2024 (2)

• Nöth, J., Busch, W., Tal, T., Lai, C., Ambekar, A., Kießling, T.R., Scholz, S. (2024):
  Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
  Arch. Toxicol. 98 (2), 537 - 549 10.1007/s00204-023-03633-x
• Wilhelmi, P., Haake, V., Zickgraf, F.M., Giri, V., Ternes, P., Driemert, P., Nöth, J., Scholz, S., Barenys, M., Flick, B., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2024):
  Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish
  Arch. Toxicol. 98 (3), 943 - 956 10.1007/s00204-023-03655-5

2023 (9)

• Bajard, L., Adamovsky, O., Audouze, K., Baken, K., Barouki, R., Beltman, J.B., Beronius, A., Bonefeld-Jørgensen, E.C., Cano-Sancho, G., de Baat, M.L., Di Tillio, F., Fernández, M.F., FitzGerald, R.E., Gundacker, C., Hernández, A.F., Hilscherova, K., Karakitsios, S., Kuchovska, E., Long, M., Luijten, M., Majid, S., Marx-Stoelting, P., Mustieles, V., Negi, C.K., Sarigiannis, D., Scholz, S., Sovadinova, I., Stierum, R., Tanabe, S., Tollefsen, K.E., van den Brand, A.D., Vogs, C., Wielsøe, M., Wittwehr, C., Blaha, L. (2023):
  Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
  Environ. Res. 217 , art. 114650 10.1016/j.envres.2022.114650
• Bashirova, N., Poppitz, D., Klüver, N., Scholz, S., Matysik, J., Alia, A. (2023):
  A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
  Sci. Rep. 13 , art. 1891 10.1038/s41598-023-28712-y
• Colbourne, J.K., Andrews, E., Barnard, M., Čavoški, A., Chaturvedi, A., Epps, D.J.T., Holden, L., Jones, M.R., Li, X., Mueller, F., Ormanin-Lewandowska, A., Orsini, L., Roberts, R., Weber, R.J.M., Zhou, J., Apic, G., Ignasiak, T., Jankovic, K., Krsmanovic, T., Leoni, B., Asole, G., Guigó, R., Marangio, P., Palumbo, E., Perez-Lluch, S., Wucher, V., Vlot, A.H., Anholt, R., Mackay, T., Escher, B.I., Grasse, N., Huchthausen, J., Massei, R., Reemtsma, T., Scholz, S., Schüürmann, G., Bondesson, M., Cherbas, P., et al. (2023):
  The Precision Toxicology initiative
  Toxicol. Lett. 383 , 33 - 42 10.1016/j.toxlet.2023.05.004
• Cramer von Clausbruch, C.A., Weiss, C., Dickmeis, T., Peravali, R., Strähle, U., Colbourne, J., Hayot, G., Scholz, S., Martinez Lopez, R. (2023):
  Quantitative and qualitative assessment of cytotoxicity by automated fluorescence microscopy in human hepatocytes
  Naunyn-Schmiedebergs Arch. Pharmacol. 396 (Suppl. 1), S61 - S62 10.1007/s00210-023-02397-6
• Escher, B.I., Altenburger, R., Blüher, M., Colbourne, J.K., Ebinghaus, R., Fantke, P., Hein, M., Köck, W., Kümmerer, K., Leipold, S., Li, X., Scheringer, M., Scholz, S., Schloter, M., Schweizer, P.-J., Tal, T., Tetko, I., Traidl-Hoffmann, C., Wick, L.Y., Fenner, K. (2023):
  Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
  Arch. Toxicol. 97 (5), 1267 - 1283 10.1007/s00204-023-03485-5
• Grasse, N., Seiwert, B., Massei, R., Scholz, S., Fu, Q., Reemtsma, T. (2023):
  Uptake and biotransformation of the tire rubber-derived contaminants 6-PPD and 6-PPD quinone in the zebrafish embryo (Danio rerio)
  Environ. Sci. Technol. 57 (41), 15598 - 15607 10.1021/acs.est.3c02819
• Hayot, G., von Clausbruch, C., Martinez Lopez, R., Scholz, S., Colbourne, J., Strähle, U., Weiss, C., Peravali, R., Dickmeis, T. (2023):
  Phenotypic anchoring for OMICS-guided assessment of liver toxicity in zebrafish
  Naunyn-Schmiedebergs Arch. Pharmacol. 396 (Suppl. 1), S61 - S61 10.1007/s00210-023-02397-6
• Scholz, S. (2023):
  sscholz-UFZ/EmbryoMotion: EmbryoMotion Version 1.1. - a software to analyse spontaneous tail contraction and photomotor response of zebrafish embryos
  Version: 1.1 Zenodo 10.5281/zenodo.8362019
• Wilhelmi, P., Giri, V., Zickgraf, F.M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2023):
  A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil
  Chem.-Biol. Interact. 382 , art. 110565 10.1016/j.cbi.2023.110565

