Research for the Environment

Dr. Ulrike E. Rolle-Kampczyk

Contact/Adress

Dr. rer. nat. Ulrike E. Rolle-Kampczyk


Scientist, 
Specialist for Toxicology
Specialist for Analytic and Spectroscopy 


Department Metabolomics
Helmholtz-Centre for Environmental Research - UFZ
Permoserstr. 15
04318 Leipzig, Germany

Tel: ++49 341 235 1537
Fax: ++49 341 235 451537
ulrike.rolle-kampczyk@ufz.de

Portrait

Picture: André Künzelmann

CV

2009-

Scientist, Department Metabolomics, Helmholtz-Centre for Environmental Research, UFZ, Leipzig, Germany
Field: „Investigation of associations between life style factors on the elimination of pollutant metabolites and changes of metabolom on health"

1996 - 2009

Scientist, Department Human Exposure Research and Epidemiology, Helmholtz-Centre for Environmental Research, UFZ, Leipzig, Germany

Field: „Internal burden and differential diagnostics for application in environmental medicine“

1993-1995

Postdoc, Department Human Exposure Research and Epidemiology, Helmholtz-Centre for Environmental Research, UFZ, Leipzig, Germany

Field: „Development and test of 15N diagnostics zur Untersuchung of disturbancies of enterohepatic circle in humans“
Co work in epidemiological studies ander application of stable isotope based organ functional tests

1991-1992

Postdoc, Faculty of Physics, University Leipzig, Germany

Field: “PFG-NMR measurements on silica gels“

1988-1991

Postgraduate study for VEB Pharmaceutical factory Dresden, PhD (Dr. rer. nat.) Faculty of Chemistry, University Leipzig, Germany

Field: “Synthessis of substituted 9-Azabicyclononanes”

1988

Diploma Faculty of Chemistry, University Leipzig, Germany

Field: "Synthesis of 5-Acylamino-2-arylureido- und 2,5-Diacylaminophenoles and investigation of their blue-green indoaniline dye stuffs"

Research topics

Biomonitoring and metabolomic markers

Cooperations / Projects

 

Department Proteomik, UFZ
Department Umweltimmunology, UFZ, Germany
UFZ Group for Core Facility und Studies, UFZ, Germany 
University Leipzig, Medical Faculty, Germany
Hospital St. Georg Leipzig, Children´s Hospital, Germany
Helmholtz Centre Munich, Institute for Epidemiology, Germany
University of Toronto, Faculty of Medicine, Canada
University Bern, Department Clinical for Research, Switzerland

Publications

 • Markle, J.G.M., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L. M. , Rolle-Kampczyk, U., von Bergen, M., McCoy, C.D., Macpherson, A.J., Danska, J.S., (2013):
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Science 339 (6123 ), 1084 - 1088

• Baumann, S., Kalkhof, S., Hackermüller, J., Otto, W., Tomm, J.M., Wissenbach, D.K., Rolle-Kampczyk, U., von Bergen, M. (2013): Requirements and perspectives for integrating metabolomics with other omics data
Current Metabolomics 1 (1), 15 - 27

• Weisse, K., Winkler, S., Stangl, G.I., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Röder, S., Rolle-Kampczyk, U., von Bergen-Tomm, M., Olek, S., Sack, U., Borte, M., Richter, T., Lehmann, I. (2012):
Maternal and newborn vitamin D status and its impact on fetal regulatory T cell development and children's atopy risk in the German LINA cohort study
J. Reprod. Immunol. 94 (1), 53 - 54

• Bauer, S., Krumbiegel, P., Richter, M., Richter, T., Röder, S., Rolle-Kampczyk, U., Herbarth, P. (2011): Influence of sociodemographic factors on Helicobacter pylori prevalence variability among schoolchildren in Leipzig, Germany. A long-term follow-up study Cent.Eur.J.Public Health 19 (1), 42 – 45, http://www.ncbi.nlm.nih.gov/pubmed/21526656

