Publication Details |
| Category | Text Publication |
| Reference Category | Preprints |
| DOI | 10.1101/2024.02.29.24303506 |
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| Title (Primary) | Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium |
| Author | Neumann, A.; Sammallahti, S.; Cosin-Tomas, M.; Reese, S.E.; Suderman, M.; Alemany, S.; Almqvist, C.; Andrusaityte, S.; Arshad, S.H.; Bakermans-Kranenburg, M.J.; Beilin, L.; Breton, C.; Bustamante, M.; Czamara, D.; Dabelea, D.; Eng, C.; Eskenazi, B.; Fuemmeler, B.F.; Gilliland, F.D.; Grazuleviciene, R.; Håberg, S.E.; Herberth, G.
; Holland, N. et al. |
| Source Titel | medRxiv |
| Year | 2024 |
| Department | IMMU |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Abstract | DNA methylation (DNAm) is a developmentally dynamic epigenetic process, yet we still know little about how epigenetic effects on health outcomes vary over time; whether DNAm alterations during certain periods of development are more informative than others; and whether epigenetic timing effects differ by outcome. To address these questions, we applied longitudinal meta-regression to published meta-analyses from the PACE consortium that examine DNAm at multiple time points (prospectively at birth and cross-sectionally in childhood) in relation to the same child outcome (ADHD, general psychopathology, sleep, BMI, asthma). Our findings reveal three new insights: (i) across outcomes, effects sizes are larger when DNAm is measured in childhood compared to at birth; (ii) higher effect sizes do not necessarily translate into more significant findings, as associations also become noisier in childhood for most outcomes (i.e. showing larger standard errors); and (iii) DNAm signals are highly time-specific while showing pleiotropy across health outcomes. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=30569 |
| Neumann, A., Sammallahti, S., Cosin-Tomas, M., Reese, S.E., Suderman, M., Alemany, S., Almqvist, C., Andrusaityte, S., Arshad, S.H., Bakermans-Kranenburg, M.J., Beilin, L., Breton, C., Bustamante, M., Czamara, D., Dabelea, D., Eng, C., Eskenazi, B., Fuemmeler, B.F., Gilliland, F.D., Grazuleviciene, R., Håberg, S.E., Herberth, G., Holland, N. et al. (2024): Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium medRxiv 10.1101/2024.02.29.24303506 |
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