Dr. Stefan Scholz
Adresse:
Permoserstr. 15
04318 Leipzig
Gebäude: 7.3
Raum: 2.023
Telefon: +49 341 6025 1080
Dr. Stefan Scholz
Forschungsinteressen
- Wirkungsmechanismen von Chemikalien
- High-content Analyse und Automatisierung Bioassays
- Entwicklung von Bioassays, insb. Alternativen zu Tierversuchen, für die Chemikalienprüfung und das Umweltmonitoring
Lebenslauf
Seit 2024
Wissenschaftlicher Mitarbeiter und stellvertretender Leiter des Dpt. Ökotoxikologie
2022 - 2023
Kommissarischer Leiter des Dpt. Bioanalytische Öktoxikologie
01/2015 - 06/2015
Forschungsaufenthalt, US-EPA (Environmental Protection Agency), Mid-continent ecology division Duluth, MN.
01/2004 - 03/2004
Gastwissenschaftler, Bioscience and Biotechnology Center, Laboratory of Freshwater Fish Stocks, University of Nagoya, Japan
Seit 2002
Wissenschaftlicher Mitarbeiter, Department Bioanalytische Ökotoxikologie, Helmholtz-Zentrum für Umweltforschung, Leipzig
04/1995 - 06/2002
Wissenschaftlicher Mitarbeiter, Institut für Zoologie, Universität Dresden
11/1992 - 03/1995
Promotion, Martin-Luther Universität Halle Wittenberg und Sektion Umweltchemie und Ökotoxikologie, Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig
Thema: Induktion von CYP1A in Leberzellkulturen der Regenbogenforelle
1987 - 1992
Biologiestudium, Ruhruniversität Bochum
Diplomarbeit: Di-myo-inositol-1,1'-phosphate: Ein neues inositol phosphate in Pyrococcus woesei
Auszeichnungen
2015
OECD Cooperative Research scholarship
2004
Scholarship of the University of Nagoya, Japan
Publikationen
Inhalt:
Weiterführende Recherchen können Sie in unserem Publikationsverzeichnis durchführen.
2026 (6)
- Aslam, M.A., Massei, R., Scholz, S. (2026):
High Content Screening (HCS) image dataset for the study "Comparative effect assessement of Bisphenol analogs by high content analysis in zebrafish (Danio rerio) embryos"
BioImage Archive
10.6019/S-BIAD3261 - Aslam, M.A., Massei, R., Scholz, S. (2026):
Comparative effect assessment of bisphenol analogs by high content analysis in zebrafish (Danio rerio) embryos
Aquat. Toxicol. 295 , art. 107822
10.1016/j.aquatox.2026.107822 - Escher, B.I., Blackwell, B.R., Cavallin, J., Dann, J.P., Jahnke, A., Jenson, C., Jensen, K., Kahl, M., Krauss, M., König, M., Neale, P.A., Scholz, S., Villeneuve, D., Ankley, G.T. (2026):
In vitro bioassays for quantifying mixture effects of organic micropollutants extracted from caged fish, water, and sediment
Environ. Toxicol. Chem. 45 (1), 137 - 151
10.1093/etojnl/vgaf255 - Grasse, N., Scholz, S., Reemtsma, T., Fu, Q. (2026):
Uptake and biotransformation govern the toxicity of reactive acrylamides in an in vivo zebrafish embryo model: implications for NAM-based hazard assessment
Environ. Sci. Technol. 60 (8), 6546 - 6557
10.1021/acs.est.5c10178 - Natha, B., Widhalm, R., Granitzer, S., Scholz, S., Timelthaler, G., Filipits, M., Koudelka, H., Mir-Karner, B., Weiß, S., Hengstschläger, M., Grasl-Kraupp, B., Derx, J., Zoboli, O., Distel, M., Gundacker, C. (2026):
Comparative analysis of four PFAS regarding their toxicity to zebrafish development
Ecotox. Environ. Safe. 314 , art. 120080
10.1016/j.ecoenv.2026.120080 - Spath, J., Raab, J., Schor, J., Scholz, S., Gutsfeld, S., Tal, T. (2026):
The zebrafish visual and acoustic motor response (VAMR) assay has the potential to add value to the developmental neurotoxicity in vitro battery (DNT IVB)
NeuroToxicology 114 , art. 103414
10.1016/j.neuro.2026.103414
2025 (10)
- Dann, J.P., Ankley, G.T., Blackwell, B.R., Escher, B.I., Jahnke, A., Jensen, K.M., Jenson, C., Krauss, M., Scholz, S., Wernicke, T., Brack, W. (2025):
Current emission vs. legacy organic pollutants: Assessing the extent to which the eco-exposome of caged fish reflects external exposure
Environ. Pollut. 383 , art. 126808
10.1016/j.envpol.2025.126808 - Hayot, G., Lloyd, G.R., Diwan, G.D., Keith, N., Smoot, S.R., Cramer von Clausbruch, C.A., Kaufman, T.C., Barnard, M., Tindall, A.J., Glaholt, S.P., Massei, R., Martínez, R., Strähle, U., Orsini, L., Russell, R.B., Tennessen, J.M., Scholz, S., Shaw, J.R., Freedman, J.H., Colbourne, J.K., Weiss, C., Dickmeis, T. (2025):
Alternative vertebrate and invertebrate model organisms show similar sensitivity as rodents to a diverse set of chemicals
Environ. Sci. Technol. 59 (48), 25634 - 25648
10.1021/acs.est.5c10177 - Herold, N.K., Sørensen, L., Creese, M.E., Nahrgang, J., Schweiger, N., Scholz, S., Tal, T. (2025):
Neuroactive behavioral fingerprinting of crude oil-derived water accommodated fractions in larval zebrafish using a new approach method
Toxicol. Lett. 411 (Supplement), S119
10.1016/j.toxlet.2025.07.302 - Martínez, R., González-Sánchez, J.C., Sampani, S.I., Scholz, S., Escher, B.I., Henneberger, L., Huchthausen, J., Whelan, M., Dickmeis, T., Weiss, C., Colbourne, J.K., Freedman, J.H. (2025):