• Oberbach, A., Bluher, M., Wirth, H., Till, H., Kovacs, P., Kullnick, Y., Schlichting, N., Tomm, J.M., Rolle-Kampczyk, U., Murugaiyan, J., Binder, H., Dietrich, A., von Bergen, M. (2011): Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes J.Proteome Res. 10 (10), 4769 – 4788 http://dx.doi.org/10.1021/pr2005555

• Strebel, K., Rolle-Kampczyk, U., Richter, M., Kindler, A., Richter, T., Schlink, U. (2010): A rigorous small area modelling-study for the helicobacter pylori epidemiology. Sci.Total Environ. 408 (18), 3931 - 3942, http://dx.doi.org/10.1016/j.scitotenv.2010.03.045

• Rolle-Kampczyk, UE, von Bergen, M:
12years of metabolite screening in epidemiological studies at UFZ in Leipzig.
Clinical Chemistry and Laboratory Medicine. 2009, 9, A10

• Herbarth O, Bauer M, Fritz GJ, Herbarth P, Rolle-Kampczyk U, Krumbiegel P, Richter M, Richter T:
Helicobacter pylori colonisation and eczema. J Epidemiol Community Health. 2007 Jul;61(7):638-40

• Rolle-Kampczyk U, Rehwagen, M, Franck, U, Weiß, H, Krumbiegel, P, Herbarth, O.:
Bioeffect monitoring with [15N]methacetin as diagnostic tool to control remediation success in a formerly high loaded industrial area. Toxicology letter 162 (2-3) (2006) 234-238.

• Roeder S, Rolle-Kampzcyk U, Herbarth O (2006):
Visualization of Depending Patterns in Metabonomics I. King et al. (Eds.): ICONIP 2006, Part III, Lecture Notes in Computer Science 4234, pp. 278 - 284, 2006.

• Roeder SW, Rolle-Kampczyk U, Herbarth, O:
Pattern Recognition in Metabonomics Using Self Organizing Maps. In: Japan Advanced Institute of Science and Technology (Ed.): Proceedings of the Second International Symposium on Knowledge Management for Strategic Creation of Technology. Kobe JP, (2005) 208-214.

• Rolle-Kampczyk U, Rehwagen M,, Diez, U, Borte, M, Richter, M, Herbarth, O.:
Biomonitoring in environmental medicine- results of LARS, Environmental Health Risk III, 2005, 41-50, WIT press, ISSN 1747-4485

• Herbarth, O., Bauer, M., Franck, U., Krumbiegel, P., Rehwagen, M., Rolle-Kampczyk, U., Weiß, H. (2005): Effect of remediation measures on exposure and liver detoxification capacity of children; In: Aral, M. M., Brebbia, C. A., Maslia, M. L., Sinks, T. (Hrsg.): Environmental exposure and health, The sustainable world 14, WIT press, Southampton, S. 429-437.

Publications

2013 (5)

  • Baumann, S., Kalkhof, S., Hackermüller, J., Otto, W., Tomm, J.M., Wissenbach, D.K., Rolle-Kampczyk, U., von Bergen, M., (2013):
    Requirements and perspectives for integrating metabolomics with other omics data
    Current Metabolomics 1 (1), 15 - 27
  • Holdt, L.M., von Delft, A., Nicolaou, A., Baumann, S., Kostrzewa, M., Thiery, J., Teupser, D., (2013):
    Quantitative trait loci mapping of the mouse plasma proteome (pQTL)
    Genetics 193 (2), 601 - 608
    full text (url)
  • Markle, J.G.M., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L. M. , Rolle-Kampczyk, U., von Bergen, M., McCoy, C.D., Macpherson, A.J., Danska, J.S., (2013):
    Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
    Science 339 (6123 ), 1084 - 1088
    full text (url)
  • Murugaiyan, J., Rockstroh, M., Wagner, J., Baumann, S., Schorsch, K., Trump, S., Lehmann, I., von Bergen, M., Tomm, J.M., (2013):
    Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism
    Toxicol. Appl. Pharmacol. 269 (3), 307 - 316
    full text (url)
  • Weisse, K., Winkler, S., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Roeder, S., Rolle-Kampczyk, U., von Bergen, M., Olek, S., Richter, T., Diez, U., Borte, M., Stangl, G.I., Lehmann, I., (2013):
    Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study
    Allergy 68 (2), 220 - 228
    full text (url)

