Research for the Environment

Dr. Werner Brack

Dr. Werner Brack
Head of Department

Department Effect-Directed Analysis
Helmholtz Centre for
Environmental Research - UFZ
Permoserstraße 15
04318 Leipzig, Germany

phone +49 341 235 1531

Dr. Werner Brack

Dr. Werner Brack

Research interests

  • Effect-directed analysis (EDA) of complex environmental contamination including
    • development and application of integrated procedures for the isolation and identification of toxicants in complex environmental mixtures such as sediments, soils, groundwater and surface waters,
    • liquid and gas chromatographic fractionation methods,
    • chemical analytical and computer tools for structure elucidation and toxicant identification,
    • effect-directed assessment of environmental transformation processes (e.g. photochemical processes).
  • Risk assessment of contaminants in aquatic ecosystems.
  • Assessment of contaminated sediments and bioavailability of sediment-associated contaminants.

Curriculum Vitae

since 2005

Head of the Department of Effect-Directed Analysis at the Helmholtz Centre for Environmental Research - UFZ
Co-ordinator of the EU-funded Integrated Project MODELKEY "Models for assessing and forecasting the impact of environmental key pollutants on freshwater and marine ecosystems and biodiversity”

1997 - 2005

Scientist at the Department of Chemical Ecotoxicology at the Helmholtz Centre for Environmental Research - UFZ

1992 - 1996

PhD at the University of Bayreuth, Chair of Ecological Chemistry (Prof Hutzinger), later Chair of Environmental Chemistry (Prof Frank). Topic: Ecotoxicological assessment of volatile components of landfill leachates

1985 - 1992

Study of geoecology at the University of Bayreuth with focus on Environmental Chemistry

Publications

Index:

2014 (10)
2013 (9)
2012 (11)
2011 (18)
2010 (12)
2009 (14)
2008 (8)
2007 (5)
2006 (5)
2005 (9)
2004 (2)
2003 (7)
2002 (4)
2000 (6)
1999 (3)
1998 (6)
1997 (1)

You could use our publication index for further requests.

2014 (10)

  • Bahlmann, A. A., Brack, W., Schneider, R.J., Krauss, M., (2014):
    Carbamazepine and its metabolites in wastewater: Analytical pitfalls and occurrence in Germany and Portugal
    Water Res. 57 , 104 - 114
    full text (url)
  • Brils, J., Barcelo, D., Blum, W., Brack, W., Harris, B., Müller-Grabherr, D., Négrel, P., Ragnarsdottir, V., Salomons, W., Slob, A., Track, T., Vegter, J., Vermaat, J.E., (2014):
    Introduction: The need for risk-informed river basin management
    In: Brils, J., Brack, W., Müller-Grabherr, D., Négrel, P., Vermaat, J.E., (eds.)
    Risk-informed management of European river basins
    Handbook of Environmental Chemistry Series 29
    Springer, Berlin, Heidelberg, p. 1 - 20
  • Brils, J., Brack, W., Müller-Grabherr, D., Négrel, P., Vermaat, J.E., (eds., 2014):
    Risk-informed management of European river basins
    Handbook of Environmental Chemistry Series 29
    Springer, Berlin, Heidelberg, 395 pp.
  • Brils, J., Harris, B., Barceló, D., Blum, W., Brack, W., Müller-Grabherr, D., Négrel, P., Ragnarsdottir, V., Salomons, W., Slob, A., Track, T., Vegter, J., Vermaat, J.E., (2014):
    Synthesis and recommendations towards risk-informed river basin management
    In: Brils, J., Brack, W., Müller-Grabherr, D., Négrel, P., Vermaat, J.E., (eds.)
    Risk-informed management of European river basins
    Handbook of Environmental Chemistry Series 29
    Springer, Berlin, Heidelberg, p. 367 - 390
  • Brinkmann, M., Maletz, S., Krauss, M., Bluhm, K., Schiwy, S., Kuckelkorn, J., Tiehm, A., Brack, W., Hollert, H., (2014):
    Heterocyclic aromatic hydrocarbons show estrogenic activity upon metabolization in a recombinant transactivation assay
    Environ. Sci. Technol. 48 (10), 5892 - 5901
    full text (url)
  • Fetter, E., Krauss, M., Brion, F., Kah, O., Scholz, S., Brack, W., (2014):
    Effect-directed analysis for estrogenic compounds in a fluvial sediment sample using transgenic cyp19a1b-GFP zebrafish embryos
    Aquat. Toxicol. 154 , 221 - 229
    full text (url)
  • Malaj, E., von der Ohe, P.C., Grote, M., Kühne, R., Mondy, C.P., Usseglio-Polatera, P., Brack, W., Schäfer, R.B., (2014):
    Organic chemicals jeopardize the health of freshwater ecosystems on the continental scale
    Proc. Natl. Acad. Sci. U.S.A. 111 (26), 9549 - 9554
    full text (url)
  • Ulrich, N., Mühlenberg, J., Schüürmann, G., Brack, W., (2014):
    Linear solvation energy relationships as classifier in non-target analysis – an approach for isocratic liquid chromatography
    J. Chromatogr. A 1324 , 96 - 103
    full text (url)
  • von der Ohe, P.C., Apitz, S.E., Arbaciauskas, K., Beketov, M.A., Borchardt, D., de Zwart, D., Goedkoop, W., Hein, M., Hellsten, S., Hering, D., Kefford, B. J., Panov, V.E., Schäfer, R.B., Segner, H., van Gils, J., Vegter, J.J., Wetzel, M.A., Brack, W., (2014):
    Status and causal pathway assessments supporting river basin management
    In: Brils, J., Brack, W., Müller-Grabherr, D., Négrel, P., Vermaat, J.E., (eds.)
    Risk-informed management of European river basins
    Handbook of Environmental Chemistry Series 29
    Springer, Berlin, Heidelberg, p. 53 - 149
  • von der Ohe, P.C., de Zwart, D., Semenzin, E., Apitz, S.E., Gottardo, S., Harris, B., Hein, M., Marcomini, A., Posthuma, L., Schäfer, R.B., Segner, H., Brack, W., (2014):
    Monitoring programmes, multiple stress analysis and decision support for river basin management
    In: Brils, J., Brack, W., Müller-Grabherr, D., Négrel, P., Vermaat, J.E., (eds.)
    Risk-informed management of European river basins
    Handbook of Environmental Chemistry Series 29
    Springer, Berlin, Heidelberg, p. 151 - 182
to index

