Dr. Carolin Huber
Adresse:
Permoserstr. 15
04318 Leipzig
Gebäude: 7.3
Raum: 1.033
Telefon: +49 341 6025 4736
Forschungsinteressen
Dr. Carolin Huber hat ihren Forschungsschwerpunkt in Umweltchemie und Humanbiomonitoring (Exposomics). Ihre Expertise liegt in der Entwicklung fortschrittlicher Analysetechniken, einschließlich non-target und suspect screening-Methoden, zur Identifizierung neuer Schadstoffe und ihrer Metaboliten in biologischen Proben wie Urin, Blut und Muttermilch sowie in Staub und Abwassereinleitungen. Sie verwendet Flüssigkeits- und Gaschromatographie gekoppelt mit hochauflösender Massenspektrometrie (GC/HPLC-HRMS) sowie automatisierte Arbeitsabläufe für die Datenanalyse.
In ihrer aktuellen Arbeit analysiert sie Kohorten und Abwassereinflüsse mit Hochdurchsatz-Probenmessungen und computergestützter Datenanalyse, um die Exposition gegenüber neu aufkommenden Schadstoffen zu bestimmen und die Quelle dieser Substanzen zu verstehen. Weitere Techniken sind Inkubationsexperimente zur Bestimmung des Metabolismus und der Marker für die Belastung durch Chemikalien wie Pestizide und Inhaltsstoffe von Körperpflegeprodukten.
Außerdem entwickelt sie Messroutinen und Datenintegrationsstrategien für die TIMS-Massenspektrometrie (Trapped Ion Mobility), um die analytischen Möglichkeiten bei der Expositionsbestimmung von Mensch und Umwelt zu verbessern.
Lebenslauf
seit 2023
PostDoc Wissenschaftlerin im Department Exposure Science
2018 - 2022
Doktorarbeit mit dem Titel ”New Methods for the Detection of Metabolites of Chemicals of
Emerging Concern in Human Biomonitoring"
2016 - 2017
Master Studium (M.Sc.) in dem Fach Environmental Chemistry and Toxicology, Norwegian University of Science and Technology (NTNU)
2011 - 2015
Bachelor of Science (B.Sc.) in Chemistry, FU Berlin, Germany
Projekte
2022 - 2029
PARC Partnership for the assessment of risks from chemicals. European Commission Horizon Partnership.
2017 - 2022
HBM4EU The Human Biomonitoring Initiative. European Commission Horizon Project
Publikationen
Inhalt:
Weiterführende Recherchen können Sie in unserem Publikationsverzeichnis durchführen.
2025 (1)
- Alvarez-Mora, I., Muratuly, A., Johann, S., Arturi, K., Jünger, F., Huber, C., Hollert, H., Krauss, M., Brack, W., Muz, M. (2025):
High-throughput effect-directed analysis of androgenic compounds in hospital wastewater: identifying effect drivers through non-target screening supported by toxicity prediction
Environ. Sci. Technol. 10.1021/acs.est.4c09942
2024 (5)
- Bade, R., Huchthausen, J., Huber, C., Dewapriya, P., Tscharke, B.J., Verhagen, R., Puljevic, C., Escher, B.I., O'Brien, J.W. (2024):
Improving wastewater-based epidemiology for new psychoactive substance surveillance by combining a high-throughput in vitro metabolism assay and LC−HRMS metabolite identification
Water Res. 253 , art. 121297 10.1016/j.watres.2024.121297 - Huber, C., Brack, W., Röder, S., von Bergen, M., Rolle-Kampczyk, U., Zenclussen, A.C., Krauss, M., Herberth, G. (2024):
Pesticide residues and polyphenols in urine – A combined LC-HRMS screening to reveal intake patterns
