Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1021/acs.est.6b05468 |
| Title (Primary) | Mutagenicity in surface waters: synergistic effects of carboline alkaloids and aromatic amines |
| Author | Muz, M.; Krauss, M.
; Kutsarova, S.; Schulze, T.
; Brack, W. |
| Source Titel | Environmental Science & Technology |
| Year | 2017 |
| Department | WANA |
| Volume | 51 |
| Issue | 3 |
| Page From | 1830 |
| Page To | 1839 |
| Language | englisch |
| UFZ wide themes | RU2; |
| Abstract | Since decades mutagenicity has been observed in many surface waters with a possible link to the presence of aromatic amines. River Rhine is a well-known example of this phenomenon but responsible compound(s) are still unknown. To identify the mutagenic compounds, we applied effect-directed analysis (EDA) utilizing novel analytical and biological approaches to a water sample extract from the lower Rhine. We could identify 21 environmental contaminants including two weakly mutagenic aromatic amines, and the known alkaloid co-mutagen norharman along with two related β-carboline alkaloids, carboline and 5-carboline, which were reported the first time in surface waters. Results of mixture tests showed a strong synergism of the identified aromatic amines not only with norharman, but also with carboline and 5-carboline. Additionally, other nitrogen-containing compounds also contributed to the mutagenicity when aromatic amines were present. Thus, co-mutagenicity of β-carboline alkaloids with aromatic amines is shown to occur in surface waters. These results strongly suggest that surface water mutagenicity is highly complex and driven by synergistic mechanisms of a complex compound mixture (of which many are yet unidentified) rather than by single compounds. Therefore, mixture effects should be considered not only from mutagens alone, but also including possible co-mutagens and non-mutagenic compounds. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=18285 |
| Muz, M., Krauss, M., Kutsarova, S., Schulze, T., Brack, W. (2017): Mutagenicity in surface waters: synergistic effects of carboline alkaloids and aromatic amines Environ. Sci. Technol. 51 (3), 1830 - 1839 10.1021/acs.est.6b05468 |
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