Dr. Stefan Scholz

Adresse:
Permoserstr. 15
04318 Leipzig
Gebäude: 6.0
Raum: 327
Telefon: +49 341 235 1080
Dr. Stefan Scholz
Forschungsinteressen
- Wirkungsmechanismen von Chemikalien
- High-content Analyse und Automatisierung Bioassays
- Entwicklung von Bioassays, insb. Alternativen zu Tierversuchen, für die Chemikalienprüfung und das Umweltmonitoring
Lebenslauf
Seit 2022
kommisarischer Leiter, Department Bioanalytische Ökotoxikologie, Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig
Seit 2018
Stellvertretender Leiter, Department Bioanalytische Ökotoxikologie, Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig
01/2015 - 06/2015
Forschungsaufenthalt, US-EPA (Environmental Protection Agency), Mid-continent ecology division Duluth, MN.
01/2004 - 03/2004
Gastwissenschaftler, Bioscience and Biotechnology Center, Laboratory of Freshwater Fish Stocks, University of Nagoya, Japan
Seit 2002
Wissenschaftlicher Mitarbeiter, Department Bioanalytische Ökotoxikologie, Helmholtz-Zentrum für Umweltforschung, Leipzig
04/1995 - 06/2002
Wissenschaftlicher Mitarbeiter, Institut für Zoologie, Universität Dresden
11/1992 - 03/1995
Promotion, Martin-Luther Universität Halle Wittenberg und Sektion Umweltchemie und Ökotoxikologie, Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig
Thema: Induktion von CYP1A in Leberzellkulturen der Regenbogenforelle
1987 - 1992
Biologiestudium, Ruhruniversität Bochum
Diplomarbeit: Di-myo-inositol-1,1'-phosphate: Ein neues inositol phosphate in Pyrococcus woesei
Auszeichnungen
2015
OECD Cooperative Research scholarship
2004
Scholarship of the University of Nagoya, Japan
Publikationen
Inhalt:
Weiterführende Recherchen können Sie in unserem Publikationsverzeichnis durchführen.
2023 (3)
- Bajard, L., Adamovsky, O., Audouze, K., Baken, K., Barouki, R., Beltman, J.B., Beronius, A., Bonefeld-Jørgensen, E.C., Cano-Sancho, G., de Baat, M.L., Di Tillio, F., Fernández, M.F., FitzGerald, R.E., Gundacker, C., Hernández, A.F., Hilscherova, K., Karakitsios, S., Kuchovska, E., Long, M., Luijten, M., Majid, S., Marx-Stoelting, P., Mustieles, V., Negi, C.K., Sarigiannis, D., Scholz, S., Sovadinova, I., Stierum, R., Tanabe, S., Tollefsen, K.E., van den Brand, A.D., Vogs, C., Wielsøe, M., Wittwehr, C., Blaha, L. (2023):
Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
Environ. Res. 217 , art. 114650
Volltext (DOI) - Bashirova, N., Poppitz, D., Klüver, N., Scholz, S., Matysik, J., Alia, A. (2023):
A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
Sci. Rep. 13 , art. 1891
Volltext (DOI) - Escher, B.I., Altenburger, R., Blüher, M., Colbourne, J.K., Ebinghaus, R., Fantke, P., Hein, M., Köck, W., Kümmerer, K., Leipold, S., Li, X., Scheringer, M., Scholz, S., Schloter, M., Schweizer, P.-J., Tal, T., Tetko, I., Traidl-Hoffmann, C., Wick, L.Y., Fenner, K. (2023):
Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
Arch. Toxicol. 97 (5), 1267 - 1283
Volltext (DOI)
2022 (11)
- Lee, J., Escher, B.I., Scholz, S., Schlichting, R. (2022):
Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells
Arch. Toxicol. 96 (4), 1039 - 1053
Volltext (DOI) - Lee, J., Huchthausen, J., Schlichting, R., Scholz, S., Henneberger, L., Escher, B.I. (2022):
Validation of an SH-SY5Y cell-based acetylcholinesterase inhibition assay for water quality assessment
Environ. Toxicol. Chem. 41 (12), 3046 - 3057
Volltext (DOI) - Lee, J., Schlichting, R., König, M., Scholz, S., Krauss, M., Escher, B.I. (2022):
Monitoring mixture effects of neurotoxicants in surface water and wastewater treatment plant effluents with neurite outgrowth inhibition in SH-SY5Y cells
ACS Environ. Au 2 (6), 523 - 535
Volltext (DOI) - Nöth, J., Michaelis, P., Busch, W., Scholz, S. (2022):
Analysis vascular disruptors in zebrafish embryos as an endpoint to predict developmental toxicity