The PrecisionTox chemical library: creation of a chemical collection to discover evolutionary conserved biomolecular signatures of toxicity
Toxicol. Sci. 208 (2), 317 - 329
10.1093/toxsci/kfaf126 - Massei, R., Busch, W., Serrano-Solano, B., Bernt, M., Scholz, S., Nicolay, E.K., Bohring, H., Bumberger, J. (2025):
High-content screening (HCS) workflows for FAIR image data management with OMERO
Sci. Rep. 15 , art. 16236
10.1038/s41598-025-00720-0 - Michaelis, P., Klüver, N., Aulhorn, S., Bohring, H., Bumberger, J., Haase, K., Kuhnert, T., Küster, E., Krüger, J., Luckenbach, T., Massei, R., Nerlich, L., Petruschke, S., Schnicke, T., Schnurpel, A., Scholz, S., Schweiger, N., Sielaff, D., Busch, W. (2025):
Leveraging zebrafish embryo phenotypic observations to advance data-driven analyses in toxicology
Environ. Sci. Technol. 59 (9), 4304 - 4317
10.1021/acs.est.4c11757 - Nöth, J., Michaelis, P., Schüler, L., Scholz, S., Krüger, J., Haake, V., Busch, W. (2025):
Correction to: Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Arch. Toxicol. 99 (4), 1579
10.1007/s00204-025-03998-1 - Nöth, J., Michaelis, P., Schüler, L., Scholz, S., Krüger, J., Haake, V., Busch, W. (2025):
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Arch. Toxicol. 99 (4), 1561 - 1578
10.1007/s00204-024-03944-7 - Scholz, S., Zanini, C., Koblitz, A.-K., Möller, T., Aslam, M.A., Ajugwo, G.C., Chukwu, E., Colbourne, J., Kader, S., Fu, Q., Grasse, N., Reemtsma, T., Massei, R. (2025):
Grouping and assessment of chemicals for hazard and risk assessment by high content analysis using the zebrafish embryos as an alternative non-sentient animal model
Toxicol. Lett. 411 (Supplement), S399
10.1016/j.toxlet.2025.07.919 - Tanabe, S., Burgdorf, T., Choi, J., Delrue, N., Edwards, S.W., Filipovska, J., FitzGerald, R., Halappanavar, S., Hench, V.K., Karschnik, T., LaLone, C., Landesmann, B., La Rocca, C., Luijten, M., Meek, B., O’Brien, J.M., Perkins, E.J., Perkins, S., Scholz, S., Song, Y., Tcheremenskaia, O., Thomas, R., Tollefsen, K.E., Villeneuve, D.L., Viviani, B., Whelan, M., Wittwehr, C., Yauk, C. (2025):
Adverse Outcome Pathway (AOP) Coaching Program—how it functions and contributes to a more harmonized approach to AOP development and construction of AOP networks with regulatory utility
Environ. Toxicol. Chem. 44 (10), 2725 - 2732
10.1093/etojnl/vgaf173
2024 (8)
- Escher, B.I., Ahlheim, J., Böhme, A., Borchardt, D., Brack, W., Braun, G., Colbourne, J.K., Dann, J.P., Gessner, J., Jahnke, A., König, M., Klüver, N., Krauss, M., Lee, J., Li, X., Lips, S., Orsini, L., Rinke, K., Schmitt-Jansen, M., Scholz, S., Schulze, T., Spahr, S., Ulrich, N., Weitere, M., Varga, E. (2024):
Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Nat. Water 2 (9), 889 - 898
10.1038/s44221-024-00297-4 - Grasse, N., Massei, R., Seiwert, B., Scholz, S., Escher, B.I., Reemtsma, T., Fu, Q. (2024):
Impact of biotransformation on internal concentrations and specificity classification of organic chemicals in the zebrafish embryo (Danio rerio)
Environ. Sci. Technol. 58 (40), 17898 - 17907
10.1021/acs.est.4c04156 - Gutsfeld, S., Wehmas, L., Omoyeni, I.E., Schweiger, N., Leuthold, D., Michaelis, P., Howey, X.M., Gaballah, S., Herold, N., Vogs, C., Wood, C., Bertotto, L., Wu, G.-M., Klüver, N., Busch, W., Scholz, S., Schor, J., Tal, T. (2024):
Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS)
Environ. Health Perspect. 132 (7), art. 077007
10.1289/EHP13667 - Hayot, G., Marcato, D., Cramer von Clausbruch, C.A., Pace, G., Strähle, U., Colbourne, J.K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T. (2024):
Evaluating toxicity of chemicals using a zebrafish vibration startle response screening system
J. Vis. Exp. 2024 (203), e66153
10.3791/66153 - Hayot, G., Massei, R., Lloyd, G., Keith, N., Diwan, G., Martinez Lopez, R., Barnard, M., Cramer von Clausbruch, C.A., Grasse, N., Smoot, S., Escher, B., Tennessen, J., Tindall, A., Oliver, B., Shaw, J., Scholz, S., Freedman, J., Strähle, U., Colbourne, J., Weiss, C., Dickmeis, T. (2024):
Systematic acquisition of toxicity data in non- sentient models across animal phylogeny: implications for read- across and estimation of toxicity in humans
Naunyn-Schmiedebergs Arch. Pharmacol. 397 (Suppl. 1), S17 - S18-69
10.1007/s00210-024-02974-3 - Nöth, J., Busch, W., Tal, T., Lai, C., Ambekar, A., Kießling, T.R., Scholz, S. (2024):
Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Arch. Toxicol. 98 (2), 537 - 549
