Dr. rer. nat. Oliver Lechtenfeld
Wissenschaftlicher Mitarbeiter
Kontakt / Adresse
Helmholtz-Zentrum für Umweltforschung GmbH - UFZ
Department Analytik
Permoserstr. 15
04318 Leipzig
Gebäude 4.0, Raum 222
Telefon: 0341 235 1020
Fax: 0341 235 451020
ORCiD 0000-0001-5313-6014ResearcherID A-6480-2013
ResearchGateHier gehts zur Homepage der Arbeitsgruppe:
News / Presse
Forschungsschwerpunkte
Meine aktuelle Forschung liegt auf der Anwendung ultrahochauflösender Massenspektrometrie (FT-ICR MS) im umweltwissenschaftlichen, biologischen und biogeochemischen Kontext.
Mein Forschungsschwerpunkt ist der schnelle und hochsensitive Nachweis von Molekülen in komplexen natürlichen Gemischen wie z.B. natürlichem organischen Material (NOM) und biologischen Metaboliten. Neben der analytischen Methodenentwicklung nutze ich auch chemoinformatische Methoden zur Datenauswertung.
Zurzeit arbeite ich an der Entwicklung und Anwendung von Methoden zur Markierung mit stabilen Isotopen. In Kombination mit der hohen Spezifität und Sensitivität der FT-ICR Massenspektrometrie ermöglicht dies molekülspezifische stabile Isotopenanalyse (CSSIA) zum Einsatz in Metabolomik und biogeochemischer Forschung.
Neben der Identifizierung von Molekülen aus komplexen Gemischen ist auch die räumliche Lokalisierung von Molekülen (Chemikalien, biologische Metabolite) in festen Proben, z.B. in Pflanzengeweben oder strukturierten Umweltsystemen wie Böden oder Sedimente ein wichtiger Forschungsschwerpunkt. Hier nutze ich (matrixunterstützte) Laser-Desorptions / Ionisations-Massenspektrometrie-Bildgebung (MALDI-MSI), um laterale Verteilung von Analyten zu untersuchen.
Ich leite die Arbeitsgruppe BioGeoOmics im Department Analytik und koordiniere die Arbeitsgruppe
FT-ICR MS and MALDI-Imaging
im ProVIS Zentrum für chemische Mikroskopie am UFZ.
Aktuelle Projekte
Abgeschlossene Projekte
Curriculum Vitae
| Seit 2018 | Arbeitsgruppenleiter BioGeoOmics |
| Seit 2015 | Wissenschaftlicher Mitarbeiter, Helmholtz Zentrum für Umweltforschung – UFZ, Department Analytik |
| 2013–2015 | PostDoc, Marine Science Program, University of South Carolina (USC) |
| 2008-2012 | Promotion in mariner Biogeochemie an der Universität Bremen / Alfred-Wegener-Institut (AWI), Sektion Ökologische Chemie |
| 2002-2008 | Studium der Chemie an der Universität Ulm mit Schwerpunkt Analytische und Umweltchemie. Diplomarbeit am Alfred-Wegener-Institut (AWI) in mariner Geochemie. |
Publikationen
- Han, L., Lohse, M., Nihemaiti, M., Reemtsma, T., Lechtenfeld, O.J. (2023):
Direct non-target analysis of dissolved organic matter and disinfection by-products in drinking water
with nano-LC-FT-ICR-MS
Environ. Sci.-Wat. Res. Technol.
