The working group BioGeoOmics integrates state-of-the art instrumental and methodological approaches to study dynamic interactions of molecules in the environment. These molecular interactions include natural processes (e.g. metabolism, organic matter diagenesis) as well as anthropogenic interferences (interaction of biological systems with chemicals).
At the core of the the analytical toolkit of the BioGeoOmics-group, we use ultra-high resolution mass spectrometry (FT-ICR MS) and mass spectrometric imaging (MSI) supported by biogeochemical and chemo-informatics methods. We use these tools to explore chemical and biological transformations of organic molecules, their spatial localization in tissues, and to identify metabolites and unknown chemicals and transformation products in complex mixtures.
The methods and concepts are applied to various research fields:
- Ultra-complex mixtures: Natural organic matter characterization and transformation
- Identification of transformation products and their interactions in complex mixtures
- Non-target analysis: Applications of stable isotope metabolomics (NT-SIM) and biogeochemistry (NT-SIB) with use of FT-ICR MS
- MSI of biological systems: Uptake and distribution of chemicals, primary and secondary metabolites in plants and zebrafish model systems
- Single-cell metabolomics/fluxomics
Our lab is equipped with a Bruker SolariX XR 12T FT-ICR MS (with ESI, APPI, APCI and MALDI ion sources) and a Bruker Autoflex Speed MALDI-ToF instrument. We use a UHPLC (Thermo Ultimate 3000 RSLC) and Nano-UHPLC (Thermo RSnLC) with an Advion TriVersa Nanomate nanoESI ion source for chromatographic pre-separation and low flow applications. Furthermore, we have access to the analytical facilities of the Department Analytical Chemistry and ProVIS .
Maria da Silva
Tim Matzeck (Bachelor, Univ Leipzig)
Dr. Julia Raeke