Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1038/s41380-023-02331-5 |
Lizenz  |
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| Titel (primär) | Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence |
| Autor | Choudhary, P.; Monasso, G.S.; Karhunen, V.; Ronkainen, J.; Mancano, G.; Howe, C.G.; Niu, Z.; Zeng, X.; Guan, W.; Dou, J.; Feinberg, J.I.; Mordaunt, C.; Pesce, G.; Baïz, N.; Alfano, R.; Martens, D.S.; Wang, C.; Isaevska, E.; Keikkala, E.; Mustaniemi, S.; Thio, C.H.L.; Fraszczyk, E.; Tobi, E.W.; Starling, A.P.; Cosin-Tomas, M.; Urquiza, J.; Röder, S.
; Hoang, T.T.; Page, C.; Jima, D.D.; House, J.S.; Maguire, R.L.; Ott, R.; Pawlow, X.; Sirignano, L.; Zillich, L.; Malmberg, A.; Rauschert, S.; Melton, P.; Gong, T.; Karlsson, R.; Fore, R.; Perng, W.; Laubach, Z.M.; Czamara, D.; Sharp, G.; Breton, C.V.; Schisterman, E.; Yeung, E.; Mumford, S.L.; Fallin, M.D.; LaSalle, J.M.; Schmidt, R.J.; Bakulski, K.M.; Annesi-Maesano, I.; Heude, B.; Nawrot, T.S.; Plusquin, M.; Ghantous, A.; Herceg, Z.; Nisticò, L.; Vafeiadi, M.; Kogevinas, M.; Vääräsmäki, M.; Kajantie, E.; Snieder, H.; Corpeleijn, E.; Steegers-Theunissen, R.P.M.; Yang, I.V.; Dabelea, D.; Fossati, S.; Zenclussen, A.C.; Herberth, G.
; Magnus, M.; Håberg, S.E.; London, S.J.; Munthe-Kaas, M.C.; Murphy, S.K.; Hoyo, C.; Ziegler, A.-G.; Hummel, S.; Witt, S.H.; Streit, F.; Frank, J.; Räikkönen, K.; Lahti, J.; Huang, R.-C.; Almqvist, C.; Hivert, M.-F.; Jaddoe, V.W.V.; Järvelin, M.-R.; Kantomaa, M.; Felix, J.F.; Sebert, S. |
| Quelle | Molecular Psychiatry |
| Erscheinungsjahr | 2023 |
| Department | IMMU |
| Sprache | englisch |
| Topic | T9 Healthy Planet |
| Supplements | https://static-content.springer.com/esm/art%3A10.1038%2Fs41380-023-02331-5/MediaObjects/41380_2023_2331_MOESM1_ESM.docx https://static-content.springer.com/esm/art%3A10.1038%2Fs41380-023-02331-5/MediaObjects/41380_2023_2331_MOESM2_ESM.xlsx |
| Abstract | Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=28343 |
| Choudhary, P., Monasso, G.S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C.G., Niu, Z., Zeng, X., Guan, W., Dou, J., Feinberg, J.I., Mordaunt, C., Pesce, G., Baïz, N., Alfano, R., Martens, D.S., Wang, C., Isaevska, E., Keikkala, E., Mustaniemi, S., Thio, C.H.L., Fraszczyk, E., Tobi, E.W., Starling, A.P., Cosin-Tomas, M., Urquiza, J., Röder, S., Hoang, T.T., Page, C., Jima, D.D., House, J.S., Maguire, R.L., Ott, R., Pawlow, X., Sirignano, L., Zillich, L., Malmberg, A., Rauschert, S., Melton, P., Gong, T., Karlsson, R., Fore, R., Perng, W., Laubach, Z.M., Czamara, D., Sharp, G., Breton, C.V., Schisterman, E., Yeung, E., Mumford, S.L., Fallin, M.D., LaSalle, J.M., Schmidt, R.J., Bakulski, K.M., Annesi-Maesano, I., Heude, B., Nawrot, T.S., Plusquin, M., Ghantous, A., Herceg, Z., Nisticò, L., Vafeiadi, M., Kogevinas, M., Vääräsmäki, M., Kajantie, E., Snieder, H., Corpeleijn, E., Steegers-Theunissen, R.P.M., Yang, I.V., Dabelea, D., Fossati, S., Zenclussen, A.C., Herberth, G., Magnus, M., Håberg, S.E., London, S.J., Munthe-Kaas, M.C., Murphy, S.K., Hoyo, C., Ziegler, A.-G., Hummel, S., Witt, S.H., Streit, F., Frank, J., Räikkönen, K., Lahti, J., Huang, R.-C., Almqvist, C., Hivert, M.-F., Jaddoe, V.W.V., Järvelin, M.-R., Kantomaa, M., Felix, J.F., Sebert, S. (2023): Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence Mol. Psychiatr. 10.1038/s41380-023-02331-5 |
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