10.1007/s00204-023-03633-x - Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P.J., Escher, B.I., Dirven, H., Hellsten, K., Dolva, K., Hessel, E., Heusinkveld, H.J., Hadzhiev, Y., Hurem, S., Jagiello, K., Judzinska, B., Klüver, N., Knoll-Gellida, A., Kühne, B.A., Leist, M., Lislien, M., Lyche, J.L., Müller, F., Colbourne, J.K., Neuhaus, W., Pallocca, G., Seeger, B., Scharkin, I., Scholz, S., Spjuth, O., Torres-Ruiz, M., Bartmann, K. (2024):
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Front. Toxicol. 6 , art. 1359507
10.3389/ftox.2024.1359507 - Wilhelmi, P., Haake, V., Zickgraf, F.M., Giri, V., Ternes, P., Driemert, P., Nöth, J., Scholz, S., Barenys, M., Flick, B., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2024):
Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish
Arch. Toxicol. 98 (3), 943 - 956
10.1007/s00204-023-03655-5
2023 (9)
- Bajard, L., Adamovsky, O., Audouze, K., Baken, K., Barouki, R., Beltman, J.B., Beronius, A., Bonefeld-Jørgensen, E.C., Cano-Sancho, G., de Baat, M.L., Di Tillio, F., Fernández, M.F., FitzGerald, R.E., Gundacker, C., Hernández, A.F., Hilscherova, K., Karakitsios, S., Kuchovska, E., Long, M., Luijten, M., Majid, S., Marx-Stoelting, P., Mustieles, V., Negi, C.K., Sarigiannis, D., Scholz, S., Sovadinova, I., Stierum, R., Tanabe, S., Tollefsen, K.E., van den Brand, A.D., Vogs, C., Wielsøe, M., Wittwehr, C., Blaha, L. (2023):
Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
Environ. Res. 217 , art. 114650
10.1016/j.envres.2022.114650 - Bashirova, N., Poppitz, D., Klüver, N., Scholz, S., Matysik, J., Alia, A. (2023):
A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
Sci. Rep. 13 , art. 1891
10.1038/s41598-023-28712-y - Colbourne, J.K., Andrews, E., Barnard, M., Čavoški, A., Chaturvedi, A., Epps, D.J.T., Holden, L., Jones, M.R., Li, X., Mueller, F., Ormanin-Lewandowska, A., Orsini, L., Roberts, R., Weber, R.J.M., Zhou, J., Apic, G., Ignasiak, T., Jankovic, K., Krsmanovic, T., Leoni, B., Asole, G., Guigó, R., Marangio, P., Palumbo, E., Perez-Lluch, S., Wucher, V., Vlot, A.H., Anholt, R., Mackay, T., Escher, B.I., Grasse, N., Huchthausen, J., Massei, R., Reemtsma, T., Scholz, S., Schüürmann, G., Bondesson, M., Cherbas, P., et al. (2023):
The Precision Toxicology initiative
Toxicol. Lett. 383 , 33 - 42
10.1016/j.toxlet.2023.05.004 - Cramer von Clausbruch, C.A., Weiss, C., Dickmeis, T., Peravali, R., Strähle, U., Colbourne, J., Hayot, G., Scholz, S., Martinez Lopez, R. (2023):
Quantitative and qualitative assessment of cytotoxicity by automated fluorescence microscopy in human hepatocytes
Naunyn-Schmiedebergs Arch. Pharmacol. 396 (Suppl. 1), S61 - S62
10.1007/s00210-023-02397-6 - Escher, B.I., Altenburger, R., Blüher, M., Colbourne, J.K., Ebinghaus, R., Fantke, P., Hein, M., Köck, W., Kümmerer, K., Leipold, S., Li, X., Scheringer, M., Scholz, S., Schloter, M., Schweizer, P.-J., Tal, T., Tetko, I., Traidl-Hoffmann, C., Wick, L.Y., Fenner, K. (2023):
Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
Arch. Toxicol. 97 (5), 1267 - 1283
10.1007/s00204-023-03485-5 - Grasse, N., Seiwert, B., Massei, R., Scholz, S., Fu, Q., Reemtsma, T. (2023):
Uptake and biotransformation of the tire rubber-derived contaminants 6-PPD and 6-PPD quinone in the zebrafish embryo (Danio rerio)
Environ. Sci. Technol. 57 (41), 15598 - 15607
10.1021/acs.est.3c02819 - Hayot, G., von Clausbruch, C., Martinez Lopez, R., Scholz, S., Colbourne, J., Strähle, U., Weiss, C., Peravali, R., Dickmeis, T. (2023):
Phenotypic anchoring for OMICS-guided assessment of liver toxicity in zebrafish
Naunyn-Schmiedebergs Arch. Pharmacol. 396 (Suppl. 1), S61 - S61
10.1007/s00210-023-02397-6 - Scholz, S. (2023):
sscholz-UFZ/EmbryoMotion: EmbryoMotion Version 1.1. - a software to analyse spontaneous tail contraction and photomotor response of zebrafish embryos
Version: 1.1 Zenodo
10.5281/zenodo.8362019 - Wilhelmi, P., Giri, V., Zickgraf, F.M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2023):
A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil
Chem.-Biol. Interact. 382 , art. 110565
10.1016/j.cbi.2023.110565
2022 (11)
- Lee, J., Escher, B.I., Scholz, S., Schlichting, R. (2022):
Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells
Arch. Toxicol. 96 (4), 1039 - 1053
10.1007/s00204-022-03237-x - Lee, J., Huchthausen, J., Schlichting, R., Scholz, S., Henneberger, L., Escher, B.I. (2022):
Validation of an SH-SY5Y cell-based acetylcholinesterase inhibition assay for water quality assessment
Environ. Toxicol. Chem. 41 (12), 3046 - 3057
10.1002/etc.5490 - Lee, J., Schlichting, R., König, M., Scholz, S., Krauss, M., Escher, B.I. (2022):
Monitoring mixture effects of neurotoxicants in surface water and wastewater treatment plant effluents with neurite outgrowth inhibition in SH-SY5Y cells
ACS Environ. Au 2 (6), 523 - 535
10.1021/acsenvironau.2c00026 - Nöth, J., Michaelis, P., Busch, W., Scholz, S. (2022):