Volltext (DOI) - Herzsprung, P., Kamjunke, N., Wilske, C., Friese, K., Boehrer, B., Rinke, K., Lechtenfeld, O.J., von Tümpling, W. (2023):
Data evaluation strategy for identification of key molecular formulas in dissolved organic matter as proxies for biogeochemical reactivity based on abundance differences from ultrahigh resolution mass spectrometry
Water Res. 232 , art. 119672
Volltext (DOI) - Jennings, E.K., Sierra Olea, M., Kaesler, J.M., Hübner, U., Reemtsma, T., Lechtenfeld, O.J. (2023):
Stable isotope labeling for detection of ozonation byproducts in effluent organic matter with FT-ICR-MS
Water Res. 229 , art. 119477
Volltext (DOI) - Lohse, M., Santangeli, M., Steininger-Mairinger, T., Oburger, E., Reemtsma, T., Lechtenfeld, O.J., Hann, S. (2023):
The effect of root hairs on exudate composition: a comparative non-targeted metabolomics approach
Anal. Bioanal. Chem. 415 (5), 823 - 840
Volltext (DOI) - Plamper, P., Lechtenfeld, O.J., Herzsprung, P., Groß, A. (2023):
A temporal graph model to predict chemical transformations in complex dissolved organic matter
Environ. Sci. Technol.
Volltext (DOI) - Sierra Olea, M., Kölle, S., Bein, E., Reemtsma, T., Lechtenfeld, O.J., Hübner, U. (2023):
Isotopically labeled ozone: A new approach to elucidate the formation of ozonation products
Water Res. 233 , art. 119740
Volltext (DOI)
- Blaurock, K., Garthen, P., da Silva, M.P., Beudert, B., Gilfedder, B.S., Fleckenstein, J.H., Peiffer, S., Lechtenfeld, O.J., Hopp, L. (2022):
Riparian microtopography affects event-driven stream DOC concentrations and DOM quality in a forested headwater catchment
J. Geophys. Res.-Biogeosci. 127 (12), e2022JG006831
Volltext (DOI) - Butturini, A., Herzsprung, P., Lechtenfeld, O.J., Alcorlo, P., Benaiges-Fernandez, R., Berlanga, M., Boadella, J., Freixinos Campillo, Z., Gomez, R.M., Sanchez-Montoya, M.M., Urmeneta, J., Romaní, A.M. (2022):
Origin, accumulation and fate of dissolved organic matter in an extreme hypersaline shallow lake
Water Res. 221 , art. 118727
Volltext (DOI) - Chen, S., Klotzbücher, T., Lechtenfeld, O.J., Hong, H., Liu, C., Kaiser, K., Mikutta, C., Mikutta, R. (2022):
Legacy effects of sorption determine the formation efficiency of mineral-associated soil organic matter
Environ. Sci. Technol. 56 (3), 2044 - 2053
Volltext (DOI) - Halbach, K., Aulhorn, S., Lechtenfeld, O.J., Lecluse, M., Leippe, S., Reemtsma, T., Seiwert, B., Wagner, S., König, J., Luckenbach, T. (2022):
Zebrafish Oatp1d1 acts as a cellular efflux transporter of the anionic herbicide bromoxynil
Chem. Res. Toxicol. 35 (2), 315 - 325
Volltext (DOI) - Jennings, E., Kremser, A., Han, L., Reemtsma, T., Lechtenfeld, O.J. (2022):
Discovery of polar ozonation byproducts via direct injection of effluent organic matter with online LC-FT-ICR-MS
Environ. Sci. Technol. 56 (3), 1894 - 1904
Volltext (DOI) - Kamjunke, N., Beckers, L.-M., Herzsprung, P., von Tümpling, W., Lechtenfeld, O., Tittel, J., Risse-Buhl, U., Rode, M., Wachholz, A., Kallies, R., Schulze, T., Krauss, M., Brack, W., Comero, S., Gawlik, B.M., Skejo, H., Tavazzi, S., Mariani, G., Borchardt, D., Weitere, M. (2022):
Lagrangian profiles of riverine autotrophy, organic matter transformation, and micropollutants at extreme drought
Sci. Total Environ. 828 , art. 154243
