Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1038/s41380-023-02331-5 |
Lizenz  |
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| Titel (primär) | Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence |
| Autor | Choudhary, P.; Monasso, G.S.; Karhunen, V.; Ronkainen, J.; Mancano, G.; Howe, C.G.; Röder, S.
; Zenclussen, A.C.; Herberth, G.
; Sebert, S., et al. |
| Quelle | Molecular Psychiatry |
| Erscheinungsjahr | 2024 |
| Department | IMMU |
| Band/Volume | 29 |
| Seite von | 348 |
| Seite bis | 358 |
| Sprache | englisch |
| Topic | T9 Healthy Planet |
| Supplements | https://static-content.springer.com/esm/art%3A10.1038%2Fs41380-023-02331-5/MediaObjects/41380_2023_2331_MOESM1_ESM.docx https://static-content.springer.com/esm/art%3A10.1038%2Fs41380-023-02331-5/MediaObjects/41380_2023_2331_MOESM2_ESM.xlsx |
| Abstract | Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=28343 |
| Choudhary, P., Monasso, G.S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C.G., Röder, S., Zenclussen, A.C., Herberth, G., Sebert, S., et al. (2024): Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence Mol. Psychiatr. 29 , 348 - 358 10.1038/s41380-023-02331-5 |
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