Dr. Sebastian Canzler
(geb. Bartschat)
Head Computational Systems Biology
Department Computational Biology & Chemistry
Permoserstr. 15
04318 Leipzig
Gebäude: Gebäude 4.1 und 4.2
Raum: Raum 239
Phone: +49 341 6025 1353
Email: sebastian.canzler@ufz.de
Raum: Raum 239
Phone: +49 341 6025 1353
Email: sebastian.canzler@ufz.de
Forschungsinteressen
- Analyse von multi-omics Daten in der Risikobewertung
- Methodenentwicklung für multi-omics basierte Datenintegration
- Nutzung von multi-omics Daten um Adverse Outcome Pathways (AOP) verlinken
- Funktionelle, nicht-kodierende RNAs
- Regulatorische Netzwerke basierend auf multi-omics Daten
- Single-cell transcriptomics und die Anwendung in Systems Toxicology
- Reproducibility und FAIR research data management
Soziale Netzwerke
Curriculum Vitae
Education
2011 Diplom in Bioinformatik / Universität Leipzig
2017 PhD in Bioinformatik / Universität Leipzig
Professional Experience
2016 - 2017 Softwareentwickler bei der Immuthera GmbH, Leipzig
2017 PostDoc und Wiss. Mitarbeiter an der Universität Leipzig,
Institut fur Mathematik & Informatik,
Lehrstuhl für Bioinformatik
seit 2018 PostDoc in Bioinformatik,
Helmholtz Zentrum für Umweltforschung – UFZ,
Department Computational Biology & Chemistry
seit 2023 Gruppenleiter Computational Systems Biology,
Helmholtz Zentrum für Umweltforschung – UFZ,
Department Computational Biology & Chemistry
Publikationen
Inhalt:
Weiterführende Recherchen können Sie in unserem Publikationsverzeichnis durchführen.
2025 (3)
- Canzler, S., Lehmann, J., Schor, J., Busch, W., Hackermüller, J. (2025):
From toxicogenomics data to cumulative assessment groups: A mechanistic framework for chemical grouping
bioRxiv 10.1101/2025.01.24.634648 - Canzler, S., Schubert, K., Rolle-Kampczyk, U.E., Wang, Z., Schreiber, S., Seitz, H., Mockly, S., Kamp, H., Haake, V., Huisinga, M., von Bergen, M., Buesen, R., Hackermüller, J. (2025):
Evaluating the performance of multi-omics integration: a thyroid toxicity case study
Arch. Toxicol. 99 (1), 309 - 332 10.1007/s00204-024-03876-2 - Lehmann, J., Yazbeck, A., Hackermüller, J., Canzler, S. (2025):
An extended miRNA repertoire in Rattus norvegicus
Front. Bioinform. 5 , art. 1545680 10.3389/fbinf.2025.1545680
2024 (3)
- Canzler, S. (2024):
Extended rat miRNA repertoire [Data set]
Zenodo 10.5281/zenodo.12626180 - Canzler, S., Hackermüller, J. (2024):
multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data (v1.14.0)
Version: v1.14.0 Zenodo 10.5281/zenodo.13359290 - Canzler, S., Schubert, K., Rolle-Kampczyk, U.E., Wang, Z., Schreiber, S., Pozhidaeva, M., Seitz, H., Kamp, H., Huisinga, M., von Bergen, M., Buesen, R., Hackermüller, J. (2024):
Enhancing toxicological insights through multi-omics: a case study on direct and indirect thyroid toxicity
Toxicol. Lett. 399 (Suppl. 2), S61 - S62 10.1016/j.toxlet.2024.07.171
2023 (5)
- Amorim, M.J.B., Peijnenburg, W., Greco, D., Saarimäki, L.A., Dumit, V.I., Bahl, A., Haase, A., Tran, L., Hackermüller, J., Canzler, S., Scott-Fordsmand, J.J. (2023):
Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials
Nano Today 48 , art. 101735 10.1016/j.nantod.2022.101735 - Canzler, S., Hackermüller, J. (2023):
multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data (v1.12.0)