Volltext (DOI) - Pertzborn, D., Arolt, C., Ernst, G., Lechtenfeld, O.J., Kaesler, J., Pelzel, D., Guntinas-Lichius, O., von Eggeling, F., Hoffmann, F. (2022):
Multi-class cancer subtyping in salivary gland carcinomas with MALDI imaging and deep learning
Cancers 14 (17), art. 4342
Volltext (DOI) - Tittel, J., Büttner, O., Friese, K., Lechtenfeld, O.J., Schuth, S., von Tümpling, W., Musolff, A. (2022):
Iron exports from catchments are constrained by redox status and topography
Glob. Biogeochem. Cycles 36 (1), e2021GB007056
Volltext (DOI) - Zherebker, A., Rukhovich, G.D., Sarycheva, A., Lechtenfeld, O.J., Nikolaev, E.N. (2022):
Aromaticity index with improved estimation of carboxyl group contribution for biogeochemical studies
Environ. Sci. Technol. 56 (4), 2729 - 2737
Volltext (DOI)
- da Silva, M.P., Blaurock, K., Beudert, B., Fleckenstein, J.H., Hopp, L., Peiffer, S., Reemtsma, T., Lechtenfeld, O.J. (2021):
Delineating source contributions to stream dissolved organic matter composition under baseflow conditions in forested headwater catchments
J. Geophys. Res.-Biogeosci. 126 (8), e2021JG006425
Volltext (DOI) - Fazia, S., Amalfitano, S., Venturi, S., Pacini, N., Vazquez, S., Olaka, L.A., Tassi, F., Crognale, S., Herzsprung, P., Lechtenfeld, O.J., Cabassi, J., Capecchiacci, F., Rossetti, S., Yakimov, M.M., Vaselli, O., Harper, D.M., Butturini, A. (2021):
High concentrations of dissolved biogenic methane associated with cyanobacterial blooms in East African lake surface water
Commun. Biol. 4 , art. 845
Volltext (DOI) - Giannopoulos, K., Benettoni, P., Holbrook, T.R., Reemtsma, T., Wagner, S., Lechtenfeld, O.J. (2021):
Direct analysis of fulvic acids adsorbed onto capped gold nanoparticles by laser desorption ionization Fourier-transform ion cyclotron resonance mass spectrometry
Environ. Sci.-Nano 8 (8), 2336 - 2346
Volltext (DOI) - Han, L., Kaesler, J., Peng, C., Reemtsma, T., Lechtenfeld, O.J. (2021):
Online counter gradient LC-FT-ICR-MS enables detection of highly polar natural organic matter fractions
Anal. Chem. 93 (3), 1740 - 1748
Volltext (DOI) - Hensgens, G., Lechtenfeld, O.J., Guillemette, F., Laudon, H., Berggren, M. (2021):
Impacts of litter decay on organic leachate composition and reactivity
Biogeochemistry 154 , 99 - 117
Volltext (DOI) - Herzsprung, P., Kamjunke, N., von Tümpling, W., Wilske, C., Reemtsma, T., Lechtenfeld, O.J. (2021):
Judgement and assessment of high resolution mass spectrometry investigations of DOM – Examples for identification of biogeochemical processes in waters
Vom Wasser 119 (2), 47 - 51
Volltext (DOI) - Lohse, M., Haag, R., Lippold, E., Vetterlein, D., Reemtsma, T., Lechtenfeld, O.J. (2021):
Direct imaging of plant metabolites in the rhizosphere using laser desorption ionization ultra-high resolution mass spectrometry
Front. Plant Sci. 12 , art. 753812
Volltext (DOI) - Muniz, M.S., Halbach, K., Araruna, I.C.A., Martins, R.X., Seiwert, B., Lechtenfeld, O., Reemtsma, T., Farias, D. (2021):
Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses
Environ. Pollut. 283 , art. 117096
Volltext (DOI) - Rummel, C.D., Lechtenfeld, O.J., Kallies, R., Benke, A., Herzsprung, P., Rynek, R., Wagner, S., Potthoff, A., Jahnke, A., Schmitt-Jansen, M. (2021):
Conditioning film and early biofilm succession on plastic surfaces
Environ. Sci. Technol. 55 (16), 11006 - 11018