Analysis vascular disruptors in zebrafish embryos as an endpoint to predict developmental toxicity
Toxicol. Lett. 368 (Suppl.), S34 - S35
10.1016/j.toxlet.2022.07.111 - Ortmann, J., Altenburger, R., Scholz, S., Luckenbach, T. (2022):
Photomotor response data analysis approach to assess chemical neurotoxicity with the zebrafish embryo
ALTEX-Altern. Anim. Exp. 39 (1), 82 - 94
10.14573/altex.2004021 - Paini, A., Campia, I., Cronin, M.T.D., Asturiol, D., Ceriani, L., Exner, T.E., Gao, W., Gomes, C., Kruisselbrink, J., Martens, M., Meek, M.E.B., Pamies, D., Pletz, J., Scholz, S., Schüttler, A., Spînu, N., Villeneuve, D.L., Wittwehr, C., Worth, A., Luijten, M. (2022):
Towards a qAOP framework for predictive toxicology - Linking data to decisions
Comput. Toxicol. 21 , art. 100195
10.1016/j.comtox.2021.100195 - Scholz, S., Brack, W., Escher, B.I., Hackermüller, J., Liess, M., von Bergen, M., Wick, L.Y., Zenclussen, A.C., Altenburger, R. (2022):
The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Arch. Toxicol. 96 (8), 2381 - 2386
10.1007/s00204-022-03313-2 - Scholz, S., Nichols, J.W., Escher, B.I., Ankley, G.T., Altenburger, R., Blackwell, B., Brack, W., Burkhard, L., Collette, T.W., Doering, J.A., Ekman, D., Fay, K., Fischer, F., Hackermüller, J., Hoffman, J.C., Lai, C., Leuthold, D., Martinovic-Weigelt, D., Reemtsma, T., Pollesch, N., Schroeder, A., Schüürmann, G., von Bergen, M. (2022):
The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45
10.1002/etc.5242 - Spînu, N., Cronin, M.T.D., Lao, J., Bal-Price, A., Campia, I., Enoch, S.J., Madden, J.C., Lagares, L.M., Novič, M., Pamies, D., Scholz, S., Villeneuve, D.L., Worth, A.P. (2022):
Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
Comput. Toxicol. 21 , art. 100206
10.1016/j.comtox.2021.100206 - Teixidó, E., Kieβling, T.R., Klüver, N., Scholz, S. (2022):
Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test
Arch. Toxicol. 96 (5), 1353 - 1369
10.1007/s00204-022-03253-x - Wilhelmi, P., Giri, V., Henkes, S., Walk, T., Haake, V., Scholz, S., Busch, W., Barenys, M., Zickgraf, F., Landsiedel, R., Funk-Weyer, D., Birk, B., Flick, B. (2022):
A targeted metabolomics approach for unraveling different modes of embryotoxicity in zebrafish
Toxicol. Lett. 368 (Suppl.), S252 - S252
10.1016/j.toxlet.2022.07.671
2021 (8)
- Ambekar, A., Poschen, C., Lai, C., Scholz, S., Teixidó, E. (2021):
Analyzing morphological changes in zebrafish embryos exposed to toxic chemicals
2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Houston, TX, USA, 9-12 December 2021
Institute of Electrical and Electronics Engineers (IEEE), New York, NY, p. 1711 - 1718
10.1109/BIBM52615.2021.9669338 - Bieczynski, F., Burkhardt-Medicke, K., Luquet, C.M., Scholz, S., Luckenbach, T. (2021):
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity
FEBS Lett. 595 (6), 828 - 843
10.1002/1873-3468.14015 - Huhn, S., Escher, B.I., Krauss, M., Scholz, S., Hackermüller, J., Altenburger, R. (2021):
Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive
Environ. Sci. Eur. 33 , art. 17
10.1186/s12302-020-00444-0 - Lee, J., Braun, G., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2021):
Critical membrane concentration and mass-balance model to identify baseline cytotoxicity of hydrophobic and ionizable organic chemicals in mammalian cell lines
Chem. Res. Toxicol. 34 (9), 2100 - 2109
10.1021/acs.chemrestox.1c00182 - Ogungbemi, A.O., Massei, R., Altenburger, R., Scholz, S., Küster, E. (2021):
Assessing combined effects for mixtures of similar and dissimilar acting neuroactive substances on zebrafish embryo movement
Toxics 9 (5), art. 104
10.3390/toxics9050104 - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2021):
Automated measurement of the spontaneous tail coiling of zebrafish embryos as a sensitive behavior endpoint using a workflow in KNIME
MethodsX 8 , art. 101330
10.1016/j.mex.2021.101330 - Paparella, M., Scholz, S., Belanger, S., Braunbeck, T., Bicherel, P., Connors, K., Faßbender, C., Halder, M., Lillicrap, A., Liska, R., Schirmer, K., Stoddart, G., Thomas, P., Walter-Rohde, S. (2021):
Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods
ALTEX-Altern. Anim. Exp. 38 (1), 20 - 32
10.14573/altex.2006051 - Teixidó, E., Klüver, N., Ogungbemi, A.O., Küster, E., Scholz, S. (2021):
Evaluation of neurotoxic effects in zebrafish embryos by automatic measurement of early motor behaviors
In: Llorens, J., Barenys, M. (eds.)
Experimental neurotoxicology methods
Neuromethods 172
Springer Nature, p. 381 - 397
10.1007/978-1-0716-1637-6_17
2020 (5)
- Halbach, K., Ulrich, N., Goss, K.-U., Seiwert, B., Wagner, S., Scholz, S., Luckenbach, T., Bauer, C., Schweiger, N., Reemtsma, T. (2020):
Yolk sac of zebrafish embryos as backpack for chemicals?