2013 (9)

  • Brack, W., (2013):
    Effect-directed analysis in ecotoxicology
    In: Férard, J.-F., Blaise, C., (eds.)
    Encyclopedia of Aquatic Ecotoxicology
    Springer, Dordrecht, p. 387 - 394
    full text (url)
  • Brack, W., Govender, S., Schulze, T., Krauss, M., Hu, M., Muz, M., Hollender, J., Schirmer, K., Schollee, J., Hidasi, A., Slobodnik, J., Rabova, Z., Ait-Aissa, S., Sonavane, M., Carere, M., Lamoree, M., Leonards, P., Tufi, S., Ouyang, X., Schriks, M., Thomas, K., de Almeida, A.C., Froment, J., Hammers-Wirtz, M., Ahel, M., Koprivica, S., Hollert, H., Seiler, T.-B., Di Paolo, C., Tindall, A., Spirhanzlova, P., (2013):
    EDA-EMERGE: an FP7 initial training network to equip the next generation of young scientists with the skills to address the complexity of environmental contamination with emerging pollutants
    Environmental Sciences Europe 25 , art. 18
    full text (pdf)
  • Burgess, R.M., Ho, K.T., Brack, W., Lamoree, M., (2013):
    Effects-directed analysis (EDA) and toxicity identification evaluation (TIE): Complementary but different approaches for diagnosing causes of environmental toxicity
    Environ. Toxicol. Chem. 32 (9), 1935 - 1945
    full text (url)
  • Gallampois, C.M.J., Schymanski, E.L., Bataineh, M., Buchinger, S., Krauss, M., Reifferscheid, G., Brack, W., (2013):
    Integrated biological–chemical approach for the isolation and selection of polyaromatic mutagens in surface waters
    Anal. Bioanal. Chem. 405 (28), 9101 - 9112
    full text (url)
  • Grummt, T., Kuckelkorn, J., Bahlmann, A. A., Baumstark-Khan, C., Brack, W., Braunbeck, T., Feles, S., Gartiser, S., Glatt, H., Heinze, R., Hellweg, C.E., Hollert, H., Junek, R., Knauer, M., Kneib-Kissinger, B., Kramer, M., Krauss, M., Küster, E., Maletz, S., Meinl, W., Noman, A., Prantl, E.-M., Rabbow, E., Redelstein, R., Rettberg, P., Schadenboeck, W., Schmidt, C., Schulze, T., Seiler, T.-B., Spitta, L., Stengel, D., Waldmann, P., Eckhardt, A., (2013):
    Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany. Tox-Box: die Tropfen des Lebens bewahren - gesundheitsbasierte Risikobewertung für Trinkwasser in Deutschland
    Environmental Sciences Europe 25 , art. 27
    full text (pdf)
  • Hug, C., Ulrich, N., Schulze, T., Brack, W., Krauss, M., (2013):
    Identification of novel micropollutants in wastewater by a combination of suspect and nontarget screening
    Environ. Pollut. 184 , 25 - 32
    full text (url)
  • Kühne, R., Ebert, R.-U., von der Ohe, P.C., Ulrich, N., Brack, W., Schüürmann, G., (2013):
    Read-across prediction of the acute toxicity of organic compounds toward the water flea Daphnia magna
    Mol. Inf. 32 (1), 108 - 120
    full text (url)
  • Nováková, K., Kohoutek, J., Adamovský, O., Brack, W., Krauss, M., Bláha, L., (2013):
    Novel metabolites in cyanobacterium Cylindrospermopsis raciborskii with potencies to inhibit gap junctional intercellular communication
    J. Hazard. Mater. 262 , 571 - 579
    full text (url)
  • Ulrich, N., Schüürmann, G., Brack, W., (2013):
    Prediction of gas chromatographic retention indices as classifier in non-target analysis of environmental samples
    J. Chromatogr. A 1285 , 139 - 147
    full text (url)
to index

2012 (11)

  • Brack, W., (2012):
    Emerging substances of toxicological concern in a world full of chemicals - the NORMAN way to find the needles in the haystack
    Norman Bulletin 2012/3
    NORMAN Network, p. 1 - 2
  • de Deckere, E., Brack, W., Van Ballaer, B., von der Ohe, P.C., (2012):
    Identifying key stressors in Danube, Elbe, Llobregat and Scheldt based on regular monitoring data
    River Systems 20 (1-2), 87 - 99
    full text (url)
  • Higley, E., Grund, S., Jones, P.D., Schulze, T., Seiler, T.-B., Lübcke-von Varel, U., Brack, W., Wölz, J., Zielke, H., Giesy, J.P., Hollert, H., Hecker, M., (2012):
    Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect-directed analysis
    Environ. Toxicol. Chem. 31 (5), 1053 - 1062
    full text (url)
  • Lübcke-von Varel, U., Bataineh, M., Löffler, I., Schulze, T., Flückiger-Isler, S., Neca, J., Machala, M., Brack, W., Lohrmann, S., (2012):
    Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments
    Environ. Int. 44 (September 2012), 31 - 39
    full text (url)
  • Malaj, E., Grote, M., Schäfer, R.B., Brack, W., von der Ohe, P.C., (2012):
    Physiological sensitivity of freshwater macroinvertebrates to heavy metals
    Environ. Toxicol. Chem. 31 (8), 1754 - 1764
    full text (url)
  • Schulze, T., Brack, W., Walz, K.-H., (2012):
    Verfahren und Vorrichtung zur Festphasenextraktion aus einer Flüssigkeit
    Europäisches Patentamt, München
  • Schulze, T., Magerl, R., Streck, G., Brack, W., (2012):
    Use of factorial design for the multivariate optimization of polypropylene membranes for the cleanup of environmental samples using the accelerated membrane-assisted cleanup approach
    J. Chromatogr. A 1225 , 26 - 36
    full text (url)
  • Schulze, T., Schymanski, E., Stravs, M., Neumann, S., Krauss, M., Singer, H., Hug, C., Gallampois, C., Hollender, J., Slobodnik, J., Brack, W., (2012):
    NORMAN MassBank: Towards a community-driven, open-access accurate mass spectral database for the identification of emerging pollutants
    Norman Bulletin 2012/3
    NORMAN Network, p. 9 - 11
  • Schymanski, E.L., Gallampois, C.M.J., Krauss, M., Meringer, M., Neumann, S., Schulze, T., Wolf, S., Brack, W., (2012):
    Consensus structure elucidation combining GC/EI-MS, structure generation and calculated properties
    Anal. Chem. 84 (7), 3287 - 3295
    full text (url)
  • Ulrich, N., Mühlenberg, J., Retzbach, H., Schüürmann, G., Brack, W., (2012):
    Linear solvation energy relationships as classifiers in non-target analysis – a gas chromatographic approach
    J. Chromatogr. A 1264 , 95 - 103
    full text (url)
  • von der Ohe, P.C., Schmitt-Jansen, M., Slobodnik, J., Brack, W., (2012):
    Triclosan – the forgotten priority substance?
    Environ. Sci. Pollut. Res. 19 (2), 585 - 591
    full text (url)
to index