2022 (11)

• Lee, J., Escher, B.I., Scholz, S., Schlichting, R. (2022):
  Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells
  Arch. Toxicol. 96 (4), 1039 - 1053 10.1007/s00204-022-03237-x
• Lee, J., Huchthausen, J., Schlichting, R., Scholz, S., Henneberger, L., Escher, B.I. (2022):
  Validation of an SH-SY5Y cell-based acetylcholinesterase inhibition assay for water quality assessment
  Environ. Toxicol. Chem. 41 (12), 3046 - 3057 10.1002/etc.5490
• Lee, J., Schlichting, R., König, M., Scholz, S., Krauss, M., Escher, B.I. (2022):
  Monitoring mixture effects of neurotoxicants in surface water and wastewater treatment plant effluents with neurite outgrowth inhibition in SH-SY5Y cells
  ACS Environ. Au 2 (6), 523 - 535 10.1021/acsenvironau.2c00026
• Nöth, J., Michaelis, P., Busch, W., Scholz, S. (2022):
  Analysis vascular disruptors in zebrafish embryos as an endpoint to predict developmental toxicity
  Toxicol. Lett. 368 (Suppl.), S34 - S35 10.1016/j.toxlet.2022.07.111
• Ortmann, J., Altenburger, R., Scholz, S., Luckenbach, T. (2022):
  Photomotor response data analysis approach to assess chemical neurotoxicity with the zebrafish embryo
  ALTEX-Altern. Anim. Exp. 39 (1), 82 - 94 10.14573/altex.2004021
• Paini, A., Campia, I., Cronin, M.T.D., Asturiol, D., Ceriani, L., Exner, T.E., Gao, W., Gomes, C., Kruisselbrink, J., Martens, M., Meek, M.E.B., Pamies, D., Pletz, J., Scholz, S., Schüttler, A., Spînu, N., Villeneuve, D.L., Wittwehr, C., Worth, A., Luijten, M. (2022):
  Towards a qAOP framework for predictive toxicology - Linking data to decisions
  Comput. Toxicol. 21 , art. 100195 10.1016/j.comtox.2021.100195
• Scholz, S., Brack, W., Escher, B.I., Hackermüller, J., Liess, M., von Bergen, M., Wick, L.Y., Zenclussen, A.C., Altenburger, R. (2022):
  The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
  Arch. Toxicol. 96 (8), 2381 - 2386 10.1007/s00204-022-03313-2
• Scholz, S., Nichols, J.W., Escher, B.I., Ankley, G.T., Altenburger, R., Blackwell, B., Brack, W., Burkhard, L., Collette, T.W., Doering, J.A., Ekman, D., Fay, K., Fischer, F., Hackermüller, J., Hoffman, J.C., Lai, C., Leuthold, D., Martinovic-Weigelt, D., Reemtsma, T., Pollesch, N., Schroeder, A., Schüürmann, G., von Bergen, M. (2022):
  The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
  Environ. Toxicol. Chem. 41 (1), 30 - 45 10.1002/etc.5242
• Spînu, N., Cronin, M.T.D., Lao, J., Bal-Price, A., Campia, I., Enoch, S.J., Madden, J.C., Lagares, L.M., Novič, M., Pamies, D., Scholz, S., Villeneuve, D.L., Worth, A.P. (2022):
  Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
  Comput. Toxicol. 21 , art. 100206 10.1016/j.comtox.2021.100206
• Teixidó, E., Kieβling, T.R., Klüver, N., Scholz, S. (2022):
  Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test
  Arch. Toxicol. 96 (5), 1353 - 1369 10.1007/s00204-022-03253-x
• Wilhelmi, P., Giri, V., Henkes, S., Walk, T., Haake, V., Scholz, S., Busch, W., Barenys, M., Zickgraf, F., Landsiedel, R., Funk-Weyer, D., Birk, B., Flick, B. (2022):
  A targeted metabolomics approach for unraveling different modes of embryotoxicity in zebrafish
  Toxicol. Lett. 368 (Suppl.), S252 - S252 10.1016/j.toxlet.2022.07.671

2021 (6)

