Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Creative Commons Lizenz creative commons licence
Titel (primär) Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio
Autor Ulrich, N.; Schweiger, N.; Pfennigsdorff, A.; Scholz, S.; Goss, K.-U.;
Journal / Serie Environmental Toxicology and Chemistry
Erscheinungsjahr 2020
Department BIOTOX; AUC;
Band/Volume 39
Heft 8
Sprache englisch;
POF III (gesamt) T42; F11;
Supplements https://setac.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fetc.4744&file=etc4744-sup-0001-SI_revised.docx
Keywords Zebrafish embryo; Danio rerio; Yolk‐water partitioning; Linear free energy relationships (pp‐LFER)
Abstract Yolk is the most important temporary biological compartment of the early life stages of the fish embryos. The sorption strength of a chemical to yolk components may significantly influence the distribution of that chemical in the fish embryo. We determined yolk/water partition coefficients (Kyolk/water in Lwater/kgyolk, normalized to dry weight) for 70 neutral organic chemicals. The log Kyolk/water values cover a range from 0.76 to 6.56. On basis of these values we developed polyparameter linear free energy relationship (pp‐LFER) models to predict yolk/water partitioning for a broad range of neutral organic chemicals with a rmse of 0.37 and a r² of 0.919. These models can be applied for the prediction of internal concentrations at equilibrium (neglecting biotransformation and active transport) in the zebrafish embryo test system.
ID 23084
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=23084
Ulrich, N., Schweiger, N., Pfennigsdorff, A., Scholz, S., Goss, K.-U. (2020):
Yolk–water partitioning of neutral organic compounds in the model organism Danio rerio
Environ. Toxicol. Chem. 39 (8), 1506 - 1516