Dr. Heike Sträuber
Contact
Dr. Heike Sträuber
Scientist
Department of Microbial Biotechnology
Working Group Microbiology of Anaerobic Systems
Helmholtz Centre for
Environmental Research - UFZ
Permoserstr. 15, 04318 Leipzig, Germany
in cooperation with
Deutsches Biomasseforschungszentrum (DBFZ)
Torgauer Str. 116, 04347 Leipzig, Germany
Phone +49 341 6025 2264
heike.straeuber@ufz.de
CV / Scientific Career
since 2015
Senior scientist in the Research Group Microbiology of Anaerobic Systems at the Helmholtz Centre for Environmental Research – UFZ, Department of Environmental Microbiology
2010 – 2014
Research fellow at the Helmholtz Centre for Environmental Research - UFZ,
Department of Bioenergy
2007 – 2009
Research fellow in the Research Group Flow Cytometry at the Helmholtz Centre for Environmental Research – UFZ
2005
Postdoc at the SIAB – Saxon Institute for Applied Biotechnology
2002 – 2003
Postdoc in the Research Group Microbial Physiology at the Helmholtz Centre for Environmental Research – UFZ
1997 – 2001
PhD student in the Research Group Microbial Physiology, Helmholtz Centre for Environmental Research – UFZ and University of Leipzig
1992 – 1997
MSc Biochemistry, University of Leipzig
Research interests
The aim of my work is to develop and analyze anaerobic fermentation processes and their embedding in biorefinery processes. The focus is on anaerobic fermentations for the production of green chemicals such as carboxylates as well as hydrogen and biomethane. Organic agro-industrial waste and residues as well as plant material and gaseous substrates (CO, CO2, H2) are used as feedstocks. In recent years, the CAPRAFERM® process has been developed for the production of medium-chain carboxylates from complex biomass (e.g. plants, organic waste), which can be implemented in a biorefinery in cooperation with academic and industrial partners in the future. In addition, research is being carried out into how carboxylic acids can be produced and marketed in existing biogas plants alongside biogas or biomethane. The work is being conducted in close cooperation with the Biochemical Conversion and Biorefineries departments of the DBFZ.
In addition to further development of the processes, systematic material and energy flow analyses are being carried out in the anaerobic fermentation processes. These are intended to provide indications of preferred or critical metabolic flows in the system under certain conditions (e.g. substrate, reactor operation). The aim is to identify indicators for stable or unstable conditions in the process, which in turn leads to measures to enhance the respective production processes in terms of process performance and stability.
Projects (selection)
PaplGas2 (completed)
AcMp (completed)
Publications
2024 (3)
- Ozbayram, E.G., Kleinsteuber, S., Sträuber, H., Grosch Schroeder, B., Nunes da Rocha, U., Borim Corrêa, F., Harms, H., Nikolausz, M. (2024):
Three-domain microbial communities in the gut of Pachnoda marginata larvae: A comparative study revealing opposing trends in gut compartments
Environ. Microbiol. Rep. 16 (4), e13324 10.1111/1758-2229.13324 - Tüllinghoff, A., Sträuber, H., Baleeiro, F.C.F., Aurich, A., Chávez Morejón, M., Meisel, K., Cyffka, K.-F., Harnisch, F., Bühler, K., Thrän, D. (2024):
Towards net zero land biotechnology – a potential assessment for selected bioprocesses in Germany
Research Square 10.21203/rs.3.rs-5460981/v1 - Undiandeye, J., Gallegos, D., Bonatelli, M.L., Kleinsteuber, S., Bin-Hudari, M.S., Abdulkadir, N., Stinner, W., Sträuber, H. (2024):
Medium-chain carboxylates production from plant waste: kinetic study and effect of an enriched microbiome
Biotechnol. Biofuels Bioprod. 17 , art. 79 10.1186/s13068-024-02528-y
2023 (3)
- Baleeiro, F.C.F., Raab, J., Kleinsteuber, S., Neumann, A., Sträuber, H. (2023):
Mixotrophic chain elongation with syngas and lactate as electron donors
Microb. Biotechnol. 16 (2), 322 - 336 10.1111/1751-7915.14163 - Baleeiro, F.C.F., Varchmin, L., Kleinsteuber, S., Sträuber, H., Neumann, A. (2023):