• Bieczynski, F., Burkhardt-Medicke, K., Luquet, C.M., Scholz, S., Luckenbach, T. (2021):
  Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity
  FEBS Lett. 595 (6), 828 - 843 10.1002/1873-3468.14015
• Huhn, S., Escher, B.I., Krauss, M., Scholz, S., Hackermüller, J., Altenburger, R. (2021):
  Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive
  Environ. Sci. Eur. 33 , art. 17 10.1186/s12302-020-00444-0
• Lee, J., Braun, G., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2021):
  Critical membrane concentration and mass-balance model to identify baseline cytotoxicity of hydrophobic and ionizable organic chemicals in mammalian cell lines
  Chem. Res. Toxicol. 34 (9), 2100 - 2109 10.1021/acs.chemrestox.1c00182
• Ogungbemi, A.O., Massei, R., Altenburger, R., Scholz, S., Küster, E. (2021):
  Assessing combined effects for mixtures of similar and dissimilar acting neuroactive substances on zebrafish embryo movement
  Toxics 9 (5), art. 104 10.3390/toxics9050104
• Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2021):
  Automated measurement of the spontaneous tail coiling of zebrafish embryos as a sensitive behavior endpoint using a workflow in KNIME
  MethodsX 8 , art. 101330 10.1016/j.mex.2021.101330
• Paparella, M., Scholz, S., Belanger, S., Braunbeck, T., Bicherel, P., Connors, K., Faßbender, C., Halder, M., Lillicrap, A., Liska, R., Schirmer, K., Stoddart, G., Thomas, P., Walter-Rohde, S. (2021):
  Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods
  ALTEX-Altern. Anim. Exp. 38 (1), 20 - 32 10.14573/altex.2006051

2020 (5)

• Halbach, K., Ulrich, N., Goss, K.-U., Seiwert, B., Wagner, S., Scholz, S., Luckenbach, T., Bauer, C., Schweiger, N., Reemtsma, T. (2020):
  Yolk sac of zebrafish embryos as backpack for chemicals?
  Environ. Sci. Technol. 54 (16), 10159 - 10169 10.1021/acs.est.0c02068
• Larras, F., Billoir, E., Scholz, S., Tarkka, M., Wubet, T., Delignette-Muller, M.-L., Schmitt-Jansen, M. (2020):
  A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus
  J. Hazard. Mater. 397 , art. 122727 10.1016/j.jhazmat.2020.122727
• Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2020):
  Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®
  Neurotoxicol. Teratol. 81 , art. 106918 10.1016/j.ntt.2020.106918
• Teixidó, E., Leuthold, D., de Crozé, N., Léonard, M., Scholz, S. (2020):
  Comparative assessment of the sensitivity of fish early‐life stage, Daphnia and algae to the chronic ecotoxicity of xenobiotics – perspectives for alternatives to animal testing
  Environ. Toxicol. Chem. 39 (1), 30 - 41 10.1002/etc.4607
• Ulrich, N., Schweiger, N., Pfennigsdorff, A., Scholz, S., Goss, K.-U. (2020):
  Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio
  Environ. Toxicol. Chem. 39 (8), 1506 - 1516 10.1002/etc.4744

2019 (5)

• Halbach, K., Wagner, S., Scholz, S., Luckenbach, T., Reemtsma, T. (2019):
  Elemental imaging (LA-ICP-MS) of zebrafish embryos to study the toxicokinetics of the acetylcholinesterase inhibitor naled
  Anal. Bioanal. Chem. 411 (3), 617 - 627 10.1007/s00216-018-1471-2
• Ogungbemi, A., Leuthold, D., Scholz, S., Küster, E. (2019):
  Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
  Environ. Sci. Eur. 31 , art. 88 10.1186/s12302-019-0270-5
• Perkins, E.J., Ashauer, R., Burgoon, L., Conolly, R., Landesmann, B., Mackay, C., Murphy, C.A., Pollesch, N., Wheeler, J.R., Zupanic, A., Scholz, S. (2019):
  Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
  Environ. Toxicol. Chem. 38 (9), 1850 - 1865 10.1002/etc.4505
• Philipp, K., Lemke, F., Scholz, S., Wallrabe, U., Wapler, M.C., Koukourakis, N., Czarske, J.W. (2019):
  Diffraction-limited axial scanning in thick biological tissue with an aberration-correcting adaptive lens
  Sci. Rep. 9 , art. 9532 10.1038/s41598-019-45993-4
• Teixidó, E., Kießling, T.R., Krupp, E., Quevedo, C., Muriana, A., Scholz, S. (2019):
  Automated morphological feature assessment for zebrafish embryo developmental toxicity screens
  Toxicol. Sci. 167 (2), 438 - 449 10.1093/toxsci/kfy250

2018 (9)

