Dr. Anna Heintz-Buschart

Contact / Address


Dr. Anna Heintz-Buschart
Scientist

Department of Soil Ecology
Helmholtz Centre for Environmental Research - UFZ
Theodor-Lieser-Strasse 4 | D-06120 Halle/Saale
Germany


Metagenomics Support Unit
German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig

Anna Heintz-Buschart
iDiv logo

Research interests

Omics and bioinformatics methods for integrated analyses of microbial communities

microbiome concept Conceptually, microbial genomes of mixed-microbial communities and gene expression are shaped by the interaction with close relatives within the same population, with other microbes, and with the environment, including multi-cellular hosts. For host-associated microbiota, the host genome, immune and defense systems, metabolism and lifestyle are important factors, which also drive the microbiota's exposure to environmental nutrients, potentially anti-microbial xenobiotics and other microbes.

Microbial communities play important roles in global nutrient cycling and energy fluxes, in addition to forming close associations and directly interacting with macrobiota. These cross-kingdom interactions are fundamental to most natural and agricultural systems, as well as to human health, but we still know relatively little about the processes that lead to the assembly and maintenance of microbe-host associations.
State-of-the-art ‘omics’ technologies, such as metagenomics, metatranscriptomics, metaproteomics and metabolomics can be applied to microbial samples to answer important questions.

Which organisms are present? what is their functional potential, i.e. which genes are encoded by their genomes? which genes are expressed, collectively by a microbial community, or by which members? which metabolic enzymes, metabolites and structural proteins are present, i.e. what is the microbial activity? The answers to these questions can provide deep insights into the capabilities and interactions within a microbial community and its interaction with the environment and potential host organisms. However, all of these answers come “hidden” in large volumes of data. My interest lies in the facilitation of biological interpretations through the application and development of bioinformatics methods that are able to extract meaningful information from omics data.


network multiomics Heintz-Buschart et al
Differentially abundant metabolic network module, with indications of the relative changes in enzyme gene expression (colour of the labels), the identity of the microorganisms contributing to the transcripts (big, left network) and enzymes (smaller network on the right) of one individual's microbiome (as published in Heintz-Buschart et al. 2016).
Multiomics Integration Heintz-Buschart et al
Schematic workflow for the integration of metagenomic, metatranscriptomic and metaproteomic data, together with host whole genomics data (as published in Heintz-Buschart et al. 2016).

Next to the processing of different omics datasets, one challenge is the integration of different omics levels. This requires suitable databases, meaningful normalization and multivariate statistics. On the other hand, synergies between multiple omic levels can be utilized, because borrowing information from one omic level can improve the detection or interpretation of entities on other omics levels. Finally, contextualization and visualization are computational tools that greatly drive biological interpretations.



Research projects

Jena Experiment

Together with François Buscot and doctoral candidate Cynthia Albracht, I study the role of arbuscular mycorrhizal fungi in the establishment of long-term biodiversity-ecosystem functioning relationships in the grassland of the Jena experiment since 2020. In the related Flexpool project RESFun we collaborate with Prof. Alexandra Weigelt of Leipzig University and her PhD student Justus Hennecke. They are interested in the fungi attracted by plants with roots that commit to different strategies for exploiting soil resources ("root economics space").

DiscoMole and iSBio

Thanks to a DFG-grant for NGS, our iDiv consortium "Soil Biodiversity and Function" could sequence metagenomes of soil samples from the iSBio-initiative. This collection comes with a deep functional characterisation. We now want to understand the relationships between microbial diversity and soil functions for these samples, taken from a wide range of environmental gradients. As part of the iDiv Flexpool project DiscoMole, Christina Weißbecker is developing scenario-based models of pathogen loads in the future.

Further collaborations:

As contact person for the omics and bioinformatics platform in the soil ecology department, I get to work with most of my colleagues at the soil ecology department and a wide range of researchers from iDiv.

The global change experimental facility (GCEF) is a field experiment to simulate consequences of climate change on ecosystem processes in different land-use types. Together with Claudia Breitkreutz, Marie-Lara Bouffaud, Mika Tarkka and Thomas Reitz, we investigate changes in microbial communities and their function. With Witoon Purahong and Sara Wahdan, we focus on decomposition processes and high-resolution analysis of the functional potential and activity of the involved microbes.

