Dr. Alexander Böhme
Adress:
Permoserstr. 15
04318 Leipzig
Germany
building: 7.3
office: 1.032
phone: +49 341 6025 1503
Alexander Böhme
Research Interests
- Chemoassay profiling of the reactivity of organic electrophiles towards biological nucleophiles in proteins in the framework of assessing the skin and respiratory allergy potential of these chemicals without animal testing
- Leaching, transformation, reactivity, and chemical analytics for plastic-associated chemicals
- qualitative and quantitative screening of plastics in diverse samples by TED-GC-MS (pyrolysis GC-MS)
- chemical analytics of environmental chemicals (target, suspect, transformation products)
Curiculum Vitae
since 2024
Scientist, Department of Exposure Science – UFZ
2019 - 2023
Scientist, Department of Ecological Chemistry – UFZ
2011 - 2018
Post-Doctoral Fellow, Department of Ecological Chemistry – UFZ
2010 - 2011
Post-Doctoral Fellow, Department of Environmental Immunology – UFZ
2006 - 2010
Doctoral Project (Dr. rer. nat.) in Environmental Chemistry & Toxicology, TU Bergakademie Freiberg & Department of Ecological Chemistry – UFZ
2000 - 2006
Diploma in Chemistry, Leipzig University
Cooperations / Projects
2024 - 2026
nanoINHALE, UFZ doctoral college , PIs & main supervisors: Dusan Materic, Elisa Rojo-Nieto, Lennart Schüler, Anran Luo
2024
ELECTROREM4PLASTICS, UFZ TransProof project, partner: UFZ Department MibiTech (Navid Saeidi, Falk Harnisch)
2022 - 2025
P-LEACH, Helmholtz Innovation Pool Project, partners: other Helmholtz Centers (AWI, Hereon, GEOMAR)
since 2018 ongoing
Screening of Tryptophane transformation products for medical research, partners: DKFZ Heidelberg (Christiane Opitz), University hospital Leipzig (Maria Theresa Völker)
2015 - 2018
BMBF funded project „ProHapTox“ (UFZ PI), partner: TU Bergakademie Freiberg
Publications
Index:
You could use our publication index for further requests.
2024 (4)
- Böhme, A., Simoneit, M., Ulrich, N., Schüürmann, G. (2024):
Amino reactivity of aromatic aldehydes - Chemoassay analysis of mechanisms underlying their skin sensitization potency
Naunyn-Schmiedebergs Arch. Pharmacol. 397 (Suppl. 1), S19 - P001 10.1007/s00210-024-02974-3 - Escher, B.I., Ahlheim, J., Böhme, A., Borchardt, D., Brack, W., Braun, G., Colbourne, J.K., Dann, J.P., Gessner, J., Jahnke, A., König, M., Klüver, N., Krauss, M., Lee, J., Li, X., Lips, S., Orsini, L., Rinke, K., Schmitt-Jansen, M., Scholz, S., Schulze, T., Spahr, S., Ulrich, N., Weitere, M., Varga, E. (2024):
Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Nat. Water 2 (9), 889 - 898 10.1038/s44221-024-00297-4 - Menger, F., Römerscheid, M., Lips, S., Klein, O., Nabi, D., Gandrass, J., Joerss, H., Wendt-Potthoff, K., Bedulina, D., Zimmermann, T., Schmitt-Jansen, M., Huber, C., Böhme, A., Ulrich, N., Beck, A.J., Pröfrock, D., Achterberg, E.P., Jahnke, A., Hildebrandt, L. (2024):
Screening the release of chemicals and microplastic particles from diverse plastic consumer products into water under accelerated UV weathering conditions
J. Hazard. Mater. 477 , art. 135256 10.1016/j.jhazmat.2024.135256 - Simoneit, M., Böhme, A. (2024):
Amino reactivity-based identification of respiratory sensitizers
Naunyn-Schmiedebergs Arch. Pharmacol. 397 (Suppl. 1), S19 - P002 10.1007/s00210-024-02974-3
2023 (6)
- Böhme, A., Ulrich, N., Schüürmann, G. (2023):
Amino chemoassay profiling of aromatic aldehydes–unraveling drivers of their skin sensitization potency
Chem. Res. Toxicol. 36 (7), 1055 - 1070 10.1021/acs.chemrestox.3c00013 - Gerhards, M., Böhme, A., Schubert, K., Kodritsch, B., Ulrich, N. (2023):
DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene
Curr. Res. Toxicol. 4 , art. 100097 10.1016/j.crtox.2022.100097 - Latz, M., Böhme, A., Ulrich, N. (2023):
Reactivity-based identification of oxygen containing functional groups of chemicals applied as potential classifier in non-target analysis
Sci. Rep. 13 , art. 22828 10.1038/s41598-023-50240-y - Liess, M., Böhme, A., Gröning, J., Liebmann, L., Lück, M., Reemtsma, T., Römerscheid, M., Schade, U., Schwarz, B., Vormeier, P., Weisner, O. (2023):
Belastung von kleinen Gewässern in der Agrarlandschaft mit Pflanzenschutzmittel-Rückständen – TV1 Datenanalyse
zur Pilotstudie Kleingewässermonitoring 2018/2019 – Abschlussbericht. German monitoring of plant protection product residues in small streams – In depth analysis of the Kleingewässermonitoring from 2018/2019
Texte Umweltbundesamt 63/2023
Umweltbundesamt, Dessau-Roßlau, 244 S. - Saleem, S., Böhme, A., Schüürmann, G. (2023):
Baseline narcosis for the glass-vial 96-h growth inhibition of the nematode C. elegans and its use for identifying electrophilic and pro-electrophilic toxicity
Environ. Sci. Technol. 57 (4), 1692 - 1700 10.1021/acs.est.2c05217 - Ulrich, N., Böhme, A., Strobel, A.B., Egert, T. (2023):
Predicting partitioning from low density polyethylene to blood and adipose tissue by linear solvation energy relationship models
J. Biomed. Mater. Res. Part B 111 (12), 2044 - 2054 10.1002/jbm.b.35304
2022 (4)
- Böhme, A., Moldrickx, J., Schüürmann, G. (2022):
Amino reactivity of Schiff base forming aldehydes - Nonanimal assessment of their skin sensitization potency
Naunyn-Schmiedebergs Arch. Pharmacol. 395 (Suppl. 1), S31 - S31 10.1007/s00210-022-02205-7 - Latz, M., Böhme, A., Ulrich, N. (2022):
Spectra_reactivity - Version v2 [Data set]
Zenodo 10.5281/zenodo.8213955 - Latz, M., Böhme, A., Ulrich, N. (2022):
Spectra_reactivity - Version v1 [Data set]
Zenodo 10.5281/zenodo.7429998 - Ulrich, N., Böhme, A. (2022):
Rapid determination of serum albumin partition coefficients using affinity chromatography
Environ. Adv. 9 , art. 100284 10.1016/j.envadv.2022.100284
2021 (1)
- Böhme, A., Moldrickx, J., Schüürmann, G. (2021):
Amino reactivity of glutardialdehyde and monoaldehydes - chemoassay profile vs skin sensitization potency
Chem. Res. Toxicol. 34 (11), 2353 - 2365 10.1021/acs.chemrestox.1c00266
2020 (3)
- Böhme, A., Moldrickx, J., Schüürmann, G. (2020):
Chemoassay profiling to characterize the skin sensitization potential and potency of organic electrophiles
Naunyn-Schmiedebergs Arch. Pharmacol. 393 (Suppl. 1), 85 - 85 10.1007/s00210-020-01828-y - Böhme, A., Werner, A., Moldrickx, J., Ebersbach, B., Mazik, M., Schüürmann, G. (2020):
Chemoassay profiling of benzoates and salicylates to assess their skin sensitization potential
Naunyn-Schmiedebergs Arch. Pharmacol. 393 (Suppl. 1), 85 - 85 10.1007/s00210-020-01828-y - Sadik, A., Somarribas Patterson, L.F., Öztürk, S., Mohapatra, S.R., Panitz, V., Secker, P.F., Pfänder, P., Loth, S., Salem, H., Prentzell, M.T., Berdel, B., Iskar, M., Faessler, E., Reuter, F., Kirst, I., Kalter, V., Foerster, K.I., Jäger, E., Ramallo Guevara, C., Sobeh, M., Hielscher, T., Poschet, G., Reinhardt, A., Hassel, J.C., Zapatka, M., Hahn, U., von Deimling, A., Hopf, C., Schlichting, R., Escher, B.I., Burhenne, J., Haefeli, W.E., Ishaque, N., Böhme, A., Schäuble, S., Thedieck, K., Trump, S., Seiffert, M., Opitz, C.A. (2020):
IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression
Cell 182 (5), 1252 - 1270.e34 10.1016/j.cell.2020.07.038
Index:
You could use our publication index for further requests.
