Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.3390/ijms242216091
Lizenz creative commons licence
Titel (primär) B cells induce early-onset maternal inflammation to protect against LPS-induced fetal rejection
Autor Uehre, G.M.; Tchaikovski, S.; Ignatov, A.; Zenclussen, A.C.; Busse, M.
Quelle International Journal of Molecular Sciences
Erscheinungsjahr 2023
Department IMMU
Band/Volume 24
Heft 22
Seite von art. 16091
Sprache englisch
Topic T9 Healthy Planet
Keywords preterm birth; pregnancy; lipopolysaccharide; inflammation; B cells
Abstract The maternal balance between B regulatory (Breg) cells and inflammatory B cells is of central importance for protection against preterm birth (PTB). However, the impact of B cell signaling in early maternal and fetal immune responses on inflammatory insults remains underinvestigated. To understand which role B cells and B-cell-specific signaling play in the pathogenesis of PTB, the later was induced by an injection of LPS in B cell-sufficient WT mice, CD19−/−, BMyD88−/− and µMT murine dams at gestational day 16 (gd 16). WT dams developed a strong inflammatory response in their peritoneal cavity (PC), with an increased infiltration of granulocytes and enhanced IL-6, TNF-α, IL-17 and MCP-1 levels. However, they demonstrated a reduced NOS2 expression of PC macrophages 4 h after the LPS injection. Simultaneously, LPS-challenged WT dams upregulated pregnancy-protective factors like IL-10 and TARC. The concentrations of inflammatory mediators in the placental supernatants, amniotic fluids, fetal serums and gestational tissues were lower in LPS-challenged WT dams compared to CD19−/−, BMyD88−/− and µMT dams, thereby protecting WT fetuses from being born preterm. B cell deficiency, or the loss of B-cell-specific CD19 or MyD88 expression, resulted in an early shift from immune regulation towards inflammation at the fetomaternal interface and fetuses, resulting in PTB
dauerhafte UFZ-Verlinkung
Uehre, G.M., Tchaikovski, S., Ignatov, A., Zenclussen, A.C., Busse, M. (2023):
B cells induce early-onset maternal inflammation to protect against LPS-induced fetal rejection
Int. J. Mol. Sci. 24 (22), art. 16091 10.3390/ijms242216091