Perinatal exposure and offspring health
Environmental factors have been shown to play a crucial role in the development of various diseases like allergies, overweight/obesity or behaviour disorders. External factors such as chemicals, pathogens or stress may act as drivers of the individual’s risk to develop diseases and as triggers of underlying genetic predispositions. Recent findings indicate that in particular the prenatal and early postnatal period appears critical to environmental exposures, probably interfering with the developmental programming of the immune system or the physiological endocrine and metabolic signalling. Using cross- and transgenerational mouse models, if possible in combination with epidemiological data, we want to explore the effects of early chemical exposures on disease development in later life and to characterize the underlying mechanisms. These findings may contribute to identify crucial disease risks and to develop new prevention strategies.
Projects supported by third-party funds
|Deutsche Forschungsgemeinschaft (DFG)||Role of CD97/ADGRE5 in allergic asthma||PD Dr. Tobias Polte|