2011 (18)

  • Bougeard, C., Gallampois, C., Brack, W., (2011):
    Passive dosing: an approach to control mutagen exposure in the Ames fluctuation test
    Chemosphere 83 (4), 409 - 414
    full text (url)
  • Brack, W., (ed., 2011):
    Effect-directed analysis of complex environmental contamination
    Handbook of Environmental Chemistry Series 15
    Springer, Berlin, Heidelberg, 345 pp.
    full text (url)
  • Brack, W., Burgess, R.M., (2011):
    Considerations for incorporating bioavailability in effect-directed analysis and toxicity identification evaluation
    In: Brack, W., (ed.)
    Effect-directed analysis of complex environmental contamination
    Handbook of Environmental Chemistry Series 15
    Springer, Berlin, Heidelberg, p. 41 - 68
    full text (url)
  • Brack, W., (2011):
    Impact assessment of environmental key pollutants on aquatic ecosystems
    In: Quevauviller, P., Borchers, U., Thompson, C., Simonart, T., (eds.)
    The water framework directive: action programmes and adaptation to climate change
    Royal Society of Chemistry (RSC), Cambridge, p. 189 - 202
  • Brack, W., Ulrich, N., Bataineh, M., (2011):
    Separation techniques in effect-directed analysis
    In: Brack, W., (ed.)
    Effect-directed analysis of complex environmental contamination
    Handbook of Environmental Chemistry Series 15
    Springer, Berlin, Heidelberg, p. 83 - 118
    full text (url)
  • Burgess, R.M., Ho, K.T., Biales, A.D., Brack, W., (2011):
    Recent developments in whole sediment toxicity identification evaluations: innovations in manipulations and endpoints
    In: Brack, W., (ed.)
    Effect-directed analysis of complex environmental contamination
    Handbook of Environmental Chemistry Series 15
    Springer, Berlin, Heidelberg, p. 19 - 40
    full text (url)
  • dos Anjos, N.A., Schulze, T., Brack, W., Val, A.L., Schirmer, K., Scholz, S., (2011):
    Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems
    Aquat. Toxicol. 103 (1-2), 46 - 52
    full text (url)
  • Grung, M., Naes, K., Fogelberg, O., Nilsen, A.J., Brack, W., Lübcke-von Varel, U., Thomas, K.V., (2011):
    Effects-directed analysis of sediments from polluted marine sites in Norway
    J. Toxicol. Env. Health Part A 74 (7 & 9), 439 - 454
    full text (url)
  • Lübcke-von Varel, U., Machala, M., Ciganek, M., Neca, J., Pencikova, K., Palkova, L., Vondracek, J., Löffler, I., Streck, G., Reifferscheid, G., Flückiger-Isler, S., Weiss, J.M., Lamoree, M., Brack, W., (2011):
    Polar compounds dominate in vitro effects of sediment extracts
    Environ. Sci. Technol. 45 (6), 2384 - 2390
    full text (url)
  • Schmitt, C., Streck, G., Lamoree, M., Leonards, P., Brack, W., de Deckere, E., (2011):
    Effect directed analysis of riverine sediments - the usefulness of Potamopyrgus antipodarum for in vivo effect confirmation of endocrine disruption
    Aquat. Toxicol. 101 (1), 237 - 243
    full text (url)
  • Schymanski, E.L., Meringer, M., Brack, W., (2011):
    Automated strategies to identify compounds on the basis of GC/EI-MS and calculated properties
    Anal. Chem. 83 (3), 903 - 912
    full text (url)
  • Schymanski, E., Schulze, T., Hermanns, J., Brack, W., (2011):
    Computer tools for structure elucidation in effect-directed analysis
    In: Brack, W., (ed.)
    Effect-directed analysis of complex environmental contamination
    Handbook of Environmental Chemistry Series 15
    Springer, Berlin, Heidelberg, p. 167 - 198
    full text (url)
  • Tuikka, A., Schmitt, C., Höss, S., Bandow, N., von der Ohe, P.C., de Zwart, D., de Deckere, E., Streck, G., Mothes, S., van Hattum, B., Kocan, A., Brix, R., Brack, W., Barceló, D., Sormunen, A.J., Kukkonen, J.V.K., (2011):
    Toxicity assessment of sediments from three European river basins using a sediment contact test battery
    Ecotox. Environ. Safe. 74 (1), 123 - 131
    full text (url)
  • Ulrich, N., Schüürmann, G., Brack, W., (2011):
    Linear solvation energy relationships as classifiers in non-target analysis - a capillary liquid chromatography approach
    J. Chromatogr. A 1218 (45), 8192 - 8196
    full text (url)
  • von der Ohe, P.C., Dulio, V., Slobodnik, J., de Deckere, E., Kühne, R., Ebert, R.U., Ginebreda, A., De Cooman, W., Schüürmann, G., Brack, W., (2011):
    A new risk assessment approach for the prioritization of 500 classical and emerging organic microcontaminants as potential river basin specific pollutants under the European Water Framework Directive
    Sci. Total Environ. 409 (11), 2064 - 2077
    full text (url)
  • Wölz, J., Grosshans, K., Streck, G., Schulze, T., Rastall, A., Erdinger, L., Brack, W., Fleig, M., Kühlers, D., Braunbeck, T., Hollert, H., (2011):
    Estrogen receptor mediated activity in bankside groundwater, with flood suspended particulate matter and floodplain soil – an approach combining tracer substance, bioassay and target analysis
    Chemosphere 85 (5), 717 - 723
    full text (url)
  • Wölz, J., Schulze, T., Lübcke-von Varel, U., Fleig, M., Reifferscheid, G., Brack, W., Kühlers, D., Braunbeck, T., Hollert, H., (2011):
    Investigation on soil contamination at recently inundated and non-inundated sites
    J. Soils Sediments 11 (1), 82 - 92
    full text (url)
  • Zielke, H., Seiler, T.-B., Niebergall, S., Leist, E., Brinkmann, M., Spira, D., Streck, G., Brack, W., Feiler, U., Braunbeck, T., Hollert, H., (2011):
    The impact of extraction methodologies on the toxicity of sediments in the zebrafish (Danio rerio) embryo test
    J. Soils Sediments 11 (2), 352 - 363
    full text (url)
to index