Toxicol. Lett. 368 (Suppl.), S34 - S35
Volltext (DOI) - Ortmann, J., Altenburger, R., Scholz, S., Luckenbach, T. (2022):
Photomotor response data analysis approach to assess chemical neurotoxicity with the zebrafish embryo
ALTEX-Altern. Anim. Exp. 39 (1), 82 - 94
Volltext (DOI) - Paini, A., Campia, I., Cronin, M.T.D., Asturiol, D., Ceriani, L., Exner, T.E., Gao, W., Gomes, C., Kruisselbrink, J., Martens, M., Meek, M.E.B., Pamies, D., Pletz, J., Scholz, S., Schüttler, A., Spînu, N., Villeneuve, D.L., Wittwehr, C., Worth, A., Luijten, M. (2022):
Towards a qAOP framework for predictive toxicology - Linking data to decisions
Comput. Toxicol. 21 , art. 100195
Volltext (DOI) - Scholz, S., Brack, W., Escher, B.I., Hackermüller, J., Liess, M., von Bergen, M., Wick, L.Y., Zenclussen, A.C., Altenburger, R. (2022):
The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Arch. Toxicol. 96 (8), 2381 - 2386
Volltext (DOI) - Scholz, S., Nichols, J.W., Escher, B.I., Ankley, G.T., Altenburger, R., Blackwell, B., Brack, W., Burkhard, L., Collette, T.W., Doering, J.A., Ekman, D., Fay, K., Fischer, F., Hackermüller, J., Hoffman, J.C., Lai, C., Leuthold, D., Martinovic-Weigelt, D., Reemtsma, T., Pollesch, N., Schroeder, A., Schüürmann, G., von Bergen, M. (2022):
The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45
Volltext (DOI) - Spînu, N., Cronin, M.T.D., Lao, J., Bal-Price, A., Campia, I., Enoch, S.J., Madden, J.C., Lagares, L.M., Novič, M., Pamies, D., Scholz, S., Villeneuve, D.L., Worth, A.P. (2022):
Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
Comput. Toxicol. 21 , art. 100206
Volltext (DOI) - Teixidó, E., Kieβling, T.R., Klüver, N., Scholz, S. (2022):
Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test
Arch. Toxicol. 96 (5), 1353 - 1369
Volltext (DOI) - Wilhelmi, P., Giri, V., Henkes, S., Walk, T., Haake, V., Scholz, S., Busch, W., Barenys, M., Zickgraf, F., Landsiedel, R., Funk-Weyer, D., Birk, B., Flick, B. (2022):
A targeted metabolomics approach for unraveling different modes of embryotoxicity in zebrafish
Toxicol. Lett. 368 (Suppl.), S252 - S252
Volltext (DOI)
2021 (6)
- Bieczynski, F., Burkhardt-Medicke, K., Luquet, C.M., Scholz, S., Luckenbach, T. (2021):
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity
FEBS Lett. 595 (6), 828 - 843
Volltext (DOI) - Huhn, S., Escher, B.I., Krauss, M., Scholz, S., Hackermüller, J., Altenburger, R. (2021):
Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive
Environ. Sci. Eur. 33 , art. 17
Volltext (DOI) - Lee, J., Braun, G., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2021):
Critical membrane concentration and mass-balance model to identify baseline cytotoxicity of hydrophobic and ionizable organic chemicals in mammalian cell lines
Chem. Res. Toxicol. 34 (9), 2100 - 2109
Volltext (DOI) - Ogungbemi, A.O., Massei, R., Altenburger, R., Scholz, S., Küster, E. (2021):
Assessing combined effects for mixtures of similar and dissimilar acting neuroactive substances on zebrafish embryo movement
Toxics 9 (5), art. 104
Volltext (DOI) - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2021):
Automated measurement of the spontaneous tail coiling of zebrafish embryos as a sensitive behavior endpoint using a workflow in KNIME
MethodsX 8 , art. 101330
Volltext (DOI) - Paparella, M., Scholz, S., Belanger, S., Braunbeck, T., Bicherel, P., Connors, K., Faßbender, C., Halder, M., Lillicrap, A., Liska, R., Schirmer, K., Stoddart, G., Thomas, P., Walter-Rohde, S. (2021):
Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods
ALTEX-Altern. Anim. Exp. 38 (1), 20 - 32
Volltext (DOI)
2020 (5)
- Halbach, K., Ulrich, N., Goss, K.-U., Seiwert, B., Wagner, S., Scholz, S., Luckenbach, T., Bauer, C., Schweiger, N., Reemtsma, T. (2020):
Yolk sac of zebrafish embryos as backpack for chemicals?