2012 (3)

  • Kermer, R., Hedrich, S., Taubert, M., Baumann, S., Schlömann, M., Johnson, D.B., Seifert, J., (2012):
    Elucidation of carbon transfer in a mixed culture of Acidiphilium cryptum and Acidithiobacillus ferrooxidans using protein-based stable isotope probing
    Journal of Integrated OMICS 2 (1), 37 - 45
    full text (url)
  • Peters, F.T., Wissenbach, D.K., (2012):
    Systematic toxicological analysis using liquid chromatography-mass spectrometry: techniques and inter-instrument reproducibility of mass spectra/Systematisch-toxikologische Analyse mittels Hochleistungsflüssigchromatographie-Massenspektrometrie: Techniken und Reproduzierbarkeit von Massenspektren zwischen Instrumenten
    LaboratoriumsMedizin 36 (2), 89 - 97
    full text (url)
  • Weisse, K., Winkler, S., Stangl, G.I., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Röder, S., Rolle-Kampczyk, U., von Bergen-Tomm, M., Olek, S., Sack, U., Borte, M., Richter, T., Lehmann, I., (2012):
    Maternal and newborn vitamin D status and its impact on fetal regulatory T cell development and children's atopy risk in the German LINA cohort study
    J. Reprod. Immunol. 94 (1), 53 - 54
    full text (url)

2011 (7)

  • Bauer, S., Krumbiegel, P., Richter, M., Richter, T., Röder, S., Rolle-Kampczyk, U., Herbarth, P., (2011):
    Influence of sociodemographic factors on Helicobacter pylori prevalence variability among schoolchildren in Leipzig, Germany. A long-term follow-up study
    Cent.Eur.J.Public Health 19 (1), 42 - 45
    full text (url)
  • Kuntze, K., Kiefer, P., Baumann, S., Seifert, J., von Bergen, M., Vorholt, J.A., Boll, M., (2011):
    Enzymes involved in the anaerobic degradation of meta-substituted halobenzoates
    Mol. Microbiol. 82 (3), 758 - 769
    full text (url)
  • Mögel, I., Baumann, S., Böhme, A., Kohajda, T., von Bergen, M., Simon, J.-C., Lehmann, I., (2011):
    The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation
    Toxicology 289 (1), 28 - 37
    full text (url)
  • Oberbach, A., Bluher, M., Wirth, H., Till, H., Kovacs, P., Kullnick, Y., Schlichting, N., Tomm, J.M., Rolle-Kampczyk, U., Murugaiyan, J., Binder, H., Dietrich, A., von Bergen, M., (2011):
    Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes
    J. Proteome Res. 10 (10), 4769 - 4788
    full text (url)
  • Taubert, M., Baumann, S., von Bergen, M., Seifert, J., (2011):
    Exploring the limits of robust detection of incorporation of 13C by mass spectrometry in protein-based stable isotope probing (protein-SIP)
    Anal. Bioanal. Chem. 401 (6), 1975 - 1982
    full text (url)
  • Thiel, U.J., Feltens, R., Adryan, B., Gieringer, R., Brochhausen, C., Schuon, R., Fillies, T., Grus, F., Mann, W.J., Brieger, J., (2011):
    Analysis of differentially expressed proteins in oral squamous cell carcinoma by MALDI-TOF MS
    J. Oral Pathol. Med. 40 (5), 369 - 379
    full text (url)
  • Weisse, K., Lehmann, I., Herberth, G., Kohajda, T., Roeder, S., Borte, M., Heroux, A., Denburg, J., (2011):
    Circulating eosinophil/basophil (Eo/B) progenitors at one year of age positively correlate with atopic eczema and indoor chemical exposure in the LINA Study
    J. Allergy Clin. Immunol. 127 (2), AB146 - AB146
    full text (url)

2010 (7)