Environ. Sci. Technol. 54 (16), 10159 - 10169
10.1021/acs.est.0c02068 - Larras, F., Billoir, E., Scholz, S., Tarkka, M., Wubet, T., Delignette-Muller, M.-L., Schmitt-Jansen, M. (2020):
A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus
J. Hazard. Mater. 397 , art. 122727
10.1016/j.jhazmat.2020.122727 - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2020):
Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®
Neurotoxicol. Teratol. 81 , art. 106918
10.1016/j.ntt.2020.106918 - Teixidó, E., Leuthold, D., de Crozé, N., Léonard, M., Scholz, S. (2020):
Comparative assessment of the sensitivity of fish early‐life stage, Daphnia and algae to the chronic ecotoxicity of xenobiotics – perspectives for alternatives to animal testing
Environ. Toxicol. Chem. 39 (1), 30 - 41
10.1002/etc.4607 - Ulrich, N., Schweiger, N., Pfennigsdorff, A., Scholz, S., Goss, K.-U. (2020):
Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio
Environ. Toxicol. Chem. 39 (8), 1506 - 1516
10.1002/etc.4744
2019 (5)
- Halbach, K., Wagner, S., Scholz, S., Luckenbach, T., Reemtsma, T. (2019):
Elemental imaging (LA-ICP-MS) of zebrafish embryos to study the toxicokinetics of the acetylcholinesterase inhibitor naled
Anal. Bioanal. Chem. 411 (3), 617 - 627
10.1007/s00216-018-1471-2 - Ogungbemi, A., Leuthold, D., Scholz, S., Küster, E. (2019):
Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
Environ. Sci. Eur. 31 , art. 88
10.1186/s12302-019-0270-5 - Perkins, E.J., Ashauer, R., Burgoon, L., Conolly, R., Landesmann, B., Mackay, C., Murphy, C.A., Pollesch, N., Wheeler, J.R., Zupanic, A., Scholz, S. (2019):
Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
Environ. Toxicol. Chem. 38 (9), 1850 - 1865
10.1002/etc.4505 - Philipp, K., Lemke, F., Scholz, S., Wallrabe, U., Wapler, M.C., Koukourakis, N., Czarske, J.W. (2019):
Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens
Sci. Rep. 9 , art. 9532
10.1038/s41598-019-45993-4 - Teixidó, E., Kießling, T.R., Krupp, E., Quevedo, C., Muriana, A., Scholz, S. (2019):
Automated morphological feature assessment for zebrafish embryo developmental toxicity screens
Toxicol. Sci. 167 (2), 438 - 449
10.1093/toxsci/kfy250
2018 (9)
- Birke, A., Scholz, S. (2018):
Zebrafish embryo and acute fish toxicity test show similar sensitivity for narcotic compounds
ALTEX-Altern. Anim. Exp. 36 (1), 131 - 135
10.14573/altex.1808101 - Fischer, F.C., Abele, C., Droge, S.T.J., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2018):
Cellular uptake kinetics of neutral and charged chemicals in in vitro assays measured by fluorescence microscopy
Chem. Res. Toxicol. 31 (8), 646 - 657
10.1021/acs.chemrestox.8b00019 - Jarque, S., Fetter, E., Veneman, W.J., Spaink, H.P., Peravali, R., Strähle, U., Scholz, S. (2018):
An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
PLOS One 13 (8), e0203087
10.1371/journal.pone.0203087 - Larras, F., Billoir, E., Baillard, V., Siberchicot, A., Scholz, S., Wubet, T., Tarkka, M., Schmitt-Jansen, M., Delignette-Muller, M.-L. (2018):
DRomics: A turnkey tool to support the use of the dose–response framework for omics data in ecological risk assessment
Environ. Sci. Technol. 52 (24), 14461 - 14468
10.1021/acs.est.8b04752 - Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
An ecotoxicological view on neurotoxicity assessment
Environ. Sci. Eur. 30 , art. 46
10.1186/s12302-018-0173-x - Scholz, S., Schreiber, R., Armitage, J., Mayer, P., Escher, B.I., Lidzba, A., Léonard, M., Altenburger, R. (2018):
Meta‐analysis of fish early life stage tests—Association of toxic ratios and acute‐to‐chronic ratios with modes of action
Environ. Toxicol. Chem. 37 (4), 955 - 969
10.1002/etc.4090 - Sobanska, M., Scholz, S., Nyman, A.-M., Cesnaitis, R., Gutierrez Alonso, S., Klüver, N., Kühne, R., Tyle, H., de Knecht, J., Dang, Z., Lundbergh, I., Carlon, C., De Coen, W. (2018):
Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)
Environ. Toxicol. Chem. 37 (3), 657 - 670
10.1002/etc.4055 - Teixido, E., Kerkhof, O., Kießling, T., Scholz, S. (2018):
Retrieving mode of action information by automated effect pattern analysis using the zebrafish embryo toxicity test
Reprod. Toxicol. 80 , 18 - 19
10.1016/j.reprotox.2018.06.074 - Teixidó, E., Krupp, E., Amberg, A., Czich, A., Scholz, S. (2018):
Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches
Reprod. Toxicol. 76 , 93 - 102
10.1016/j.reprotox.2018.01.005
2017 (3)
- Andrade, T.S., Henriques, J.F., Almeida, A.R., Soares, A.M.V.M., Scholz, S., Dominigues, I. (2017):
Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV-light irradiation
Environ. Toxicol. Chem. 36 (3), 682 - 690
10.1002/etc.3579 - Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106
10.1016/j.envint.2016.11.029 - Teixido, E., Kießling, T., Leuthold, D., Scholz, S. (2017):
Effect signatures in zebrafish embryos exposed to compounds with potential developmental toxicity
Reprod. Toxicol. 72 , 49
10.1016/j.reprotox.2017.06.179
2016 (6)
- Klüver, N., Vogs, C., Altenburger, R., Escher, B.I., Scholz, S. (2016):
Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test
Chemosphere 164 , 164 - 173
10.1016/j.chemosphere.2016.08.079 - Scholz, S., Jarque, S., Fetter, E. (2016):
A fully automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
Reprod. Toxicol. 64 (Special Issue), 30
10.1016/j.reprotox.2016.06.064 - Scholz, S., Klüver, N., Kühne, R. (2016):
Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. Report ECHA-UFZ contract ECHA/2014/341
Helmholtz Centre for Environmental Research - UFZ, Leipzig, 104 pp. - Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016):
Zebrafish biosensor for toxicant induced muscle hyperactivity
Sci. Rep. 6 , art. 23768
10.1038/srep23768 - Teixidó, E., Leuthold, D., Amberg, A., Czich, A., Krupp, E., Scholz, S. (2016):
ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA)
Reprod. Toxicol. 64 , 22
10.1016/j.reprotox.2016.06.048 - Teixidó, E., Leuthold, D., Scholz, S., Quevedo, C., Muriana, A., Czich, A., Krupp, E. (2016):
An inter-laboratory validation of the zebrafish embryo assay for the detection of developmental toxicity
Reprod. Toxicol. 64 , 44
10.1016/j.reprotox.2016.06.096
2015 (8)
- Fetter, E., Baldauf, L., Da Fonte, D.F., Ortmann, J., Scholz, S. (2015):
Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos
Reprod. Toxicol. 57 , 10 - 20
10.1016/j.reprotox.2015.04.012 - Fetter, E., Smetanová, S., Baldauf, L., Lidzba, A., Altenburger, R., Schüttler, A., Scholz, S. (2015):
Identification and characterization of androgen-responsive genes in zebrafish embryos
Environ. Sci. Technol. 49 (19), 11789 - 11798
10.1021/acs.est.5b01034 - Hernández, R.B., Nishita, M.I., Espósito, B.P., Scholz, S., Michalke, B. (2015):
The role of chemical speciation, chemical fractionation and calcium disruption in manganese-induced developmental toxicity in zebrafish (Danio rerio) embryos
J. Trace Elem. Med. Biol. 32 , 209 - 217
10.1016/j.jtemb.2015.07.004 - Jonas, A., Scholz, S., Fetter, E., Sychrova, E., Novakova, K., Ortmann, J., Benisek, M., Adamovsky, O., Giesy, J.P., Hilscherova, K. (2015):
Endocrine, teratogenic and neurotoxic effects of cyanobacteria detected by cellular in vitro and zebrafish embryos assays
Chemosphere 120 , 321 - 327
10.1016/j.chemosphere.2014.07.074 - Klüver, N., König, M., Ortmann, J., Massei, R., Paschke, A., Kühne, R., Scholz, S. (2015):
Fish embryo toxicity test: Identification of compounds with weak toxicity and analysis of behavioral effects to improve prediction of acute toxicity for neurotoxic compounds
Environ. Sci. Technol. 49 (11), 7002 - 7011
10.1021/acs.est.5b01910 - Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
What determines chemical uptake by the zebrafish embryo model?
