Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.mce.2008.06.008
Titel (primär) Molecular biomarkers of endocrine disruption in small model fish
Autor Scholz, S. ORCID logo ; Mayer, I.
Quelle Molecular and Cellular Endocrinology
Erscheinungsjahr 2008
Department ZELLTOX
Band/Volume 293
Heft 1-2
Seite von 57
Seite bis 70
Sprache englisch
Keywords Endocrine disruption; Biomarker; Hormone receptors; Vitellogenin; Spiggin; Teleost
Abstract A wide range of environmental contaminants can interfere with hormonal regulation in vertebrates. These endocrine disrupting chemicals (EDCs) are of high relevance for human and wildlife health, since endocrine signalling controls many essential physiological processes which impact on the individual's health, such as growth and development, stress response, and ultimately reproduction and population development. Small fish represent a cost-effective model for testing potential EDCs allowing the possibility to integrate from molecular to phenotypic and functional effects. We have comprehensively reviewed exposure-effect data from four different small model fish: zebrafish, medaka, fathead minnow, and the three-spined stickleback. The majority of available data refer to EDCs interfering with reproductive hormones. However, we have also included interactions with other hormone systems, particularly the thyroid hormones. We demonstrate that the available data clearly indicates the predictive potential of molecular biomarkers, supporting the development and regulatory application of simple molecular-based screening assays using small model fish for EDC testing.
dauerhafte UFZ-Verlinkung
Scholz, S., Mayer, I. (2008):
Molecular biomarkers of endocrine disruption in small model fish
Mol. Cell. Endocrinol. 293 (1-2), 57 - 70 10.1016/j.mce.2008.06.008