Dr. Sebastian Canzler
(née Bartschat)
Postdoc
Young Investigators Group Bioinformatics and Transcriptomics
Department Molecular Systems Biology
Permoserstr. 15
04318 Leipzig
GERMANY
Building: Building 4.1 und 4.2
Room: Room 239
Phone: +49 341 6025 1353
Email: sebastian.canzler@ufz.de
Room: Room 239
Phone: +49 341 6025 1353
Email: sebastian.canzler@ufz.de
Research interests
- Methodenenwicklung für die Integration von Multi-omics Daten
- Datenintegration in der Systembiologie
- Multi-omics Datenanalyse im Bereich der Risikobewertung von Chemikalien
- Nutzung von Methoden des Maschinellen Lernerns zur Unterscheidung von adaptiven und adversen Reaktionen
- Nutzung von Multi-omics Daten zur Erstellung bzw. der Erweiterung von Adverse Outcome Pathways (AOP)
- Nicht-kodierende RNAs
- Regulatorische Netzwerke
Research interests
- Method development for multi-omics data integration
- Data integration in systems biology
- Multi-omics data analysis in chemical risk assessment
- Machine learning principles to discriminate adaptive from adverse responses
- Using multi-omics to detect and refine Adverse Outcome Pathways (AOP)
- Functional, non-coding RNAs
- Regulatory networks involving non-coding RNAs
- Non-coding RNAs in disease and toxicity, drug discovery, and biomarkers
Publications
Index:
You could use our publication index for further requests.
2023 (3)
- Amorim, M.J.B., Peijnenburg, W., Greco, D., Saarimäki, L.A., Dumit, V.I., Bahl, A., Haase, A., Tran, L., Hackermüller, J., Canzler, S., Scott-Fordsmand, J.J. (2023):
Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials
Nano Today 48 , art. 101735 10.1016/j.nantod.2022.101735 - Carido, M., Völkner, M., Steinheuer, L.M., Wagner, F., Kurth, T., Dumler, N., Ulusoy, S., Wieneke, S., Norniella, A.V., Golfieri, C., Khattak, S., Schönfelder, B., Scamozzi, M., Zoschke, K., Canzler, S., Hackermüller, J., Ader, M., Karl, M.O. (2023):
Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts
Front. Cell. Neurosci. 17 , art. 1166641 10.3389/fncel.2023.1166641 - Wang, Z., Haange, S.-B., Haake, V., Huisinga, M., Kamp, H., Buesen, R., Schubert, K., Canzler, S., Hackermüller, J., Rolle-Kampczyk, U., von Bergen, M. (2023):
Assessing the influence of propylthiouracil and phenytoin on the metabolomes of the thyroid, liver, and plasma in a rats
Metabolites 13 (7), art. 847 10.3390/metabo13070847
2022 (3)
- Canzler, S., Fischer, M., Ulbricht, D., Ristic, N., Hildebrand, P.W., Staritzbichler, R. (2022):
ProteinPrompt: a webserver for predicting protein–protein interactions
Bioinform. Adv. 2 (1), vbac059 10.1093/bioadv/vbac059 - Canzler, S., Hackermüller, J., Haake, V., Kamp, H. (2022):
Mechanistic study on direct and indirect thyroid toxicity in male Wistar rats - Serum Metabolomics [Data set]
Zenodo 10.5281/zenodo.5900664 - Völkner, M., Wagner, F., Steinheuer, L.M., Carido, M., Kurth, T., Yazbeck, A., Schor, J., Wieneke, S., Ebner, L.J.A., Del Toro Runzer, C., Taborsky, D., Zoschke, K., Vogt, M., Canzler, S., Hermann, A., Khattak, S., Hackermüller, J., Karl, M.O. (2022):
HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids
Nat. Commun. 13 , art. 6183 10.1038/s41467-022-33848-y
2021 (2)
- Petruschke, H., Schori, C., Canzler, S., Riesbeck, S., Poehlein, A., Daniel, R., Frei, D., Segessemann, T., Zimmerman, J., Marinos, G., Kaleta, C., Jehmlich, N., Ahrens, C.H., von Bergen, M. (2021):
Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome
Microbiome 9 , art. 55 10.1186/s40168-020-00981-z - Wang, Z., Karkossa, I., Großkopf, H., Canzler, S., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M., Schubert, K. (2021):
Quantitative proteomics reveal mechanistic insights into direct and indirect drug-induced thyroid toxicity in rats
Toxicol. Lett. 350 (Suppl.), S129 10.1016/S0378-4274(21)00550-6
2020 (2)
- Canzler, S., Hackermüller, J. (2020):
multiGSEA: a GSEA-based pathway enrichment analysis for multi-omics data
BMC Bioinformatics 21 , art. 561 10.1186/s12859-020-03910-x - Canzler, S., Schor, J., Busch, W., Schubert, K., Rolle-Kampczyk, U.E., Seitz, H., Kamp, H., von Bergen, M., Buesen, R., Hackermüller, J. (2020):
Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388 10.1007/s00204-020-02656-y
Publications processed at the university of Leipzig
Professur für Bioinformatik
Institut für Informatik
Universität Leipzig
Härtelstr. 16-18
D-04107 Leipzig
2018
- Canzler S., Stadler P. F., and Hertel J. The fungal snoRNAome.
