Dr. Niculina Musat
Contact / Addess:
Phone +49 (0) 341 235 4656
Fax +49 (0) 341 235 450822
Helmholtz Centre for Environmental Research - UFZ
Permoserstrasse 15
04318 Leipzig
Curriculum Vitae
| Since April 2012 |
Scientific Head of Centre for Chemical Microscopy (ProVIS) Helmholtz Centre for Environmental Research – UFZ Department of Isotope Biogeochemistry |
| 2008 - 2012 |
Scientist Max-Planck Institute for Marine Microbiology, Bremen, Germany |
| 2006 - 2008 |
Post-Doctoral Fellow Max-Planck Institute for Marine Microbiology, Bremen, Germany. |
|
June 2006 |
Ph.D. in Life Sciences (Dr.rer.nat) University of Bremen and Max-Planck Institute, Bremen, Germany |
|
Apr. - Dec. 2001 |
Research Assistant, National Institute for Research and Development in Physics and Nuclear Engineering, ‘Horia-Hulubei’, Romania |
| 2000 - 2001 |
Research Assistant University of Bucharest, Faculty of Biology (half-time job) |
| 2000 - 2001 |
Biologist Shigella – Pseudomonas Department, Cantacuzino Institute, Bucharest, Romania |
|
Feb. 2001 |
M.Sc. in Microbiology and Microbial Genetics University of Bucharest, Faculty of Biology, Romania |
|
Jul. 1999 |
B.Sc. in Biology University of Bucharest, Faculty of Biology, Romania |
Field of Expertise
- Microbial Ecology and Ecophysiology
- Single cell imaging techniques (FISH, CARD-FISH, NanoSIMS, Laser dissection microscopy - LMD)
- Inter-species nutritional interactions
- Stable isotope probing (SIP) to trace cellular metabolic activity and cell to cell metabolic interactions
- SIP-Nano-scale Secondary Ion Mass Spectrometry (NanoSIMS) applications in microbiology/biology
- Correlative microscopy, chemical imaging and underlying sample preparation concepts and techniques for environmental samples
Main Research Interests
- Inter-species nutritional interactions in microbial associations, including nutrient transfer between autotrophic and heterotrophic communities in fresh water and marine environments, trophic interactions in multi-species assemblages, and symbiotic associations.
- Development of new correlative imaging approaches for visualization, identification and chemical mapping of microbial cells and sub-cellular components. These include species identification and visualization by fluorescence microscopy (FISH &CARD-FISH), high resolution structure imaging (SEM, TEM, HIM) and high resolution chemical mapping (nanoSIMS, ToFSIMS, Raman microspectroscopy, EDX).
- Impact and fate of antibiotics in natural environments: effect of antibiotics on the metabolism of natural microbial communities, impact on single-cell metabolism, dynamics of environmental communities under antibiotic stress, biodegradation/biotransformation of antibiotics by microorganisms.
- Microbe-plant nutritional interactions in the rhizosphere, including colonization of Zea mays roots by soil microorganisms and transfer of carbon between roots and associated microorganisms.
Publications
Theses
M.Sc. thesis: “Comparative analyses of Pseudomonas aeruginosa strains isolated from clinical products and natural environments.” University of Bucharest, Romania (February 2001)
Ph.D thesis: “Molecular characterization of symbiotic associations between chemoautotrophic sulphur-oxidizing microorganisms and nematodes in shallow marine sediments”. University of Bremen and Max-Planck Institute, Bremen, Germany (June 2006)
Index:
You could use our publication index for further requests.