2010 (12)

  • Altenburger, R., Berns, A.E., Bittens, M., Brack, W., Burauel, P., Centler, F., Daus, B., Goss, K.-U., Harms, H., Kopinke, F.-D., Kühnel, D., Liess, M., Mackenzie, K., Miltner, A., Thullner, M., Wennrich, R., Wick, L.Y., (2010):
    Chemicals in the environment (CITE). Report of the First Annual Conference of the Helmholtz research topic CITE
    UWSF 22 (4), 502 - 506
    full text (url)
  • Bandow, N., Altenburger, R., Brack, W., (2010):
    Application of nd-SPME to determine freely dissolved concentrations in the presence of green algae and algae-water partition coefficients
    Chemosphere 79 (11), 1070 - 1076
    full text (url)
  • Bataineh, M., Lübcke-von Varel, U., Hayen, H., Brack, W., (2010):
    HPLC/APCI-FTICR-MS as a tool for identification of partial polar mutagenic compounds in effect-directed analysis
    J. Am. Soc. Mass Spectrom. 21 (6), 1016 - 1027
    full text (url)
  • Brack, W., Bakker, J.F., de Deckere, E., de Zwart, D., Hamers, T., Hein, M., Leonards, P., Lübcke-von Varel, U., Schmitt, C., Schmitt-Jansen, M., von der Ohe, P.C., (2010):
    MODELKEY. European rivers under toxic stress
    In: Settele, J., Penev, L., Georgiev, T., Grabaum, R., Grobelnik, V., Hammen, V., Klotz, S., Kotarac, M., Kühn, I., (eds.)
    Atlas of biodiversity risk
    Pensoft, Sofia, p. 116 - 118
    full text (url)
  • Brills, J., Quevauviller, P., Slob, A., Blind, M., Davy, T., Carere, M., Amorsi, N., Brack, W., Borchers, U., Thompson, C., Villessot, D., (2010):
    The European Water Framework Directive beyond 2010: let actions speak louder than words
    J. Environ. Monit. 12 (12), 2204 - 2206
    full text (url)
  • Hein, M., Rotter, S., Schmitt-Jansen, M., von der Ohe, P.C., Brack, W., de Deckere, E., Schmitt, C., de Zwart, D., Posthuma, L., Foekema, E.M., Muñoz, I., Sabater, S., Segner, H., Semenzin, E., Markomini, A., van Gils, J., van Hattum, B., van Vliet, L.A., (2010):
    MODELKEY. Key findings and recommendations for reaching the EU Water Framework Directive's quality objectives
    UWSF 22 (3), 217 - 228
    full text (url)
  • Meinert, C., Brack, W., (2010):
    Optimisation of trapping parameters in preparative capillary gas chromatography for the application in effect-directed analysis
    Chemosphere 78 (3), 416 - 422
    full text (url)
  • Meinert, C., Schymanski, E., Küster, E., Kühne, R., Schüürmann, G., Brack, W., (2010):
    Application of preparative capillary gas chromatography (pcGC), automated structure generation and mutagenicity prediction to improve effect-directed analysis of genotoxicants in a contaminated groundwater
    Environ. Sci. Pollut. Res. 17 (4), 885 - 897
    full text (url)
  • Schmitt, C., Balaam, J., Leonards, P., Brix, R., Streck, G., Tuikka, A., Bervoets, L., Brack, W., van Hattum, B., Meire, P., de Deckere, E., (2010):
    Characterizing field sediments from three European river basins with special emphasis on endocrine effects - A recommendation for Potamopyrgus antipodarum as test organism
    Chemosphere 80 (1), 13 - 19
    full text (url)
  • Schulze, T., Weiss, S., Schymanski, E., von der Ohe, P.C., Schmitt-Jansen, M., Altenburger, R., Streck, G., Brack, W., (2010):
    Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis
    Environ. Pollut. 158 (5), 1461 - 1466
    full text (url)
  • Wölz, J., Brack, W., Moehlenkamp, C., Claus, E., Braunbeck, T., Hollert, H., (2010):
    Effect-directed analysis of Ah receptor-mediated activities caused by PAHs in suspended particulate matter sampled in flood events
    Sci. Total Environ. 408 (16), 3327 - 3333
    full text (url)
  • Wölz, J., Fleig, M., Schulze, T., Maletz, S., Lübcke-von Varel, U., Reifferscheid, G., Kühlers, D., Braunbeck, T., Brack, W., Hollert, H., (2010):
    Impact of contaminants bound to suspended particulate matter in the context of flood events
    J. Soils Sediments 10 (6), 1174 - 1185
    full text (url)
to index

2009 (14)