  • Feltens, R., Mögel, I., Röder-Stolinski, C., Simon, J.-C., Herberth, G., Lehmann, I., (2010):
    Chlorobenzene induces oxidative stress in human lung epithelial cells in vitro
    Toxicol. Appl. Pharmacol. 242 (1), 100 - 108
    full text (url)
  • Müller, S.A., Kohajda, T., Findeiß, S., Stadler, P.F., Washietl, S., Kellis, M., von Bergen, M., Kalkhof, S., (2010):
    Optimization of parameters for coverage of low molecular weight proteins
    Anal. Bioanal. Chem. 398 (7-8), 2867 - 2881
    full text (url)
  • Rzehak, P., Scherag, A., Grallert, H., Sausenthaler, S., Koletzko, S., Bauer, C.P., Schaaf, B., von Berg, A., Berdel, D., Borte, M., Herbarth, O., Krämer, U., Illig, T., Wichmann, H.E., Hebebrand, J., Heinrich, J., Schoetzau, A., Popescu, M., Mosetter, M., Schindler, J., Franke, K., Laubereau, B., Thaqi, A., Zirngibl, A., Zutavern, A., Filipiak, B., Gehring, U., Albrecht, B., Baumgart, A., Bollrath, C., Büttner, S., Diekamp, S., Gross, I., Jakob, T., Klemke, K.K., Kurpiun, K.S., Möllermann, M., Neusüss, J., Varhelyi, A., Zorn, C., Reinhard, D., Weigand, H., Antonie, I., Bäumler-Merl, B., Tasch, C., Göhlert, R., Sönnichsen, C., Grübl, A., Bartels, P., Brockow, I., Hoffmann, U., Lötzbeyer, F., Mayrl, R., Negele, K., Schill, E.M., Wolf, B., Link, E., Sugiri, D., Ranft, U., Bolte, G., Belcredi, P., Jacob, B., Schoetznau, A., Höhnke, A., Schulz, R., Sierig, G., Mirow, K., Gebauer, C., Schulze, B., Hainich, J., Sack, U., Emmrich, F., Scholten, C., Diez, U., Rehwagen, M., Schlink, U., Franck, U., Jorks, A., Röder, S., Lehmann, I., Herberth, G., Daegelmann, C., Weiss, M., Albert, M., Fahlbusch, B., Bischof, W., Koch, A., Schins, R., Ring, J., Grosch, J., Weidinger, S., (2010):
    Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years
    Obes. Facts 3 (3), 173 - 180
    full text (url)
  • Schlink, U., Thiem, A., Kohajda, T., Richter, M., Strebel, K., (2010):
    Quantile regression of indoor air concentrations of volatile organic compounds (VOC)
    Sci. Total Environ. 408 (18), 3840 - 3851
    full text (url)
  • Selesi, D., Jehmlich, N., von Bergen, M., Schmidt, F., Rattei, T., Tischler, P., Lueders, T., Meckenstock, R.U., (2010):
    Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the dulfate-reducing enrichment culture N47
    J. Bacteriol. 192 (1), 295 - 306
    full text (url)
  • Sträuber, H., Hübschmann, T., Jehmlich, N., Schmidt, F., von Bergen, M., Harms, H., Müller, S., (2010):
    NBDT (3-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-3-toluene) - A novel fluorescent dye for studying mechanisms of toluene uptake into vital bacteria
    Cytom. Part A 77A (2), 113 - 120
    full text (url)
  • Strebel, K., Rolle-Kampczyk, U., Richter, M., Kindler, A., Richter, T., Schlink, U., (2010):
    A rigorous small area modelling-study for the helicobacter pylori epidemiology
    Sci. Total Environ. 408 (18), 3931 - 3942
    full text (url)

2009 (12)

