Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.14573/altex.2006051
Lizenz creative commons licence
Titel (primär) Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods
Autor Paparella, M.; Scholz, S. ORCID logo ; Belanger, S.; Braunbeck, T.; Bicherel, P.; Connors, K.; Faßbender, C.; Halder, M.; Lillicrap, A.; Liska, R.; Schirmer, K.; Stoddart, G.; Thomas, P.; Walter-Rohde, S.
Quelle ALTEX - Alternatives to Animal Experimentation
Erscheinungsjahr 2021
Department BIOTOX
Band/Volume 38
Heft 1
Seite von 20
Seite bis 32
Sprache englisch
Topic T9 Healthy Planet
Keywords uncertainty; chemical safety; acute fish toxicity; animal test; alternative methods; environmental toxicology
Abstract Information about acute fish toxicity is routinely required in many jurisdictions for environmental risk assessment of chem­icals. This information is typically obtained using a 96-hour juvenile fish test for lethality according to OECD test guideline (TG) 203 or equivalent regional guidelines. However, TG 203 has never been validated using the criteria currently required for new test methods including alternative methods. Characterization of the practicality and validity of TG 203 is important to provide a benchmark for alternative methods. This contribution systematically summarizes the available knowledge on limitations and uncertainties of TG 203, based on methodological, statistical, and biological consider­ations. Uncertainties stem from the historic flexibility (e.g., use of a broad range of species) and constraints of the basic test design (e.g., no replication). Other sources of uncertainty arise from environmental safety extrapolation based on TG 203 data. Environmental extrapolation models, combined with data from alternative methods, including mechanistic indicators of toxicity, may provide at least the same level of environmental protection. Yet, most importantly, the 3R advan­tages of alternative methods allow a better standardization, characterization, and an improved basic study design. This can enhance data reliability and thus facilitate the comparison of chemical toxicity, as well as the environmental classifi­cations and prediction of no-effect concentrations of chemicals. Combined with the 3R gains and the potential for higher throughput, a reliable assessment of more chemicals can be achieved, leading to improved environmental protection.
dauerhafte UFZ-Verlinkung
Paparella, M., Scholz, S., Belanger, S., Braunbeck, T., Bicherel, P., Connors, K., Faßbender, C., Halder, M., Lillicrap, A., Liska, R., Schirmer, K., Stoddart, G., Thomas, P., Walter-Rohde, S. (2021):
Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods
ALTEX-Altern. Anim. Exp. 38 (1), 20 - 32 10.14573/altex.2006051