Projects supported by third-party funds

Third-party donor	Project	Coordinator
Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF)	Virological and immunological determinants of COVID-19 pathogenesis - lessons to get prepared for future pandemics	Prof. Ana Zenclussen
Deutsche Forschungsgemeinschaft (DFG)	Impact of endocrine disrupting chemicals on innate immune cell-mediated tissue remodeling in reproductive events	Prof. Ana Zenclussen
HEXAL-AG	Hormonal control of immune responses in pregnancy and autoimmune diseases	PD Dr. Anne Schumacher
Deutsche Forschungsgemeinschaft (DFG)	The Triangle of Pregnancy Success – Decoding the Network between Regulatory T Cells, Dendritic Cells and Human Chorionic Gonadotropin in Embryo Implantation	PD Dr. Anne Schumacher
Deutsche Forschungsgemeinschaft (DFG)	Dissecting the participation of cold shock proteins in reproductive processes: relevance of trophoblast specific YB-1 expression for embryo development	Prof. Ana Zenclussen
Deutsche Forschungsgemeinschaft (DFG)	Role of CD97/ADGRE5 in allergic asthma	PD Dr. Tobias Polte
Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF)	International Fellow Award Prof. Janine Felix	Dr. Gunda Herberth
Deutsche Forschungsgemeinschaft (DFG)	Understanding the molecular mechanisms underlying uterine spiral artery remodeling, a critical process for pregnancy and fetal well-being: importance of chymases.	Dr. Nicole Meyer
Deutsche Forschungsgemeinschaft (DFG)	Study of the mechanisms underlying the salutary effects of Heme Oxygenase-1 in implantation, placentation and fetal growth using a mouse model and in vitro approaches. Participation of carbon monoxide in the preparation of the murine uterine microenvironment for pregnancy.	Prof. Ana Zenclussen

Department News

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@UFZ_Immu

The 25th Interdisziplinäre Kinderimmunologische Arbeitstreffen (KIAT) took place on November 11th in Leipzig. Prof. Ana Zenclussen and Dr. Gunda Herberth gave talks about immunology during pregnancy, the role of T cells and current results from cohort studies.

f.l.t.r.: Prof. Dr. Ulrich Sack, Dr. Gunda Herberth, Prof. Ana C. Zenclussen, Prof. Dr. Michael Borte
Photo: privat

We welcome our new project coordinator Susann Hähnel and the new medical doctoral students Elisabeth, Jonas and Lukas in our team!

Congratulations to our colleague Dr. Violeta Stojanovska for being the 3rd winner of the Participants Choice Awards at the Helmholtz Imaging Conference 2022!

https://helmholtz-imaging.de/

The first joint workshop with our Argentinian cooperation partners took place on 11 and 12 July. The participants were able to discuss the progress of the DFG project "Influence of endocrine disruptors on reproductive processes mediated by immune cells of the innate immune system", methods and to-dos. There was also space to plan further joint collaborations. We thank all participants for the exciting and productive exchange!

Back: Tobias Kretschmer, Anne Schumacher, Horacio Rodriguez, Ana Zenclussen, Nicole Meyer, Maria Zenclussen, Florence Fischer
Front: Violeta Stojanovska, Ambra Maddalon, Ningjuan Zhang, Federica Romanelli
Photo: Ana Zenclussen/UFZ

Congratulations to our colleague Dr. Violeta Stojanovska for being the 1st prize European Organoid Research Grant winner!

@biotechne

To what extent do older siblings influence the healthy development of children? Answers from our LiNA study can be found in our latest press release.

Photo: PD Dr. Stefan Fest

Prof. Ana Zenclussen and Dr. Violeta Stojanovska, together with PD Dr. Stefan Fest, took part in the annual conference of the American Society for Reproductive Immunology in Nashville. In addition to presenting their own results on the topic of "Characterization of 3D trophoblast spheroids as a model of placenta functionality", our scientists also had the opportunity to finally exchange ideas in person with colleagues from all over the world.

We congratulate Prof. Ana Zenclussen on her appointment as a member of the BfR Commission on Contaminants in the Food Chain for the session period 2022 to 2025 and wish her every success!

We may present: the Helmholtz portrait of Prof. Ana Zenclussen.

Latest publications

2022

Index:

2023 (3)
2022 (39)

You could use our publication index for further requests.