The biodiversity exploratories are a central project in our department. Julia Moll studies bacterial, archaean and fungal communities in deadwood and their interaction networks. Currently we're also taking insects on board. With Kezia Goldmann we've finished a study on spatial-temporal patterns of AMF diversity in a grassland: Scalemic.

Within SPP2089 Rhizosphere Spatiotemporal Organisation, Mika Tarkka and Minh Ganther investigate spatially and temporally resolved gene expression of maize roots. In the future, we will also take into account plant-microbe interactions.

The work of François Buscots PhD students Luis Daniel Prada Salcedo and Jean de Dieu Habiyaremye on soil microbiota in the Soil for Europe project and with the PhytOakmeters of Sylvie Herrmann is supported with pipeline development.

The scientific consortium "Soil Biodiversity and Function" bundles complementary soil expertise and activities within iDiv to advance science and education in soil biodiversity.

With the iDiv Soil Biodiversity and Function consortium, in particular Nico Eisenhauer's Experimental Interaction Ecology group and Ika Djukic's TeaComposition initiative, we explore microbial communities and soil functions along environmental gradients.

Kezia Goldmann und ich bestimmen mit Olga Ferlian aus Nico Eisenhauer's Experimental Interaction Ecology Gruppe die Zusammensetzung und Vielfalt von Mykorrhizapilzen im myDiv Experiment.

I collaborate with Hjalmar Kühl and others of the Max Planck Institute for Evolutionary Anthropology and Alexandra Muellner-Riehl's Molecular Evolution and Plant Systematics group at University Leipzig on the Pan-African Chimpanzee Microbiome and Diet Research Project.


Past projects

With Marie Spohn's group, formerly on Soil Biogeochemistry at the University Bayreuth, we analysed effects of long-term nitrogen and phosphorus fertilization on grassland microbial communities.


Selected publications

M. Marselle, T. Hartig, D. Cox, S. de Bell, S. Knapp, S. Lindley, M. Triguero-Mas, K. Böhning-Gaese, P.A. Cook, S. de Vries, A. Heintz-Buschart, M. Hofmann, K.N. Irvine, N. Kabisch, F. Kolek, R. Kraemer, I. Markevych, D. Martens, R. Müller, M. Nieuwenhuijsen, J.M. Potts, J. Stadler, S. Walton, S.L. Warber, A. Bonn (2021): Pathways linking biodiversity to human health: a conceptual framework. Environment International, 150: 106420.

C. Weißbecker, B. Schnabel, A. Heintz-Buschart (2020): dadasnake, a Snakemake implementation of DADA2 to process amplicon sequencing data for microbial ecology. GigaScience 9: giaa135.

C.A. Guerra, A. Heintz-Buschart, J. Sikorski, A. Chatzinotas, N. Guerrero-Ramírez, S. Cesarz, L. Beaumelle, M.C. Rillig, F.T. Maestre, M. Delgado-Baquerizo, F. Buscot, J. Overmann, G. Patoine, H.R.P. Phillips, M. Winter, T. Wubet, K. Küsel, R.D. Bardgett, E.K. Cameron, D. Cowan, T. Grebenc, C. Marín, A. Orgiazzi, B.K. Singh, D.H. Wall, N. Eisenhauer (2020): Blind spots in global soil biodiversity and ecosystem function research. Nature Communications 11: 3870.

P.-M. Schleuss, M. Widdig, A. Heintz-Buschart, A. Guhr, S. Martin, K. Kirkman, M. Spohn (2019): Stoichiometric controls of soil carbon and nitrogen cycling after long-term nitrogen and phosphorus addition in a mesic grassland in South Africa. Soil Biology & Biochemistry 135: 294-303.

L. Wampach*, A. Heintz-Buschart*, J.V. Fritz*, J. Ramiro-Garcia, J. Habier, M. Herold, S. Narayanasamy, A. Kaysen, A.H. Hogan, L. Bindl, J. Bottu, R. Halder, C. Sjöqvist, P. May, A.F. Andersson, C. de Beaufort, P. Wilmes (2018): Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential. Nature Communications 9: 5091.

