UFZ - Publikationsverzeichnis - Helmholtz-Zentrum für Umweltforschung UFZ

Details zur Publikation

Kategorie	Textpublikation
Referenztyp	Berichte
URL	https://echa.europa.eu/documents/10162/17231/fet_report_en.pdf/b6036bdb-9041-41c8-a390-d9b66b244a4b?t=1466155378221
Titel (primär)	Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. Report ECHA-UFZ contract ECHA/2014/341
Autor	Scholz, S. ; Klüver, N.; Kühne, R.
Erscheinungsjahr	2016
Department	OEC; BIOTOX
Seite bis	104
Sprache	englisch
Abstract	The acute fish toxicity (AFT, OECD TG 203) is required to provide information on the acute toxicity of chemicals for environmental hazards and risk assessment. It is conducted as part of the registration of (industrial) chemicals under European regulations as well as other regulations. To reduce the number of tests on animals, the REACH Regulation promotes alternative methods for the hazard assessment of substances. For example, testing according to OECD Technical Guideline 236 (fish embryo acute toxicity test (FET)) has been suggested as one of the alternative methods to toxicity testing in adult fish. The aim of this study was to assess the capacity of the FET test in predicting acute fish toxicity and to define the applicability domain of the FET test for regulatory purposes. The existing fish embryo data (acute - 96h LC50) were compared to data on adult fish toxicity (acute - 96h LC50) and the limits of applicability investigated by analysis of the relation of the results with respect to physicochemical parameters, structural domains, excess toxicities (i.e. the ratio of predicted baseline toxicity LC50 versus observed acute LC50, also called toxic ratio).
dauerhafte UFZ-Verlinkung	https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=24916
Scholz, S., Klüver, N., Kühne, R. (2016): Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. Report ECHA-UFZ contract ECHA/2014/341 Helmholtz Centre for Environmental Research - UFZ, Leipzig, 104 pp.