  • Bandow, N., Altenburger, R., Lübcke-von Varel, U., Paschke, A., Streck, G., Brack, W., (2009):
    Partitioning-based dosing: an approach to include bioavailability in the effect-directed analysis of contaminated sediment samples
    Environ. Sci. Technol. 43 (10), 3891 - 3896
    full text (url)
  • Bandow, N., Altenburger, R., Streck, G., Brack, W., (2009):
    Effect-directed analysis of contaminated sediments with partition-based dosing using green algae cell multiplication inhibition
    Environ. Sci. Technol. 43 (19), 7343 - 7349
    full text (url)
  • Brack, W., Apitz, S.E., Borchardt, D., Brils, J., Cardoso, A.C., Foekema, E.M., van Gils, J., Jansen, S., Harris, B., Hein, M., Heise, S., Hellsten, S., de Maagd, P.G.-J., Müller, D., Panov, V.E., Posthuma, L., Quevauviller, P., Verdonschot, P.F.M., von der Ohe, P.C., (2009):
    Towards a holistic and risk-based management of European river basins
    Integrated Environmental Assessment and Management 5 (1), 5 - 10
    full text (url)
  • Brack, W., Bandow, N., Schwab, K., Schulze, T., Streck, G., (2009):
    Bioavailability in effect-directed analysis of organic toxicants in sediments
    Trac-Trends Anal. Chem. 28 (5), 543 - 549
    full text (url)
  • Brack, W., Bandow, N., Schwab, K., Schulze, T., Streck, G., (2009):
    Identifizierung toxischer Verbindungen in Sedimenten: Ansätze zur Integration von Wirkung und Bioverfügbarkeit
    UWSF 21 (3), 240 - 244
    full text (url)
  • Brack, W., Posthuma, L., Hein, M., von der Ohe, P.C., (2009):
    European river basins at risk
    Integrated Environmental Assessment and Management 5 (1), 2 - 4
    full text (url)
  • Gaspare, L., Machiwa, J.F., Mdachi, S.J.M., Streck, G., Brack, W., (2009):
    Polycyclic aromatic hydrocarbon (PAH) contamination of surface sediments and oysters from the inter-tidal areas of Dar es Salaam, Tanzania
    Environ. Pollut. 157 (1), 24 - 34
    full text (url)
  • Hollert, H., Claus, E., Ahlf, W., Brack, W., Braunbeck, T., Hudjetz, S., Manz, W., Ratte, H.T., Reifferscheid, G., Schäffer, A., Schulze, T., Schwarzbauer, J., Heininger, P., (2009):
    Über die Notwendigkeit der wirkungsorientierten Analytik in einer umfassenden Wasserforschung
    UWSF 21 (3), 235 - 237
    full text (url)
  • Kaisarevic, S., Lübcke-von Varel, U., Orcic, D., Streck, G., Schulze, T., Pogrmic, K., Teodorovic, I., Brack, W., Kovacevic, R., (2009):
    Effect-directed analysis of contaminated sediment from the wastewater canal in Pancevo industrial area, Serbia
    Chemosphere 77 (7), 907 - 913
    full text (url)
  • Schwab, K., Altenburger, R., Lübcke-von Varel, U., Streck, G., Brack, W., (2009):
    Effect-directed analysis of sediment-associated algal toxicants at selected hot spots in the river Elbe basin with a special focus on bioaccessibility
    Environ. Toxicol. Chem. 28 (7), 1506 - 1517
    full text (url)
  • Schymanski, E., Bataineh, M., Goss, K.U., Brack, W., (2009):
    Integrated analytical and computer tools for structure elucidation in effect-directed analysis
    Trac-Trends Anal. Chem. 28 (5), 550 - 561
    full text (url)
  • Schymanski, E., Meringer, M., Brack, W., (2009):
    Matching structures to mass spectra using fragmentation patterns: are the results as good as they look?
    Anal. Chem. 81 (9), 3608 - 3617
    full text (url)
  • von der Ohe, P.C., de Deckere, E., Prüß, A., Muñoz, I., Wolfram, G., Villagrasa, M., Ginebreda, A., Hein, M., Brack, W., (2009):
    Toward an integrated assessment of the ecological and chemical status of European river basins
    Integrated Environmental Assessment and Management 5 (1), 50 - 61
    full text (url)
  • Vykopalova, L., Pencikova, K., Ciganek, M., Neca, J., Vondracek, J., Brack, W., Luebcke-Von Varel, U., Streck, G., Machala, M., (2009):
    Identification and toxicological evaluation of musk fragrances and thiophenes in extracts of river sediment samples
    Toxicol. Lett. 189 (Suppl. 1), S198 - S199
    full text (url)
to index

2008 (8)

  • Brack, W., Bláha, L., Giesy, J.P., Grote, M., Möder, M., Schrader, S., Hecker, M., (2008):
    Polychlorinated naphthalenes and other dioxin-like acting compounds in Elbe river sediments
    Environ. Toxicol. Chem. 27 (3), 519 - 528
    full text (url)
  • Brack, W., Schmitt-Jansen, M., Machala, M., Brix, R., Barceló, D., Schymanski, E., Streck, G., Schulze, T., (2008):
    How to confirm identified toxicants in effect-directed analysis
    Anal. Bioanal. Chem. 390 (8), 1959 - 1973
    full text (url)
  • Lübcke-von Varel, U., Streck, G., Brack, W., (2008):
    Automated fractionation procedure for polycyclic aromatic compounds in sediment extracts on three coupled normal-phase high-performance liquid chromatography columns
    J. Chromatogr. A 1185 (1), 31 - 42
    full text (url)
  • Mages, M., Bandow, N., Küster, E., Brack, W., von Tümpling, W., (2008):
    Zinc and cadmium accumulation in single zebrafish (Danio rerio) embryos - A total reflection X-ray fluorescence spectrometry application
    Spectrochim. Acta B 63 (12), 1443 - 1449
    full text (url)
  • Schäfer, R.B., Mueller, R., Brack, W., Wenzel, K.-D., Streck, G., Ruck, W., Liess, M., (2008):
    Determination of 10 particle-associated multiclass polar and semi-polar pesticides from small streams using accelerated solvent extraction
    Chemosphere 70 (11), 1952 - 1960
    full text (url)
  • Schymanski, E., Meinert, C., Meringer, M., Brack, W., (2008):
    The use of MS classifiers and structure generation to assist in the identification of unknowns in effect-directed analysis
    Anal. Chim. Acta 615 (2), 136 - 147
    full text (url)
  • Streck, G., Schulze, T., Brack, W., (2008):
    Accelerated Membrane Assisted Clean-up: Eine leistungsfähige Methode zur Aufreinigung matrixbehafteter Extrakte
    LC-GC Ads März/April 2008 , 6 - 10
  • Streck, G., Schulze, T., Brack, W., (2008):
    Accelerated membrane-assisted clean-up as a tool for the clean-up of extracts from biological tissues
    J. Chromatogr. A 1196-1197 , 33 - 40
    full text (url)
to index