Environ. Int. 191 , art. 108981 10.1016/j.envint.2024.108981 - Krauss, M., Huber, C., Schulze, T., Bartel-Steinbach, M., Weber, T., Kolossa-Gehring, M., Lermen, D. (2024):
Assessing background contamination of sample tubes used in human biomonitoring by non-targeted liquid chromatography–high resolution mass spectrometry
Environ. Int. 138 , art. 108426 10.1016/j.envint.2024.108426 - Lennon, S., Chaker, J., Price, E.J., Hollender, J., Huber, C., Schulze, T., Ahrens, L., Béen, F., Creusot, N., Debrauwer, L., Dervilly, G., Gabriel, C., Guérin, T., Habchi, B., Jamin, E.L., Klánová, J., Kosjek, T., Le Bizec, B., Meijer, J., Mol, H., Nijssen, R., Oberacher, H., Papaioannou, N., Parinet, J., Sarigiannis, D., Stravs, M.A., Tkalec, Ž., Schymanski, E.L., Lamoree, M., Antignac, J.-P., David, A. (2024):
Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening and non-targeted analysis
Trac-Trends Anal. Chem. 174 , art. 117674 10.1016/j.trac.2024.117674 - Menger, F., Römerscheid, M., Lips, S., Klein, O., Nabi, D., Gandrass, J., Joerss, H., Wendt-Potthoff, K., Bedulina, D., Zimmermann, T., Schmitt-Jansen, M., Huber, C., Böhme, A., Ulrich, N., Beck, A.J., Pröfrock, D., Achterberg, E.P., Jahnke, A., Hildebrandt, L. (2024):
Screening the release of chemicals and microplastic particles from diverse plastic consumer products into water under accelerated UV weathering conditions
J. Hazard. Mater. 477 , art. 135256 10.1016/j.jhazmat.2024.135256
2023 (2)
- Krauss, M., Huber, C., Schulze, T., Bartel-Steinbach, M., Weber, T., Kolossa-Gehring, M., Lermen, D. (2023):
Assessing background contamination of sample tubes used in human biomonitoring by non-targeted liquid chromatography–high resolution mass spectrometry (Version v1) [Data set]
Zenodo 10.5281/zenodo.8182598 - Ottenbros, I., Lebret, E., Huber, C., Lommen, A., Antignac, J.-P., Čupr, P., Šulc, L., Mikeš, O., Szigeti, T., Középesy, S., Martinsone, I., Martinsone, Z., Akulova, L., Pardo, O., Fernández, S.F., Coscollá, C., Pedraza-Diaz, S., Krauss, M., Debrauwer, L., Wagner, K., Nijssen, R., Mol, H., Vitale, C.M., Klanova, J., Garlito Molina, B., León, N., Vermeulen, R., Luijten, M., Vlaanderen, J. (2023):
Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach
Int. J. Hyg. Environ. Health. 248 , art. 114105 10.1016/j.ijheh.2022.114105
2022 (4)
- Huber, C., Krauss, M., Reinstadler, V., Denicolò, S., Mayer, G., Schulze, T., Brack, W., Oberacher, H. (2022):
In silico deconjugation of glucuronide conjugates enhances tandem mass spectra library annotation of human samples
Anal. Bioanal. Chem. 414 (8), 2629 - 2640 10.1007/s00216-022-03899-7 - Huber, C., Nijssen, R., Mol, H., Antignac, J.P., Krauss, M., Brack, W., Wagner, K., Debrauwer, L., Vitale, C.M., Price, E.J., Klanova, J., Garlito Molina, B., Leon, N., Pardo, O., Fernández, S.F., Szigeti, T., Középesy, S., Šulc, L., Čupr, P., Mārtiņsone, I., Akülova, L., Ottenbros, I., Vermeulen, R., Vlaanderen, J., Luijten, M., Lommen, A. (2022):
A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences
Environ. Int. 168 , art. 107452 10.1016/j.envint.2022.107452 - Meijer, J., Lamoree, M., Hamers, T., Antignac, J.-P., Hutinet, S., Debrauwer, L., Covaci, A., Huber, C., Krauss, M., Walker, D.I., Schymanski, E.L., Schymanski, R., Vlaanderen, J. (2022):
S71 | CECSCREEN | HBM4EU CECscreen: Screening list for chemicals of emerging concern plus metadata and predicted phase 1 metabolites (NORMAN-SLE-S71.0.1.2) [Data set]
Zenodo 10.5281/zenodo.7305138 - Vitale, C.M., Lommen, A., Huber, C., Wagner, K., Garlito Molina, B., Nijssen, R., Price, E.J., Blokland, M., van Tricht, F., Mol, H.G.J., Krauss, M., Debrauwer, L., Pardo, O., Leon, N., Klanova, J., Antignac, J.-P. (2022):
Harmonized quality assurance/quality control provisions for nontargeted measurement of urinary pesticide biomarkers in the HBM4EU multisite SPECIMEn study
Anal. Chem. 94 (22), 7833 - 7843 10.1021/acs.analchem.2c00061
2021 (4)
- Caballero‑Casero, N., Belova, L., Vervliet, P., Antignac, J.-P., Castaño, A., Debrauwer, L., Esteban López, M., Huber, C., Klanova, J., Krauss, M., Lommen, A., Mol, H.G.J., Oberacher, H., Pardo, O., Price, E.J., Reinstadler, V., Vitale, C.M., van Nuijs, A.L.N., Covaci, A. (2021):
Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring
Trac-Trends Anal. Chem. 136 , art. 116201 10.1016/j.trac.2021.116201 - Huber, C., Müller, E., Schulze, T., Brack, W., Krauss, M. (2021):
Improving the screening analysis of pesticide metabolites in human biomonitoring by combining high-throughput in vitro íncubation and automated LC–HRMS data processing
Anal. Chem. 93 (26), 9149 - 9157 10.1021/acs.analchem.1c00972 - Meijer, J., Lamoree, M., Hamers, T., Antignac, J.-P., Hutinet, S., Debrauwer, L., Covaci, A., Huber, C., Krauss, M., Walker, D.I., Schymanski, E.L., Schymanski, R., Vlaanderen, J. (2021):
An annotation database for chemicals of emerging concern in exposome research
Environ. Int. 152 , art. 106511 10.1016/j.envint.2021.106511 - Müller, E., Huber, C.E., Brack, W., Krauss, M., Schulze, T. (2021):
Correction to: Symbolic aggregate approximation improves gap filling in high-resolution mass spectrometry data processing
Anal. Chem. 93 (8), 4141 10.1021/acs.analchem.1c00530
2020 (2)
- Müller, E., Huber, C., Beckers, L.-M., Brack, W., Krauss, M., Schulze, T. (2020):
A data set of 255,000 randomly selected and manually classified extracted ion chromatograms for evaluation of peak detection methods
Metabolites 10 (4), art. 162 10.3390/metabo10040162 - Müller, E., Huber, C.E., Brack, W., Krauss, M., Schulze, T. (2020):
Symbolic aggregate approximation improves gap filling in high-resolution mass spectrometry data processing
Anal. Chem. 92 (15), 10425 - 10432 10.1021/acs.analchem.0c00899
2019 (1)
- Aslam, S.N., Huber, C., Asimakopoulos, A.G., Steinnes, E., Mikkelsen, Ø. (2019):
Trace elements and polychlorinated biphenyls (PCBs) in terrestrial compartments of Svalbard, Norwegian Arctic
Sci. Total Environ. 685 , 1127 - 1138 10.1016/j.scitotenv.2019.06.060
2018 (1)
- Gys, C., Kovačič, A., Huber, C., Lai, F.Y., Heath, E., Covaci, A. (2018):
Suspect and untargeted screening of bisphenol S metabolites produced by in vitro human liver metabolism
Toxicol. Lett. 295 , 115 - 123 10.1016/j.toxlet.2018.05.034