Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| Title (Primary) | Identification of potential skin sensitizers based on non-animal chemoassay and in vitro bioassay information |
| Author | Böhme, A.; Zhang, W.; Schüürmann, G. |
| Journal | Abstracts of Papers of the American Chemical Society |
| Year | 2013 |
| Department | OEC |
| Volume | 246 |
| Page From | 336-ENVR |
| Language | englisch |
| UFZ wide themes | RU3; |
| Abstract | In Europe, the REACH regulation requires that industrial chemicals with market volumes ≥ 1 t/a are assessed regarding their skin sensitization potential. The latter is typically based on data from the local lymph node assay (LLNA) and thus on animal testing. At the molecular level, skin sensitization is initiated by a chemical reaction between an electrophilic toxicant and nucleophilic sites of dermal proteins. Accordingly, an opportunity for a non-animal identification of potential sensitizers is to determine their electrophilic reactivity toward model nucleophiles through chemoassays,1-3 possibly augmented by in vitro bioassay data focussing on the excess toxicity driven by electrophilic reactivity.4-6 The approach is demonstrated for different classes of organic electrophiles, employing sulphur and nitrogen nucleophiles as well as in vitro EC50 growth inhibition data in order to discriminate between non-sensitizers and potential sensitizers. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14498 |
| Böhme, A., Zhang, W., Schüürmann, G. (2013): Identification of potential skin sensitizers based on non-animal chemoassay and in vitro bioassay information Abstr. Paper Am. Chem. Soc. 246 , 336-ENVR |
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