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, C. Bellora, A. Krishna, L. Wampach, J.G. Schneider, A. Hogan, C. de Beaufort, P. Wilmes (2016): Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes. Nat. Microbiol. 2: 16180. Erratum in Nat. Microbiol. 2: 16227

H. Roume*, A. Heintz-Buschart*, E.E.L. Muller, P. May, V.P. Satagopam, C.C. Laczny, S. Narayanasamy, L.A. Lebrun, M.R. Hoopmann, J.M. Schupp, J.D. Gillece, N.D, Hicks, D.M. Engelthaler, T. Sauter, P.S. Keim, R.L. Moritz, P. Wilmes (2015). Comparative integrated omics: identification of key functionalities in microbial community-wide metabolic networks. NPJ Biofilms Microbiomes 1: 15007.


Code from publications

dadasnake pipeline: https://github.com/a-h-b/dadasnake

Text mining und automatisierter Zugriff auf Sequenzdaten für Jurburg et al. (2020): https://github.com/a-h-b/pdf_to_sequence

R-script from Goldmann et al., Environmental Microbiology (2019): https://a-h-b.github.io/SCALEMIC-betaDiv/

Repository for Wampach, Heintz-Buschart and Fritz et al., Nature Communications (2018): https://git-r3lab.uni.lu/Cosmic/Earliest

Repository for Heintz-Buschart et al., BMC Biology (2018): https://git.ufz.de/metaOmics/contaminomics

Repository for Heintz-Buschart et al., Nature Microbiology (2016): https://git-r3lab.uni.lu/anna.buschart/MuStMultiomics


CV / Scientific career

since
September 2017

Scientist
Helmholtz Centre for Environmental Research, Halle - Department of Soil Ecology
German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig - Metagenomics Support Unit (2017-2020 Bioinformatics Unit)
Bioinformatics and statistics for metagenomics and functional (meta-)omics:

  • methods development for multi-omics of mixed microbial communities.
  • integration of physiological, environmental and community census data.
  • analysis of microbial community structure and function of mixed microbial communities.

2012 - 2017

Postdoc
Luxembourg Centre for Systems Biomedicine, Luxembourg - Eco-Systems Biology group
Multi-omics analyses of mixed microbial communities:

  • statistical and ecological analysis of microbial community structure and function of human microbiota and activated sludge.
  • bioinformatics methods development for the integration of multi-omics data from next generation sequencing and mass-spectrometry experiments.
  • development and supervision of an automated robotic platform for biomolecular extraction.

2011 - 2012

Postdoc
Helmholtz Centre for Infection Research, Braunschweig - Biological Systems Analysis group
Work on the interaction of mammalian innate immune cells with Candida albicans:

  • modelling and experimental validation of signal transduction and gene regulatory networks.
  • analysis of transcriptome data.

2008 - 2011

PhD
Helmholtz Centre for Infection Research, Braunschweig - Biological Systems Analysis group
Thesis: "Development of screening assays and characterisation of new antifungal compounds against Candida albicans"

2002 - 2008

Diploma in Biology
University Bremen, Germany
Major in Microbiology with botany and cellular biology - thesis: "Investigation of the bacterial and plant gene expression in the interaction of Azoarcus sp. strain BH72 and rice"


Complete list of publications

J. Moll*, A. Heintz-Buschart*, C. Bässler, M. Hofrichter, H. Kellner, F. Buscot, B. Hoppe (2021): Amplicon sequencing-based bipartite network analysis confirms a high degree of specialization and modularity for fungi and prokaryotes in deadwood. mSphere, DOI: 10.1128/mSphere.00856-20.

S.F.M. Wahdan, A. Heintz-Buschart, C. Sansupa, B. Tanunchai, Y.-T. Wu, M. Schädler, M. Noll, W. Purahong, F. Buscot (2021). Targeting the active rhizosphere microbiome of Trifolium pratense in grassland evidences a stronger-than-expected belowground biodiversity-ecosystem functioning link. Frontiers in Microbiology 12: 73.

L. Gebauer, M.-L. Bouffaud, M. Ganther, B. Yim, D. Vetterlein, K. Smalla, F. Buscot, A. Heintz-Buschart, M.T. Tarkka (2021). Soil texture, sampling depth and root hairs shape the structure of ACC deaminase bacterial community composition in maize rhizosphere. Frontiers in Microbiology 12:128.

C. Weißbecker, B. Schnabel, A. Heintz-Buschart (2020): dadasnake, a Snakemake implementation of DADA2 to process amplicon sequencing data for microbial ecology. GigaScience 9: giaa135.