Formate-induced CO tolerance and methanogenesis inhibition in fermentation of syngas and plant biomass for carboxylate production
Biotechnol. Biofuels Bioprod. 16 , art. 26 10.1186/s13068-023-02271-w - Liu, B., Sträuber, H., Centler, F., Harms, H., Nunes da Rocha, U., Kleinsteuber, S. (2023):
Functional redundancy secures resilience of chain elongation communities upon pH shifts in closed bioreactor ecosystems
Environ. Sci. Technol. 57 (46), 18350 - 18361 10.1021/acs.est.2c09573
2022 (5)
- Baleeiro, F.C.F., Kleinsteuber, S., Sträuber, H. (2022):
Recirculation of H2, CO2, and ethylene improves carbon fixation and carboxylate yields in anaerobic fermentation
ACS Sustain. Chem. Eng. 10 (13), 4073 - 4081 10.1021/acssuschemeng.1c05133 - Braune, M., Yuan, B., Sträuber, H., Mcdowall, S.C., Nitzsche, R., Gröngröft, A. (2022):
Corrigendum: A downstream processing cascade for separation of caproic and caprylic acid from maize silage-based fermentation broth
Front. Bioeng. Biotechnol. 10 , art. 1049451 10.3389/fbioe.2022.1049451 - Liu, B., Sträuber, H., Saraiva, J., Harms, H., Silva, S.G., Kasmanas, J.C., Kleinsteuber, S., Nunes da Rocha, U. (2022):
Machine learning-assisted identification of bioindicators predicts medium-chain carboxylate production performance of an anaerobic mixed culture
Microbiome 10 , art. 48 10.1186/s40168-021-01219-2 - Undiandeye, J., Gallegos, D., Sträuber, H., Nelles, M., Stinner, W. (2022):
Ensiling parameters in vertical columns and multiple kinetic models evaluation of biomethane potential of ensiled sugar beet leaves
Biofuels-UK 13 (8), 995 - 1005 10.1080/17597269.2022.2059964 - Xiong, B.-J., Kleinsteuber, S., Sträuber, H., Dusny, C., Harms, H., Wick, L.Y. (2022):
Impact of fungal hyphae on growth and dispersal of obligate anaerobic bacteria in aerated habitats
mBio 13 (3), e00769-22 10.1128/mbio.00769-22
2021 (3)
- Baleeiro, F.C.F., Ardila, M.S., Kleinsteuber, S., Sträuber, H. (2021):
Effect of oxygen contamination on propionate and caproate formation in anaerobic fermentation
Front. Bioeng. Biotechnol. 9 , art. 725443 10.3389/fbioe.2021.725443 - Baleeiro, F.C.F., Kleinsteuber, S., Sträuber, H. (2021):
Hydrogen as a co-electron donor for chain elongation with complex communities
Front. Bioeng. Biotechnol. 9 , art. 650631 10.3389/fbioe.2021.650631 - Braune, M., Yuan, B., Sträuber, H., Mcdowall, S.C., Nitzsche, R., Gröngröft, A. (2021):
A downstream processing cascade for separation of caproic and caprylic acid from maize silage-based fermentation broth
Front. Bioeng. Biotechnol. 9 , art. 725578 10.3389/fbioe.2021.725578
2020 (6)
- Formann, S., Hahn, A., Janke, L., Stinner, W., Sträuber, H., Logroño, W., Nikolausz, M. (2020):
Beyond sugar and ethanol production: Value generation opportunities through sugarcane residues
Front. Energy Res. 8 , art. 579577 10.3389/fenrg.2020.579577 - Liu, B., Kleinsteuber, S., Centler, F., Harms, H., Sträuber, H. (2020):
Competition between butyrate fermenters and chain-elongating bacteria limits the efficiency of medium-chain carboxylate production
Front. Microbiol. 11 , art. 336 10.3389/fmicb.2020.00336 - Liu, B., Popp, D., Müller, N., Sträuber, H., Harms, H., Kleinsteuber, S. (2020):
Three novel Clostridia isolates produce n-caproate and iso-butyrate from lactate: comparative genomics of chain-elongating bacteria
Microorganisms 8 (12), art. 1970 10.3390/microorganisms8121970 - Liu, B., Popp, D., Sträuber, H., Harms, H., Kleinsteuber, S. (2020):
Draft genome sequences of three Clostridia isolates involved in lactate-based chain elongation
Microbiol. Resour. Ann. 9 (32), e00679-20 10.1128/MRA.00679-20 - Logroño, W., Popp, D., Kleinsteuber, S., Sträuber, H., Harms, H., Nikolausz, M. (2020):
Microbial resource management for ex situ biomethanation of hydrogen at alkaline pH
Microorganisms 8 , art. 614 10.3390/microorganisms8040614 - Mogodiniyai Kasmaei, K., Schlosser, D., Sträuber, H., Kleinsteuber, S. (2020):
Does glucose affect the de-esterification of methyl ferulate by Lactobacillus buchneri?