2022 (4)
- Arandia-Gorostidi, N., Berthelot, H., Calabrese, F., Stryhanyuk, H., Klawonn, I., Iversen, M., Nahar, N., Grossart, H.-P., Ploug, H., Musat, N. (2022):
Efficient carbon and nitrogen transfer from marine diatom aggregates to colonizing bacterial groups
Sci. Rep. 12 , art. 14949 10.1038/s41598-022-18915-0 - Chakaroun, R., Massier, L., Musat, N., Kovacs, P. (2022):
New paradigms for familiar diseases: Lessons learned on circulatory bacterial signatures in cardiometabolic diseases
Exp. Clin. Endocrinol. Diabet. 130 (5), 313 - 326 10.1055/a-1756-4509 - Malyi, T., Tsiumra, V., Vistovskyy, V., Mitina, N., Musat, N., Stryhanyuk, H., Kondyr, A., Zaichenko, A., Voloshinovskii, A. (2022):
Template synthesis of luminescent oligoperoxide coated YBO3 nanoparticles doped with Ce3+, Tb3+ and Eu3+ ions
Opt. Mater. 124 , art. 112008 10.1016/j.optmat.2022.112008 - Tamisier, M., Schmidt, M., Vogt, C., Kümmel, S., Stryhanyuk, H., Musat, N., Richnow, H.-H., Musat, F. (2022):
Iron corrosion by methanogenic archaea characterized by stable isotope effects and crust mineralogy
Environ. Microbiol. 24 (2), 583 - 595 10.1111/1462-2920.15658
2021 (7)
- Bandara, C.D., Schmidt, M., Davoudpour, Y., Stryhanyuk, H., Richnow, H.H., Musat, N. (2021):
Microbial identification, high-resolution microscopy and spectrometry of the rhizosphere in its native spatial context
Front. Plant Sci. 12 , art. 668929 10.3389/fpls.2021.668929 - Calabrese, F., Stryhanyuk, H., Moraru, C., Schlömann, M., Wick, L.Y., Richnow, H.H., Musat, F., Musat, N. (2021):
Metabolic history and metabolic fitness as drivers of anabolic heterogeneity in isogenic microbial populations
Environ. Microbiol. 23 (11), 6764 - 6776 10.1111/1462-2920.15756 - Chakaroun, R.M., Massier, L., Heintz-Buschart, A., Said, N., Fallmann, J., Crane, A., Schütz, T., Dietrich, A., Blüher, M., Stumvoll, M., Musat, N., Kovacs, P. (2021):
Circulating bacterial signature is linked to metabolic disease and shifts with metabolic alleviation after bariatric surgery
Genome Med. 13 , art. 105 10.1186/s13073-021-00919-6 - Chen, S.-C., Budhraja, R., Adrian, L., Calabrese, F., Stryhanyuk, H., Musat, N., Richnow, H.-H., Duan, G.-L., Zhu, Y.-G., Musat, F. (2021):
Novel clades of soil biphenyl degraders revealed by integrating isotope probing, multi-omics, and single-cell analyses
ISME J. 15 (12), 3508 - 3521 10.1038/s41396-021-01022-9 - Decelle, J., Veronesi, G., LeKieffre, C., Gallet, B., Chevalier, F., Stryhanyuk, H., Marro, S., Ravanel, S., Tucoulou, R., Schieber, N., Finazzi, G., Schwab, Y., Musat, N. (2021):
Subcellular architecture and metabolic connection in the planktonic photosymbiosis between Collodaria (radiolarians) and their microalgae
Environ. Microbiol. 23 (11), 6569 - 6586 10.1111/1462-2920.15766 - Imihami Mudiyanselage, C.C.D.B., Schmidt, M., Davoudpour, Y., Stryhanyuk, H., Richnow, H., Musat, N. (2021):
High-resolution chemical mapping and identifying spatial distribution of microbes in the Zea mays rhizosphere using correlative microscopy
EGU General Assembly 2021, online, 19–30 Apr 2021
EGUsphere
Copernicus Publications, EGU21-12160 10.5194/egusphere-egu21-12160 - Uwizeye, C., Mars Brisbin, M., Gallet, B., Chevalier, F., LeKieffre, C., Schieber, N.L., Falconet, D., Wangpraseurt, D., Schertel, L., Stryhanyuk, H., Musat, N., Mitarai, S., Schwab, Y., Finazzi, G., Decelle, J. (2021):
Cytoklepty in the plankton: A host strategy to optimize the bioenergetic machinery of endosymbiotic algae