C.A. Guerra, A. Heintz-Buschart, J. Sikorski, A. Chatzinotas, N. Guerrero-Ramírez, S. Cesarz, L. Beaumelle, M.C. Rillig, F.T. Maestre, M. Delgado-Baquerizo, F. Buscot, J. Overmann, G. Patoine, H.R.P. Phillips, M. Winter, T. Wubet, K. Küsel, R.D. Bardgett, E.K. Cameron, D. Cowan, T. Grebenc, C. Marín, A. Orgiazzi, B.K. Singh, D.H. Wall, N. Eisenhauer (2020): Blind spots in global soil biodiversity and ecosystem function research. Nature Communications 11: 3870.

S.D. Jurburg, M. Konzack, N. Eisenhauer, A. Heintz-Buschart (2020): The archives are half-empty: an assessment of the availability of microbial community sequencing data. Communications Biology 3: 474.

L.D. Prada-Salcedo, K. Goldmann, A. Heintz-Buschart, T. Reitz, J. Wambsganss, J. Bauhus, F. Buscot (2020): Fungal guilds and soil functionality respond to tree community traits rather than to tree diversity in European forests. Molecular Ecology, https://doi.org/10.1111/mec.15749.

M. Widdig, A. Heintz-Buschart, P.M. Schleuss, A. Guhr, E.T. Borer, E.W. Seabloom, M. Spohn (2020): Effects of nitrogen and phosphorus addition on microbial community composition and element cycling in a grassland soil. Soil Biology and Biochemistry 151: 108041.

M. Herold, S. Martinez Arbas, S. Narayanasamy, A.R. Sheik, L.A.K. Kleine Borgmann, L. A. Lebrun, B. Kunath, H. Roume, I. Bessarab, R.B.H. Williams, J. Gillece, J. Schupp, P.S. Keim, C. Jäger, M. Hoopmann, R. Moritz, Y. Ye, S. Li, H. Tang, A. Heintz-Buschart, P. May, E.E.L. Muller, C.C. Laczny, P. Wilmes (2020): Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance. Nature Communications 11, 5281.

F. Fischer, R. Romero, A. Hellhund, U. Linne, W. Bertrams, O. Pinkenburg, H. Shams Eldin, K. Binder, R. Jacob, A. Walker, B. Stecher, M. Basic, M. Luu, R. Mahdavi, A. Heintz-Buschart, A. Visekruna, U. Steinhoff (2020): Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota. Gut Microbes 12: 1-17.

M. Ganther, B. Yim, Z. Ibrahim, M.D. Bienert, E. Lippold, L. Maccario, S.J. Sørensen, G.P. Bienert, D. Vetterlein, A. Heintz-Buschart, E. Blagodatskaya, K. Smalla, M.T. Tarkka (2020): Compatibility of X-ray computed tomography with plant gene expression, rhizosphere bacterial communities and enzyme activities. Journal of Experimental Botany eraa262.

P.-M. Schleuss, M. Widdig, A. Heintz-Buschart, K. Kirkman, M. Spohn (2020): Interactions of nitrogen and phosphorus cycling promote P acquisition and explain synergistic plant growth responses. Ecology e03003.


K. Goldmann, R.S. Boeddinghaus, S. Klemmer, K.M. Regan, A. Heintz-Buschart, M. Fischer, D. Prati, H.-P. Piepho, D. Berner, S. Marhan, E. Kandeler, F. Buscot, T. Wubet (2019): Unraveling spatio-temporal variability of arbuscular mycorrhiza fungi in a temperate grassland plot. Environmental Microbiology 22(3): 873-888.


C. Weißbecker, A. Heintz-Buschart, H. Bruelheide, F. Buscot, T. Wubet (2019): Linking Soil Fungal Generality to Tree Richness in Young Subtropical Chinese Forests. Microorganisms 7(11): 547.

O. Hickl, A. Heintz-Buschart, A. Trautwein-Schult, R. Hercog, P. Bork, P. Wilmes, D. Becher (2019): Sample preservation and storage significantly impact taxonomic and functional profiles in metaproteomics studies of the human gut microbiome. Microorganisms 7: 367.


P.-M. Schleuss, M. Widdig, A. Heintz-Buschart, A. Guhr, S. Martin, K. Kirkman, M. Spohn (2019): Stoichiometric controls of soil carbon and nitrogen cycling after long-term nitrogen and phosphorus addition in a mesic grassland in South Africa. Soil Biology & Biochemistry 135: 294-303.