• Birke, A., Scholz, S. (2018):
  Zebrafish embryo and acute fish toxicity test show similar sensitivity for narcotic compounds
  ALTEX-Altern. Anim. Exp. 36 (1), 131 - 135 10.14573/altex.1808101
• Fischer, F.C., Abele, C., Droge, S.T.J., Henneberger, L., König, M., Schlichting, R., Scholz, S., Escher, B.I. (2018):
  Cellular uptake kinetics of neutral and charged chemicals in in vitro assays measured by fluorescence microscopy
  Chem. Res. Toxicol. 31 (8), 646 - 657 10.1021/acs.chemrestox.8b00019
• Jarque, S., Fetter, E., Veneman, W.J., Spaink, H.P., Peravali, R., Strähle, U., Scholz, S. (2018):
  An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
  PLOS One 13 (8), e0203087 10.1371/journal.pone.0203087
• Larras, F., Billoir, E., Baillard, V., Siberchicot, A., Scholz, S., Wubet, T., Tarkka, M., Schmitt-Jansen, M., Delignette-Muller, M.-L. (2018):
  DRomics: A turnkey tool to support the use of the dose–response framework for omics data in ecological risk assessment
  Environ. Sci. Technol. 52 (24), 14461 - 14468 10.1021/acs.est.8b04752
• Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
  An ecotoxicological view on neurotoxicity assessment
  Environ. Sci. Eur. 30 , art. 46 10.1186/s12302-018-0173-x
• Scholz, S., Schreiber, R., Armitage, J., Mayer, P., Escher, B.I., Lidzba, A., Léonard, M., Altenburger, R. (2018):
  Meta‐analysis of fish early life stage tests—Association of toxic ratios and acute‐to‐chronic ratios with modes of action
  Environ. Toxicol. Chem. 37 (4), 955 - 969 10.1002/etc.4090
• Sobanska, M., Scholz, S., Nyman, A.-M., Cesnaitis, R., Gutierrez Alonso, S., Klüver, N., Kühne, R., Tyle, H., de Knecht, J., Dang, Z., Lundbergh, I., Carlon, C., De Coen, W. (2018):
  Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)
  Environ. Toxicol. Chem. 37 (3), 657 - 670 10.1002/etc.4055
• Teixido, E., Kerkhof, O., Kießling, T., Scholz, S. (2018):
  Retrieving mode of action information by automated effect pattern analysis using the zebrafish embryo toxicity test
  Reprod. Toxicol. 80 , 18 - 19 10.1016/j.reprotox.2018.06.074
• Teixidó, E., Krupp, E., Amberg, A., Czich, A., Scholz, S. (2018):
  Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches
  Reprod. Toxicol. 76 , 93 - 102 10.1016/j.reprotox.2018.01.005

2017 (3)

• Andrade, T.S., Henriques, J.F., Almeida, A.R., Soares, A.M.V.M., Scholz, S., Dominigues, I. (2017):
  Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV-light irradiation
  Environ. Toxicol. Chem. 36 (3), 682 - 690 10.1002/etc.3579
• Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
  From the exposome to mechanistic understanding of chemical-induced adverse effects
  Environ. Int. 99 , 97 - 106 10.1016/j.envint.2016.11.029
• Teixido, E., Kießling, T., Leuthold, D., Scholz, S. (2017):
  Effect signatures in zebrafish embryos exposed to compounds with potential developmental toxicity
  Reprod. Toxicol. 72 , 49 10.1016/j.reprotox.2017.06.179

2016 (6)

• Klüver, N., Vogs, C., Altenburger, R., Escher, B.I., Scholz, S. (2016):
  Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test
  Chemosphere 164 , 164 - 173 10.1016/j.chemosphere.2016.08.079
• Scholz, S., Jarque, S., Fetter, E. (2016):
  A fully automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
  Reprod. Toxicol. 64 (Special Issue), 30 10.1016/j.reprotox.2016.06.064
• Scholz, S., Klüver, N., Kühne, R. (2016):
  Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. Report ECHA-UFZ contract ECHA/2014/341
  Helmholtz Centre for Environmental Research - UFZ, Leipzig, 104 pp.
• Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016):
  Zebrafish biosensor for toxicant induced muscle hyperactivity
  Sci. Rep. 6 , art. 23768 10.1038/srep23768
• Teixidó, E., Leuthold, D., Amberg, A., Czich, A., Krupp, E., Scholz, S. (2016):
  ZFminus1: A strategy to reduce animal tests for developmental toxicity testing by a combined use of mammalian models and the zebrafish embryotoxicity test (ZFET or ZETA)
  Reprod. Toxicol. 64 , 22 10.1016/j.reprotox.2016.06.048
• Teixidó, E., Leuthold, D., Scholz, S., Quevedo, C., Muriana, A., Czich, A., Krupp, E. (2016):
  An inter-laboratory validation of the zebrafish embryo assay for the detection of developmental toxicity
  Reprod. Toxicol. 64 , 44 10.1016/j.reprotox.2016.06.096

2015 (8)