2023 (3)

Hofsink, N., Dijkstra, D.J., Stojanovska, V., Scherjon, S.A., Plösch, T. (2023):
Preeclampsia-induced alterations in brain and liver gene expression and DNA methylation patterns in fetal mice
J. Dev. Orig. Health Dis. 14 (1), 146 - 151
full text (doi)
Thürmann, L., Klös, M., Mackowiak, S.D., Bieg, M., Bauer, T., Schäuble, S., Faessler, E., Hahn, U., Weichenhan, D., Mücke, O., Plass, C., Borte, M., von Mutius, E., Stangl, G.I., Lauener, R., Karvonen, A.M., Divaret-Chauveau, A., Riedler, J., Heinrich, J., Standl, M., von Berg, A., Schaaf, B., Herberth, G., Kabesch, M., Eils, R., Trump, S., Lehmann, I. (2023):
Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions
Allergy
full text (doi)
Wang, M., Flexeder, C., Kilanowski, A., Kress, S., Herberth, G., Schikowski, T., Peters, A., Standl, M. (2023):
Changes in sleep duration and sleep difficulties from adolescence to young adulthood and the risk of obesity: Bidirectional evidence in the GINIplus and LISA studies
Sleep Med. 101 , 401 - 410
full text (doi)

to index

2022 (39)

