Dr. Carolin Huber
Address:
Permoserstr. 15
04318 Leipzig
Building: 7.3
Room: 1.033
Telefon: +49 341 6025 4736
Research Interests
Dr. Carolin Huber is focusing on environmental chemistry and human biomonitoring (Exposomics). Her expertise lies in developing advanced analytical techniques, including non-targeted and suspect screening methods, to identify emerging contaminants and their metabolites in human biological samples like urine, blood and breastmilk, as well as dust and wastewater influents. She uses liquid and gas chromatography coupled with high-resolution mass spectrometry (GC/HPLC-HRMS), along with automated workflows for data analysis.
In her current work, she analyzes large-scale human cohorts and wastewater influents with high-throughput sample measurement and computational data analysis to define exposure to new emerging contaminants and understand the source of these substances. Further techniques are human liver S9 incubation experiments and non-target screening for determining the metabolism and biomarkers of exposure to chemicals, such as pesticides and ingredients of personal care products.
Besides, she is developing measurement routines and data integration strategies for trapped ion mobility (TIMS) mass spectrometry to enhance analytical capabilities in human and environmental monitoring.
Curiculum Vitae
since 2023
PostDoc in the Department of Exposure Science - UFZ
2018 - 2022
PhD canidadate, Department Effect-Directed Analysis, UFZ
Thesis ”New Methods for the Detection of Metabolites of Chemicals of Emerging Concern in Human Biomonitoring"
2016 - 2017
Master of Science (M.Sc.) Environmental Chemistry and Toxicology, Norwegian University of Science and Technology (NTNU)
2011 - 2015
Bachelor of Science (B.Sc.) in Chemistry, FU Berlin, Germany
Projects
2022 - 2029
PARC Partnership for the assessment of risks from chemicals. European Commission Horizon Partnership.
2017 - 2022
HBM4EU The Human Biomonitoring Initiative. European Commission Horizon Project
Publications
Index:
You could use our publication index for further requests.
2025 (1)
- Alvarez-Mora, I., Muratuly, A., Johann, S., Arturi, K., Jünger, F., Huber, C., Hollert, H., Krauss, M., Brack, W., Muz, M. (2025):
High-throughput effect-directed analysis of androgenic compounds in hospital wastewater: identifying effect drivers through non-target screening supported by toxicity prediction
Environ. Sci. Technol. 10.1021/acs.est.4c09942
2024 (5)
- Bade, R., Huchthausen, J., Huber, C., Dewapriya, P., Tscharke, B.J., Verhagen, R., Puljevic, C., Escher, B.I., O'Brien, J.W. (2024):
Improving wastewater-based epidemiology for new psychoactive substance surveillance by combining a high-throughput in vitro metabolism assay and LC−HRMS metabolite identification
Water Res. 253 , art. 121297 10.1016/j.watres.2024.121297 - Huber, C., Brack, W., Röder, S., von Bergen, M., Rolle-Kampczyk, U., Zenclussen, A.C., Krauss, M., Herberth, G. (2024):
Pesticide residues and polyphenols in urine – A combined LC-HRMS screening to reveal intake patterns
Environ. Int. 191 , art. 108981 10.1016/j.envint.2024.108981 - Krauss, M., Huber, C., Schulze, T., Bartel-Steinbach, M., Weber, T., Kolossa-Gehring, M., Lermen, D. (2024):
Assessing background contamination of sample tubes used in human biomonitoring by non-targeted liquid chromatography–high resolution mass spectrometry
Environ. Int. 138 , art. 108426 10.1016/j.envint.2024.108426 - Lennon, S., Chaker, J., Price, E.J., Hollender, J., Huber, C., Schulze, T., Ahrens, L., Béen, F., Creusot, N., Debrauwer, L., Dervilly, G., Gabriel, C., Guérin, T., Habchi, B., Jamin, E.L., Klánová, J., Kosjek, T., Le Bizec, B., Meijer, J., Mol, H., Nijssen, R., Oberacher, H., Papaioannou, N., Parinet, J., Sarigiannis, D., Stravs, M.A., Tkalec, Ž., Schymanski, E.L., Lamoree, M., Antignac, J.-P., David, A. (2024):
Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening and non-targeted analysis
Trac-Trends Anal. Chem. 174 , art. 117674 10.1016/j.trac.2024.117674 - Menger, F., Römerscheid, M., Lips, S., Klein, O., Nabi, D., Gandrass, J., Joerss, H., Wendt-Potthoff, K., Bedulina, D., Zimmermann, T., Schmitt-Jansen, M., Huber, C., Böhme, A., Ulrich, N., Beck, A.J., Pröfrock, D., Achterberg, E.P., Jahnke, A., Hildebrandt, L. (2024):
Screening the release of chemicals and microplastic particles from diverse plastic consumer products into water under accelerated UV weathering conditions
J. Hazard. Mater. 477 , art. 135256 10.1016/j.jhazmat.2024.135256
2023 (2)
- Krauss, M., Huber, C., Schulze, T., Bartel-Steinbach, M., Weber, T., Kolossa-Gehring, M., Lermen, D. (2023):