• Fetter, E., Baldauf, L., Da Fonte, D.F., Ortmann, J., Scholz, S. (2015):
  Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos
  Reprod. Toxicol. 57 , 10 - 20 10.1016/j.reprotox.2015.04.012
• Fetter, E., Smetanová, S., Baldauf, L., Lidzba, A., Altenburger, R., Schüttler, A., Scholz, S. (2015):
  Identification and characterization of androgen-responsive genes in zebrafish embryos
  Environ. Sci. Technol. 49 (19), 11789 - 11798 10.1021/acs.est.5b01034
• Hernández, R.B., Nishita, M.I., Espósito, B.P., Scholz, S., Michalke, B. (2015):
  The role of chemical speciation, chemical fractionation and calcium disruption in manganese-induced developmental toxicity in zebrafish (Danio rerio) embryos
  J. Trace Elem. Med. Biol. 32 , 209 - 217 10.1016/j.jtemb.2015.07.004
• Jonas, A., Scholz, S., Fetter, E., Sychrova, E., Novakova, K., Ortmann, J., Benisek, M., Adamovsky, O., Giesy, J.P., Hilscherova, K. (2015):
  Endocrine, teratogenic and neurotoxic effects of cyanobacteria detected by cellular in vitro and zebrafish embryos assays
  Chemosphere 120 , 321 - 327 10.1016/j.chemosphere.2014.07.074
• Klüver, N., König, M., Ortmann, J., Massei, R., Paschke, A., Kühne, R., Scholz, S. (2015):
  Fish embryo toxicity test: Identification of compounds with weak toxicity and analysis of behavioral effects to improve prediction of acute toxicity for neurotoxic compounds
  Environ. Sci. Technol. 49 (11), 7002 - 7011 10.1021/acs.est.5b01910
• Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
  What determines chemical uptake by the zebrafish embryo model?
  Toxicol. Lett. 238 (2, Suppl.), S54 10.1016/j.toxlet.2015.08.151
• Massei, R., Vogs, C., Renner, P., Altenburger, R., Scholz, S. (2015):
  Differential sensitivity in embryonic stages of the zebrafish (Danio rerio): The role of toxicokinetics for stage-specific susceptibility for azinphos-methyl lethal effects
  Aquat. Toxicol. 166 , 36 - 41 10.1016/j.aquatox.2015.06.011
• Scholz, S. (2015):
  In response: Quantitative adverse outcome pathways for prediction of adverse effects—An academic perspective
  Environ. Toxicol. Chem. 34 (9), 1935 - 1937 10.1002/etc.3043

2014 (7)

• Busquet, F., Strecker, R., Rawlings, J.M., Belanger, S.E., Braunbeck, T., Carr, G.J., Cenijn, P., Fochtman, P., Gourmelon, A., Hübler, N., Kleensang, A., Knöbel, M., Kussatz, C., Legler, J., Lillicrap, A., Martínez-Jerónimo, F., Polleichtner, C., Rzodeczko, H., Salinas, E., Schneider, K.E., Scholz, S., van den Brandhof, E.-J., van der Ven, L.T.M., Walter-Rohde, S., Weigt, S., Witters, H., Halder, M. (2014):
  OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing
  Regul. Toxicol. Pharmacol. 69 (3), 496 - 511 10.1016/j.yrtph.2014.05.018
• Escher, B.I., Allinson, M., Altenburger, R., Bain, P.A., Balaguer, P., Busch, W., Crago, J., Denslow, N.D., Dopp, E., Hilscherova, K., Humpage, A.R., Kumar, A., Grimaldi, M., Jayasinghe, B.S., Jarosova, B., Jia, A., Makarov, S., Maruya, K.A., Medvedev, A., Mehinto, A.C., Mendez, J.E., Poulsen, A., Prochazka, E., Richard, J., Schifferli, A., Schlenk, D., Scholz, S., Shiraishi, F., Snyder, S., Su, G., Tang, J.Y.M., van der Burg, B., van der Linden, S.C., Werner, I., Westerheide, S.D., Wong, C.K.C., Yang, M., Yeung, B.H.Y., Zhang, X., Leusch, F.D.L. (2014):
  Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays
  Environ. Sci. Technol. 48 (3), 1940 - 1956 10.1021/es403899t
• Fetter, E., Krauss, M., Brion, F., Kah, O., Scholz, S., Brack, W. (2014):
  Effect-directed analysis for estrogenic compounds in a fluvial sediment sample using transgenic cyp19a1b-GFP zebrafish embryos
  Aquat. Toxicol. 154 , 221 - 229 10.1016/j.aquatox.2014.05.016
• Jonas, A., Buranova, V., Scholz, S., Fetter, E., Novakova, K., Kohoutek, J., Hilscherova, K. (2014):
  Retinoid-like activity and teratogenic effects of cyanobacterial exudates
  Aquat. Toxicol. 155 , 283 - 293 10.1016/j.aquatox.2014.06.022
• Klüver, N., Ortmann, J., Paschke, H., Renner, P., Ritter, A.P., Scholz, S. (2014):
  Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos
  PLOS One 9 (3), e90619 10.1371/journal.pone.0090619
• Scholz, S., Ortmann, J., Klüver, N., Léonard, M. (2014):
  Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories
  Regul. Toxicol. Pharmacol. 69 (3), 572 - 579 10.1016/j.yrtph.2014.06.004
• Tollefsen, K.E., Scholz, S., Cronin, M.T., Edwards, S.W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A., Patlewicz, G. (2014):
  Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)
  Regul. Toxicol. Pharmacol. 70 (3), 629 - 640 10.1016/j.yrtph.2014.09.009