MicrobiologyOpen 9 (2), e971 10.1002/mbo3.971
2019 (6)
- Baleeiro, F.C.F., Kleinsteuber, S., Neumann, A., Sträuber, H. (2019):
Syngas-aided anaerobic fermentation for medium-chain carboxylate and alcohol production: the case for microbial communities
Appl. Microbiol. Biotechnol. 103 (21-22), 8689 - 8709 10.1007/s00253-019-10086-9 - Bonk, F., Popp, D., Weinrich, S., Sträuber, H., Becker, D., Kleinsteuber, S., Harms, H., Centler, F. (2019):
Determination of microbial maintenance in acetogenesis and methanogenesis by experimental and modeling techniques
Front. Microbiol. 10 , art. 166 10.3389/fmicb.2019.00166 - Chowdhury, R., Ghosh, S., Manna, D., Das, S., Dutta, S., Kleinsteuber, S., Sträuber, H., Hassan, M.K., Kuittinen, S., Pappinen, A. (2019):
Hybridization of sugar-carboxylate-syngas platforms for the production of bio-alcohols from lignocellulosic biomass (LCB) – A state-of-the-art review and recommendations
Energy Conv. Manag. 200 , art. 112111 10.1016/j.enconman.2019.112111 - Janke, L., Weinrich, S., Leite, A.F., Sträuber, H., Nikolausz, M., Nelles, M. (2019):
Pre-treatment of filter cake for anaerobic digestion in sugarcane biorefineries: Assessment of batch versus semi-continuous experiments
Renew. Energy 143 , 1416 - 1426 10.1016/j.renene.2019.05.029 - Lambrecht, J., Cichocki, N., Schattenberg, F., Kleinsteuber, S., Harms, H., Müller, S., Sträuber, H. (2019):
Key sub‑community dynamics of medium‑chain carboxylate production
Microb. Cell. Fact. 18 , art. 92 10.1186/s12934-019-1143-8 - Liebetrau, J., Sträuber, H., Kretzschmar, J., Denysenko, V., Nelles, M. (2019):
Anaerobic digestion
In: Wagemann, K., Tippkötter, N. (eds.)
Biorefineries
Adv. Biochem. Eng. Biotechnol. 166
Springer Nature, p. 281 - 299 10.1007/10_2016_67
2018 (6)
- Bonk, F., Popp, D., Weinrich, S., Sträuber, H., Kleinsteuber, S., Harms, H., Centler, F. (2018):
Ammonia inhibition of anaerobic volatile fatty acid degrading microbial communities
Front. Microbiol. 9 , art. 2921 10.3389/fmicb.2018.02921 - Bonk, F., Popp, D., Weinrich, S., Sträuber, H., Kleinsteuber, S., Harms, H., Centler, F. (2018):
Intermittent fasting for microbes: how discontinuous feeding increases functional stability in anaerobic digestion
Biotechnol. Biofuels 11 , art. 274 10.1186/s13068-018-1279-5 - Janke, L., Weinrich, S., Leite, A.F., Sträuber, H., Radetski, C.M., Nikolausz, M., Nelles, M., Stinner, W. (2018):
Year-round biogas production in sugarcane biorefineries: Process stability, optimization and performance of a two-stage reactor system
Energy Conv. Manag. 168 , 188 - 199 10.1016/j.enconman.2018.04.101 - Liebetrau, J., Weinrich, S., Sträuber, H., Kretzschmar, J. (2018):
Anaerobic fermentation of organic material: biological processes and their control parameters
In: Meyers, R.A. (ed.)