Volltext (DOI) - Sartori Jeunon Gontijo, E., Herzsprung, P., Lechtenfeld, O.J., de Castro Bueno, C., Barth, J.A.C., Rosa, A.H., Friese, K. (2021):
Multi-proxy approach involving ultrahigh resolution mass spectrometry and self-organising maps to investigate the origin and quality of sedimentary organic matter across a subtropical reservoir
Org. Geochem. 151 , art. 104165
Volltext (DOI) - Werner, B.J., Lechtenfeld, O.J., Musolff, A., de Rooij, G.H., Yang, J., Gründling, R., Werban, U., Fleckenstein, J.H. (2021):
Small-scale topography explains patterns and dynamics of dissolved organic carbon exports from the riparian zone of a temperate, forested catchment
Hydrol. Earth Syst. Sci. 25 (12), 6067 - 6086
Volltext (DOI) - Wilske, C., Herzsprung, P., Lechtenfeld, O.J., Kamjunke, N., Einax, J.W., von Tümpling, W. (2021):
New insights into the seasonal variation of DOM quality of a humic-rich drinking-water reservoir—coupling 2D-fluorescence and FTICR MS measurements
Water 13 (12), art. 1703
Volltext (DOI)
- Butturini, A., Amalfitano, S., Herzsprung, P., Lechtenfeld, O.J., Venturi, S., Olaka, L.A., Pacini, N., Harper, D.M., Tassi, F., Fazi, S. (2020):
Dissolved organic matter in continental hydro-geothermal systems: Insights from two hot springs of the East African Rift Valley
Water 12 (12), art. 3512
Volltext (DOI) - Butturini, A., Herzsprung, P., Lechtenfeld, O.J., Venturi, S., Amalfitano, S., Vazquez, E., Pacini, N., Harper, D.M., Tassi, F., Fazi, S. (2020):
Dissolved organic matter in a tropical saline-alkaline lake of the East African Rift Valley
Water Res. 173 , art. 115532
Volltext (DOI) - da Silva, M.P., Kaesler, J.M., Reemtsma, T., Lechtenfeld, O.J. (2020):
Absorption mode spectral processing improves data quality of natural organic matter analysis by Fourier-transform ion cyclotron resonance mass spectrometry
J. Am. Soc. Mass Spectrom. 31 (7), 1615 - 1618
Volltext (DOI) - Giannopoulos, K., Lechtenfeld, O.J., Holbrook, T.R., Reemtsma, T., Wagner, S. (2020):
Exploring the potential of laser desorption ionization time-of-flight mass spectrometry to analyse organic capping agents on inorganic nanoparticle surfaces
Anal. Bioanal. Chem. 412 (22), 5261 - 5271
Volltext (DOI) - Herzsprung, P., Wentzky, V.C., Kamjunke, N., von Tümpling, W., Wilske, C., Friese, K., Boehrer, B., Reemtsma, T., Rinke, K., Lechtenfeld, O.J. (2020):
Improved understanding of dissolved organic matter processing in freshwater using complementary experimental and machine learning approaches
Environ. Sci. Technol. 54 (21), 13556 - 13565
Volltext (DOI) - Kamjunke, N., Lechtenfeld, O.J., Herzsprung, P. (2020):
Quality of dissolved organic matter driven by autotrophic and heterotrophic microbial processes in a large river
Water 12 (6), art. 1577
Volltext (DOI) - Lohse, M., Blaser, S.R.G.A., Vetterlein, D., Schlüter, S., Oburger, E., Reemtsma, T., Lechtenfeld, O.J. (2020):
Online nano solid phase extraction Fourier-transform ion cyclotron resonance mass spectrometry workflow to analyze small scale gradients of soil solution organic matter in the rhizosphere
Anal. Chem. 92 (15), 10442 - 10449
Volltext (DOI) - Lohse, M., Dusny, C., Kaesler, J., Lechtenfeld, O.J. (2020):
MRMS powered single cell metabolomics – Quantification of picogram amounts of a biocatalytic product from few living cells
Bruker Application Note 05-2020, MRMS-70, 1877441
Bruker Daltonics, 6 pp.