2007 (5)

  • Bakker, J.F., Belzunce-Segarra, M.J., Castro, R., van de Heuvel-Greve, M., Klamer, H.J.C., Brack, W., Altenburger, R., Poulsen, V., Thomas, K.V., Leonards, P.E.G., (2007):
    Effect directed analysis and toxicity identification evaluation
    In: Barceló, D., Petrovic, M., (eds.)
    Sustainable management of sediment resources. Sediment quality and impact assessment of pollutants
    Elsevier, Amsterdam, p. 163 - 214
  • Brack, W., Klamer, H.J.C., López de Alda, M., Barceló, D., (2007):
    Effect-directed analysis of key toxicants in European river basins - a review
    Environ. Sci. Pollut. Res. 14 (1), 30 - 38
    full text (url)
  • Meinert, C., Moeder, M., Brack, W., (2007):
    Fractionation of technical p-nonylphenol with preparative capillary gas chromatography
    Chemosphere 70 (2), 215 - 223
    full text (url)
  • Schwab, K., Brack, W., (2007):
    Large volume TENAX® extraction of the bioaccessible fraction of sediment-associated organic compounds for a subsequent effect-directed analysis
    J. Soils Sediments 7 (3), 178 - 186
    full text (url)
  • von der Ohe, P.C., Prüß, A., Schäfer, R.B., Liess, M., de Deckere, E., Brack, W., (2007):
    Water quality indices across Europe - a comparison of the good ecological status of five river basins
    J. Environ. Monit. 9 (9), 970 - 978
    full text (url)
to index

2006 (5)

  • Altenburger, R., Brack, W., Greco, W.R., Grote, M., Jung, K., Ovari, A., Riedl, J., Schwab, K., Küster, E., (2006):
    On the mode of action of N-phenyl-2-naphthylamine in plants
    Environ. Sci. Technol. 40 (19), 6163 - 6169
    full text (url)
  • Böhmler, G., Brack, W., Gareis, M., Goehrlich, R., (2006):
    Von der Wirkung zur Substanz: Wirkungsbezogene Analytik als neue Untersuchungsstrategie in der Lebensmittelkontrolle
    J. Verbr. Lebensm. 1 (4), 294 - 300
    full text (url)
  • Brack, W., (2006):
    MODELKEY: Entschlüsselung von Ursache-Wirkungs-Beziehungen für ein besseres Flussgebietsmanagement
    Forum der Geoökologie 17 (1), 37 - 39
  • Brack, W., (2006):
    MODELKEY: towards a better impact and cause analysis
    SETAC Globe 7 (2), 13
  • Brack, W., (2006):
    Wirkungsorientierte Analytik komplexer Mischungen. Erfahrungen aus der Umwelt- und Ökotoxikologie für die Lebensmitteluntersuchung
    J. Verbr. Lebensm. 1 (4), 301 - 309
    full text (url)
to index

2005 (9)

  • Brack, W., Bakker, J., de Deckere, E., Deerenberg, C., van Gils, J., Hein, M., Jurajda, P., Kooijman, B., Lamoree, M., Lek, S., López de Alda, M.J., Marcomini, A., Muñoz, I., Rattei, S., Segner, H., Thomas, K., von der Ohe, P.C., Westrich, B., de Zwart, D., Schmitt-Jansen, M., (2005):
    MODELKEY. Models for assessing and forecasting the impact of environmental key pollutants on freshwater and marine ecosystems and biodiversity
    Environ. Sci. Pollut. Res. 12 (5), 252 - 256
    full text (url)
  • Brack, W., Schirmer, K., Erdinger, L., Hollert, H., (2005):
    Effect-directed analysis of mutagens and ethoxyresorufin-O-deethylase inducers in aquatic sediments
    Environ. Toxicol. Chem. 24 (10), 2445 - 2458
    full text (url)
  • Grote, M., Altenburger, R., Brack, W., Moschütz, S., Mothes, S., Michael, C., Narten, G.-B., Paschke, A., Schirmer, K., Walter, H.A., Wennrich, R., Wenzel, K.-D., Schüürmann, G., (2005):
    Ecotoxicological profiling of transect river Elbe sediments
    Acta Hydrochim. Hydrobiol. 33 (5), 555 - 569
    full text (url)
  • Grote, M., Brack, W., Altenburger, R., (2005):
    Identification of toxicants from marine sediment using effect-directed analysis
    Environ.Toxicol. 20 (5), 475 - 486
    full text (url)
  • Grote, M., Brack, W., Walter, H.A., Altenburger, R., (2005):
    Light as a confounding factor for toxicity assessment of complex contaminated sediments
    Environ. Toxicol. Chem. 24 (12), 3143 - 3152
    full text (url)
  • Grote, M., Brack, W., Walter, H.A., Altenburger, R., (2005):
    Confirmation of cause-effect relationships using effect-directed analysis for complex environmental samples
    Environ. Toxicol. Chem. 24 (6), 1420 - 1427
    full text (url)
  • Hollert, H., Dürr, M., Holtey-Weber, R., Islinger, M., Brack, W., Färber, H., Erdinger, L., Braunbeck, T., (2005):
    Endocrine disruption of water and sediment extracts in a non-radioactive dot blot/RNAse protection-assay using isolated hepatocytes of rainbow trout. Deficiencies between bioanalytical effectiveness and chemically determined concentrations and how to explain them
    Environ. Sci. Pollut. Res. 12 (6), 347 - 360
    full text (url)
  • Olajire, A.A., Altenburger, R., Küster, E., Brack, W., (2005):
    Chemical and ecotoxicological assessment of polycyclic aromatic hydrocarbon-contaminated sediments of the Niger Delta, Southern Nigeria
    Sci. Total Environ. 340 (1-3), 123 - 136
    full text (url)
  • Olajire, A.A., Brack, W., (2005):
    Polycyclic aromatic hydrocarbons in Niger Delta soil: contamination sources and profiles
    Int. J. Environ. Sci. Technol. 2 (4), 343 - 352
    full text (url)
to index

2004 (2)