Toxicol. Lett. 238 (2, Suppl.), S54
10.1016/j.toxlet.2015.08.151 - Massei, R., Vogs, C., Renner, P., Altenburger, R., Scholz, S. (2015):
Differential sensitivity in embryonic stages of the zebrafish (Danio rerio): The role of toxicokinetics for stage-specific susceptibility for azinphos-methyl lethal effects
Aquat. Toxicol. 166 , 36 - 41
10.1016/j.aquatox.2015.06.011 - Scholz, S. (2015):
In response: Quantitative adverse outcome pathways for prediction of adverse effects—An academic perspective
Environ. Toxicol. Chem. 34 (9), 1935 - 1937
10.1002/etc.3043
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2014 (7)
- Busquet, F., Strecker, R., Rawlings, J.M., Belanger, S.E., Braunbeck, T., Carr, G.J., Cenijn, P., Fochtman, P., Gourmelon, A., Hübler, N., Kleensang, A., Knöbel, M., Kussatz, C., Legler, J., Lillicrap, A., Martínez-Jerónimo, F., Polleichtner, C., Rzodeczko, H., Salinas, E., Schneider, K.E., Scholz, S., van den Brandhof, E.-J., van der Ven, L.T.M., Walter-Rohde, S., Weigt, S., Witters, H., Halder, M. (2014):
OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing
Regul. Toxicol. Pharmacol. 69 (3), 496 - 511
10.1016/j.yrtph.2014.05.018 - Escher, B.I., Allinson, M., Altenburger, R., Bain, P.A., Balaguer, P., Busch, W., Crago, J., Denslow, N.D., Dopp, E., Hilscherova, K., Humpage, A.R., Kumar, A., Grimaldi, M., Jayasinghe, B.S., Jarosova, B., Jia, A., Makarov, S., Maruya, K.A., Medvedev, A., Mehinto, A.C., Mendez, J.E., Poulsen, A., Prochazka, E., Richard, J., Schifferli, A., Schlenk, D., Scholz, S., Shiraishi, F., Snyder, S., Su, G., Tang, J.Y.M., van der Burg, B., van der Linden, S.C., Werner, I., Westerheide, S.D., Wong, C.K.C., Yang, M., Yeung, B.H.Y., Zhang, X., Leusch, F.D.L. (2014):
Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays
Environ. Sci. Technol. 48 (3), 1940 - 1956
10.1021/es403899t - Fetter, E., Krauss, M., Brion, F., Kah, O., Scholz, S., Brack, W. (2014):
Effect-directed analysis for estrogenic compounds in a fluvial sediment sample using transgenic cyp19a1b-GFP zebrafish embryos
Aquat. Toxicol. 154 , 221 - 229
10.1016/j.aquatox.2014.05.016 - Jonas, A., Buranova, V., Scholz, S., Fetter, E., Novakova, K., Kohoutek, J., Hilscherova, K. (2014):
Retinoid-like activity and teratogenic effects of cyanobacterial exudates
Aquat. Toxicol. 155 , 283 - 293
10.1016/j.aquatox.2014.06.022 - Klüver, N., Ortmann, J., Paschke, H., Renner, P., Ritter, A.P., Scholz, S. (2014):
Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos
PLOS One 9 (3), e90619
10.1371/journal.pone.0090619 - Scholz, S., Ortmann, J., Klüver, N., Léonard, M. (2014):
Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories
Regul. Toxicol. Pharmacol. 69 (3), 572 - 579
10.1016/j.yrtph.2014.06.004 - Tollefsen, K.E., Scholz, S., Cronin, M.T., Edwards, S.W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A., Patlewicz, G. (2014):
Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)
Regul. Toxicol. Pharmacol. 70 (3), 629 - 640
10.1016/j.yrtph.2014.09.009
2013 (4)
- Petersen, K., Fetter, E., Kah, O., Brion, F., Scholz, S., Tollefsen, K.E. (2013):
Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals
Aquat. Toxicol. 138-139 , 88 - 97
10.1016/j.aquatox.2013.05.001 - Scholz, S. (2013):
Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity
Arch. Toxicol. 87 (5), 767 - 769
10.1007/s00204-013-1044-2 - Scholz, S., Renner, P., Belanger, S.E., Busquet, F., Davi, R., Demeneix, B.A., Denny, J.S., Léonard, M., McMaster, M.E., Villeneuve, D.L., Embry, M.R. (2013):
Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians – screening for estrogen, androgen and thyroid hormone disruption
Crit. Rev. Toxicol. 43 (1), 45 - 70
10.3109/10408444.2012.737762 - Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013):
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Regul. Toxicol. Pharmacol. 67 (3), 506 - 530
10.1016/j.yrtph.2013.10.003
2012 (5)
- Altenburger, R., Scholz, S., Schmitt-Jansen, M., Busch, W., Escher, B.I. (2012):
Mixture toxicity revisited from a toxicogenomic perspective
Environ. Sci. Technol. 46 (5), 2508 - 2522
10.1021/es2038036 - Büttner, A., Busch, W., Klüver, N., Giannis, A., Scholz, S. (2012):
Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine
Reprod. Toxicol. 33 (2), 254 - 263
10.1016/j.reprotox.2011.12.010 - Knöbel, M., Busser, F.J.M., Rico-Rico, A., Kramer, N.I., Hermens, J.L.M., Hafner, C., Tanneberger, K., Schirmer, K., Scholz, S. (2012):
Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
Environ. Sci. Technol. 46 (17), 9690 - 9700
10.1021/es301729q - Scholz, S. (2012):
Special issue: zebrafish teratogenesis
Reprod. Toxicol. 33 (2), 127 - 127