2013 (4)

• Petersen, K., Fetter, E., Kah, O., Brion, F., Scholz, S., Tollefsen, K.E. (2013):
  Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals
  Aquat. Toxicol. 138-139 , 88 - 97 10.1016/j.aquatox.2013.05.001
• Scholz, S. (2013):
  Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity
  Arch. Toxicol. 87 (5), 767 - 769 10.1007/s00204-013-1044-2
• Scholz, S., Renner, P., Belanger, S.E., Busquet, F., Davi, R., Demeneix, B.A., Denny, J.S., Léonard, M., McMaster, M.E., Villeneuve, D.L., Embry, M.R. (2013):
  Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians – screening for estrogen, androgen and thyroid hormone disruption
  Crit. Rev. Toxicol. 43 (1), 45 - 70 10.3109/10408444.2012.737762
• Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013):
  A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
  Regul. Toxicol. Pharmacol. 67 (3), 506 - 530 10.1016/j.yrtph.2013.10.003

2012 (5)

• Altenburger, R., Scholz, S., Schmitt-Jansen, M., Busch, W., Escher, B.I. (2012):
  Mixture toxicity revisited from a toxicogenomic perspective
  Environ. Sci. Technol. 46 (5), 2508 - 2522 10.1021/es2038036
• Büttner, A., Busch, W., Klüver, N., Giannis, A., Scholz, S. (2012):
  Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine
  Reprod. Toxicol. 33 (2), 254 - 263 10.1016/j.reprotox.2011.12.010
• Knöbel, M., Busser, F.J.M., Rico-Rico, A., Kramer, N.I., Hermens, J.L.M., Hafner, C., Tanneberger, K., Schirmer, K., Scholz, S. (2012):
  Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis
  Environ. Sci. Technol. 46 (17), 9690 - 9700 10.1021/es301729q
• Scholz, S. (2012):
  Special issue: zebrafish teratogenesis
  Reprod. Toxicol. 33 (2), 127 - 127 10.1016/j.reprotox.2012.01.008
• Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., Braunbeck, T. (2012):
  Zebrafish embryos as an alternative to animal experiments - a commentary on the definition of the onset of protected life stages in animal welfare regulations
  Reprod. Toxicol. 33 (2), 128 - 132 10.1016/j.reprotox.2011.06.121

2011 (7)

• Busch, W., Duis, K., Fenske, M., Maack, G., Legler, J., Padilla, S., Strähle, U., Witters, H., Scholz, S. (2011):
  The zebrafish embryo model in toxicology and teratology, September 2-3, 2010, Karlsruhe, Germany
  Reprod. Toxicol. 31 (4), 585 - 588 10.1016/j.reprotox.2011.02.010
• dos Anjos, N.A., Schulze, T., Brack, W., Val, A.L., Schirmer, K., Scholz, S. (2011):
  Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems
  Aquat. Toxicol. 103 (1-2), 46 - 52 10.1016//j.aquatoc.2011.02.004
• Georgi, A., Mackenzie, K., Scholz, S., Potthoff, A., Springer, A. (2011):
  Eisenbasierte Nanopartikel und Nanokompositstrukturen zur Schadstoffentfernung aus Grund- und Abwässern
  WING.DE 2011 – Tagungsband : Werkstoffe gestalten Zukunft, 4.-6. Oktober 2011 Berlin
  Bundesministerium für Bildung und Forschung (BMBF), Berlin, S. 86 - 88
• Klüver, N., Yang, L., Busch, W., Scheffler, K., Scheffler, P., Strähle, U., Scholz, S. (2011):
  Transcriptional response of zebrafish embryos exposed to neurotoxic compounds reveals a muscle activity dependent hspb11 expression
  PLoS One 6 (12), e29063 10.1371/journal.pone.0029063
• Scholz, S., Büttner, A., Klüver, N., Guinea, J. (2011):
  Fish embryos as alternative models for drug safety evaluation
  In: Xu, J.J., Urban, L. (eds.)
  Predictive toxicology in drug safety
  Cambridge University Press, New York, p. 244 - 268 10.1017/CBO9780511779053.015
• Siegert, F., Erdmann, F., Schwan, G., Scholz, S., Briel, D., Altenburger, R., Nieber, K. (2011):
  Pharmacological and cytotoxic effects of new selective PDE10A ligands
  Naunyn-Schmiedebergs Arch. Pharmacol. 383 (Suppl. 1), 21 - 21 10.1007/s00210-011-0617-y
• Volz, D.C., Belanger, S., Embry, M., Padilla, S., Sanderson, H., Schirmer, K., Scholz, S., Villeneuve, D. (2011):
  Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies
  Toxicol. Sci. 123 (3), 349 - 358 10.1093/toxsci/kfr185