Assessing background contamination of sample tubes used in human biomonitoring by non-targeted liquid chromatography–high resolution mass spectrometry (Version v1) [Data set]
Zenodo 10.5281/zenodo.8182598 - Ottenbros, I., Lebret, E., Huber, C., Lommen, A., Antignac, J.-P., Čupr, P., Šulc, L., Mikeš, O., Szigeti, T., Középesy, S., Martinsone, I., Martinsone, Z., Akulova, L., Pardo, O., Fernández, S.F., Coscollá, C., Pedraza-Diaz, S., Krauss, M., Debrauwer, L., Wagner, K., Nijssen, R., Mol, H., Vitale, C.M., Klanova, J., Garlito Molina, B., León, N., Vermeulen, R., Luijten, M., Vlaanderen, J. (2023):
Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach
Int. J. Hyg. Environ. Health. 248 , art. 114105 10.1016/j.ijheh.2022.114105
2022 (4)
- Huber, C., Krauss, M., Reinstadler, V., Denicolò, S., Mayer, G., Schulze, T., Brack, W., Oberacher, H. (2022):
In silico deconjugation of glucuronide conjugates enhances tandem mass spectra library annotation of human samples
Anal. Bioanal. Chem. 414 (8), 2629 - 2640 10.1007/s00216-022-03899-7 - Huber, C., Nijssen, R., Mol, H., Antignac, J.P., Krauss, M., Brack, W., Wagner, K., Debrauwer, L., Vitale, C.M., Price, E.J., Klanova, J., Garlito Molina, B., Leon, N., Pardo, O., Fernández, S.F., Szigeti, T., Középesy, S., Šulc, L., Čupr, P., Mārtiņsone, I., Akülova, L., Ottenbros, I., Vermeulen, R., Vlaanderen, J., Luijten, M., Lommen, A. (2022):
A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences
Environ. Int. 168 , art. 107452 10.1016/j.envint.2022.107452 - Meijer, J., Lamoree, M., Hamers, T., Antignac, J.-P., Hutinet, S., Debrauwer, L., Covaci, A., Huber, C., Krauss, M., Walker, D.I., Schymanski, E.L., Schymanski, R., Vlaanderen, J. (2022):
S71 | CECSCREEN | HBM4EU CECscreen: Screening list for chemicals of emerging concern plus metadata and predicted phase 1 metabolites (NORMAN-SLE-S71.0.1.2) [Data set]
Zenodo 10.5281/zenodo.7305138 - Vitale, C.M., Lommen, A., Huber, C., Wagner, K., Garlito Molina, B., Nijssen, R., Price, E.J., Blokland, M., van Tricht, F., Mol, H.G.J., Krauss, M., Debrauwer, L., Pardo, O., Leon, N., Klanova, J., Antignac, J.-P. (2022):
Harmonized quality assurance/quality control provisions for nontargeted measurement of urinary pesticide biomarkers in the HBM4EU multisite SPECIMEn study
Anal. Chem. 94 (22), 7833 - 7843 10.1021/acs.analchem.2c00061
2021 (4)
- Caballero‑Casero, N., Belova, L., Vervliet, P., Antignac, J.-P., Castaño, A., Debrauwer, L., Esteban López, M., Huber, C., Klanova, J., Krauss, M., Lommen, A., Mol, H.G.J., Oberacher, H., Pardo, O., Price, E.J., Reinstadler, V., Vitale, C.M., van Nuijs, A.L.N., Covaci, A. (2021):
Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring
Trac-Trends Anal. Chem. 136 , art. 116201 10.1016/j.trac.2021.116201 - Huber, C., Müller, E., Schulze, T., Brack, W., Krauss, M. (2021):
Improving the screening analysis of pesticide metabolites in human biomonitoring by combining high-throughput in vitro íncubation and automated LC–HRMS data processing
Anal. Chem. 93 (26), 9149 - 9157 10.1021/acs.analchem.1c00972 - Meijer, J., Lamoree, M., Hamers, T., Antignac, J.-P., Hutinet, S., Debrauwer, L., Covaci, A., Huber, C., Krauss, M., Walker, D.I., Schymanski, E.L., Schymanski, R., Vlaanderen, J. (2021):
An annotation database for chemicals of emerging concern in exposome research
Environ. Int. 152 , art. 106511 10.1016/j.envint.2021.106511 - Müller, E., Huber, C.E., Brack, W., Krauss, M., Schulze, T. (2021):
Correction to: Symbolic aggregate approximation improves gap filling in high-resolution mass spectrometry data processing
Anal. Chem. 93 (8), 4141 10.1021/acs.analchem.1c00530
2020 (2)
- Müller, E., Huber, C., Beckers, L.-M., Brack, W., Krauss, M., Schulze, T. (2020):
A data set of 255,000 randomly selected and manually classified extracted ion chromatograms for evaluation of peak detection methods
Metabolites 10 (4), art. 162 10.3390/metabo10040162 - Müller, E., Huber, C.E., Brack, W., Krauss, M., Schulze, T. (2020):
Symbolic aggregate approximation improves gap filling in high-resolution mass spectrometry data processing
Anal. Chem. 92 (15), 10425 - 10432 10.1021/acs.analchem.0c00899
2019 (1)
- Aslam, S.N., Huber, C., Asimakopoulos, A.G., Steinnes, E., Mikkelsen, Ø. (2019):
Trace elements and polychlorinated biphenyls (PCBs) in terrestrial compartments of Svalbard, Norwegian Arctic
Sci. Total Environ. 685 , 1127 - 1138 10.1016/j.scitotenv.2019.06.060
2018 (1)
- Gys, C., Kovačič, A., Huber, C., Lai, F.Y., Heath, E., Covaci, A. (2018):
Suspect and untargeted screening of bisphenol S metabolites produced by in vitro human liver metabolism
Toxicol. Lett. 295 , 115 - 123 10.1016/j.toxlet.2018.05.034