A. Peters, P. Krumbholz, E. Jäger, A. Heintz-Buschart, M.V. Çakir, S. Rothemund, A. Gaudl, U. Ceglarek, T. Schöneberg, C. Stäubert (2019): Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3. PLoS Genetics 15: e1008145.

T.S.B. Schmidt, M.R. Hayward, L.P. Coelho, S.S. Li, P.I. Costea, A.Y. Voigt, J. Wirbel, O.M. Maistrenko, R.J. Alves, E. Bergsten, C. de Beaufort, I. Sobhani, A. Heintz-Buschart, S. Sunagawa, G. Zeller, P. Wilmes, P. Bork (2019): Extensive Transmission of Microbes along the Gastrointestinal Tract. eLife 8: e42693.

L. Wampach*, A. Heintz-Buschart*, J.V. Fritz*, J. Ramiro-Garcia, J. Habier, M. Herold, S. Narayanasamy, A. Kaysen, A.H. Hogan, L. Bindl, J. Bottu, R. Halder, C. Sjöqvist, P. May, A.F. Andersson, C. de Beaufort, P. Wilmes (2018): Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential. Nature Communications 9: 5091.

A. Malabirade, J. Habier, A. Heintz-Buschart, P. May, J. Godet, R. Halder, A. Etheridge, D.J. Galas, P. Wilmes, J.V. Fritz (2018): The RNA Complement of Outer Membrane Vesicles From Salmonella enterica Serovar Typhimurium Under Distinct Culture Conditions. Frontiers in Microbiology 9: 2015.

A. Heintz-Buschart, D. Yusuf, A. Kaysen, A. Etheridge, J.V. Fritz, P. May, C. de Beaufort, B.B. Upadhyaya, A. Ghosal, D.J. Galas, P. Wilmes (2018): Small RNA profiling of low biomass samples: identification and removal of contaminants. BMC Biology 16: 52.

A.E. Laloo, J. Wei, D. Wang, S. Narayanasamy, I. Vanwonterghem, D.W. Waite, J. Steen, A. Kaysen, A. Heintz-Buschart, Q. Wang, B.L. Schulz, A.S. Nouwens, P. Wilmes, P. Hugenholtz, Z. Yuan, P.L. Bond (2018): Mechanisms of persistence of the ammonia oxidising bacteria- Nitrosomonas to the biocide Free Nitrous Acid (FNA). Environmental Science & Technology 52: 5386–97.

J. Habier, P. May, A. Heintz-Buschart, A. Ghosal, A.K. Wienecke-Baldacchino, E.N.M. Nolte-'t Hoen, P. Wilmes, J.V. Fritz (2018): Extraction and analysis of RNA isolated from pure bacteria-derived outer membrane vesicles. Methods in Molecular Biology. 1737:213-230.

A. Heintz-Buschart, U. Pandey, T. Wicke, A. Janzen, E. Sittig-Wiegand, C. Trenkwalder, W.H. Oertel, B. Mollenhauer, P. Wilmes (2017): The nasal and gastrointestinal microbiome in Parkinson’s disease and idiopathic REM sleep behavior disorder. Movement Disorders 6: e28032–11.

A. Kaysen, A. Heintz-Buschart, E.E.L. Muller, S. Narayanasamy, L. Wampach, C.C. Laczny, K. Franke, J. Bittenbring, J.G. Schneider, P. Wilmes (2017): Integrated meta-omic analyses of the gastrointestinal tract microbiome in patients undergoing allogeneic stem cell transplantation. Translational Research 186: 79-94.

L. Wampach, A. Heintz-Buschart, A. Hogan, E.E.L. Muller, S. Narayanasamy, C.C. Laczny, L.W. Hugerth, L. Bindl, J. Bottu, A.F. Andersson, C. de Beaufort, P. Wilmes (2017): The dynamics of archaea, bacteria and microeukaryotes within the human gastrointestinal microbiome during the first year of life according to birth mode. Frontiers in Microbiology 2: 738.

S. Narayanasamy, Y. Jarosz, E.E.L. Muller, A. Heintz-Buschart, M. Herold, A. Kaysen, C.C. Laczny, N. Pinel, P. May, P. Wilmes: IMP: a reproducible pipeline for reference-independent integrated metagenomic and metatranscriptomic analyses. Genome Biology 17: 260.