Environ. Sci. Technol. 54 (16), 10159 - 10169
Volltext (DOI) - Larras, F., Billoir, E., Scholz, S., Tarkka, M., Wubet, T., Delignette-Muller, M.-L., Schmitt-Jansen, M. (2020):
A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus
J. Hazard. Mater. 397 , art. 122727
Volltext (DOI) - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2020):
Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®
Neurotoxicol. Teratol. 81 , art. 106918
Volltext (DOI) - Teixidó, E., Leuthold, D., de Crozé, N., Léonard, M., Scholz, S. (2020):
Comparative assessment of the sensitivity of fish early‐life stage, Daphnia and algae to the chronic ecotoxicity of xenobiotics – perspectives for alternatives to animal testing
Environ. Toxicol. Chem. 39 (1), 30 - 41
Volltext (DOI) - Ulrich, N., Schweiger, N., Pfennigsdorff, A., Scholz, S., Goss, K.-U. (2020):
Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio
Environ. Toxicol. Chem. 39 (8), 1506 - 1516
Volltext (DOI)
2019 (5)
- Halbach, K., Wagner, S., Scholz, S., Luckenbach, T., Reemtsma, T. (2019):
Elemental imaging (LA-ICP-MS) of zebrafish embryos to study the toxicokinetics of the acetylcholinesterase inhibitor naled
Anal. Bioanal. Chem. 411 (3), 617 - 627
Volltext (DOI) - Ogungbemi, A., Leuthold, D., Scholz, S., Küster, E. (2019):
Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
Environ. Sci. Eur. 31 , art. 88
Volltext (DOI) - Perkins, E.J., Ashauer, R., Burgoon, L., Conolly, R., Landesmann, B., Mackay, C., Murphy, C.A., Pollesch, N., Wheeler, J.R., Zupanic, A., Scholz, S. (2019):
Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
Environ. Toxicol. Chem. 38 (9), 1850 - 1865
Volltext (DOI) - Philipp, K., Lemke, F., Scholz, S., Wallrabe, U., Wapler, M.C., Koukourakis, N., Czarske, J.W. (2019):
Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens
Sci. Rep. 9 , art. 9532
Volltext (DOI) - Teixidó, E., Kießling, T.R., Krupp, E., Quevedo, C., Muriana, A., Scholz, S. (2019):
Automated morphological feature assessment for zebrafish embryo developmental toxicity screens
Toxicol. Sci. 167 (2), 438 - 449
Volltext (DOI)
2018 (9)
- Birke, A., Scholz, S. (2018):
Zebrafish embryo and acute fish toxicity test show similar sensitivity for narcotic compounds
ALTEX-Altern. Anim. Exp. 36 (1), 131 - 135
Volltext (DOI) - Fischer, F.C., Abele, C., Droge, S.T.J., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2018):
Cellular uptake kinetics of neutral and charged chemicals in in vitro assays measured by fluorescence microscopy
Chem. Res. Toxicol. 31 (8), 646 - 657
Volltext (DOI) - Jarque, S., Fetter, E., Veneman, W.J., Spaink, H.P., Peravali, R., Strähle, U., Scholz, S. (2018):
An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
PLOS One 13 (8), e0203087
Volltext (DOI) - Larras, F., Billoir, E., Baillard, V., Siberchicot, A., Scholz, S., Wubet, T., Tarkka, M., Schmitt-Jansen, M., Delignette-Muller, M.-L. (2018):
DRomics: A turnkey tool to support the use of the dose–response framework for omics data in ecological risk assessment
Environ. Sci. Technol. 52 (24), 14461 - 14468
Volltext (DOI) - Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
An ecotoxicological view on neurotoxicity assessment
Environ. Sci. Eur. 30 , art. 46
Volltext (DOI) - Scholz, S., Schreiber, R., Armitage, J., Mayer, P., Escher, B.I., Lidzba, A., Léonard, M., Altenburger, R. (2018):
Meta‐analysis of fish early life stage tests—Association of toxic ratios and acute‐to‐chronic ratios with modes of action
Environ. Toxicol. Chem. 37 (4), 955 - 969
Volltext (DOI) - Sobanska, M., Scholz, S., Nyman, A.-M., Cesnaitis, R., Gutierrez Alonso, S., Klüver, N., Kühne, R., Tyle, H., de Knecht, J., Dang, Z., Lundbergh, I., Carlon, C., De Coen, W. (2018):
Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)
Environ. Toxicol. Chem. 37 (3), 657 - 670
Volltext (DOI) - Teixido, E., Kerkhof, O., Kießling, T., Scholz, S. (2018):
Retrieving mode of action information by automated effect pattern analysis using the zebrafish embryo toxicity test
Reprod. Toxicol. 80 , 18 - 19
Volltext (DOI) - Teixidó, E., Krupp, E., Amberg, A., Czich, A., Scholz, S. (2018):
Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches
Reprod. Toxicol. 76 , 93 - 102
Volltext (DOI)
2017 (3)
- Andrade, T.S., Henriques, J.F., Almeida, A.R., Soares, A.M.V.M., Scholz, S., Dominigues, I. (2017):
Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV-light irradiation
Environ. Toxicol. Chem. 36 (3), 682 - 690
Volltext (DOI) - Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106
Volltext (DOI) - Teixido, E., Kießling, T., Leuthold, D., Scholz, S. (2017):
Effect signatures in zebrafish embryos exposed to compounds with potential developmental toxicity
Reprod. Toxicol. 72 , 49
Volltext (DOI)
2016 (6)
- Klüver, N., Vogs, C., Altenburger, R., Escher, B.I., Scholz, S. (2016):
Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test
Chemosphere 164 , 164 - 173
Volltext (DOI) - Scholz, S., Jarque, S., Fetter, E. (2016):
A fully automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
Reprod. Toxicol. 64 (Special Issue), 30
Volltext (DOI) - Scholz, S., Klüver, N., Kühne, R. (2016):
Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. Report ECHA-UFZ contract ECHA/2014/341
Helmholtz Centre for Environmental Research - UFZ, Leipzig, 104 pp.
Volltext (URL) - Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016):
Zebrafish biosensor for toxicant induced muscle hyperactivity
Sci. Rep. 6 , art. 23768
Volltext (DOI) - Teixidó, E., Leuthold, D., Amberg, A., Czich, A., Krupp, E., Scholz, S. (2016):
ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA)
Reprod. Toxicol. 64 , 22
Volltext (DOI) - Teixidó, E., Leuthold, D., Scholz, S., Quevedo, C., Muriana, A., Czich, A., Krupp, E. (2016):
An inter-laboratory validation of the zebrafish embryo assay for the detection of developmental toxicity
Reprod. Toxicol. 64 , 44
Volltext (DOI)
2015 (8)
- Fetter, E., Baldauf, L., Da Fonte, D.F., Ortmann, J., Scholz, S. (2015):
Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos
Reprod. Toxicol. 57 , 10 - 20
Volltext (DOI) - Fetter, E., Smetanová, S., Baldauf, L., Lidzba, A., Altenburger, R., Schüttler, A., Scholz, S. (2015):
Identification and characterization of androgen-responsive genes in zebrafish embryos
Environ. Sci. Technol. 49 (19), 11789 - 11798
Volltext (DOI) - Hernández, R.B., Nishita, M.I., Espósito, B.P., Scholz, S., Michalke, B. (2015):
The role of chemical speciation, chemical fractionation and calcium disruption in manganese-induced developmental toxicity in zebrafish (Danio rerio) embryos
J. Trace Elem. Med. Biol. 32 , 209 - 217
Volltext (DOI) - Jonas, A., Scholz, S., Fetter, E., Sychrova, E., Novakova, K., Ortmann, J., Benisek, M., Adamovsky, O., Giesy, J.P., Hilscherova, K. (2015):
Endocrine, teratogenic and neurotoxic effects of cyanobacteria detected by cellular in vitro and zebrafish embryos assays
Chemosphere 120 , 321 - 327
Volltext (DOI) - Klüver, N., König, M., Ortmann, J., Massei, R., Paschke, A., Kühne, R., Scholz, S. (2015):
Fish embryo toxicity test: Identification of compounds with weak toxicity and analysis of behavioral effects to improve prediction of acute toxicity for neurotoxic compounds
Environ. Sci. Technol. 49 (11), 7002 - 7011
Volltext (DOI) - Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
What determines chemical uptake by the zebrafish embryo model?
