Projects supported by third-party funds

Third-party donor	Project	Coordinator
Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF)	Virological and immunological determinants of COVID-19 pathogenesis - lessons to get prepared for future pandemics	Prof. Ana Zenclussen
Deutsche Forschungsgemeinschaft (DFG)	Impact of endocrine disrupting chemicals on innate immune cell-mediated tissue remodeling in reproductive events	Prof. Ana Zenclussen
HEXAL-AG	Hormonal control of immune responses in pregnancy and autoimmune diseases	PD Dr. Anne Schumacher
Deutsche Forschungsgemeinschaft (DFG)	The Triangle of Pregnancy Success – Decoding the Network between Regulatory T Cells, Dendritic Cells and Human Chorionic Gonadotropin in Embryo Implantation	PD Dr. Anne Schumacher
Deutsche Forschungsgemeinschaft (DFG)	Dissecting the participation of cold shock proteins in reproductive processes: relevance of trophoblast specific YB-1 expression for embryo development	Prof. Ana Zenclussen
Deutsche Forschungsgemeinschaft (DFG)	Role of CD97/ADGRE5 in allergic asthma	PD Dr. Tobias Polte
Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF)	International Fellow Award Prof. Janine Felix	Dr. Gunda Herberth
Deutsche Forschungsgemeinschaft (DFG)	Understanding the molecular mechanisms underlying uterine spiral artery remodeling, a critical process for pregnancy and fetal well-being: importance of chymases.	Dr. Nicole Meyer
Deutsche Forschungsgemeinschaft (DFG)	Study of the mechanisms underlying the salutary effects of Heme Oxygenase-1 in implantation, placentation and fetal growth using a mouse model and in vitro approaches. Participation of carbon monoxide in the preparation of the murine uterine microenvironment for pregnancy.	Prof. Ana Zenclussen

Department News

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Since recently you can follow us on the platform. There you will find interesting information about our working group, but also everything about our research activities and publications.

@UFZ_Immu

Researchers from the German Cancer Research Centre (DKFZ) Heidelberg, Friedrich Schiller University Jena and UFZ have discovered new biomarkers for the detection and quantification of cancers and starting points for new cancer immunotherapies.

A team with the participation of UFZ alumni Saskia Trump from our department has now founded cAHRmeleon Bioscience GmbH and is developing biomarker and companion diagnostic services for precision medicine in cancer immunotherapy for the biopharmaceutical market.

To what extent do older siblings influence the healthy development of children? Answers from our LiNA study can be found in our latest press release.

Photo: PD Dr. Stefan Fest

Prof. Ana Zenclussen and Dr. Violeta Stojanovska, together with PD Dr. Stefan Fest, took part in the annual conference of the American Society for Reproductive Immunology in Nashville. In addition to presenting their own results on the topic of "Characterization of 3D trophoblast spheroids as a model of placenta functionality", our scientists also had the opportunity to finally exchange ideas in person with colleagues from all over the world.

Dr. Clarisa Santamaria gave an oral presentation at this years IFFS World Congress, topic: Uncovering the participation of Regulatory T cells and Dendritic cells in embryo implantation using human heterologous in vitro implantation models. She was awarded during the Junior researchers panel - Prize Giving session. Congratulations!

We congratulate Prof. Ana Zenclussen on her appointment as a member of the BfR Commission on Contaminants in the Food Chain for the session period 2022 to 2025 and wish her every success!

We may present: the Helmholtz portrait of Prof. Ana Zenclussen.

Latest publications

2022

Index:

2022 (20)

You could use our publication index for further requests.

2022 (20)