Amici, F., Röder, S., Kiess, W., Borte, M., Zenclussen, A.C., Widdig, A., Herberth, G. (2022):
Maternal stress, child behavior and the promotive role of older siblings
BMC Public Health 22 , art. 863
full text (doi)
Bauer, M., Fink, B., Anderegg, U., Röder, S., Zenclussen, A.C. (2022):
IL17F expression as an early sign of oxidative stress-induced cytotoxicity/apoptosis
Genes 13 (10), art. 1739
full text (doi)
Buchenauer, L., Junge, K.M., Haange, S.-B., Simon, J.C., von Bergen, M., Hoh, A.-L., Aust, G., Zenclussen, A.C., Stangl, G.I., Polte, T. (2022):
Glyphosate differentially affects the allergic immune response across generations in mice
Sci. Total Environ. 850 , art. 157973
full text (doi)
Busse, M., Langwisch, S., Tedford, K., Fischer, K.-D., Zenclussen, A.C. (2022):
Maternal B cell signaling orchestrates fetal development in mice
Development 149 (8), dev.199783
full text (doi)
Busse, M., Scharm, M., Oettel, A., Redlich, A., Costa, S.-D., Zenclussen, A.C. (2022):
Enhanced S100B expression in T and B lymphocytes in spontaneous preterm birth and preeclampsia
J. Perinat. Med. 50 (2), 157 - 166
full text (doi)
Busse, M., Zenclussen, A.C. (2022):
IL-10 producing B cells protect against LPS-induced murine preterm birth by promoting PD1- and ICOS-expressing T cells
Cells 11 (17), art. 2690
full text (doi)
Campe, K.-N.J., Redlich, A., Zenclussen, A.C., Busse, M. (2022):
An increased proportion of progesterone receptor A in peripheral B cells from women who ultimately underwent spontaneous preterm birth
J. Reprod. Immunol. 154 , art. 103756
full text (doi)
Fischer, F., Schumacher, A., Meyer, N., Fink, B., Bauer, M., Stojanovska, V., Zenclussen, A.C. (2022):
An old friend with a new face: YB-1 and its role in healthy pregnancy and pregnancy-associated complications
Front. Cell. Dev. Biol. 10 , art. 1039206
full text (doi)
Fraser, R., Zenclussen, A.C. (2022):
Killer timing: The temporal uterine natural killer cell differentiation pathway and implications for female reproductive health
Front. Endocrinol. 13 , art. 904744
full text (doi)
Ganther, M., Lippold, E., Bienert, M.D., Bouffaud, M.-L., Bauer, M., Baumann, L., Bienert, G.P., Vetterlein, D., Heintz-Buschart, A., Tarkka, M.T. (2022):
Plant age and soil texture rather than the presence of root hairs cause differences in maize resource allocation and root gene expression in the field
Plants 11 (21), art. 2883
full text (doi)
Greimel, E., Adams, L., Zsigo, C., Berdel, D., von Berg, A., Koletzko, S., Bauer, C.-P., Schikowski, T., Herberth, G., Heinrich, J., Schulte-Körne, G., Standl, M. (2022):
Psychopathological symptoms as precursors of depressive symptoms in adolescence: a prospective analysis of the GINIplus and LISA birth cohort studies
Soc. Psychiatry Psychiatr. Epidemiol. 57 (8), 1627 - 1639
full text (doi)
Junge, K.M., Buchenauer, L., Strunz, S., Seiwert, B., Thürmann, L., Rolle-Kampczyk, U.E., Röder, S., Borte, M., Kiess, W., von Bergen, M., Simon, J.C., Zenclussen, A.C., Schöneberg, T., Stangl, G.I., Herberth, G., Lehmann, I., Reemtsma, T., Polte, T. (2022):
Effects of exposure to single and multiple parabens on asthma development in an experimental mouse model and a prospective cohort study
Sci. Total Environ. 814 , art. 152676
full text (doi)
Juskiene, I., Prokopciuk, N., Franck, U., Valiulis, A., Valskys, V., Mesceriakova, V., Kvedariene, V., Valiulyte, I., Poluzioroviene, E., Sauliene, I., Valiulis, A. (2022):
Indoor air pollution effects on pediatric asthma are submicron aerosol particle–dependent
Eur. J. Pediatr. 181 (6), 2469 - 2480
full text (doi)
Kempf, E., Landgraf, K., Stein, R., Hanschkow, M., Hilbert, A., Abou Jamra, R., Boczki, P., Herberth, G., Kühnapfel, A., Tseng, Y.-H., Stäubert, C., Schöneberg, T., Kühnen, P., Rayner, N.W., Zeggini, E., Kiess, W., Blüher, M., Körner, A. (2022):
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity
Nat. Metab. 4 , 1697 - 1712
full text (doi)
Kilanowski, A., Thiering, E., Wang, G., Kumar, A., Kress, S., Flexeder, C., Bauer, C.-P., Berdel, D., von Berg, A., Bergström, A., Gappa, M., Heinrich, J., Herberth, G., Koletzko, S., Kull, I., Melen, E., Schikowski, T., Peters, A., Standl, M. (2022):
Allergic disease trajectories up to adolescence: Characteristics, early-life and genetic determinants