2010 (2)

• Busch, W., Kühnel, D., Schirmer, K., Scholz, S. (2010):
  Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
  BMC Genomics 11 , art. 65 10.1186/1471-2164-11-65
• Scholz, S., Schirmer, K., Altenburger, R. (2010):
  Pharmaceutical contaminants in urban water cycles - a discussion of novel concepts for environmental risk assessment
  In: Fatta-Kassinos, D., Bester, K., Kümmerer, K. (eds.)
  Xenobiotics in the urban water cycle: mass flows, environmental processes and mitigation strategies
  Environ. Pollut. 16
  Springer, Heidelberg, p. 227 - 244 10.1007/978-90-481-3509-7

2009 (8)

• Bastian, S., Busch, W., Kühnel, D., Springer, A., Meißner, T., Holke, R., Scholz, S., Iwe, M., Pompe, W., Gelinsky, M., Potthoff, A., Richter, V., Ikonomidou, H., Schirmer, K. (2009):
  Toxicity of tungsten carbide and cobalt-doped tungsten carbide nanoparticles in mammalian cells in vitro
  Environ. Health Perspect. 117 (4), 530 - 536 10.1289/ehp.0800121
• Busch, W., Kühnel, D., Springer, A., Meissner, T., Gelinsky, M., Potthoff, A., Scholz, S., Richter, V., Schirmer, K. (2009):
  Tungsten carbide and tungsten carbide cobalt nanoparticle toxicity: The role of cellular particle uptake, leached ions and cobalt bioavailability
  Toxicol. Lett. 189 (Suppl. 1), S185 - S185 10.1016/j.toxlet.2009.06.645
• Büttner, A., Seifert, K., Cottin, T., Sarli, V., Tzagkaroulaki, L., Scholz, S., Giannis, A. (2009):
  Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
  Bioorg. Med. Chem. 17 (14), 4943 - 4954 10.1016/j.bmc.2009.06.008
• Klüver, N., Scheffler, K., Renner, P., Scholz, S. (2009):
  Toxicogenomic response of azinphos-methyl treated zebrafish embryos and implication for the development of predictive models for chronic (fish) toxicity
  Toxicol. Lett. 189 (Suppl. 1), S94 - S94 10.1016/j.toxlet.2009.06.284
• Kühnel, D., Busch, W., Meissner, T., Springer, A., Potthoff, A., Richter, V., Gelinsky, M., Scholz, S., Schirmer, K. (2009):
  Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line
  Aquat. Toxicol. 93 (2-3), 91 - 99 10.1016/j.aquatox.2009.04.003
• Scholz, S., Klüver, N. (2009):
  Effects of endocrine disrupters on sexual, gonadal development in fish
  Sex. Dev. 3 (2-3), 136 - 151 10.1159/000223078
• Scholz, S., Knöbel, M., Ortmann, J., Busser, F., Kramer, N., Hermens, J., Tanneberger, K., Schirmer, K. (2009):
  The fish embryo test as an alternative to acute fish toxicity testing: Optimisation for difficult compounds and role of metabolic activation
  Toxicol. Lett. 189 (Suppl. 1), S205 - S205 10.1016/j.toxlet.2009.06.620
• Weil, M., Scholz, S., Zimmer, M., Sacher, F., Duis, K. (2009):
  Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the early life stage test
  Environ. Toxicol. Chem. 28 (9), 1970 - 1978 10.1897/08-627.1

2008 (5)

• Richter, V., Potthoff, A., Pompe, W., Gelinsky, M., Ikonomidou, H., Bastian, S., Schirmer, K., Scholz, S., Hofinger, J. (2008):
  Evaluation of health risks of nano- and microparticles
  Powder Metall. 51 (1), 8 - 9 10.1179/174329008X286640
• Schirmer, K., Tanneberger, K., Kramer, N.I., Völker, D., Scholz, S., Hafner, C., Lee, L.E.J., Bols, N.C., Hermens, J.L.M. (2008):
  Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
  Aquat. Toxicol. 90 (2), 128 - 137 10.1016/j.aquatox.2008.08.005
• Scholz, S., Fischer, S., Gündel, U., Küster, E., Luckenbach, T., Voelker, D. (2008):
  The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
  Environ. Sci. Pollut. Res. 15 (5), 394 - 404 10.1007/s11356-008-0018-z
• Scholz, S., Mayer, I. (2008):
  Molecular biomarkers of endocrine disruption in small model fish
  Mol. Cell. Endocrinol. 293 (1-2), 57 - 70 10.1016/j.mce.2008.06.008
• Voelker, D., Stetefeld, N., Schirmer, K., Scholz, S. (2008):
  The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos
  Aquat. Toxicol. 86 (1), 112 - 120 10.1016/j.aquatox.2007.10.007