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, C. Bellora, A. Krishna, L. Wampach, J.G. Schneider, A. Hogan, C. de Beaufort, P. Wilmes (2016): Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes. Nature Microbiology 2: 16180. Erratum in Nature Microbiology 2: 16227.

C.C. Laczny, E.E.L. Muller, A. Heintz-Buschart, M. Herold, L.A. Lebrun, A. Hogan, P. May, C. de Beaufort, P. Wilmes (2016): Identification, recovery, and refinement of hitherto undescribed population-level genomes from the human gastrointestinal tract. Frontiers in Microbiology 7: 884.

S. Cui, R.Y. Hassan, A. Heintz-Buschart, U. Bilitewski (2016): Regulation of Candida albicans interaction with macrophages through the activation of HOG pathway by genistein. Molecules 21: E162.

H. Roume*, A. Heintz-Buschart*, E.E.L. Muller, P. May, V.P. Satagopam, C.C. Laczny, S. Narayanasamy, L.A. Lebrun, M.R. Hoopmann, J.M. Schupp, J.D. Gillece, N.D, Hicks, D.M. Engelthaler, T. Sauter, P.S. Keim, R.L. Moritz, P. Wilmes (2015). Comparative integrated omics: identification of key functionalities in microbial community-wide metabolic networks. NPJ Biofilms Microbiomes 1: 15007.

X. Chen, L. Miché, S. Sachs, Q. Wang, A. Buschart, H. Yang, C. Vera Cruz, B. Reinhold-Hurek, T. Hurek, (2015): Rice responds to endophytic colonization which is independent of the common symbiotic signaling pathway. New Phytologist 208: 531-43.

C. Mathay, G. Hamot, E. Henry, L. Georges, C. Bellora, L. Lebrun, B. de Witt, W. Ammerlaan, A. Buschart, P. Wilmes, F. Betsou (2015): Method optimization for fecal sample collection and fecal DNA extraction. Biopreservation and Biobanking 13: 79-93.

A. Ghosal, B.B. Upadhyaya, J.V. Fritz, A. Heintz-Buschart, M.S. Desai, D. Yusuf, D. Huang, A. Baumuratov, K. Wang, D. Galas, P. Wilmes (2015): The extracellular RNA complement of Escherichia coli. Microbiologyopen doi: 10.1002/mbo3.235.

E.E.L. Muller, N. Pinel, C.C. Laczny, M.R. Hoopmann, S. Narayanasamy, L.A. Lebrun, H. Roume, J. Lin, P. May, N.D. Hicks, A. Heintz-Buschart, L. Wampach, C.M. Liu, L.B. Price, J.D. Gillece, C. Guignard, J.M. Schupp, N. Vlassis, N.S. Baliga, R.L. Moritz, P.S. Keim, P. Wilmes (2014): Community-integrated omics links dominance of a microbial generalist to fine-tuned resource usage. Nature Communications 26: 5603.

H. Roume, A. Heintz-Buschart, E.E.L. Muller, P. Wilmes (2013): Sequential isolation of metabolites, RNA, DNA, and proteins from the same unique sample. Methods in Enzymology 531: 219-36.

A. Heintz-Buschart, H. Eickhoff, E. Hohn, U. Bilitewski (2013): Identification of inhibitors of yeast-to-hyphae transition in Candida albicans by a reporter screening assay. Journal of Biotechnology 164: 137-42.

A. Buschart, A. Burakowska, U. Bilitewski (2012): The fungicide fludioxonil antagonizes fluconazole activity in the human fungal pathogen Candida albicans. Journal of Medical Microbiology 61: 1696-703.

A. Buschart*, K. Gremmer*, M. El-Mowafy, J. van den Heuvel, P.P. Müller, U. Bilitewski (2012): A novel functional assay for inhibitors of fungal histidine kinases type III reveals the role of HAMP domains for fungicide sensitivity. Journal of Biotechnology 157: 268-77.

A. Buschart*, S. Sachs*, X. Chen, J. Herglotz, A. Krause, B. Reinhold-Hurek (2012): Flagella mediate endophytic competence rather than act as MAMPS in rice-Azoarcus sp. strain BH72 interaction. Molecular Plant Microbe Interactions 25: 191-9.