Amici, F., Röder, S., Kiess, W., Borte, M., Zenclussen, A.C., Widdig, A., Herberth, G., (2022):
Maternal stress, child behavior and the promotive role of older siblings
BMC Public Health 22 , art. 863
full text (doi)
Busse, M., Langwisch, S., Tedford, K., Fischer, K.-D., Zenclussen, A.C., (2022):
Maternal B cell signaling orchestrates fetal development in mice
Development 149 (8), dev.199783
full text (doi)
Busse, M., Scharm, M., Oettel, A., Redlich, A., Costa, S.-D., Zenclussen, A.C., (2022):
Enhanced S100B expression in T and B lymphocytes in spontaneous preterm birth and preeclampsia
J. Perinat. Med. 50 (2), 157 - 166
full text (doi)
Fraser, R., Zenclussen, A.C., (2022):
Killer timing: The temporal uterine Natural killer cell differentiation pathway and implications for female reproductive healthn
Front. Endocrinol. 13 , art. 904744
full text (doi)
Greimel, E., Adams, L., Zsigo, C., Berdel, D., von Berg, A., Koletzko, S., Bauer, C.-P., Schikowski, T., Herberth, G., Heinrich, J., Schulte-Körne, G., Standl, M., (2022):
Psychopathological symptoms as precursors of depressive symptoms in adolescence: a prospective analysis of the GINIplus and LISA birth cohort studies
Soc. Psychiatry Psychiatr. Epidemiol.
full text (doi)
Junge, K.M., Buchenauer, L., Strunz, S., Seiwert, B., Thürmann, L., Rolle-Kampczyk, U.E., Röder, S., Borte, M., Kiess, W., von Bergen, M., Simon, J.C., Zenclussen, A.C., Schöneberg, T., Stangl, G.I., Herberth, G., Lehmann, I., Reemtsma, T., Polte, T., (2022):
Effects of exposure to single and multiple parabens on asthma development in an experimental mouse model and a prospective cohort study
Sci. Total Environ. 814 , art. 152676
full text (doi)
Juskiene, I., Prokopciuk, N., Franck, U., Valiulis, A., Valskys, V., Mesceriakova, V., Kvedariene, V., Valiulyte, I., Poluzioroviene, E., Sauliene, I., Valiulis, A., (2022):
Indoor air pollution effects on pediatric asthma are submicron aerosol particle–dependent
Eur. J. Pediatr. 181 (6), 2469 - 2480
full text (doi)
Krause, J.L., Engelmann, B., Nunes da Rocha, U., Pierzchalski, A., Chang, H.D., Zenclussen, A.C., von Bergen, M., Rolle-Kampczyk, U., Herberth, G., (2022):
MAIT cell activation is reduced by direct and microbiota-mediated exposure to bisphenols
Environ. Int. 158 , art. 106985
full text (doi)
Kretschmer, T., Turnwald, E.-M., Janoschek, R., Wohlfarth, M., Handwerk, M., Dötsch, J., Hucklenbruch-Rother, E., Appel, S., (2022):
Treatment of high fat diet‐induced obese pregnant mice with IL‐6 receptor antibody does not ameliorate placental function and fetal growth restriction
Am. J. Reprod. Immunol. 88 (1), e13564
full text (doi)
Lokossou, G.A.G., Kouakanou, L., Schumacher, A., Zenclussen, A.C., (2022):
Human breast milk: From food to active immune response with disease protection in infants and mothers
Front. Immunol. 13 , art. 849012
full text (doi)
Marb, A., Libuda, L., Standl, M., Koletzko, S., Bauer, C.-P., Schikowski, T., Berdel, D., von Berg, A., Herberth, G., Bühlmeier, J., Harris, C.P., (2022):
Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies
Eur. J. Clin. Nutr.
full text (doi)
Markevych, I., Astell-Burt, T., Altug, H., Triebner, K., Standl, M., Flexeder, C., Heinrich, J., Schikowski, T., Koletzko, S., Herberth, G., Bauer, C.-P., von Berg, A., Berdel, D., Feng, X., (2022):
Residential green space and age at menarche in German and Australian adolescent girls: A longitudinal study
Int. J. Hyg. Environ. Health. 240 , 113917
full text (doi)
Meijer, M., Klein, M., Caramaschi, D., Mulder, R., Cosin, M., Lu, X., Zhang, Y., Röder, S., Zilich, L., Huels, A., Hartman, C., Snieder, H., Bustamante, M., Herberth, G., Franke, B., Copeland, B., Aberg, K., van den Oord, E., (2022):
Meta-analysis of cell type-sSpecific DNA methylation of childhood attention-deficit/hyperactivity disorder symptoms
Biol. Psychiatry 91 (9 (Suppl.)), S111 - S112
full text (doi)
Schicketanz, J., Röder, S., Herberth, G., Kabisch, S., Lakes, T., (2022):
On foot or by car: what determines children’s active school travel?
Child. Geogr. 20 (2), 174 - 188
full text (doi)
Schmitz, K., Turnwald, E.-M., Kretschmer, T., Janoschek, R., Bae-Gartz, I., Voßbrecher, K., Kammerer, M.D., Köninger, A., Gellhaus, A., Handwerk, M., Wohlfarth, M., Gründemann, D., Hucklenbruch-Rother, E., Dötsch, J., Appel, S., (2022):
Metformin prevents key mechanisms of obesity-related complications in visceral white adipose tissue of obese pregnant mice
Nutrients 14 (11), art. 2288
full text (doi)
Scholz, S., Brack, W., Escher, B.I., Hackermüller, J., Liess, M., von Bergen, M., Wick, L.Y., Zenclussen, A.C., Altenburger, R., (2022):
The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Arch. Toxicol. 96 (8), 2381 - 2386
full text (doi)
Schütte, O., Bachmann, L., Shivappa, N., Hebert, J.R., Felix, J.F., Röder, S.W., Sack, U., Borte, M., Kiess, W., Zenclussen, A.C., Stangl, G.I., Herberth, G., Junge, K.M., (2022):
Pro-inflammatory diet pictured in children with atopic dermatitis or food allergy: nutritional data of the LiNA cohort
Front. Nutr. 9 , art. 868872
full text (doi)
Stojanovska, V., Voss, H., Fest, S., Zenclussen, A.C., (2022):
P45: Characterization of 3D trophoblast spheroids as a model of placenta functionality
Am. J. Reprod. Immunol. 87 (S1), 98 - 99
full text (doi)
Wang, J., Tischer, C., Standl, M., Weidinger, S., von Berg, A., Herberth, G., Yew, Y.W., Heinrich, J., Schmitt, J., Apfelbacher, C., (2022):
Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15-year follow-up of the LISA cohort study
J. Eur. Acad. Dermatol. Venereol. 36 (4), 547 - 556
full text (doi)
Zhang, N., Schumacher, A., Fink, B., Bauer, M., Zenclussen, A.C., Meyer, N., (2022):
Insights into early-pregnancy mechanisms: Mast cells and chymase CMA1 shape the phenotype and modulate the functionality of human trophoblast cells, vascular smooth-muscle cells and endothelial cells
Cells 11 (7), art. 1158
full text (doi)

to index

Projects

We participate in the joint research project SaxoChiLD.

@SaxoChiLD

We participate in the joint research project
CoViPa.

@CoViPa