Volltext (DOI) - Tayyebi Sabet Khomami, N., Philippe, A., Abu Quba, A.A., Lechtenfeld, O.J., Guigner, J.-M., Heissler, S., Schaumann, G.E. (2020):
Validation of a field deployable reactor for in situ formation of NOM-engineered nanoparticle corona
Environ. Sci.-Nano 7 (2), 486 - 500
Volltext (DOI) - Wilske, C., Herzsprung, P., Lechtenfeld, O.J., Kamjunke, N., von Tümpling, W. (2020):
Photochemically induced changes of dissolved organic matter in a humic‐rich and forested stream
Water 12 , art. 331
Volltext (DOI) - Zherebker, A., Kim, S., Schmitt-Kopplin, P., Spencer, R.G.M., Lechtenfeld, O.J., Podgorski, D.C., Hertkorn, N., Harir, M., Nurfajin, N., Koch, B., Nikolaev, E.N., Shirshin, E.A., Berezin, S.A., Kats, D.S., Rukhovich, G.D., Perminova, I.V. (2020):
Interlaboratory comparison of humic substances compositional space as measured by Fourier transform ion cyclotron resonance mass spectrometry (IUPAC Technical Report)
Pure Appl. Chem. 92 (9), 1447 - 1467
Volltext (DOI) - Zherebker, A., Lechtenfeld, O.J., Sarycheva, A., Kostyukevich, Y., Kharybin, O., Fedoros, E.I., Nikolaev, E.N. (2020):
Refinement of compound aromaticity in complex organic mixtures by stable isotope label assisted ultrahigh-resolution mass spectrometry
Anal. Chem. 92 (13), 9032 - 9038
Volltext (DOI)
- Chen, S.-C., Musat, N., Lechtenfeld, O.J., Paschke, H., Schmidt, M., Said, N., Popp, D., Calabrese, F., Stryhanyuk, H., Jaekel, U., Zhu, Y.-G., Joye, S.B., Richnow, H.-H., Widdel, F., Musat, F. (2019):
Anaerobic oxidation of ethane by archaea from a marine hydrocarbon seep
Nature 568 (7750), 108 - 111
Volltext (DOI) - Dusny, C., Lohse, M., Reemtsma, T., Schmid, A., Lechtenfeld, O.J. (2019):
Quantifying a biocatalytic product from a few living microbial cells using microfluidic cultivation coupled to FT-ICR-MS
Anal. Chem. 91 (11), 7012 - 7018
Volltext (DOI) - Lian, S., Wu, L., Nikolausz, M., Lechtenfeld, O.J., Richnow, H.H. (2019):
2H and 13C isotope fractionation analysis of organophosphorus compounds for characterizing transformation reactions in biogas slurry: Potential for anaerobic treatment of contaminated biomass
Water Res. 163 , art. 114882
Volltext (DOI) - Spranger, T., van Pinxteren, D., Reemtsma, T., Lechtenfeld, O.J., Herrmann, H. (2019):
2D liquid chromatographic fractionation with ultra-high resolution MS analysis resolves a vast molecular diversity of tropospheric particle organics
Environ. Sci. Technol. 53 (19), 11353 - 11363
Volltext (DOI) - Vernet, M., Geibert, W., Hoppema, M., Brown, P.J., Haas, C., Hellmer, H.H., Jokat, W., Jullion, L., Mazloff, M., Bakker, D.C.E., Brearley, J.A., Croot, P., Hattermann, T., Hauck, J., Hillenbrand, C.-D., Hoppe, C.J.M., Huhn, O., Koch, B.P., Lechtenfeld, O.J., Meredith, M.P., Naveira Garabato, A.C., Nöthig, E.-M., Peeken, I., Rutgers van der Loeff, M.M., Schmidtko, S., Schröder, M., Strass, V.H., Torres-Valdés, S., Verdy, A. (2019):
The Weddell Gyre, Southern Ocean: present knowledge and future challenges
Rev. Geophys. 57 (3), 623 - 708
Volltext (DOI) - Werner, B.J., Musolff, A., Lechtenfeld, O.J., de Rooij, G.H., Oosterwoud, M.R., Fleckenstein, J.H. (2019):