Proc. Natl. Acad. Sci. U.S.A. 118 (27), e2025252118 10.1073/pnas.2025252118
2020 (5)
- Arandia‐Gorostidi, N., Alonso‐Sáez, L., Stryhanyuk, H., Richnow, H.H., Morán, X.A.G., Musat, N. (2020):
Warming the phycosphere: Differential effect of temperature on the use of diatom‐derived carbon by two copiotrophic bacterial taxa
Environ. Microbiol. 22 (4), 1381 - 1396 10.1111/1462-2920.14954 - Benettoni, P., Ye, J.-Y., Holbrook, T.R., Calabrese, F., Wagner, S., Zarejousheghani, M., Griebel, J., Ullrich, M.K., Musat, N., Schmidt, M., Flyunt, R., Reemtsma, T., Richnow, H.-H., Stryhanyuk, H. (2020):
Surface cleaning and sample carrier for complementary high-resolution imaging techniques
Biointerphases 15 (2), art. 021005 10.1116/1.5143203 - Davoudpour, Y., Schmidt, M., Calabrese, F., Richnow, H.H., Musat, N. (2020):
High resolution microscopy to evaluate the efficiency of surface sterilization of Zea Mays seeds
PLOS One 15 (11), e0242247 10.1371/journal.pone.0242247 - Decelle, J., Veronesi, G., Gallet, B., Stryhanyuk, H., Benettoni, P., Schmidt, M., Tucoulou, R., Passarelli, M., Bohic, S., Clode, P., Musat, N. (2020):
Subcellular chemical imaging: New avenues in cell biology
Trends Cell Biol. 30 (3), 173 - 188 10.1016/j.tcb.2019.12.007 - Massier, L., Chakaroun, R., Tabei, S., Crane, A., Didt, K.D., Fallmann, J., von Bergen, M., Haange, S.-B., Heyne, H., Stumvoll, M., Gericke, M., Dietrich, A., Blüher, M., Musat, N., Kovacs, P. (2020):
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes
Gut 69 (10), 1796 - 1806 10.1136/gutjnl-2019-320118
2019 (7)
- Calabrese, F., Voloshynovska, I., Musat, F., Thullner, M., Schlömann, M., Richnow, H.H., Lambrecht, J., Müller, S., Wick, L.Y., Musat, N., Stryhanyuk, H. (2019):
Quantitation and comparison of phenotypic heterogeneity among single cells of monoclonal microbial populations
Front. Microbiol. 10 , art. 2814 10.3389/fmicb.2019.02814 - Cassarini, C., Bhattarai, S., Rene, E.R., Vogt, C., Musat, N., Esposito, G., Lens, P.N.L. (2019):
Enrichment of anaerobic methanotrophs in biotrickling filters using different sulfur compounds as electron acceptor
Environ. Eng. Sci. 36 (4), 431 - 443 10.1089/ees.2018.0283 - Cassarini, C., Rene, E.R., Bhattarai, S., Vogt, C., Musat, N., Lens, P.N.L. (2019):
Anaerobic methane oxidation coupled to sulfate reduction in a biotrickling filter: Reactor performance and microbial community analysis
Chemosphere 236 , art. 124290 10.1016/j.chemosphere.2019.07.021 - Chen, S.-C., Musat, N., Lechtenfeld, O.J., Paschke, H., Schmidt, M., Said, N., Popp, D., Calabrese, F., Stryhanyuk, H., Jaekel, U., Zhu, Y.-G., Joye, S.B., Richnow, H.-H., Widdel, F., Musat, F. (2019):
Anaerobic oxidation of ethane by archaea from a marine hydrocarbon seep
Nature 568 (7750), 108 - 111 10.1038/s41586-019-1063-0 - Decelle, J., Stryhanyuk, H., Gallet, B., Veronesi, G., Schmidt, M., Balzano, S., Marro, S., Uwizeye, C., Jouneau, P.-H., Lupette, J., Jouhet, J., Maillot-Maréchal, E., Schwab, Y., Schieber, N.L., Tucoulou, R., Richnow, H., Finazzi, G., Musat, N. (2019):
Algal remodeling in a ubiquitous planktonic photosymbiosis
Curr. Biol. 29 (6), 968 - 978.e4 10.1016/j.cub.2019.01.073 - Moreno Osorio, J.H., Benettoni, P., Schmidt, M., Stryhanyuk, H., Schmitt-Jansen, M., Pinto, G., Pollio, A., Frunzo, L., Lens, P.N.L., Richnow, H.H., Esposito, G., Musat, N. (2019):
Investigation of architecture development and phosphate distribution in Chlorella biofilm by complementary microscopy techniques