Toxicol. Lett. 238 (2, Suppl.), S54
Volltext (DOI) - Massei, R., Vogs, C., Renner, P., Altenburger, R., Scholz, S. (2015):
Differential sensitivity in embryonic stages of the zebrafish (Danio rerio): The role of toxicokinetics for stage-specific susceptibility for azinphos-methyl lethal effects
Aquat. Toxicol. 166 , 36 - 41
Volltext (DOI) - Scholz, S. (2015):
In response: Quantitative adverse outcome pathways for prediction of adverse effects—An academic perspective
Environ. Toxicol. Chem. 34 (9), 1935 - 1937
Volltext (DOI)
Inhalt:
Weiterführende Recherchen können Sie in unserem Publikationsverzeichnis durchführen.
2014 (7)
- Busquet, F., Strecker, R., Rawlings, J.M., Belanger, S.E., Braunbeck, T., Carr, G.J., Cenijn, P., Fochtman, P., Gourmelon, A., Hübler, N., Kleensang, A., Knöbel, M., Kussatz, C., Legler, J., Lillicrap, A., Martínez-Jerónimo, F., Polleichtner, C., Rzodeczko, H., Salinas, E., Schneider, K.E., Scholz, S., van den Brandhof, E.-J., van der Ven, L.T.M., Walter-Rohde, S., Weigt, S., Witters, H., Halder, M. (2014):
OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing
Regul. Toxicol. Pharmacol. 69 (3), 496 - 511
Volltext (DOI) - Escher, B.I., Allinson, M., Altenburger, R., Bain, P.A., Balaguer, P., Busch, W., Crago, J., Denslow, N.D., Dopp, E., Hilscherova, K., Humpage, A.R., Kumar, A., Grimaldi, M., Jayasinghe, B.S., Jarosova, B., Jia, A., Makarov, S., Maruya, K.A., Medvedev, A., Mehinto, A.C., Mendez, J.E., Poulsen, A., Prochazka, E., Richard, J., Schifferli, A., Schlenk, D., Scholz, S., Shiraishi, F., Snyder, S., Su, G., Tang, J.Y.M., van der Burg, B., van der Linden, S.C., Werner, I., Westerheide, S.D., Wong, C.K.C., Yang, M., Yeung, B.H.Y., Zhang, X., Leusch, F.D.L. (2014):
Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays
Environ. Sci. Technol. 48 (3), 1940 - 1956
Volltext (DOI) - Fetter, E., Krauss, M., Brion, F., Kah, O., Scholz, S., Brack, W. (2014):
Effect-directed analysis for estrogenic compounds in a fluvial sediment sample using transgenic cyp19a1b-GFP zebrafish embryos
Aquat. Toxicol. 154 , 221 - 229
Volltext (DOI) - Jonas, A., Buranova, V., Scholz, S., Fetter, E., Novakova, K., Kohoutek, J., Hilscherova, K. (2014):
Retinoid-like activity and teratogenic effects of cyanobacterial exudates
Aquat. Toxicol. 155 , 283 - 293
Volltext (DOI) - Klüver, N., Ortmann, J., Paschke, H., Renner, P., Ritter, A.P., Scholz, S. (2014):
Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos
PLOS One 9 (3), e90619
Volltext (DOI) - Scholz, S., Ortmann, J., Klüver, N., Léonard, M. (2014):
Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories
Regul. Toxicol. Pharmacol. 69 (3), 572 - 579
Volltext (DOI) - Tollefsen, K.E., Scholz, S., Cronin, M.T., Edwards, S.W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A., Patlewicz, G. (2014):
Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)
Regul. Toxicol. Pharmacol. 70 (3), 629 - 640
Volltext (DOI)
2013 (4)
- Petersen, K., Fetter, E., Kah, O., Brion, F., Scholz, S., Tollefsen, K.E. (2013):
Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals
Aquat. Toxicol. 138-139 , 88 - 97
Volltext (DOI) - Scholz, S. (2013):
Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity
Arch. Toxicol. 87 (5), 767 - 769
Volltext (DOI) - Scholz, S., Renner, P., Belanger, S.E., Busquet, F., Davi, R., Demeneix, B.A., Denny, J.S., Léonard, M., McMaster, M.E., Villeneuve, D.L., Embry, M.R. (2013):
Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians – screening for estrogen, androgen and thyroid hormone disruption
Crit. Rev. Toxicol. 43 (1), 45 - 70
Volltext (DOI) - Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013):
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Regul. Toxicol. Pharmacol. 67 (3), 506 - 530
Volltext (DOI)
2012 (5)
- Altenburger, R., Scholz, S., Schmitt-Jansen, M., Busch, W., Escher, B.I. (2012):
Mixture toxicity revisited from a toxicogenomic perspective
Environ. Sci. Technol. 46 (5), 2508 - 2522
Volltext (DOI) - Büttner, A., Busch, W., Klüver, N., Giannis, A., Scholz, S. (2012):
Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine
Reprod. Toxicol. 33 (2), 254 - 263
Volltext (DOI) - Knöbel, M., Busser, F.J.M., Rico-Rico, A., Kramer, N.I., Hermens, J.L.M., Hafner, C., Tanneberger, K., Schirmer, K., Scholz, S. (2012):
Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
Environ. Sci. Technol. 46 (17), 9690 - 9700
Volltext (DOI) - Scholz, S. (2012):
Special issue: zebrafish teratogenesis
Reprod. Toxicol. 33 (2), 127 - 127
Volltext (DOI) - Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., Braunbeck, T. (2012):
Zebrafish embryos as an alternative to animal experiments - a commentary on the definition of the onset of protected life stages in animal welfare regulations
Reprod. Toxicol. 33 (2), 128 - 132
Volltext (DOI)
2011 (7)
- Busch, W., Duis, K., Fenske, M., Maack, G., Legler, J., Padilla, S., Strähle, U., Witters, H., Scholz, S. (2011):
The zebrafish embryo model in toxicology and teratology, September 2-3, 2010, Karlsruhe, Germany
Reprod. Toxicol. 31 (4), 585 - 588
Volltext (DOI) - dos Anjos, N.A., Schulze, T., Brack, W., Val, A.L., Schirmer, K., Scholz, S. (2011):
Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems
Aquat. Toxicol. 103 (1-2), 46 - 52
Volltext (DOI) - Georgi, A., Mackenzie, K., Scholz, S., Potthoff, A., Springer, A. (2011):
Eisenbasierte Nanopartikel und Nanokompositstrukturen zur Schadstoffentfernung aus Grund- und Abwässern
WING.DE 2011 – Tagungsband : Werkstoffe gestalten Zukunft, 4.-6. Oktober 2011 Berlin
Bundesministerium für Bildung und Forschung (BMBF), Berlin, S. 86 - 88 - Klüver, N., Yang, L., Busch, W., Scheffler, K., Scheffler, P., Strähle, U., Scholz, S. (2011):
Transcriptional response of zebrafish embryos exposed to neurotoxic compounds reveals a muscle activity dependent hspb11 expression
PLoS One 6 (12), e29063
Volltext (DOI) - Scholz, S., Büttner, A., Klüver, N., Guinea, J. (2011):
Fish embryos as alternative models for drug safety evaluation
In: Xu, J.J., Urban, L. (eds.)