10.1016/j.reprotox.2012.01.008 - Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., Braunbeck, T. (2012):
Zebrafish embryos as an alternative to animal experiments - a commentary on the definition of the onset of protected life stages in animal welfare regulations
Reprod. Toxicol. 33 (2), 128 - 132
10.1016/j.reprotox.2011.06.121
2011 (7)
- Busch, W., Duis, K., Fenske, M., Maack, G., Legler, J., Padilla, S., Strähle, U., Witters, H., Scholz, S. (2011):
The zebrafish embryo model in toxicology and teratology, September 2-3, 2010, Karlsruhe, Germany
Reprod. Toxicol. 31 (4), 585 - 588
10.1016/j.reprotox.2011.02.010 - dos Anjos, N.A., Schulze, T., Brack, W., Val, A.L., Schirmer, K., Scholz, S. (2011):
Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems
Aquat. Toxicol. 103 (1-2), 46 - 52
10.1016//j.aquatoc.2011.02.004 - Georgi, A., Mackenzie, K., Scholz, S., Potthoff, A., Springer, A. (2011):
Eisenbasierte Nanopartikel und Nanokompositstrukturen zur Schadstoffentfernung aus Grund- und Abwässern
WING.DE 2011 – Tagungsband : Werkstoffe gestalten Zukunft, 4.-6. Oktober 2011 Berlin
Bundesministerium für Bildung und Forschung (BMBF), Berlin, S. 86 - 88 - Klüver, N., Yang, L., Busch, W., Scheffler, K., Scheffler, P., Strähle, U., Scholz, S. (2011):
Transcriptional response of zebrafish embryos exposed to neurotoxic compounds reveals a muscle activity dependent hspb11 expression
PLoS One 6 (12), e29063
10.1371/journal.pone.0029063 - Scholz, S., Büttner, A., Klüver, N., Guinea, J. (2011):
Fish embryos as alternative models for drug safety evaluation
In: Xu, J.J., Urban, L. (eds.)
Predictive toxicology in drug safety
Cambridge University Press, New York, p. 244 - 268
10.1017/CBO9780511779053.015 - Siegert, F., Erdmann, F., Schwan, G., Scholz, S., Briel, D., Altenburger, R., Nieber, K. (2011):
Pharmacological and cytotoxic effects of new selective PDE10A ligands
Naunyn-Schmiedebergs Arch. Pharmacol. 383 (Suppl. 1), 21 - 21
10.1007/s00210-011-0617-y - Volz, D.C., Belanger, S., Embry, M., Padilla, S., Sanderson, H., Schirmer, K., Scholz, S., Villeneuve, D. (2011):
Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies
Toxicol. Sci. 123 (3), 349 - 358
10.1093/toxsci/kfr185
2010 (2)
- Busch, W., Kühnel, D., Schirmer, K., Scholz, S. (2010):
Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
BMC Genomics 11 , art. 65
10.1186/1471-2164-11-65 - Scholz, S., Schirmer, K., Altenburger, R. (2010):
Pharmaceutical contaminants in urban water cycles - a discussion of novel concepts for environmental risk assessment
In: Fatta-Kassinos, D., Bester, K., Kümmerer, K. (eds.)
Xenobiotics in the urban water cycle: mass flows, environmental processes and mitigation strategies
Environ. Pollut. 16
Springer, Heidelberg, p. 227 - 244
10.1007/978-90-481-3509-7
2009 (8)
- Bastian, S., Busch, W., Kühnel, D., Springer, A., Meißner, T., Holke, R., Scholz, S., Iwe, M., Pompe, W., Gelinsky, M., Potthoff, A., Richter, V., Ikonomidou, H., Schirmer, K. (2009):
Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
Environ. Health Perspect. 117 (4), 530 - 536
10.1289/ehp.0800121 - Busch, W., Kühnel, D., Springer, A., Meissner, T., Gelinsky, M., Potthoff, A., Scholz, S., Richter, V., Schirmer, K. (2009):
Tungsten carbide and tungsten carbide cobalt nanoparticle toxicity: The role of cellular particle uptake, leached ions and cobalt bioavailability
Toxicol. Lett. 189 (Suppl. 1), S185 - S185
10.1016/j.toxlet.2009.06.645 - Büttner, A., Seifert, K., Cottin, T., Sarli, V., Tzagkaroulaki, L., Scholz, S., Giannis, A. (2009):
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
Bioorg. Med. Chem. 17 (14), 4943 - 4954
10.1016/j.bmc.2009.06.008 - Klüver, N., Scheffler, K., Renner, P., Scholz, S. (2009):
Toxicogenomic response of azinphos-methyl treated zebrafish embryos and implication for the development of predictive models for chronic (fish) toxicity
Toxicol. Lett. 189 (Suppl. 1), S94 - S94
10.1016/j.toxlet.2009.06.284 - Kühnel, D., Busch, W., Meissner, T., Springer, A., Potthoff, A., Richter, V., Gelinsky, M., Scholz, S., Schirmer, K. (2009):
Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line
Aquat. Toxicol. 93 (2-3), 91 - 99
10.1016/j.aquatox.2009.04.003 - Scholz, S., Klüver, N. (2009):
Effects of endocrine disrupters on sexual, gonadal development in fish
Sex. Dev. 3 (2-3), 136 - 151
10.1159/000223078 - Scholz, S., Knöbel, M., Ortmann, J., Busser, F., Kramer, N., Hermens, J., Tanneberger, K., Schirmer, K. (2009):
The fish embryo test as an alternative to acute fish toxicity testing: Optimisation for difficult compounds and role of metabolic activation
Toxicol. Lett. 189 (Suppl. 1), S205 - S205
