Carolin Dahley
Kontakt
Department Computational Biology and Chemistry
Helmholtz-Zentrum für Umweltforschung GmbH - UFZ
Gruppe Toxikokinetische Modellierung
Permoserstr. 15
04318 Leipzig
Tel: ++49 341 6025 1434
carolin.dahley@ufz.de
Forschungsinteressen
• Passive membrane permeability
• Cell-based (Caco-2, MDCK) and cell-free (PAMPA, BLM) in vitro permeability assays
• In silico models for predicting permeability
Publikationen
2024 (2)
- Dahley, C., Böckmann, T., Ebert, A., Goss, K.-U. (2024):
Predicting the intrinsic membrane permeability of Caco-2/MDCK cells by the solubility-diffusion model
Eur. J. Pharm. Sci. 195 , art. 106720 10.1016/j.ejps.2024.106720 - Ebert, A., Dahley, C., Goss, K.-U. (2024):
Pitfalls in evaluating permeability experiments with Caco-2/MDCK cell monolayers
Eur. J. Pharm. Sci. 194 , art. 106699 10.1016/j.ejps.2024.106699
2023 (1)
- Dahley, C., Goss, K.-U., Ebert, A. (2023):
Revisiting the pKa-Flux method for determining intrinsic membrane permeability
Eur. J. Pharm. Sci. 191 , art. 106592 10.1016/j.ejps.2023.106592
2022 (1)
- Dahley, C., Garessus, E.D.G., Ebert, A., Goss, K.-U. (2022):
Impact of cholesterol and sphingomyelin on intrinsic membrane permeability
Biochim. Biophys. Acta-Biomembr. 1864 (9), art. 183953 10.1016/j.bbamem.2022.183953