of our children
Best Pract. Res. Clin. Endoc. Metab. 35 (5), art. 101568 10.1016/j.beem.2021.101568 - Stojanovska, V., Shah, A., Woidacki, K., Fischer, F., Bauer, M., Lindquist, J.A., Mertens, P.R., Zenclussen, A.C. (2021):
YB-1 is altered in pregnancy-associated disorders and affects trophoblast in vitro properties via alternation of multiple molecular traits
Int. J. Mol. Sci. 22 (13), art. 7226 10.3390/ijms22137226
Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota
Gut Microbes, 2020, accepted
The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium.
European Journal of Immunology, 2020, doi: 10.1002/eji.201948314
Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U.
Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.
The Journal of Clinical Investigation, 2019, doi: 10.1172/JCI98929
Domann E, Fischer F, Glowatzki F, Fritzenwanker M, Hain T, Zechel-Gran S, Giffhorn-Katz S, Neubauer BA.
Draft genome sequence of Lactobacillus delbrueckii strain #22 isolated from a patient with short bowel syndrome and previous d-lactic acidosis and encephalopathy.
Genome Announcements, 2016, doi: 10.1128/genomeA.00747-16