Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.3389/ftox.2024.1359507
Lizenz creative commons licence
Titel (primär) New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Autor Tal, T. ORCID logo ; Myhre, O.; Fritsche, E.; Rüegg, J.; Craenen, K.; Aiello-Holden, K.; Agrillo, C.; Babin, P.J.; Escher, B.I. ORCID logo ; Dirven, H.; Hellsten, K.; Dolva, K.; Hessel, E.; Heusinkveld, H.J.; Hadzhiev, Y.; Hurem, S.; Jagiello, K.; Judzinska, B.; Klüver, N.; Knoll-Gellida, A.; Kühne, B.A.; Leist, M.; Lislien, M.; Lyche, J.L.; Müller, F.; Colbourne, J.K.; Neuhaus, W.; Pallocca, G.; Seeger, B.; Scharkin, I.; Scholz, S. ORCID logo ; Spjuth, O.; Torres-Ruiz, M.; Bartmann, K.
Quelle Frontiers in Toxicology
Erscheinungsjahr 2024
Department ZELLTOX; ETOX
Band/Volume 6
Seite von art. 1359507
Sprache englisch
Topic T9 Healthy Planet
Keywords new approach method (NAM); developmental neurotoxicity (DNT); adult neurotoxicity (ANT); DNT-IVB; zebrafish; applicability domain
Abstract In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While the public expects chemicals and products to be safe for the developing and mature nervous systems, considerable numbers of chemicals in commerce have not, or only to a limited extent, been assessed for their potential to cause neurotoxicity. As such, there is a societal push toward the replacement of animal models with in vitro or alternative methods. New approach methods (NAMs) can contribute to the regulatory knowledge base, increase chemical safety, and modernize chemical hazard and risk assessment. Provided they reach an acceptable level of regulatory relevance and reliability, NAMs may be considered as replacements for specific in vivo studies. The European Partnership for the Assessment of Risks from Chemicals (PARC) addresses challenges to the development and implementation of NAMs in chemical risk assessment. In collaboration with regulatory agencies, Project 5.2.1e (Neurotoxicity) aims to develop and evaluate NAMs for developmental neurotoxicity (DNT) and adult neurotoxicity (ANT) and to understand the applicability domain of specific NAMs for the detection of endocrine disruption and epigenetic perturbation. To speed up assay time and reduce costs, we identify early indicators of later-onset effects. Ultimately, we will assemble second-generation developmental neurotoxicity and first-generation adult neurotoxicity test batteries, both of which aim to provide regulatory hazard and risk assessors and industry stakeholders with robust, speedy, lower-cost, and informative next-generation hazard and risk assessment tools
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29094
Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P.J., Escher, B.I., Dirven, H., Hellsten, K., Dolva, K., Hessel, E., Heusinkveld, H.J., Hadzhiev, Y., Hurem, S., Jagiello, K., Judzinska, B., Klüver, N., Knoll-Gellida, A., Kühne, B.A., Leist, M., Lislien, M., Lyche, J.L., Müller, F., Colbourne, J.K., Neuhaus, W., Pallocca, G., Seeger, B., Scharkin, I., Scholz, S., Spjuth, O., Torres-Ruiz, M., Bartmann, K. (2024):
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Front. Toxicol. 6 , art. 1359507 10.3389/ftox.2024.1359507