Version: v1.12.0 Zenodo 10.5281/zenodo.13359285 - Carido, M., Völkner, M., Steinheuer, L.M., Wagner, F., Kurth, T., Dumler, N., Ulusoy, S., Wieneke, S., Norniella, A.V., Golfieri, C., Khattak, S., Schönfelder, B., Scamozzi, M., Zoschke, K., Canzler, S., Hackermüller, J., Ader, M., Karl, M.O. (2023):
Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts
Front. Cell. Neurosci. 17 , art. 1166641 10.3389/fncel.2023.1166641 - Völkner, M., Steinheuer, L.M., Carido, M., Canzler, S., Hackermüller, J., Karl, M.O. (2023):
Reliability of human retinal organoid generation from hiPSC-derived neuroepithelial cysts
Gene Expression Omnibus - Wang, Z., Haange, S.-B., Haake, V., Huisinga, M., Kamp, H., Buesen, R., Schubert, K., Canzler, S., Hackermüller, J., Rolle-Kampczyk, U., von Bergen, M. (2023):
Assessing the influence of propylthiouracil and phenytoin on the metabolomes of the thyroid, liver, and plasma in a rats
Metabolites 13 (7), art. 847 10.3390/metabo13070847
2022 (5)
- Canzler, S., Fischer, M., Ulbricht, D., Ristic, N., Hildebrand, P.W., Staritzbichler, R. (2022):
ProteinPrompt: a webserver for predicting protein–protein interactions
Bioinform. Adv. 2 (1), vbac059 10.1093/bioadv/vbac059 - Canzler, S., Hackermüller, J. (2022):
multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data (v1.8.0)
Version: v1.8.0 Zenodo 10.5281/zenodo.13359264 - Canzler, S., Hackermüller, J., Haake, V., Kamp, H. (2022):
Mechanistic study on direct and indirect thyroid toxicity in male Wistar rats - Serum Metabolomics [Data set]
Zenodo 10.5281/zenodo.5900664 - Völkner, M., Steinheuer, L.M., Carido, M., Canzler, S., Hackermüller, J., Karl, M.O. (2022):
HBEGF-TNF induces a complex retinal pathology with macular degeneration hallmarks in human organoids
Gene Expression Omnibus - Völkner, M., Wagner, F., Steinheuer, L.M., Carido, M., Kurth, T., Yazbeck, A., Schor, J., Wieneke, S., Ebner, L.J.A., Del Toro Runzer, C., Taborsky, D., Zoschke, K., Vogt, M., Canzler, S., Hermann, A., Khattak, S., Hackermüller, J., Karl, M.O. (2022):
HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids
Nat. Commun. 13 , art. 6183 10.1038/s41467-022-33848-y
2021 (2)
- Petruschke, H., Schori, C., Canzler, S., Riesbeck, S., Poehlein, A., Daniel, R., Frei, D., Segessemann, T., Zimmerman, J., Marinos, G., Kaleta, C., Jehmlich, N., Ahrens, C.H., von Bergen, M. (2021):
Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome
Microbiome 9 , art. 55 10.1186/s40168-020-00981-z - Wang, Z., Karkossa, I., Großkopf, H., Canzler, S., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M., Schubert, K. (2021):
Quantitative proteomics reveal mechanistic insights into direct and indirect drug-induced thyroid toxicity in rats
Toxicol. Lett. 350 (Suppl.), S129 10.1016/S0378-4274(21)00550-6
2020 (2)
- Canzler, S., Hackermüller, J. (2020):
multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data
BMC Bioinformatics 21 , art. 561 10.1186/s12859-020-03910-x - Canzler, S., Schor, J., Busch, W., Schubert, K., Rolle-Kampczyk, U.E., Seitz, H., Kamp, H., von Bergen, M., Buesen, R., Hackermüller, J. (2020):
Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388 10.1007/s00204-020-02656-y
Publikationen entstanden an der Uni Leipzig
Professur für Bioinformatik
Institut für Informatik
Universität Leipzig
Härtelstr. 16-18
D-04107 Leipzig
2018
- Canzler S., Stadler P. F., and Hertel J. The fungal snoRNAome.