FEMS Microbiol. Ecol. 95 (4), fiz029 10.1093/femsec/fiz029 - Worrich, A., Musat, N., Harms, H. (2019):
Associational effects in the microbial neighborhood
ISME J. 13 (9), 2143 - 2149 10.1038/s41396-019-0444-6
2018 (4)
- Bader, M., Rossberg, A., Steudtner, R., Drobot, B., Großmann, K., Schmidt, M., Musat, N., Stumpf, T., Ikeda-Ohno, A., Cherkouk, A. (2018):
Impact of Haloarchaea on speciation of uranium—A multispectroscopic approach
Environ. Sci. Technol. 52 (12), 12895 - 12904 10.1021/acs.est.8b02667 - McNichol, J., Stryhanyuk, H., Sylva, S.P., Thomas, F., Musat, N., Seewald, J.S., Sievert, S.M. (2018):
Primary productivity below the seafloor at deep-sea hot springs
Proc. Natl. Acad. Sci. U.S.A. 115 (26), 6756 - 6761 10.1073/pnas.1804351115 - Rotaru, A.-E., Calabrese, F., Stryhanyuk, H., Musat, F., Shrestha, P.M., Weber, H.S., Snoeyenbos-West, O.L.O., Hall, P.O.J., Richnow, H.H., Musat, N., Thamdrup, B. (2018):
Conductive particles enable syntrophic acetate oxidation between Geobacter and Methanosarcina from coastal sediments
mBio 9 (3), e00226-18 10.1128/mBio.00226-18 - Stryhanyuk, H., Calabrese, F., Kümmel, S., Musat, F., Richnow, H.-H., Musat, N. (2018):
Calculation of single cell assimilation rates from SIP-nanoSIMS-derived isotope ratios: a comprehensive approach
Front. Microbiol. 9 , art. 2342 10.3389/fmicb.2018.02342
2017 (3)
- Bader, M., Müller, K., Foerstendorf, H., Drobot, B., Schmidt, M., Musat, N., Swanson, J.S., Reed, D.T., Stumpf, T., Cherkouk, A. (2017):
Multistage bioassociation of uranium onto an extremely halophilic archaeon revealed by a unique combination of spectroscopic and microscopic techniques
J. Hazard. Mater. 327 , 225 - 232 10.1016/j.jhazmat.2016.12.053 - Musat, F., Musat, N. (2017):
Measuring the impact of hydrocarbons on rates of nitrogen fixation
In: McGenity, T.J., Timmis, K.N., Nogales, B. (eds.)
Hydrocarbon and lipid microbiology protocols. Activities and phenotypes
Springer Protocols Handbooks
Springer, Berlin, Heidelberg, p. 81 - 97 10.1007/8623_2015_58 - Worrich, A., Stryhanyuk, H., Musat, N., König, S., Banitz, T., Centler, F., Frank, K., Thullner, M., Harms, H., Richnow, H.-H., Miltner, A., Kästner, M., Wick, L.Y. (2017):
Mycelium-mediated transfer of water and nutrients stimulates bacterial activity in dry and oligotrophic environments
Nat. Commun. 8 , art. 15472 10.1038/ncomms15472
2016 (3)
- Jiang, H., Kilburn, M.R., Decelle, J., Musat, N. (2016):
NanoSIMS chemical imaging combined with correlative microscopy for biological sample analysis
Curr. Opin. Biotechnol. 41 , 130 - 135 10.1016/j.copbio.2016.06.006 - Musat, N., Musat, F., Weber, P.K., Pett-Ridge, J. (2016):
Tracking microbial interactions with NanoSIMS
Curr. Opin. Biotechnol. 41 , 114 - 121 10.1016/j.copbio.2016.06.007 - Saatz, J., Stryhanyuk, H., Vetterlein, D., Musat, N., Otto, M., Reemtsma, T., Richnow, H.H., Daus, B. (2016):
Location and speciation of gadolinium and yttrium in roots of Zea mays by LA-ICP-MS and ToF-SIMS
Environ. Pollut. 216 , 245 - 252 10.1016/j.envpol.2016.05.069
2015 (4)
- Schkolnik, G., Schmidt, M., Mazza, M.G., Harnisch, F., Musat, N. (2015):
In situ analysis of a silver nanoparticle-precipitating Shewanella biofilm by surface enhanced confocal Raman microscopy
PLOS One 10 (12), e0145871 10.1371/journal.pone.0145871 - Stryhanyuk, H., Musat, N., Richnow, H.-H. (2015):
Quantitative imaging of microbial-mediated biochemical processes with secondary ion mass spectrometry
In: Daus, B., Bings, N., Leopold, K., Otto, M., Panne, U., Welz, U., Wennrich, R. (eds.)