  • Grote, M., Altenburger, R., Brack, W., Möckel, C., Moschütz, S., Mothes, S., Michael, C., Narten, G.-B., Paschke, A., Schirmer, K., Walter, H., Wennrich, R., Wenzel, K.-D., Schüürmann, G., (2004):
    Identifizierung und Analyse des ökotoxischen Potentials von Flusssedimenten als Folge der durch Hochwasser mobilisierten Kontamination
    In: Geller, W., Ockenfeld, K., Böhme, M., Knöchel, A., (eds.)
    Schadstoffbelastung nach dem Elbe-Hochwasser 2002. Endbericht des Ad-hoc-Verbundprojekts
    UFZ Leipzig-Halle GmbH, Magdeburg, p. 314 - 329
  • Vondracek, J., Chramostová, K., Plísková, M., Bláha, L., Brack, W., Kozubík, A., Machala, M., (2004):
    Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans
    Environ. Toxicol. Chem. 23 (9), 2214 - 2220
    full text (url)
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2003 (7)

  • Altenburger, R., Brack, W., Grote, M., Moschütz, S., Paschke, A., Schirmer, K., Walter, H., Wenzel, K., Schüürmann, G., (2003):
    Identifizierung und Analyse des ökotoxikologischen Potentials von Flußsedimenten als Folge der durch Hochwasser mobilisierten Kontaminationen
    Statusseminar des BMBF-Ad-hoc-Verbundprojektes: Schadstoffbelastung im Mulde- und Elbe-Einzugsgebiet nach dem Augusthochwasser 2002, Freiberg, 27.-29.8.2003
    UFZ Leipzig-Halle GmbH, Magdeburg, p. 9 - 12
  • Brack, W., (2003):
    Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures?
    Anal. Bioanal. Chem. 377 (3), 397 - 407
    full text (url)
  • Brack, W., Altenburger, R., Küster, E., Meißner, B., Wenzel, K.-D., Schüürmann, G., (2003):
    Identification of toxic products of anthracene photomodification in simulated sunlight
    Environ. Toxicol. Chem. 22 (10), 2228 - 2237
    full text (url)
  • Brack, W., Kind, T., Hollert, H., Schrader, S., Möder, M., (2003):
    Sequential fractionation procedure for the identification of potentially cytochrome P4501A-inducing compounds
    J. Chromatogr. A 986 (1), 55 - 66
    full text (url)
  • Brack, W., Kind, T., Hollert, H., Schrader, S., Möder, M., (2003):
    Erratum to "Sequential fractionation procedure for the identification of potentially cytochrome P4501A-inducing compounds" (vol 986, pg 55, 2003)
    J. Chromatogr. A 993 (1-2), 223 - 223
    full text (url)
  • Brack, W., Kind, T., Schrader, S., Möder, M., Schüürmann, G., (2003):
    Polychlorinated naphthalenes in sediments from the industrial region of Bitterfeld
    Environ. Pollut. 121 (1), 81 - 85
    full text (url)
  • Brack, W., Schirmer, K., (2003):
    Effect-directed identification of oxygen and sulfur heterocycles as major polycyclic aromatic cytochrome P4501A-inducers in a contaminated sediment
    Environ. Sci. Technol. 37 (14), 3062 - 3070
    full text (url)
to index

2002 (4)

  • Brack, W., Altenburger, R., (2002):
    Effektorientierte Identifikation toxischer Verbindungen
    Mitteilungen der Fachgruppe Umweltchemie und Ökotoxikologie / Gesellschaft Deutscher Chemiker 8 , 6 - 8
  • Brack, W., Altenburger, R., Dorusch, F., Hubert, A., Möder, M., Morgenstern, P., Moschütz, S., Mothes, S., Schirmer, K., Wennrich, R., Wenzel, K.-D., Schüürmann, G., (2002):
    Hochwasser 2002 - Chemische und toxische Belastung überschwemmter Gemeinden im Raum Bitterfeld
    UWSF 14 (4), 213 - 220
    full text (url)
  • Brack, W., Schirmer, K., Kind, T., Schrader, S., Schüürmann, G., (2002):
    Effect-directed fractionation and identification of cytochrome P4501A-inducing halogenated aromatic hydrocarbons in a contaminated sediment
    Environ. Toxicol. Chem. 21 (12), 2654 - 2662
    full text (url)
  • Hollert, H., Dürr, M., Olsmann, H., Halldin, K., van Bavel, B., Brack, W., Tysklind, M., Engwall, M., Braunbeck, T., (2002):
    Biological and chemical determination of dioxin-like compounds in sediments by means of a sediment triad approach in the catchment area of the river Neckar
    Ecotoxicology 11 (5), 323 - 336
    full text (url)
to index

2000 (6)

  • Brack, W., Altenburger, R., (2000):
    Identifikation giftiger Inhaltsstoffe - ein wichtiger Schritt zur Gefährdungsabschätzung und Sanierung
    UFZ-Jahresbericht '98-'99
    UFZ Leipzig-Halle GmbH, Leipzig, S. 26 - 34
    full text (url)
  • Brack, W., Altenburger, R., Ensenbach, U., Nehls, S., Segner, H., (2000):
    Biotestorientierte Identifikation toxischer organischer Sedimentinhaltstoffe - Ein Beitrag zur Risikoanalyse komplexer Kontaminationen am Beispiel des Spittelwassers. Mitteilung Nr. 22. Sedimentbewertung in europäischen Flußgebieten. Beiträge zum internationalen Symposium vom 12.-14. April 1999
    "Sedimentbewertung in europäischen Flußgebieten", Koblenz, 12.-14.4.1999
    Bundesanstalt für Gewässerkunde, Koblenz, p. 135 - 141
  • Brack, W., Altenburger, R., Ensenbach, U., Nehls, S., Segner, H., Schüürmann, G., (2000):
    Wirkungsorientierte Identifikation toxischer organischer Inhaltsstoffe in Flußsedimenten
    In: Friese, K., Witter, B., Miehlich, G., Rode, M., (Hrsg.)
    Stoffhaushalt von Auenökosystemen. Böden und Hydrologie, Schadstoffe, Bewertungen
    Springer, Berlin, Heidelberg, New York, S. 337 - 346
    full text (url)
  • Brack, W., Paschke, A., Segner, H., Schüürmann, G., Wennrich, R., (2000):
    Urease inhibition: a tool for toxicity identification in sediment elutriates
    Chemosphere 40 (8), 829 - 834
    full text (url)
  • Brack, W., Segner, H., Möder, M., Schüürmann, G., (2000):
    Fixed-effect level toxicity equivalents - A suitable parameter for assessing ethoxyresorufin-o-dethylase induction potency in complex environmental samples
    Environ. Toxicol. Chem. 19 (10), 2493 - 2501
    full text (url)
  • Friese, K., Witter, B., Brack, W., Büttner, O., Krüger, F., Kunert, M., Rupp, H., Miehlich, G., Gröngröft, G., Schwartz, R., van der Veen, A., Zachmann, D.R., (2000):
    Distribution and fate of organic and inorganic contaminants in a river floodplain - results of a case study on the River Elbe, Germany
    In: Wise, D.L., Trantolo, D., Cichon, E.J., Inyang, H.I., Stottmeister, U., (eds.)
    Remediation engineering of contaminated soils
    Environmental Science and Pollution Control 23
    Marcel Dekker, New York, p. 373 - 426
to index