RNA, 24(3):342-360, Mar 2018
2017
- Canzler S., Stadler P. F., and Hertel J. Evolution of Fungal U3 snoRNAs:
Structural Variation and Introns. Non-Coding RNA, 3(1), Jan 2017.
2016
- Patra Bhattacharya D., Canzler S., Kehr S., Hertel J., Grosse I., and Stadler
P. F. Phylogenetic distribution of plant snorna families.
BMC Genomics, 17(1):969, Nov 2016. - Canzler S., Stadler P. F., and Hertel J. U6 snRNA Intron Insertion Occurred
Multiple Times during Fungi Evolution.
RNA Biol, 13(2):119–27, Feb 2016.
2014
- Schneider H., Bartschat S., Doose G., Maciel L., Pizani E., Bassani M., Torres
F. A., Will S., Raiol T., Brígido M., Walter M. E., and Stadler P. F. Genome-
Wide Identification of Non-coding RNAs in Komagatella pastoris str. GS115.
In Campos S., editor, Advances in Bioinformatics and Computational Biology,
volume 8826 of Lecture Notes in Computer Science,
pages 115–122. Springer International Publishing, 2014. - Kehr S., Bartschat S., Tafer H., Stadler P. F., and Hertel J. Matching of
Soulmates: coevolution of snoRNAs and their targets. Mol Biol Evol,
31(2):455–67, Feb 2014. - Bartschat S., Kehr S., Tafer H., Stadler P. F., and Hertel J. snoStrip: a
snoRNA annotation pipeline. Bioinformatics, 30(1):115–6, Jan 2014. - Anthon C., Tafer H., Havgaard J. H., Thomsen B., Hedegaard J., Seemann
S. E., Pundhir S., Kehr S., Bartschat S., Nielsen M., Nielsen R. O., Fredholm
M., Stadler P. F., and Gorodkin J. Structured RNAs and synteny regions in
the pig genome. BMC Genomics, 15:459, 2014.
2013
- Huang Y., Li Y., Burt D. W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S., Magor K. E.,
Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T., Kim K. W., Sheng
Z., An Y., Searle S., Herrero J., Groenen M. A., Crooijmans R. P., Faraut
T., Cai Q., Webster R. G., Aldridge J. R., Warren W. C., Bartschat S., Kehr
S., Marz M., Stadler P. F., Smith J., Kraus R. H., Zhao Y., Ren L., Fei J.,
Morisson M., Kaiser P., Griffin D. K., Rao M., Pitel F., Wang J., and Li N.
The duck genome and transcriptome provide insight into an avian influenza
virus reservoir species. Nat Genet, 45(7):776–83, Jul 2013.
2012
- Hertel J., Bartschat S., Wintsche A., Otto C., Students of the Bioinformatics
Computer Lab, and Stadler P. F. Evolution of the let-7 microRNA family.
RNA Biol, 9(3):231–41, Mar 2012.
2011
- Marz M., Gruber A. R., Höner Zu Siederdissen C., Amman F., Badelt S.,
Bartschat S., Bernhart S. H., Beyer W., Kehr S., Lorenz R., Tanzer A., Yusuf
D., Tafer H., Hofacker I. L., and Stadler P. F. Animal snoRNAs and scaRNAs
with exceptional structures. RNA Biol, 8(6):938–46, 2011. - Langenberger D., Bartschat S., Hertel J., Hoffmann S., Tafer H., and Stadler
P. F. MicroRNA or Not MicroRNA? In Norberto de Souza O., Telles G. P., and
Palakal M., editors, Advances in Bioinformatics and Computational Biology,
volume 6832 of Lecture Notes in Computer Science, pages 1–9. Springer Berlin
Heidelberg, 2011. - Kehr S., Bartschat S., Stadler P. F., and Tafer H. PLEXY: efficient target
prediction for box C/D snoRNAs. Bioinformatics, 27(2):279–80, Jan 2011.
2010
- Bartschat S. and Samuelsson T. U12 type introns were lost at multiple occasions
during evolution. BMC Genomics, 11:106, 2010.