Encyclopedia of sustainability science and technology
Springer, New York, p. 1 - 30 10.1007/978-1-4939-2493-6_962-1 - Sträuber, H. (2018):
Mittelkettige Fettsäuren als Teilstrom des Biogasprozesses
DBFZ-Jahrestagung 2018: Energie & Stoffe aus Biomasse: Konkurrenten oder Partner? 19./20. September 2018
DBFZ Deutsches Biomasseforschungszentrum gemeinnützige GmbH, Leipzig, 156 - Sträuber, H., Bühligen, F., Kleinsteuber, S., Dittrich‐Zechendorf, M. (2018):
Carboxylic acid production from ensiled crops in anaerobic solid‐state fermentation ‐ trace elements as pH controlling agents support microbial chain elongation with lactic acid
Eng. Life Sci. 18 (7), 447 - 458 10.1002/elsc.201700186
2017 (4)
- Braune, M., Daniel-Gromke, J., Sträuber, H. (2017):
Von der Biogasanlage zur modernen Bioraffinerie
11. Rostocker Bioenergieforum "Beitrag der Bioenergie zur Senkung der Treibhausgasemission" am 22. und 23. Juni 2017 an der Universität Rostock : Tagungsband
Schriftenreihe Umweltingenieurwesen 68
Universität Rostock, Agrar- und Umweltwissenschaftliche Fakultät, Rostock, S. 105 - 113 - Popp, D., Plugge, C.M., Kleinsteuber, S., Harms, H., Sträuber, H. (2017):
Inhibitory effect of coumarin on syntrophic fatty acid-oxidizing and methanogenic cultures and biogas reactor microbiomes
Appl. Environ. Microb. 83 (13), e00438-17 10.1128/AEM.00438-17 - Popp, D., von Gillhaussen, P., Weidlich, E.W.A., Sträuber, H., Harms, H., Temperton, V.M. (2017):
Methane yield of biomass from extensive grassland is affected by compositional changes induced by order of arrival
GCB Bioenergy 9 (10), 1555 - 1562 10.1111/gcbb.12441 - Urban, C., Xu, J., Sträuber, H., dos Santos Dantas, T.R., Mühlenberg, J., Härtig, C., Angenent, L.T., Harnisch, F. (2017):
Production of drop-in fuels from biomass at high selectivity by combined microbial and electrochemical conversion
Energy Environ. Sci. 10 (10), 2231 - 2244 10.1039/c7ee01303e
2016 (7)
- Dieckmann, C., Edelmann, W., Kaltschmitt, M., Liebetrau, J., Oldenburg, S., Ritzkowski, M., Scholwin, F., Sträuber, H., Weinrich, S. (2016):
Biogaserzeugung und –nutzung
In: Kaltschmitt, M., Hartmann, H., Hofbauer, H. (Hrsg.)
Energie aus Biomasse : Grundlagen, Techniken und Verfahren. 3., aktualisierte Aufl.
Springer, Berlin, Heidelberg, S. 1609 - 1635 10.1007/978-3-662-47438-9_19 - Hofmann, J., Peltri, G., Sträuber, H., Müller, L., Schumacher, B., Müller, U., Liebetrau, J. (2016):
Statistical interpretation of semi-continuous anaerobic digestion experiments on the laboratory scale
Chem. Eng. Technol. 39 (4), 643 - 651 10.1002/ceat.201500473 - Janke, A., Leite, A., Batista, K., Weinrich, S., Sträuber, H., Nikolausz, M., Nelles, M., Stinner, W. (2016):
Optimization of hydrolysis and volatile fatty acids production from sugarcane filter cake: Effects of urea supplementation and sodium hydroxide pretreatment
Bioresour. Technol. 199 , 235 - 244 10.1016/j.biortech.2015.07.117 - Popp, D., Harms, H., Sträuber, H. (2016):
The alkaloid gramine in the anaerobic digestion process—inhibition and adaptation of the methanogenic community
Appl. Microbiol. Biotechnol. 100 (16), 7311 - 7322 10.1007/s00253-016-7571-z - Pröter, J., Lorenz, H., Sträuber, H. (2016):
Herausforderungen in der mikrobiellen biochemischen Konversion – welche Innovationen brauchen wir? Challenges for the microbial biochemical conversion – what kind of innovations do we need?