M. Marselle, T. Hartig, D. Cox, S. de Bell, S. Knapp, S. Lindley, M. Triguero-Mas, K. Böhning-Gaese, P.A. Cook, S. de Vries, A. Heintz-Buschart, M. Hofmann, K.N. Irvine, N. Kabisch, F. Kolek, R. Kraemer, I. Markevych, D. Martens, R. Müller, M. Nieuwenhuijsen, J.M. Potts, J. Stadler, S. Walton, S.L. Warber, A. Bonn (2021): Pathways linking biodiversity to human health: a conceptual framework. Environment International, 150: 106420.

N. Eisenhauer, F. Buscot, A. Heintz-Buschart, S.D. Jurburg, K. Küsel, J. Sikorski, H.-J. Vogel, C.A. Guerra (2021): The multidimensionality of soil macroecology. Global Ecology and Biogeography 30: 4-10.

H.R.P. Phillips, A. Heintz-Buschart, N. Eisenhauer (2020): Putting soil invertebrate diversity on the map. Molecular Ecology 9: 655–657.

A. Heintz-Buschart, P. Wilmes (2017): Human Gut Microbiome: Function Matters. Trends in Microbiology 26: 563-574.

J.V. Fritz, A. Heintz-Buschart, A. Ghosal, L. Wampach, A. Etheridge, D. Galas, P. Wilmes (2016): Sources and functions of extracellular small RNAs in human circulation. Ann. Rev. Nutr. 36: 301--36.

P. Wilmes, A. Heintz-Buschart, P.L. Bond (2015): A decade of metaproteomics: where we stand and what the future holds. Proteomics 15: 3409--17.


Conference Contributions

Neues vom Mikrobiom und seiner Interaktion mit dem Immunsystem. Gemeinsame Jahrestagung der AGPD und der DGKED, Saarbrücken, November 2019.

Functional analysis of the human microbiome using integrated multi-omics. Symposium of SFB1052 - Understanding obesity. Grimma, 2017.

Beeinflusst das Mikrobiom den Typ 1-Diabetes? 12. Karl-Stolte-Seminar zur Pädiatrischen Diabetologie, Hannover, Germany, 2016.

The role of the microbiome in the pathogenesis of type 1 diabetes - what do we know? ISPAD & APEG conference 2015, Brisbane, Australia, 2015.

Integrating multi-omics for analyses of microbial communities, from the human gut to the wastewater treatment plant. Queensland University, Australia, 2015.

Beitrag der mikrobiellen Ökologie zur Abwasserbehandlung. 35. Assistententreffen der Siedlungswasserwirtschaft, Luxembourg, 2014.

A. Heintz-Buschart: Data structures for fast querying and statistical analysis of multi-omics datasets in microbial ecology. Workshop "Integrating computational meta-omics for microbiome research" at German Conference on Bioinformatics, Heidelberg, Germany, 2019.

S.F.M. Wahdan, W. Purahong, A. Heintz-Buschart. Genome-centric views on decomposer activity. Annual Conference 2019 of the Association for General and Applied Microbiology, Mainz, Germany, 2019.

A. Heintz-Buschart. Integration of microbial omics datasets for biodiversity research. 3. Central German Meeting on Bioinformatics, Mittweida, Germany, 2018.

A. Heintz-Buschart, B. Rommes, P. Wilmes, P. May. Functional analyses of the coding and non-coding metatranscriptome of the human gut microbiome. Prokagenomics, Göttingen, Germany, 2017.

A. Heintz-Buschart, P. May, A. Hogan, C. de Beaufort, P. Wilmes. Integration of multi-omics data of the human microbiome. IUMS – Bacteriology and Applied Microbiology Conference, Singapore, 2017.

A. Heintz-Buschart. How to know what your microbiome is doing for you. 1st Luxembourg Microbiology Day, Dudelange, Luxembourg, 2017 (price for the best oral presentation).

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, C. Bellora, A. Krishna, L. Wampach, J.G. Schneider, A. Hogan, C. de Beaufort, P. Wilmes. Integrated multi-omic analysis of the human gastrointestinal microbiome in familial type 1 diabetes. ICAN symposium, Paris, France, 2016 (price for the best oral presentation).

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, C. Bellora, A. Krishna, L. Wampach, J.G. Schneider, A. Hogan, C. de Beaufort, P. Wilmes. Integrated multi-omic analysis of the human gastrointestinal microbiome in familial type 1 diabetes. de.nbi conference Bioinfomatics in Health and Disease, Heidelberg, Germany, 2016.

