Dr. Arkadiusz Pierzchalski

Kontakt

Dr. Arkadiusz Pierzchalski

Wissenschaftler

Department Umweltimmunologie
Helmholtz-Zentrum für Umweltforschung – UFZ
Permoserstr. 15
04318 Leipzig


Tel.: +49 341 235-1548
Fax: +49 341 235-1787

Arkadiusz Pierzchalski

Research Interests

  • Cytometry technology development
  • Influence of environmental factors on regulatory T cells and mucosal-associated invariant T cells function
  • Cell therapy (ATMP – advanced therapy medicinal products) development for tolerance induction and allergy
  • In-depth immune cells characterization with flow cytometry

Curriculum vitae / Scientific career

1995 - 2000

Student at Intercollegiate Faculty of Biotechnology at University of Gdañsk (Danzig, Poland)
Diploma thesis: "Analysis of IL-1 and TNF-induced cell death of KB cells"

2000 - 2007

PhD Student at the Institute for Medical Biotechnology, Medical University Gdañsk,
PhD thesis: "Analysis of TNF receptor activation by soluble and membrane form of TNF in U937 cells"

2001 - 2005

PhD Student of Postgraduate School of Molecular Medicine in Warsaw

02/2006 - 08/2007

Scientist at the Medical University of Gdañsk, Poland

08/2006 - 09/2006

Internship at the LIONEX GmbH, Braunschweig

10/2006 - 12/2006

Internship at the University of Stuttgart, Institute of Cell Biology and Immunology

04/2007 - 12/2008

Scientist at the Heart Centre at Medical University of Leipzig

01/2009 - 03/2011

Scientist at the Translational Centre for Regenerative Medicine (TRM), University of Leipzig

04/2011 - 05/2013

Principal Investigator “Cytomics parameters for ex vivo expansion of regulatory Cells (Tregs) for immune tolerance ", Translational Centre for Regenerative Medicine (TRM), University of Leipzig

02/2014 - 12/2014

Scientist at the Clinics of University of Leipzig, “Pathogenesis of New Allergies”

since 2015

Scientist at the Helmholtz Centre for Environmental Research Leipzig - UFZ, Department Environmental Immunology


Awards and Scholarships

1999 

Letter of Congratulations from a Dean of the Faculty of Biotechnology

1999 - 2000

Scholarship from the Major of Sopot

06/2000 - 09/2000

SOCRATES/ERASMUS Grant, Santiago de Compostela, Spain - Mechanisms of the cell cycle regulation

2003

Team reward by Rector of Medical Academy of Gdañsk for the work on TNF receptors

2006

Personal reward of Council of Faculty of Biotechnology for the success in education of biotechnology students


 Publications

Doszczak M., Pierzchalski A., Bigda J., (2001): Mechanisms of IL-1 signalling Advances in Cell Biology, (28), 1: 99-127

Doszczak M, Kaszubowska L, Pierzchalski A, Bigda J., (2002): NF-_B activation by TNF” Advances in Biochemistry, (28), 1:54-65

Pierzchalski A, Mittag A, Tarnok A (2007): Observing the invisible: molecular and cellular imaging by multimodal virtual anatomy. Cytometry A. Aug;71(8):538-9.

Doszczak M, Pierzchalski A, Grzenkowicz J, Stasiłojc G, Bigda JJ., (2008): Cytocidal effect of interleukin 1(IL-1) on HeLa cells is mediated by both soluble and transmembrane tumor necrosis factor (TNF).Cytokine. May;42(2):243-55.

Pierzchalski A, Robitzki A, Mittag A, Emmrich F, Sack U, O'Connor JE, Bocsi J, Tárnok A., (2008): Cytomics and nanobioengineering. Cytometry B Clin Cytom. 74(6): 416-26.

Tárnok A, Pierzchalski A, Valet G., (2010): Potential of a cytomics top-down strategy for drug discovery. Curr Med Chem. 17(16):1719-29.

Cheung KC, Di Berardino M, Schade-Kampmann G, Hebeisen M, Pierzchalski A, Bocsi J, Mittag A, Tárnok A., (2010) Microfluidic impedance-based flow cytometry. Cytometry A. Jul;77(7):648-66.

Pierzchalski A, Mittag A, Tárnok A., (2011) Introduction A: recent advances in cytometry instrumentation, probes, and methods--review. Methods Cell Biol. 102:1-21. Review.

Pierzchalski A, Hebeisen M, Mittag A, Bocsi J, Di Berardino M, Tarnok A., (2012): Label-free hybridoma cell culture quality control by a chip-based impedance flow cytometer. Lab Chip. Oct 2;12(21):4533-43.

Pierzchalski A, Mittag A, Bocsi J, Tarnok A., (2013): An innovative cascade system for simultaneous separation multiple cell types. PLoS One. Sep 6;8(9):e74745.

Dieterlen M T, Bittner H, Pierzchalski A, Dhein S, Mohr F, Barten M., (2014): Immunological monitoring of extracorporeal photopheresis after heart transplantation Clin Exp Immunol. Apr;176(1):120-8.