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Title (Primary) Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis
Author Schulze, T.; Weiss, S.; Schymanski, E.; von der Ohe, P.C.; Schmitt-Jansen, M.; Altenburger, R.; Streck, G.; Brack, W.;
Journal Environmental Pollution
Year 2010
Department BIOTOX; WANA;
Volume 158
Issue 5
Language englisch;
Keywords Diclofenac; 2-[2-(Chlorophenyl)amino]benzaldehyde; Effect-directed analysis; Photo-transformation; Scenedesmus vacuolatus; MODELKEY
Abstract The pharmaceutical diclofenac (DCF) is released in considerably high amounts to the aquatic environment. Photo-transformation of DCF was reported as the main degradation pathway in surface waters and was found to produce metabolites with enhanced toxicity to the green algae Scenedesmus vacuolatus. We identified and subsequently confirmed 2-[2-(chlorophenyl)amino]benzaldehyde (CPAB) as a transformation product with enhanced toxicity using effect-directed analysis. The EC50 of CPAB (4.8 mg/L) was a factor of 10 lower than that for DCF (48.1 mg/L), due to the higher hydrophobicity of CPAB (log Kow = 3.62) compared with DCF (log Dow = 2.04) at pH 7.0. Effect-directed analysis of irradiated diclofenac results in the identification of one photo-transformation product responsible for the enhanced toxicity to Scenedesmus vacuolatus.
ID 10495
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=10495
Schulze, T., Weiss, S., Schymanski, E., von der Ohe, P.C., Schmitt-Jansen, M., Altenburger, R., Streck, G., Brack, W. (2010):
Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis
Environ. Pollut. 158 (5), 1461 - 1466