2007 (3)

• Voelker, D., Veß, C., Tillmann, M., Nagel, R., Otto, G.W., Geisler, R., Schirmer, K., Scholz, S. (2007):
  Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae
  Aquat. Toxicol. 81 (4), 355 - 364 10.1016/j.aquatox.2006.12.013
• Völker, D., Veß, C., Schirmer, K., Scholz, S. (2007):
  Gen-DarT- ein Vorhersagemodell für die chronische Toxizität durch Analyse veränderter Genexpression in Embryonen des Zebrabärblings (Danio rerio)?
  Mitt Umweltchem Ökotox 13 (4), 91 - 94
• Watzke, J., Schirmer, K., Scholz, S. (2007):
  Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio)
  Fish Shellfish Immunol. 23 (4), 901 - 905 10.1016/j.fsi.2007.03.004

2005 (2)

• Scholz, S., Kurauchi, K., Kinoshita, M., Oshima, Y., Ozato, K., Schirmer, K., Wakamatsu, Y. (2005):
  Analysis of estrogenic effects by quantification of green flourescent protein in juvenile fish of a transgenic medaka
  Environ. Toxicol. Chem. 24 (10), 2553 - 2561 10.1897/04-525R.1
• Zierau, O., Hamann, J., Tischer, S., Schwab, P., Metz, P., Vollmer, G., Gutzeit, H.O., Scholz, S. (2005):
  Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
  Biochem. Biophys. Res. Commun. 326 (4), 909 - 916 10.1016/j.bbrc.2004.11.124

2004 (2)

• Scholz, S., Domaschke, H., Kanamori, A., Ostermann, K., Rödel, G., Gutzeit, H.O. (2004):
  Germ cell-less expression in Medaka (Oryzias latipes)
  Mol. Reprod. Dev. 67 (1), 15 - 18 10.1002/mrd.20012
• Scholz, S., Kordes, C., Hamann, J., Gutzeit, H.O. (2004):
  Induction of vitellogenin in vivo and in vitro in the model teleost medaka (Oryzias latipes): comparison of gene expression and protein levels
  Mar. Environ. Res. 57 (3), 235 - 244 10.1016/s0141-1136(03)00082-5

2003 (1)

• Scholz, S., Rösler, S., Schäffer, M., Hornung, U., Schartl, M., Gutzeit, H.O. (2003):
  Hormonal induction and stability of monosex populations in the medaka (Oryzias latipes): expression of sex-specific marker genes
  Biol. Reprod. 69 (2), 673 - 678 10.1095/biolreprod.103.016873

2000 (1)

• Scholz, S., Gutzeit, H.O. (2000):
  17-α-ethinylestradiol affects reproduction, sexual differentiation and aromatase gene expression of the medaka (Oryzias latipes)
  Aquat. Toxicol. 50 (4), 363 - 373 10.1016/S0166-445X(00)00090-4

1999 (1)

• Scholz, S., Segner, H. (1999):
  Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: concentration-response relationships for four model substances
  Ecotox. Environ. Safe. 43 (3), 252 - 260 10.1006/eesa.1999.1786

1998 (1)

• Scholz, S., Braunbeck, T., Segner, H. (1998):
  Viability and differential function of rainbow trout liver cells in primary culture: Coculture with two permanent fish cells
  In Vitro Cell. Dev. Biol.-Anim. 34 (10), 762 - 771 10.1007/s11626-998-0030-0

1997 (1)

• Scholz, S., Behn, I., Honeck, H., Hauck, C., Braunbeck, T., Segner, H. (1997):
  Development of a monoclonal antibody for ELISA of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes
  Biomarkers 2 (5), 287 - 294 10.1080/135475097231517

1996 (2)

• Braunbeck, T., Hauck, C., Scholz, S., Segner, H. (1996):
  Mixed function oxygenases in cultured fish cells: contributions of in vitro studies to the understanding of MFO induction
  Z. Angew. Zool. 81 (1), 55 - 72
• Scholz, S. (1996):
  Induktion von CYP1A1 durch Xenobiotica in Leberzellkulturen von Regenbogenforellen
  UFZ-Bericht 13/1996
  UFZ Leipzig-Halle GmbH, Leipzig, 105 S.