  • Benndorf, D., Vogt, C., Jehmlich, N., Schmidt, Y., Thomas, H., Woffendin, G., Shevchenko, A., Richnow, H.H., von Bergen, M., (2009):
    Improving protein extraction and separation methods for investigating the metaproteome of anaerobic benzene communities within sediments
    Biodegradation 20 (6), 737 - 750
    full text (url)
  • Bruegel, M., Planert, M., Baumann, S., Focke, A., Bergh, F.T., Leichtle, A., Ceglarek, U., Thiery, J., Fiedler, G.M., (2009):
    Standardized peptidome profiling of human cerebrospinal fluid by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    J. Proteomics 72 (4), 608 - 615
    full text (url)
  • Fiedler, G.M., Leichtle, A.B., Kase, J., Baumann, S., Ceglarek, U., Felix, K., Conrad, T., Witzigmann, H., Weimann, A., Schütte, C., Hauss, J., Büchler, M., Thiery, J., (2009):
    Serum peptidome profiling revealed platelet factor 4 as a potential discriminating peptide associated with pancreatic cancer
    Clin. Cancer Res. 15 (11), 3812 - 3819
    full text (url)
  • Heine, F., Stahl, F., Sträuber, H., Wiacek, C., Benndorf, D., Repenning, C., Schmidt, F., Scheper, T., von Bergen, M., Harms, H., Müller, S., (2009):
    Prediction of flocculation ability of brewing yeast inoculates by flow cytometry, proteome analysis, and mRNA profiling
    Cytom. Part A 75A (2), 140 - 147
    full text (url)
  • Jehmlich, N., Schmidt, F., Taubert, M., Seifert, J., von Bergen, M., Richnow, H.H., Vogt, C., (2009):
    Comparison of methods for simultaneous identification of bacterial species and determination of metabolic activity by protein-based stable isotope probing (Protein-SIP) experiments
    Rapid Commun. Mass Spectrom. 23 (12), 1871 - 1878
    full text (url)
  • Matysik, S., Matysik, F.M., (2009):
    Microextraction by packed sorbent coupled with gas chromatography-mass spectrometry: application to the determination of metabolites of monoterpenes in small volumes of human urine
    Microchim. Acta 166 (1-2), 109 - 114
    full text (url)
  • Mörbt, N., Mögel, I., Kalkhof, S., Feltens, R., Röder-Stolinski, C., Zheng, J., Vogt, C., Lehmann, I., von Bergen, M., (2009):
    Proteome changes in human bronchoalveolar cells following styrene exposure indicate involvement of oxidative stress in the molecular-response mechanism
    Proteomics 9 (21), 4909 - 4933
    full text (url)
  • Rehders, D., Classen, B., Redecke, L., Buschke, A., Reibe, C., Jehmlich, N., von Bergen, M., Betzel, A., Meyer, B., (2009):
    Peptide NMHRYPNQ of the Cellular Prion Protein (PrPC) Inhibits Aggregation and Is a Potential Key for Understanding Prion-Prion Interactions
    J. Mol. Biol. 392 (1), 198 - 207
    full text (url)
  • Risch, M., Georgieva, D., von Bergen, M., Jehmlich, N., Genov, N., Arni, R.K., Betzel, C., (2009):
    Snake venomics of the Siamese Russell's viper (Daboia russelli siamensis) - Relation to pharmacological activities
    J. Proteomics 72 (2), 256 - 269
    full text (url)
  • Seifert, J., Jehmlich, N., Schmidt, F., Taubert, M., von Bergen, M., Richnow, H.H., Vogt, C., (2009):
    Protein-stable isotope probing (Protein-SIP) for simultaneous identification of bacterial species and determination of metabolic activity
    Geochim. Cosmochim. Acta 73 (Suppl. 13), A1191 - A1191
    full text (url)
  • von Bergen, M., Eidner, A., Schmidt, F., Murugaiyan, J., Wirth, H., Binder, H., Maier, T., Roesler, U., (2009):
    Identification of harmless and pathogenic algae of the genus Prototheca by MALDI-MS
    Proteom. Clin. Appl. 3 (7), 774 - 787
    full text (url)
  • Wischgoll, S., Taubert, M., Peters, F., Jehmlich, N., von Bergen, M., Boll, M., (2009):
    Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria
    J. Bacteriol. 191 (13), 4401 - 4409
    full text (url)