10.1016/j.toxlet.2009.06.620 - Weil, M., Scholz, S., Zimmer, M., Sacher, F., Duis, K. (2009):
Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the early life stage test
Environ. Toxicol. Chem. 28 (9), 1970 - 1978
10.1897/08-627.1
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2008 (5)
- Richter, V., Potthoff, A., Pompe, W., Gelinsky, M., Ikonomidou, H., Bastian, S., Schirmer, K., Scholz, S., Hofinger, J. (2008):
Evaluation of health risks of nano- and microparticles
Powder Metall. 51 (1), 8 - 9
10.1179/174329008X286640 - Schirmer, K., Tanneberger, K., Kramer, N.I., Völker, D., Scholz, S., Hafner, C., Lee, L.E.J., Bols, N.C., Hermens, J.L.M. (2008):
Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
Aquat. Toxicol. 90 (2), 128 - 137
10.1016/j.aquatox.2008.08.005 - Scholz, S., Fischer, S., Gündel, U., Küster, E., Luckenbach, T., Voelker, D. (2008):
The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
Environ. Sci. Pollut. Res. 15 (5), 394 - 404
10.1007/s11356-008-0018-z - Scholz, S., Mayer, I. (2008):
Molecular biomarkers of endocrine disruption in small model fish
Mol. Cell. Endocrinol. 293 (1-2), 57 - 70
10.1016/j.mce.2008.06.008 - Voelker, D., Stetefeld, N., Schirmer, K., Scholz, S. (2008):
The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos
Aquat. Toxicol. 86 (1), 112 - 120
10.1016/j.aquatox.2007.10.007
2007 (3)
- Voelker, D., Veß, C., Tillmann, M., Nagel, R., Otto, G.W., Geisler, R., Schirmer, K., Scholz, S. (2007):
Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae
Aquat. Toxicol. 81 (4), 355 - 364
10.1016/j.aquatox.2006.12.013 - Völker, D., Veß, C., Schirmer, K., Scholz, S. (2007):
Gen-DarT- ein Vorhersagemodell für die chronische Toxizität durch Analyse veränderter Genexpression in Embryonen des Zebrabärblings (Danio rerio)?
Mitt Umweltchem Ökotox 13 (4), 91 - 94 - Watzke, J., Schirmer, K., Scholz, S. (2007):
Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio)
Fish Shellfish Immunol. 23 (4), 901 - 905
10.1016/j.fsi.2007.03.004
2005 (2)
- Scholz, S., Kurauchi, K., Kinoshita, M., Oshima, Y., Ozato, K., Schirmer, K., Wakamatsu, Y. (2005):
Analysis of estrogenic effects by quantification of green flourescent protein in juvenile fish of a transgenic medaka
Environ. Toxicol. Chem. 24 (10), 2553 - 2561
10.1897/04-525R.1 - Zierau, O., Hamann, J., Tischer, S., Schwab, P., Metz, P., Vollmer, G., Gutzeit, H.O., Scholz, S. (2005):
Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
Biochem. Biophys. Res. Commun. 326 (4), 909 - 916
10.1016/j.bbrc.2004.11.124
2004 (2)
- Scholz, S., Domaschke, H., Kanamori, A., Ostermann, K., Rödel, G., Gutzeit, H.O. (2004):
Germ cell-less expression in Medaka (Oryzias latipes)
Mol. Reprod. Dev. 67 (1), 15 - 18
10.1002/mrd.20012 - Scholz, S., Kordes, C., Hamann, J., Gutzeit, H.O. (2004):
Induction of vitellogenin in vivo and in vitro in the model teleost medaka (Oryzias latipes): comparison of gene expression and protein levels
Mar. Environ. Res. 57 (3), 235 - 244
10.1016/s0141-1136(03)00082-5
2003 (1)
- Scholz, S., Rösler, S., Schäffer, M., Hornung, U., Schartl, M., Gutzeit, H.O. (2003):
Hormonal induction and stability of monosex populations in the medaka (Oryzias latipes): expression of sex-specific marker genes
Biol. Reprod. 69 (2), 673 - 678
10.1095/biolreprod.103.016873
2000 (1)
- Scholz, S., Gutzeit, H.O. (2000):
17-α-ethinylestradiol affects reproduction, sexual differentiation and aromatase gene expression of the medaka (Oryzias latipes)
Aquat. Toxicol. 50 (4), 363 - 373
10.1016/S0166-445X(00)00090-4
1999 (1)
- Scholz, S., Segner, H. (1999):
Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: concentration-response relationships for four model substances
Ecotox. Environ. Safe. 43 (3), 252 - 260
10.1006/eesa.1999.1786
1998 (1)
- Scholz, S., Braunbeck, T., Segner, H. (1998):
Viability and differential function of rainbow trout liver cells in primary culture: Coculture with two permanent fish cells
In Vitro Cell. Dev. Biol.-Anim. 34 (10), 762 - 771
10.1007/s11626-998-0030-0
1997 (1)
- Scholz, S., Behn, I., Honeck, H., Hauck, C., Braunbeck, T., Segner, H. (1997):
Development of a monoclonal antibody for ELISA of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes
Biomarkers 2 (5), 287 - 294
10.1080/135475097231517
1996 (2)
- Braunbeck, T., Hauck, C., Scholz, S., Segner, H. (1996):
Mixed function oxygenases in cultured fish cells: contributions of in vitro studies to the understanding of MFO induction
Z. Angew. Zool. 81 (1), 55 - 72 - Scholz, S. (1996):
Induktion von CYP1A1 durch Xenobiotica in Leberzellkulturen von Regenbogenforellen
UFZ-Bericht 13/1996
UFZ Leipzig-Halle GmbH, Leipzig, 105 S.