Mikroorganismen und Wirbellose – entscheidende Dienstleister für Landwirtschaft und Ernährung. Tagungsband eines Symposiums am 26./27. November 2015 in Berlin
Agrobiodiversität : Schriftenreihe des Informations- und Koordinationszentrums für Biologische Vielfalt 39
Bundesanstalt für Landwirtschaft und Ernährung , Bonn, S. 104 - 119 - Sträuber, H., Lucas, R., Kleinsteuber, S. (2016):
Metabolic and microbial community dynamics during the anaerobic digestion of maize silage in a two-phase process
Appl. Microbiol. Biotechnol. 100 (1), 479 - 491 10.1007/s00253-015-6996-0 - Wintsche, B., Glaser, K., Sträuber, H., Centler, F., Liebetrau, J., Harms, H., Kleinsteuber, S. (2016):
Trace elements induce predominance among methanogenic activity in anaerobic digestion
Front. Microbiol. 7 , art. 2034 10.3389/fmicb.2016.02034
2015 (2)
- Popp, D., Schrader, S., Kleinsteuber, S., Harms, H., Sträuber, H. (2015):
Biogas production from coumarin-rich plants—inhibition by coumarin and recovery by adaptation of the bacterial community
FEMS Microbiol. Ecol. 91 (9), fiv103 10.1093/femsec/fiv103 - Sträuber, H., Bühligen, F., Kleinsteuber, S., Nikolausz, M., Porsch, K. (2015):
Improved anaerobic fermentation of wheat straw by alkaline pre-treatment and addition of alkali-tolerant microorganisms
Bioengineering-Basel 2 (2), 66 - 93 10.3390/bioengineering2020066
2013 (1)
- Nikolausz, M., Walter, R.F.H., Sträuber, H., Liebetrau, J., Schmidt, T., Kleinsteuber, S., Bratfisch, F., Günther, U., Richnow, H.H. (2013):
Evaluation of stable isotope fingerprinting techniques for the assessment of the predominant methanogenic pathways in anaerobic digesters
Appl. Microbiol. Biotechnol. 97 (5), 2251 - 2262 10.1007/s00253-012-4657-0
2012 (2)
- Maskow, T., Paufler, S., Sträuber, H., Kleinsteuber, S. (2012):
The potential of calorespirometry for control and analysis of biogas processes
1st UFZ Energy Days 2012: 4-5 April 2012. Book of abstracts
UFZ Report 6/2012
Helmholtz Centre for Environmental Research - UFZ, Leipzig, p. 8 - Sträuber, H., Schröder, M., Kleinsteuber, S. (2012):
Metabolic and microbial community dynamics during the hydrolytic and acidogenic fermentation in a leach-bed process
Energy Sustain. Soc. 2 , art. 13 10.1186/2192-0567-2-13
2010 (2)
- Sträuber, H., Hübschmann, T., Jehmlich, N., Schmidt, F., von Bergen, M., Harms, H., Müller, S. (2010):
NBDT (3-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-3-toluene) - A novel fluorescent dye for studying mechanisms of toluene uptake into vital bacteria
Cytom. Part A 77A (2), 113 - 120 10.1002/cyto.a.20811 - Sträuber, H., Müller, S. (2010):
Viability states of bacteria - specific mechanisms of selected probes
Cytom. Part A 77A (7), 623 - 634 10.1002/cyto.a.20920
2009 (2)
- Heine, F., Stahl, F., Sträuber, H., Wiacek, C., Benndorf, D., Repenning, C., Schmidt, F., Scheper, T., von Bergen, M., Harms, H., Müller, S. (2009):
Prediction of flocculation ability of brewing yeast inoculates by flow cytometry, proteome analysis, and mRNA profiling
Cytom. Part A 75A (2), 140 - 147 10.1002/cyto.a.20661 - Sträuber, H., Hübschmann, T., Harms, H., Müller, S. (2009):