2019 (1)
- Hovorka, S., Vrbka, P., Bermúdez-Salguero, C., Böhme, A. (2019):
Air–water partitioning of C5 and C6 alkanones: Measurement, critical compilation, correlation, and recommended data
J. Chem. Eng. Data 64 (12), 5765 - 5774 10.1021/acs.jced.9b00726
2017 (4)
- Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106 10.1016/j.envint.2016.11.029 - Shafique, U., Schulze, S., Slawik, C., Böhme, A., Paschke, A., Schüürmann, G. (2017):
Perfluoroalkyl acids in aqueous samples from Germany and Kenya
Environ. Sci. Pollut. Res. 24 (12), 11031 - 11043 10.1007/s11356-016-7076-4 - Shafique, U., Schulze, S., Slawik, C., Chepchirchir, B.S., Böhme, A., Paschke, A., Schüürmann, G. (2017):
Erratum to: Perfluoroalkyl acids in aqueous samples from Germany and Kenya
Environ. Sci. Pollut. Res. 24 (12), 11044 - 11044 10.1007/s11356-016-7721-y - Slawik, C., Rickmeyer, C., Brehm, M., Böhme, A., Schüürmann, G. (2017):
Glutathione adduct patterns of Michael-acceptor carbonyls
Environ. Sci. Technol. 51 (7), 4018 - 4026 10.1021/acs.est.6b04981
2016 (1)
- Böhme, A., Laqua, A., Schüürmann, G. (2016):
Chemoavailability of organic electrophiles: impact of hydrophobicity and reactivity on their aquatic excess toxicity
Chem. Res. Toxicol. 29 (6), 952 - 962 10.1021/acs.chemrestox.5b00398
2014 (1)
- Fenclová, D., Blahut, A., Vrbka, P., Dohnal, V., Böhme, A. (2014):
Temperature dependence of limiting activity coefficients, Henry's law constants, and related infinite dilution properties of C4–C6 isomeric n-alkyl ethanoates/ethyl n-alkanoates in water. Measurement, critical compilation, correlation, and recommended data
Fluid Phase Equilib. 375 , 347 - 359 10.1016/j.fluid.2014.05.023
2013 (1)
- Böhme, A., Zhang, W., Schüürmann, G. (2013):
Identification of potential skin sensitizers based on non-animal chemoassay and in vitro bioassay information
Abstr. Paper Am. Chem. Soc. 246 , 336-ENVR
2012 (3)
- Blaschke, U., Eismann, K., Böhme, A., Paschke, A., Schüürmann, G. (2012):
Structural alerts for the excess toxicity of acrylates, methacrylates, and propiolates derived from their short-term and long-term bacterial toxicity
Chem. Res. Toxicol. 25 (1), 170 - 180 10.1021/tx200395k - Bönisch, U., Böhme, A., Kohajda, T., Mögel, I., Schütze, N., von Bergen, M., Simon, J.C., Lehmann, I., Polte, T. (2012):
Volatile organic compounds enhance allergic airway inflammation in an experimental mouse model
PLoS One 7 (7), e39817 10.1371/journal.pone.0039817 - Thaens, D., Heinzelmann, D., Böhme, A., Paschke, A., Schüürmann, G. (2012):
Chemoassay screening of DNA-reactive mutagenicity with 4-(4-nitrobenzyl)pyridine – application to epoxides, oxetanes, and sulfur heterocycles
Chem. Res. Toxicol. 25 (10), 2092 - 2102 10.1021/tx3001412
2011 (1)
- Mögel, I., Baumann, S., Böhme, A., Kohajda, T., von Bergen, M., Simon, J.-C., Lehmann, I. (2011):
The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation
Toxicology 289 (1), 28 - 37 10.1016/j.tox.2011.07.006
2010 (4)
- Böhme, A., Schramm, F., Wondrousch, D., Schüürmann, G. (2010):
Alternativmethoden zur toxikologischen Bewertung chemischer Stoffe
Zeitschrift für Freunde und Förderer der Technischen Universität Bergakademie Freiberg 17 (Sonderdruck), 117 - 121 - Böhme, A., Thaens, D., Schramm, F., Paschke, A., Schüürmann, G. (2010):
Thiol reactivity and its impact on the ciliate toxicity of α,β-unsaturated aldehydes, ketones, and esters
Chem. Res. Toxicol. 23 (12), 1905 - 1912 10.1021/tx100226n - Dohnal, V., Vrbka, P., Rehák, K., Böhme, A., Paschke, A. (2010):
Activity coefficients and partial molar excess enthalpies at infinite dilution for four esters in water
Fluid Phase Equilib. 295 (2), 194 - 200 10.1016/j.fluid.2010.05.010 - Wondrousch, D., Böhme, A., Thaens, D., Ost, N., Schüürmann, G. (2010):
Local electrophilicity predicts toxicity-relevant reactivity of Michael acceptors
J. Phys. Chem. Lett. 1 (10), 1605 - 1610 10.1021/jz100247x
2009 (2)
- Böhme, A., Thaens, D., Paschke, A., Schüürmann, G. (2009):
Kinetic glutathione chemoassay-A non-animal component of integrated testing strategies to identify compounds with an electrophilic potential for reactive toxicity
Toxicol. Lett. 189 (Suppl. 1), S62 - S62 10.1016/j.toxlet.2009.06.308 - Böhme, A., Thaens, D., Paschke, A., Schüürmann, G. (2009):
Kinetic glutathione chemoassay to quantify thiol reactivity of organic electrophiles - application to α,β-unsaturated ketones, acrylates, and propiolates
Chem. Res. Toxicol. 22 (4), 742 - 750 10.1021/tx800492x
2008 (1)
- Böhme, A., Paschke, A., Vrbka, P., Dohnal, V., Schüürmann, G. (2008):
Determination of temperature-dependent Henry's law constant of four oxygenated solutes in water using headspace solid phases microextraction technique
J. Chem. Eng. Data 53 (12), 2873 - 2877 10.1021/je800623x