1999 (3)

  • Brack, W., Altenburger, R., Ensenbach, U., Möder, M., Segner, H., Schüürmann, G., (1999):
    Bioassay-directed identification of organic toxicants in river sediment in the industrial region of Bitterfeld (Germany) - a contribution to hazard assessment
    Arch. Environ. Contam. Toxicol 37 (2), 164 - 174
    full text (url)
  • Brack, W., (1999):
    Sequentielle Teststrategie zur Identifikation toxischer organischer Substanzen in Porengewässern und Sedimentextraten. DVWK-Methodenstudie
    In: Kern, U., Westrich, B., (Hrsg.)
    Methoden zur Erkundung, Untersuchung und Bewertung von Sedimentablagerungen und Schwebstoffen in Gewässern
    DVWK-Schriften Band 128
    Wirtschafts- und Verlagsgesellschaft Gas und Wasser, Bonn, S. 282 - 289
  • Friese, K., Krüger, F., Brack, W., Lohse, M., Miehlich, G., Schwartz, R., Witter, B., Khalamtzeva, P., Yashin, V., (1999):
    Hochwassergebundener Schadstoffeintrag in Auen der Elbe und der Oka: Aktueller Stand des russisch-deutschen Kooperationsprojektes
    Russisch-Deutsches Seminar "Ökomonitoring großer Gewässer und Umwelttechnologien zur Vermeidung von Schadstoffeinträgen", 9./10.2.1999, Haus der Wissenschaft und Kultur der Russischen Förderation, Berlin
    p. 27 - 30
to index

1998 (6)

  • Brack, W., Altenburger, R., Ensenbach, U., Nehls, S., Segner, H., Schüürmann, G., (1998):
    Identifikation ökotoxikologisch wirksamer Substanzen in Sedimenten des Spittelwassers
    In: Geller, W., Punčochář, P., Bornhöft, D., Bouček, J., Feldmann, H., Guhr, H., Mohaupt, V., Simon, M., Smrtˇák, J., Spoustová, J., Uhlmann, O., (Hrsg.)
    Gewässerschutz im Einzugsgebiet der Elbe. 8. Magdeburger Gewässerschutzseminar, Oktober 1998, Karlsbad (Tschechien)
    B.G. Teubner, Stuttgart, Leipzig, S. 149 - 150
    full text (url)
  • Brack, W., Frank, H., (1998):
    Chlorophyll a fluorescence: A tool for the investigation of toxic effects in the photosynthetic apparatus
    Ecotox. Environ. Safe. 40 (1-2), 34 - 41
    full text (url)
  • Brack, W., Rottler, H., Frank, H., (1998):
    Volatile fractions of landfill leachates and their effect on Chlamydomonas reinhardtii: In vivo chlorophyll a fluorescence
    Environ. Toxicol. Chem. 17 (10), 1982 - 1991
    full text (url)
  • Ensenbach, U., Altenburger, R., Behrens, A., Brack, W., Knops, M., Navas, J.M., Nehls, S., (1998):
    Ökotoxikologische Analyse komplexer Stoffgemische
    Tagungsbericht Jahrestagung der Deutschen Gesellschaft für Limnologie (DGL), Frankfurt, 22.-26.9.1997, Band II
    p. 882 - 885
  • Ensenbach, U., Altenburger, R., Brack, W., Paschke, A., Popp, P., Segner, H., Wennrich, R., Schüürmann, G., (1998):
    Ökotoxikologische Charakterisierung von Sedimenten der Saale
    In: Geller, W., Punčochář, P., Bornhöft, D., Bouček, J., Feldmann, H., Guhr, H., Mohaupt, V., Simon, M., Smrtˇák, J., Spoustová, J., Uhlmann, O., (Hrsg.)
    Gewässerschutz im Einzugsgebiet der Elbe. 8. Magdeburger Gewässerschutzseminar, Oktober 1998, Karlsbad (Tschechien)
    B.G. Teubner, Stuttgart, Leipzig, S. 151 - 152
    full text (url)
  • Friese, K., Brack, W., Krüger, F., Lohse, M., Miehlich, G., Rupp, H., Schwartz, R., Witter, B., Khalamtzeva, I., Pylenok, P., Sergueev, S., Iashin, V., (1998):
    Hochwassergebundener Schadstoffeintrag in Auen der Elbe und der Oka: Aktueller Stand eines BMBF- und UFZ-geförderten russisch-deutschen Kooperationsprojektes
    In: Geller, W., Punčochář, P., Bornhöft, D., Bouček, J., Feldmann, H., Guhr, H., Mohaupt, V., Simon, M., Smrtˇák, J., Spoustová, J., Uhlmann, O., (Hrsg.)
    Gewässerschutz im Einzugsgebiet der Elbe. 8. Magdeburger Gewässerschutzseminar, Oktober 1998, Karlsbad (Tschechien)
    B.G. Teubner, Stuttgart, Leipzig, S. 58 - 61
    full text (url)
to index

1997 (1)

  • Brack, W., Frank, H., (1997):
    A bioassay-directed method for the separation of volatile compounds from landfill leachates
    Chemosphere 34 (4), 849 - 854
    full text (url)
to index

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