Screening of potential toluene degraders in communities using a novel fluorescent toluene analogue and flow cytometry
Cytom. Part A 75A (8), 717 10.1002/cyto.a.20752
2007 (2)
- Heine, F., Wiacek, C., Benndorf, D., Sträuber, H., Stahl, F., von Bergen, M., Harms, H., Müller, S. (2007):
Evidence of flocculation in brewing yeast strains by flow cytometry, proteome and mRNA profiling
Cytom. Part A 71A (7), 513 10.1002/cyto.a.20421 - Heine, F., Wiacek, C., Benndorf, D., Sträuber, H., Stahl, F., von Bergen, M., Harms, H., Müller, S. (2007):
Evidence of flocculation in brewing yeast strains by flow cytometry, proteome and mRNA profiling
Cytom. Part A 71A (9), 761 10.1002/cyto.a.20451
2003 (1)
- Sträuber, H., Müller, R.H., Babel, W. (2003):
Evidence of cytochrome P450-catalyzed cleavage of the ether bond of phenoxybutyrate herbicides in Rhodococcus erythropolis K2-3
Biodegradation 14 (1), 41 - 50 10.1023/A:1023550209155
2002 (3)
- Müller, S., Sträuber, H., Lösche, A., Babel, W. (2002):
Population analysis of a binary bacterial culture by multi-parametric flow cytometry
J. Biotechnol. 97 (2), 163 - 176 10.1016/S0168-1656(02)00063-9 - Sträuber, H. (2002):
Proportionskonstante Vermehrung einer binären Mischkultur beim produktiven Abbau von 4-(2,4-Dichlorphenoxy)buttersäure
Dissertation, Universität Leipzig
Cuvillier, Göttingen, 110 S. - Sträuber, H., Müller, S., Lösche, A., Babel, W. (2002):
Degradation of a xenobiotic using a binary culture and multiparametric flow cytometry
Proceedings 15th Heidelberg Cytometry Symposium, Annual Conference of the German Society of Cytometry (DGfZ), Heidelberg, 17.-19.10.2002
2001 (2)
- Lösche, A., Müller, S., Mertingk, H., Babel, W. (2001):
Biodegradation of chlorinated phenols - a flow cytometric analysis
International symposium on biotechnological remediation of water pollution by aicd inorganic and aromatic chlorinated compounds, Leipzig, 21.-23.3.2001 - Lösche, A., Sträuber, H., Müller, S. (2001):
Dynamics of a mixed bacterial population during degradation of xenobiotics
14. Heidelberger Zytometriesymposium, Heidelberg, 21.-23.10.2001
2000 (2)
- Müller, S., Lösche, A., Mertingk, H., Babel, W. (2000):
Flow cytometric monitoring of Rhodococcus erythropoplis and Ochrobactrum antropi in a mixed culture
Cytometry. ISAC XX International Congress, Montpellier, France, 20.-25.5.2000
Suppl. 10 - Müller, S., Lösche, A., Mertingk, H., Beisker, W., Babel, W. (2000):
Flow cytometric monitoring of Rhodococcus erythropolis and Ochrobactrum anthropi in a mixed culture
Acta Biotechnol. 20 (3-4), 219 - 233 10.1002/abio.370200306
1999 (1)
- Mertingk, H., Müller, R.H., Babel, W. (1999):
Degradation of 2,4-dichlorophenoxybutyrate by a bacterial consortium
Jahrestagung der VAAM, 7.-10.3.1999, Göttingen
Biospektrum Sonderausgabe 1999
Spektrum Akademischer Verlag, Heidelberg, 89 - 89
1998 (1)
- Mertingk, H., Müller, R.H., Babel, W. (1998):
Etherolytic cleavage of 4-(2,4-dichlorophenoxy)butyric acid and 4-(4-chloro-2-methylphenoxy)butyric acid by species of Rhodococcus and Aureobacterium isolated from an alkaline environment
J. Basic Microbiol. 38 (4), 257 - 267 10.1002/(SICI)1521-4028(199809)38:4<257::AID-JOBM257>3.0.CO;2-0