Predictive toxicology in drug safety
Cambridge University Press, New York, p. 244 - 268
Volltext (DOI) - Siegert, F., Erdmann, F., Schwan, G., Scholz, S., Briel, D., Altenburger, R., Nieber, K. (2011):
Pharmacological and cytotoxic effects of new selective PDE10A ligands
Naunyn-Schmiedebergs Arch. Pharmacol. 383 (Suppl. 1), 21 - 21
Volltext (DOI) - Volz, D.C., Belanger, S., Embry, M., Padilla, S., Sanderson, H., Schirmer, K., Scholz, S., Villeneuve, D. (2011):
Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies
Toxicol. Sci. 123 (3), 349 - 358
Volltext (DOI)
2010 (2)
- Busch, W., Kühnel, D., Schirmer, K., Scholz, S. (2010):
Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
BMC Genomics 11 , art. 65
Volltext (DOI) - Scholz, S., Schirmer, K., Altenburger, R. (2010):
Pharmaceutical contaminants in urban water cycles - a discussion of novel concepts for environmental risk assessment
In: Fatta-Kassinos, D., Bester, K., Kümmerer, K. (eds.)
Xenobiotics in the urban water cycle: mass flows, environmental processes and mitigation strategies
Environ. Pollut. 16
Springer, Heidelberg, p. 227 - 244
Volltext (DOI)
2009 (8)
- Bastian, S., Busch, W., Kühnel, D., Springer, A., Meißner, T., Holke, R., Scholz, S., Iwe, M., Pompe, W., Gelinsky, M., Potthoff, A., Richter, V., Ikonomidou, H., Schirmer, K. (2009):
Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
Environ. Health Perspect. 117 (4), 530 - 536
Volltext (DOI) - Busch, W., Kühnel, D., Springer, A., Meissner, T., Gelinsky, M., Potthoff, A., Scholz, S., Richter, V., Schirmer, K. (2009):
Tungsten carbide and tungsten carbide cobalt nanoparticle toxicity: The role of cellular particle uptake, leached ions and cobalt bioavailability
Toxicol. Lett. 189 (Suppl. 1), S185 - S185
Volltext (DOI) - Büttner, A., Seifert, K., Cottin, T., Sarli, V., Tzagkaroulaki, L., Scholz, S., Giannis, A. (2009):
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
Bioorg. Med. Chem. 17 (14), 4943 - 4954
Volltext (DOI) - Klüver, N., Scheffler, K., Renner, P., Scholz, S. (2009):
Toxicogenomic response of azinphos-methyl treated zebrafish embryos and implication for the development of predictive models for chronic (fish) toxicity
Toxicol. Lett. 189 (Suppl. 1), S94 - S94
Volltext (DOI) - Kühnel, D., Busch, W., Meissner, T., Springer, A., Potthoff, A., Richter, V., Gelinsky, M., Scholz, S., Schirmer, K. (2009):
Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line
Aquat. Toxicol. 93 (2-3), 91 - 99
Volltext (DOI) - Scholz, S., Klüver, N. (2009):
Effects of endocrine disrupters on sexual, gonadal development in fish
Sex. Dev. 3 (2-3), 136 - 151
Volltext (DOI) - Scholz, S., Knöbel, M., Ortmann, J., Busser, F., Kramer, N., Hermens, J., Tanneberger, K., Schirmer, K. (2009):
The fish embryo test as an alternative to acute fish toxicity testing: Optimisation for difficult compounds and role of metabolic activation
Toxicol. Lett. 189 (Suppl. 1), S205 - S205
Volltext (DOI) - Weil, M., Scholz, S., Zimmer, M., Sacher, F., Duis, K. (2009):
Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the early life stage test
Environ. Toxicol. Chem. 28 (9), 1970 - 1978
Volltext (DOI)
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2008 (5)
- Richter, V., Potthoff, A., Pompe, W., Gelinsky, M., Ikonomidou, H., Bastian, S., Schirmer, K., Scholz, S., Hofinger, J. (2008):
Evaluation of health risks of nano- and microparticles
Powder Metall. 51 (1), 8 - 9
Volltext (DOI) - Schirmer, K., Tanneberger, K., Kramer, N.I., Völker, D., Scholz, S., Hafner, C., Lee, L.E.J., Bols, N.C., Hermens, J.L.M. (2008):
Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
Aquat. Toxicol. 90 (2), 128 - 137
Volltext (DOI) - Scholz, S., Fischer, S., Gündel, U., Küster, E., Luckenbach, T., Voelker, D. (2008):
The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
Environ. Sci. Pollut. Res. 15 (5), 394 - 404
Volltext (DOI) - Scholz, S., Mayer, I. (2008):
Molecular biomarkers of endocrine disruption in small model fish
Mol. Cell. Endocrinol. 293 (1-2), 57 - 70
Volltext (DOI) - Voelker, D., Stetefeld, N., Schirmer, K., Scholz, S. (2008):
The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos
Aquat. Toxicol. 86 (1), 112 - 120
Volltext (DOI)
2007 (3)
- Voelker, D., Veß, C., Tillmann, M., Nagel, R., Otto, G.W., Geisler, R., Schirmer, K., Scholz, S. (2007):
Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae
Aquat. Toxicol. 81 (4), 355 - 364
Volltext (DOI) - Völker, D., Veß, C., Schirmer, K., Scholz, S. (2007):
Gen-DarT- ein Vorhersagemodell für die chronische Toxizität durch Analyse veränderter Genexpression in Embryonen des Zebrabärblings (Danio rerio)?