Canas ’15. Colloquium Analytische Atomspektroskopie, 8.–11. März 2015, Helmholtz-Zentrum für Umweltforschung – UFZ Leipzig. Colloquium Analytical Atomic Spectroscopy, 8–11 March, 2015, Helmholtz Centre for Environmental Research – UFZ Leipzig
Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig, 59 - Svedén, J.B., Adam, B., Walve, J., Nahar, N., Musat, N., Lavik, G., Whitehouse, M.J., Kuypers, M.M.M., Ploug, H. (2015):
High cell-specific rates of nitrogen and carbon fixation by the cyanobacterium Aphanizomenon sp. at low temperatures in the Baltic Sea
FEMS Microbiol. Ecol. 91 (12), fiv131 10.1093/femsec/fiv131 - Zimmermann, M., Escrig, S., Hübschmann, T., Kirf, M.K., Brand, A., Inglis, R.F., Musat, N., Müller, S., Meibom, A., Ackermann, M., Schreiber, F. (2015):
Phenotypic heterogeneity in metabolic traits among single cells of a rare bacterial species in its natural environment quantified with a combination of flow cell sorting and NanoSIMS
Front. Microbiol. 6 , art. 243 10.3389/fmicb.2015.00243
2014 (2)
- Musat, N., Stryhanyuk, H., Bombach, P., Adrian, L., Audinot, J.-N., Richnow, H.H. (2014):
The effect of FISH and CARD-FISH on the isotopic composition of 13C- and 15N-labeled Pseudomonas putida cells measured by nanoSIMS
Syst. Appl. Microbiol. 37 (4), 267 - 276 10.1016/j.syapm.2014.02.002 - Sheik, A.R., Brussaard, C.P.D., Lavik, G., Lam, P., Musat, N., Krupke, A., Littmann, S., Strous, M., Kuypers, M.M.M. (2014):
Responses of the coastal bacterial community to viral infection of the algae Phaeocystis globosa
ISME J. 8 (1), 212 - 225 10.1038/ismej.2013.135
2013 (3)
- Jaekel, U., Musat, N., Adam, B., Kuypers, M., Grundmann, O., Musat, F. (2013):
Anaerobic degradation of propane and butane by sulfate-reducing bacteria enriched from marine hydrocarbon cold seeps
ISME J. 7 (5), 885 - 895 10.1038/ISMEJ.2012.159 - Krupke, A., Musat, N., LaRoche, J., Mohr, W., Fuchs, B.M., Amann, R.I., Kuypers, M.M.M., Foster, R.A. (2013):
In situ identification and N2 and C fixation rates of uncultivated cyanobacteria populations
Syst. Appl. Microbiol. 36 (4), 259 - 271 10.1016/j.syapm.2013.02.002 - Sheik, A.R., Brussaard, C.P.D., Lavik, G., Foster, R.A., Musat, N., Adam, B., Kuypers, M.M.M. (2013):
Viral infection of Phaeocystis globosa impedes release of chitinous star-like structures: quantification using single cell approaches
Environ. Microbiol. 15 (5), 1441 - 1451 10.1111/j.1462-2920.2012.02838.x
2012 (2)
- Alonso, C., Musat, N., Kuypers, M.M.M., Amann, R. (2012):
HISH–SIMS analysis of bacterial uptake of algal-derived carbon in the Río de la Plata estuary
Syst. Appl. Microbiol. 35 (8), 541 - 548 10.1016/j.syapm.2012.08.004 - Thompson, A.W., Foster, R.A., Krupke, A., Carter, B.J., Musat, N., Vaulot, D., Kuypers, M.M.M., Zehr, J.P. (2012):
Unicellular cyanobacterium symbiotic with a single-celled eukaryotic alga
Science 337 (6101), 1546 - 1550 10.1126/science.1222700