RNA, 24(3):342-360, Mar 2018
2017
- Canzler S., Stadler P. F., and Hertel J. Evolution of Fungal U3 snoRNAs:
Structural Variation and Introns. Non-Coding RNA, 3(1), Jan 2017.
2016
- Patra Bhattacharya D., Canzler S., Kehr S., Hertel J., Grosse I., and Stadler
P. F. Phylogenetic distribution of plant snorna families.
BMC Genomics, 17(1):969, Nov 2016. - Canzler S., Stadler P. F., and Hertel J. U6 snRNA Intron Insertion Occurred
Multiple Times during Fungi Evolution.
RNA Biol, 13(2):119–27, Feb 2016.
2014
- Schneider H., Bartschat S., Doose G., Maciel L., Pizani E., Bassani M., Torres
F. A., Will S., Raiol T., Brígido M., Walter M. E., and Stadler P. F. Genome-
Wide Identification of Non-coding RNAs in Komagatella pastoris str. GS115.
In Campos S., editor, Advances in Bioinformatics and Computational Biology,
volume 8826 of Lecture Notes in Computer Science,
pages 115–122. Springer International Publishing, 2014.
- Kehr S., Bartschat S., Tafer H., Stadler P. F., and Hertel J. Matching of
Soulmates: coevolution of snoRNAs and their targets. Mol Biol Evol,
31(2):455–67, Feb 2014. - Bartschat S., Kehr S., Tafer H., Stadler P. F., and Hertel J. snoStrip: a
snoRNA annotation pipeline. Bioinformatics, 30(1):115–6, Jan 2014. - Anthon C., Tafer H., Havgaard J. H., Thomsen B., Hedegaard J., Seemann
S. E., Pundhir S., Kehr S., Bartschat S., Nielsen M., Nielsen R. O., Fredholm
M., Stadler P. F., and Gorodkin J. Structured RNAs and synteny regions in
the pig genome. BMC Genomics, 15:459, 2014.
2013
- Huang Y., Li Y., Burt D. W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S., Magor K. E.,
Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T., Kim K. W., Sheng
Z., An Y., Searle S., Herrero J., Groenen M. A., Crooijmans R. P., Faraut
T., Cai Q., Webster R. G., Aldridge J. R., Warren W. C., Bartschat S., Kehr
S., Marz M., Stadler P. F., Smith J., Kraus R. H., Zhao Y., Ren L., Fei J.,
Morisson M., Kaiser P., Griffin D. K., Rao M., Pitel F., Wang J., and Li N.
The duck genome and transcriptome provide insight into an avian influenza
virus reservoir species. Nat Genet, 45(7):776–83, Jul 2013.
2012
- Hertel J., Bartschat S., Wintsche A., Otto C., Students of the Bioinformatics
Computer Lab, and Stadler P. F. Evolution of the let-7 microRNA family.
RNA Biol, 9(3):231–41, Mar 2012.
2011
- Marz M., Gruber A. R., Höner Zu Siederdissen C., Amman F., Badelt S.,
Bartschat S., Bernhart S. H., Beyer W., Kehr S., Lorenz R., Tanzer A., Yusuf
D., Tafer H., Hofacker I. L., and Stadler P. F. Animal snoRNAs and scaRNAs
with exceptional structures. RNA Biol, 8(6):938–46, 2011. - Langenberger D., Bartschat S., Hertel J., Hoffmann S., Tafer H., and Stadler
P. F. MicroRNA or Not MicroRNA? In Norberto de Souza O., Telles G. P., and
Palakal M., editors, Advances in Bioinformatics and Computational Biology,
volume 6832 of Lecture Notes in Computer Science, pages 1–9. Springer Berlin
Heidelberg, 2011. - Kehr S., Bartschat S., Stadler P. F., and Tafer H. PLEXY: efficient target
prediction for box C/D snoRNAs. Bioinformatics, 27(2):279–80, Jan 2011.
2010
- Bartschat S. and Samuelsson T. U12 type introns were lost at multiple occasions
during evolution. BMC Genomics, 11:106, 2010.