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, C. Bellora, A. Krishna, L. Wampach, J.G. Schneider, A. Hogan, C. de Beaufort, P. Wilmes. Integrated multi-omic analysis of the human gastrointestinal microbiome in familial type 1 diabetes. ISME 16, Montréal, Canada, 2016.

C. Bebek, A. Heintz-Buschart, S. Makhali, C. Schließler, T. Schröpfer, A, Seitz, J. Holkenbrink. C COPY A, ENCRYPTED. The Power of/in Academia: Critical Interventions in Production an Society, Frankfurt (Main), Germany, 2015.

A. Heintz-Buschart, E.E.L. Muller, B. Lange, B. Mollenhauer, W.H. Oertel, P. Wilmes. Characterization of the gastrointestinal microbiome in patients with REM-sleep behaviour disorder and newly diagnosed Parkinson’s disease. 2nd International PD symposium, Munsbach, Luxembourg, 2014.

A. Buschart, U. Bilitewski. Novel targets for antifungals in Candida albicans. Status Workshop of subject group Eukaryotic Pathogens of the DGHM, Düsseldorf, Germany, 2011.

A. Buschart, K. Gremmer, R. Geffers, J. van den Heuvel, P.P. Müller, U. Bilitewski. Functional analysis of Candida albicans Nik1p in Saccharomyces cerevisiae. Joint conference of VAAM und DGHM, Hannover, Germany, 2010.

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, L. Wampach, A. Hogan, J.G. Schneider, C. de Beaufort, P. Wilmes. Integrated omic analyses of microbial communities and populations in the human gut. EMBL conference - The Human Microbiome, Heidelberg, Germany, 2015 (poster and flash talk).

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, L. Wampach, A. Hogan, J.G. Schneider, C. de Beaufort, P. Wilmes. Integrated omics analyses of the human gut microbiome in a multiplex family study of type 1 diabetes mellitus. IHMC 2015, Luxembourg, 2015.

A. Heintz-Buschart, E.E.L. Muller, B. Lange, B. Mollenhauer, W.H. Oertel, P. Wilmes. Characterization of the gastrointestinal microbiome in patients with REM-sleep behaviour disorder and newly diagnosed Parkinson’s disease. 2nd European Conference of Microbiology and Immunology, Berlin, Germany, 2014.

A. Heintz-Buschart, P. May, C.C. Laczny, L.A. Lebrun, L. Wampach, J.G. Schneider, A. Hogan, P. Wilmes, C. de Beaufort. Integrated Omic Analyses of the Human Gut Microbiome in a Multiplex Family Study of Type 1 Diabetes Mellitus. EMBO|EMBL Symposium: Translating Diabetes, Heidelberg, Germany, 2014.

A. Heintz-Buschart, P. May, L.A. Lebrun, J.Y. Ferrand, J.-P. Trezzi, S. Collignon, L. Wampach, E. Glaab, C.C. Laczny, A. Kaysen, J.G. Schneider, K. Schneider, A. Hogan, C. de Beaufort, P. Wilmes. Integrated Meta-omic Analyses of the Microbiome in the Luxembourg-based Family Study into Diabetes Mellitus. 3rd Luxembourgish Nutrition Conference, Luxembourg, 2013 (poster prize).

A. Buschart, S. Cui, R.Y.A. Hassan, A. Burakowska, M. Suarez Diez, U. Bilitewski. Interplay of metabolism and regulation of cell wall structure in Candida albicans - Inhibitors of ubiquinol - cytochrome c reductase. European Conference on Fungal Genomics 11, Marburg, Germany, 2012.

A. Buschart, A. Burakowska, U. Bilitewski: Induction of the ABC-transporters Cdr1p and Cdr2p and resistance to fluconazoleby the fungicide fludioxonil in Candida albicans. European Conference on Fungal Genomics 11, Marburg, Germany, 2012.

A. Buschart, K. Gremmer, R. Geffers, F. Sasse, J. van den Heuvel, P.P. Müller, U. Bilitewski. Fungicides activate the osmotic stress response network in S. cerevisiae via the Candida albicans histidine kinase Nik1p. International Mycological Conference 9, Edinburgh, UK, 2010.