Allergy
full text (doi)
Kocatürk, E., Podder, I., Zenclussen, A.C., Kasperska Zajac, A., Elieh-Ali-Komi, D., Church, M.K., Maurer, M. (2022):
Urticaria in pregnancy and lactation
Front. Allergy 3 , art. 892673
full text (doi)
Krause, J.L., Engelmann, B., Nunes da Rocha, U., Pierzchalski, A., Chang, H.D., Zenclussen, A.C., von Bergen, M., Rolle-Kampczyk, U., Herberth, G. (2022):
MAIT cell activation is reduced by direct and microbiota-mediated exposure to bisphenols
Environ. Int. 158 , art. 106985
full text (doi)
Kretschmer, T., Turnwald, E.-M., Janoschek, R., Wohlfarth, M., Handwerk, M., Dötsch, J., Hucklenbruch-Rother, E., Appel, S. (2022):
Treatment of high fat diet‐induced obese pregnant mice with IL‐6 receptor antibody does not ameliorate placental function and fetal growth restriction
Am. J. Reprod. Immunol. 88 (1), e13564
full text (doi)
Lentz, L.S., Stutz, A.J., Meyer, N., Schubert, K., Karkossa, I., von Bergen, M., Zenclussen, A.C., Schumacher, A. (2022):
Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses
Front. Immunol. 13 , art. 989247
full text (doi)
Lokossou, G.A.G., Kouakanou, L., Schumacher, A., Zenclussen, A.C. (2022):
Human breast milk: From food to active immune response with disease protection in infants and mothers
Front. Immunol. 13 , art. 849012
full text (doi)
Marb, A., Libuda, L., Standl, M., Koletzko, S., Bauer, C.-P., Schikowski, T., Berdel, D., von Berg, A., Herberth, G., Bühlmeier, J., Harris, C.P. (2022):
Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies
Eur. J. Clin. Nutr. 76 , 1478 - 1485
full text (doi)
Markevych, I., Astell-Burt, T., Altug, H., Triebner, K., Standl, M., Flexeder, C., Heinrich, J., Schikowski, T., Koletzko, S., Herberth, G., Bauer, C.-P., von Berg, A., Berdel, D., Feng, X. (2022):
Residential green space and age at menarche in German and Australian adolescent girls: A longitudinal study
Int. J. Hyg. Environ. Health. 240 , 113917
full text (doi)
Meijer, M., Klein, M., Caramaschi, D., Mulder, R., Cosin, M., Lu, X., Zhang, Y., Röder, S., Zilich, L., Huels, A., Hartman, C., Snieder, H., Bustamante, M., Herberth, G., Franke, B., Copeland, B., Aberg, K., van den Oord, E. (2022):
Meta-analysis of cell type-sSpecific DNA methylation of childhood attention-deficit/hyperactivity disorder symptoms
Biol. Psychiatry 91 (9 (Suppl.)), S111 - S112
full text (doi)
Musiol, S., Harris, C.P., Karlina, R., Gostner, J.M., Rathkolb, B., Schnautz, B., Schneider, E., Mair, L., Elorduy Vergara, E., Flexeder, C., Koletzko, S., Bauer, C.-P., Schikowski, T., Berdel, D., von Berg, A., Herberth, G., Rozman, J., Hrabe de Angelis, M., Standl, M., Schmidt-Weber, C.B.., Ussar, S., Alessandrini, F. (2022):
Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice
Allergy
full text (doi)
Röder, S., Herberth, G., Zenclussen, A.C., Bauer, M. (2022):
EpiVisR: exploratory data analysis and visualization in epigenome-wide association analyses
BMC Bioinformatics 23 , art. 292
full text (doi)
Romero Perez, R.V., Zarzycka, A., Preussner, M., Fischer, F., Roth, K., Keber, C.U., Suryamohan, K., Raifer, H., Luu, M., Leister, H., Bertrams, W., Klein, M., Shams-Eldin, H., Jacob, R., Mollenkopf, H.-J., Rajalingam, K., Visekruna, A., Steinhoff, U. (2022):
A defined bacterial community restores immunity in germ-free mice via maturation of the intestinal vascular system
Eur. J. Immunol. 52 (S1), 49 - 50
full text (doi)
Romero, R., Zarzycka, A., Preussner, M., Fischer, F., Hain, T., Herrmann, J.-P., Roth, K., Keber, C.U., Suryamohan, K., Raifer, H., Luu, M., Leister, H., Bertrams, W., Klein, M., Shams-Eldin, H., Jacob, R., Mollenkopf, H.-J., Rajalingam, K., Visekruna, A., Steinhoff, U. (2022):
Selected commensals educate the intestinal vascular and immune system for immunocompetence
Microbiome 10 , art. 158
full text (doi)
Sammallahti, S., Koopman‑Verhoeff, M.E., Binter, A.-C., Mulder, R.H., Cabré‑Riera, A., Kvist, T., Malmberg, A.L.K., Pesce, G., Plancoulaine, S., Heiss, J.A., Rifas‐Shiman, S.L., Röder, S.W., Starling, A.P., Wilson, R., Guerlich, K., Haftorn, K.L., Page, C.M., Luik, A.I., Tiemeier, H., Felix, J.F., Raikkonen, K., Lahti, J., Relton, C.L., Sharp, G.C., Waldenberger, M., Grote, V., Heude, B., Annesi‑Maesano, I., Hivert, M.-F., Zenclussen, A.C., Herberth, G., Dabelea, D., Grazuleviciene, R., Vafeiadi, M., Håberg, S.E., London, S.J., Guxens, M., Richmond, R.C., Cecil, C.A.M. (2022):