Gesellschaft Deutscher Chemiker / Mitteilungen der Fachgruppe Umweltchemie und Ökotoxikologie 13 (4), 91 - 94 - Watzke, J., Schirmer, K., Scholz, S. (2007):
Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio)
Fish Shellfish Immunol. 23 (4), 901 - 905
Volltext (DOI)
2005 (2)
- Scholz, S., Kurauchi, K., Kinoshita, M., Oshima, Y., Ozato, K., Schirmer, K., Wakamatsu, Y. (2005):
Analysis of estrogenic effects by quantification of green flourescent protein in juvenile fish of a transgenic medaka
Environ. Toxicol. Chem. 24 (10), 2553 - 2561
Volltext (DOI) - Zierau, O., Hamann, J., Tischer, S., Schwab, P., Metz, P., Vollmer, G., Gutzeit, H.O., Scholz, S. (2005):
Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
Biochem. Biophys. Res. Commun. 326 (4), 909 - 916
Volltext (DOI)
2004 (2)
- Scholz, S., Domaschke, H., Kanamori, A., Ostermann, K., Rödel, G., Gutzeit, H.O. (2004):
Germ cell-less expression in Medaka (Oryzias latipes)
Mol. Reprod. Dev. 67 (1), 15 - 18
Volltext (DOI) - Scholz, S., Kordes, C., Hamann, J., Gutzeit, H.O. (2004):
Induction of vitellogenin in vivo and in vitro in the model teleost medaka (Oryzias latipes): comparison of gene expression and protein levels
Mar. Environ. Res. 57 (3), 235 - 244
Volltext (DOI)
2003 (1)
- Scholz, S., Rösler, S., Schäffer, M., Hornung, U., Schartl, M., Gutzeit, H.O. (2003):
Hormonal induction and stability of monosex populations in the medaka (Oryzias latipes): expression of sex-specific marker genes
Biol. Reprod. 69 (2), 673 - 678
Volltext (DOI)
2000 (1)
- Scholz, S., Gutzeit, H.O. (2000):
17-α-ethinylestradiol affects reproduction, sexual differentiation and aromatase gene expression of the medaka (Oryzias latipes)
Aquat. Toxicol. 50 (4), 363 - 373
Volltext (DOI)
1999 (1)
- Scholz, S., Segner, H. (1999):
Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: concentration-response relationships for four model substances
Ecotox. Environ. Safe. 43 (3), 252 - 260
Volltext (DOI)
1998 (1)
- Scholz, S., Braunbeck, T., Segner, H. (1998):
Viability and differential function of rainbow trout liver cells in primary culture: Coculture with two permanent fish cells
In Vitro Cell. Dev. Biol.-Anim. 34 (10), 762 - 771
Volltext (DOI)
1997 (1)
- Scholz, S., Behn, I., Honeck, H., Hauck, C., Braunbeck, T., Segner, H. (1997):
Development of a monoclonal antibody for ELISA of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes
Biomarkers 2 (5), 287 - 294
Volltext (DOI)
1996 (1)
- Scholz, S. (1996):
Induktion von CYP1A1 durch Xenobiotica in Leberzellkulturen von Regenbogenforellen
UFZ-Bericht 13/1996
UFZ Leipzig-Halle GmbH, Leipzig, 105 S.