High-frequency measurements explain quantity and quality of dissolved organic carbon mobilization in a headwater catchment
Biogeosciences 16 , 4497 - 4516
Volltext (DOI)
- Bercovici, S.K., Koch, B.P., Lechtenfeld, O.J., McCallister, S.L., Schmitt-Kopplin, P., Hansell, D.A. (2018):
Aging and molecular changes of dissolved organic matter between two deep oceanic end-members
Glob. Biogeochem. Cycles 32 (10), 1449 - 1456
Volltext (DOI) - Schlitzer, R., Anderson, R.F., Dodas, E.M., Lohan, M., Geibert, W., Tagliabue, A., Bowie, A., Jeandel, C., Maldonado, M.T., Landing, W.M., Cockwell, D., Abadie, C., Abouchami, W., Achterberg, E.P., Agather, A., Aguliar-Islas, A., van Aken, H.M., Andersen, M., Archer, C., Lechtenfeld, O.J., Auro, M., et al. (2018):
The GEOTRACES Intermediate Data Product 2017
Chem. Geol. 493 , 210 - 223
Volltext (DOI) - Wu, L., Chládková, B., Lechtenfeld, O.J., Lian, S., Schindelka, J., Herrmann, H., Richnow, H.H. (2018):
Characterizing chemical transformation of organophosphorus compounds by 13C and 2H stable isotope analysis
Sci. Total Environ. 615 , 20 - 28
Volltext (DOI) - Wünsch, U.J., Geuer, J.K., Lechtenfeld, O.J., Koch, B.P., Murphy, K.R., Stedmon, C.A. (2018):
Quantifying the impact of solid-phase extraction on chromophoric dissolved organic matter composition
Mar. Chem. 207 , 33 - 41
Volltext (DOI)
- Koch, B.P., Ksionzek, K.B., Lechtenfeld, O.J., McCallister, S.L., Schmitt-Kopplin, P., Geuer, J.K., Geibert, W. (2017):
Response to comment on "Dissolved organic sulfur in the ocean: Biogeochemistry of a petagram inventory"
Science 356 (6340), 813 - 813
Volltext (DOI) - Raeke, J., Lechtenfeld, O.J., Seiwert, B., Meier, T., Riemenschneider, C., Reemtsma, T. (2017):
Photochemically induced bound residue formation of carbamazepine with dissolved organic matter
Environ. Sci. Technol. 51 (10), 5523 - 5530
Volltext (DOI) - Raeke, J., Lechtenfeld, O.J., Tittel, J., Oosterwoud, M.R., Bornmann, K., Reemtsma, T. (2017):
Linking the mobilization of dissolved organic matter in catchments and its removal in drinking water treatment to its molecular characteristics
Water Res. 113 , 149 - 159
Volltext (DOI)
- Ksionzek, K.B., Lechtenfeld, O.J., McCallister, S.L., Schmitt-Kopplin, P., Geuer, J.K., Geibert, W., Koch, B.P. (2016):
Dissolved organic sulfur in the ocean: Biogeochemistry of a petagram inventory
Science 354 (6311), 456 - 459
Volltext (DOI) - Laso-Pérez, R., Wegener, G., Knittel, K., Widdel, F., Harding, K.J., Krukenberg, V., Meier, D.V., Richter, M., Tegetmeyer, H.E., Riedel, D., Richnow, H.-H., Adrian, L., Reemtsma, T., Lechtenfeld, O.J., Musat, F. (2016):
Thermophilic archaea activate butane via alkyl-coenzyme M formation
Nature 539 (7629), 396 - 401
Volltext (DOI) - Raeke, J., Lechtenfeld, O.J., Wagner, M., Herzsprung, P., Reemtsma, T. (2016):
Selectivity of solid phase extraction of freshwater dissolved organic matter and its effect on ultrahigh resolution mass spectra
Environ. Sci.-Proc. Imp. 18 (7), 918 - 927
Volltext (DOI)
- Lechtenfeld, O.J., Hertkorn, N., Shen, Y., Witt, M., Benner, R. (2015):
Marine sequestration of carbon in bacterial metabolites
Nat. Commun. 6 , art. 6711
Volltext (DOI)