Longitudinal associations of DNA methylation and sleep in children: a meta‑analysis
Clin. Epigenetics 14 , art. 83
full text (doi)
Schicketanz, J., Röder, S., Herberth, G., Kabisch, S., Lakes, T. (2022):
On foot or by car: what determines children’s active school travel?
Child. Geogr. 20 (2), 174 - 188
full text (doi)
Schmitz, K., Turnwald, E.-M., Kretschmer, T., Janoschek, R., Bae-Gartz, I., Voßbrecher, K., Kammerer, M.D., Köninger, A., Gellhaus, A., Handwerk, M., Wohlfarth, M., Gründemann, D., Hucklenbruch-Rother, E., Dötsch, J., Appel, S. (2022):
Metformin prevents key mechanisms of obesity-related complications in visceral white adipose tissue of obese pregnant mice
Nutrients 14 (11), art. 2288
full text (doi)
Scholz, S., Brack, W., Escher, B.I., Hackermüller, J., Liess, M., von Bergen, M., Wick, L.Y., Zenclussen, A.C., Altenburger, R. (2022):
The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Arch. Toxicol. 96 (8), 2381 - 2386
full text (doi)
Schütte, O., Bachmann, L., Shivappa, N., Hebert, J.R., Felix, J.F., Röder, S.W., Sack, U., Borte, M., Kiess, W., Zenclussen, A.C., Stangl, G.I., Herberth, G., Junge, K.M. (2022):
Pro-inflammatory diet pictured in children with atopic dermatitis or food allergy: nutritional data of the LiNA cohort
Front. Nutr. 9 , art. 868872
full text (doi)
Stojanovska, V., Arnold, S., Bauer, M., Voss, H., Fest, S., Zenclussen, A.C. (2022):
Characterization of three-dimensional trophoblast spheroids: an alternative model to study the physiological properties of the placental unit
Cells 11 (8), art. 2884
full text (doi)
Stojanovska, V., Voss, H., Fest, S., Zenclussen, A.C. (2022):
P45: Characterization of 3D trophoblast spheroids as a model of placenta functionality
Am. J. Reprod. Immunol. 87 (S1), 98 - 99
full text (doi)
Stutz, A., Nishanth, G., Zenclussen, A.C., Schumacher, A. (2022):
Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment
BMC Res. Notes 15 , art. 341
full text (doi)
van Meel, E.R., Mensink-Bout, S.M., den Dekker, H.T., Ahluwalia, T.S., Annesi-Maesano, I., Arshad, S.H., Baïz, N., Barros, H., von Berg, A., Bisgaard, H., Bønnelykke, K., Carlsson, C.J., Casas, M., Chatzi, L., Chevrier, C., Dalmeijer, G., Dezateux, C., Duchen, K., Eggesbø, M., van der Ent, C., Fantini, M., Flexeder, C., Frey, U., Forastiere, F., Gehring, U., Gori, D., Granell, R., Griffiths, L.J., Inskip, H., Jerzynska, J., Karvonen, A.M., Keil, T., Kelleher, C., Kogevinas, M., Koppen, G., Kuehni, C.E., Lambrechts, N., Lau, S., Lehmann, I., Ludvigsson, J., Magnus, M.C., Mélen, E., Mehegan, J., Mommers, M., Nybo Andersen, A.-M., Nystad, W., Pedersen, E.S.L., Pekkanen, J., Peltola, V., Pike, K.C., Pinot de Moira, A., Pizzi, C., Polanska, K., Popovic, M., Porta, D., Roberts, G., Santos, A.C., Schultz, E.S., Standl, M., Sunyer, J., Thijs, C., Toivonen, L., Uphoff, E., Usemann, J., Vafeidi, M., Wright, J., de Jongste, J.C., Jaddoe, V.W.V., Duijts, L. (2022):
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Eur. Resp. J. 60 (4), art. 2102395
full text (doi)
Wang, J., Tischer, C., Standl, M., Weidinger, S., von Berg, A., Herberth, G., Yew, Y.W., Heinrich, J., Schmitt, J., Apfelbacher, C. (2022):
Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15-year follow-up of the LISA cohort study
J. Eur. Acad. Dermatol. Venereol. 36 (4), 547 - 556
full text (doi)
Weißenborn, C., von Lenthe, S., Hinz, N., Langwisch, S., Busse, M., Schumacher, A., Zenclussen, A.C., Fest, S. (2022):
Depletion of Foxp3+ regulatory T cells but not the absence of CD19+IL-10+ regulatory B cells hinders tumor growth in a para-orthotopic neuroblastoma mouse model
Int. J. Cancer 151 (11), 2021 - 2042
full text (doi)
Zhang, N., Schumacher, A., Fink, B., Bauer, M., Zenclussen, A.C., Meyer, N. (2022):
Insights into early-pregnancy mechanisms: Mast cells and chymase CMA1 shape the phenotype and modulate the functionality of human trophoblast cells, vascular smooth-muscle cells and endothelial cells
Cells 11 (7), art. 1158
full text (doi)

to index

Projects

We participate in the joint research project SaxoChiLD.

@SaxoChiLD

We participate in the joint research project
CoViPa.

@CoViPa