Prof. Dr. Tamara Tal
Adresse:
Permoserstr. 15
04318 Leipzig
Gebäude: 6.0
Raum: 519
Telefon: +49 341 6025 1524
Forschungsinteressen
- Entwicklung neuer Methoden (NAMs) für die Entwicklungsneurotoxizität
- Verwendung molekularer Ansätze zur Klärung der Mechanismen, durch die eine chemische Exposition nachteilige Folgen hervorruft
- Untersuchung der Wechselwirkungen zwischen Chemikalien und Mikrobiom, die die Ergebnisse der Wirts-Toxizität beeinflussen
Lebenslauf
Seit 2021
Professorin für Integrierte Systemtoxikologie, Universität Leipzig, Medizinische Fakultät, Leipzig, Deutschland
Seit 2019
Gruppenleiterin, Gruppe Molekulare Toxikologie, Department für Bioanalytische Ökotoxikologie, Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig, Deutschland
Hauptuntersuchungsleiterin, Abteilung für integrierte Systemtoxikologie, US-Umweltschutzbehörde (US EPA), RTP, NC, USA
2011-2015
R-Authority Postdoc-Stipendium, Abteilung Integrierte Systemtoxikologie, US EPA, RTP, NC, USA
2008-2011
NIEHS-Postdoktorand, Abteilung für Umwelt- und Molekulartoxikologie, Oregon State University (OSU), Corvallis, Oregon, USA
2003-2008
Doktorand, Lehrplan für Toxikologie, Universität von North Carolina (UNC) Chapel Hill, Chapel Hill, NC, USA
Auszeichnungen
2021 - 2026
Helmholtz W2 Award
NEURO-XENO-MICROBIOME: Examining microbiome-xenobiotic interactions that affect host neurodevelopment
2020 - 2022
UFZ Chemicals in the Environment (CITE) TB College
MibiTox: The role of the intestinal microbiome as driver between pesticide exposure and disease pathogenesis.
2020
Paper of the Year Award, Society of Toxicology, Molecular and Systems Biology Specialty Section
2018 - 2019
US EPA Pathfinder Innovation Project Award
In vivo bioremediation of PFAS in zebrafish
2017
US EPA Science and Technological Achievement Award (STAA) – Level III Award, Using novel zebrafish toxicity assays to evaluate a predictive model of developmental vascular toxicity
2016 - 2018
US EPA Pathfinder Innovation Project Stage Three Award
Gut microbiome influence on developmental toxicity: Does the microbiome
modify chemical toxicity during brain development?
2015
First Place, Reproductive and Developmental Specialty Section Postdoctoral Poster Award, Society of Toxicology
2015
First Place, Emil A. Pfitzer Post-Doc Award, Drug Discovery Toxicology Specialty Section, Society of Toxicology
2015
US EPA STAA Honorable Mention, Using novel zebrafish toxicity assays to evaluate a predictive model of developmental vascular toxicity
2014 - 2016
US EPA Pathfinder Innovation Project Stage 1-2 Awards
Gut microbiome influence on developmental toxicity: Does the microbiome
modify chemical toxicity during brain development?
2014
Exemplary Poster Award, EPA Chemical Safety Data Summit
2014
Research Award, Future Tox II Meeting
2014
US EPA Bronze Medal for Commendable Service
2012
First Place, US EPA NLTO Oral Presentation Competition
2012
US EPA Peer Ovation Award, Top Innovation, Virtual Embryo Project
2011
Environmental Health Sciences Fellow Award
2010
Second Place, Pacific Northwest Association of Toxicologists Regional Conference Poster Award
2010
First Place, International Neurotoxicology Conference Postdoctoral Research Award
2010
Society of Toxicology Molecular Biology Specialty Section Postdoctoral Research Award
2010
Second Place, Society of Toxicology Neurotoxicology Specialty Section Poster Award
2008 - 2011
T32 National Institute of Environmental Health Sciences Postdoctoral Fellowship
2008
Society of Toxicology Inhalation Specialty Section Graduate Student Award
2008
Society of Toxicology Graduate Student Travel Award
2007
University of North Carolina at Chapel Hill Graduate Education Advancement Board Impact Award
2007
NIH National Graduate Student Research Festival Award
2006
North Carolina Society of Toxicology Graduate Student Poster Award
2006
Third Place, Society of Toxicology Metals Specialty Section Student Award
2005
North Carolina Society of Toxicology Graduate Student Poster Award
1998 - 2003
University of Central Florida Honors College
1998 - 2002
Florida Bright Future Scholarship
Publikationen
2024 (1)
- Nöth, J., Busch, W., Tal, T., Lai, C., Ambekar, A., Kießling, T.R., Scholz, S. (2024):
Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Arch. Toxicol. 98 (2), 537 - 549 10.1007/s00204-023-03633-x
2023 (3)
- Avila Santos, A.P., Kabiru Nata’ala, M., Kasmanas, J.C., Bartholomäus, A., Keller-Costa, T., Jurburg, S.D., Tal, T., Camarinha-Silva, A., Saraiva, J.P., de Carvalho, A.C.P.L.F., Stadler, P.F., Sipoli Sanches, D., Nunes da Rocha, U. (2023):
The AnimalAssociatedMetagenomeDB reveals a bias towards livestock and developed countries and blind spots in functional-potential studies of animal-associated microbiomes
Animal Microbiome 5 , art. 48 10.1186/s42523-023-00267-3 - De Castelbajac, T., Aiello, K., Arenas, C.G., Svingen, T., Ramhøj, L., Zalko, D., Barouki, R., Vanhaecke, T., Rogiers, V., Audebert, M., Oelgeschlaeger, M., Braeuning, A., Blanc, E., Tal, T., Rüegg, J., Fritsche, E., Marx-Stoelting, P., Rivière, G. (2023):
Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment
Front. Toxicol. 5 , art. 1216369 10.3389/ftox.2023.1216369 - Escher, B.I., Altenburger, R., Blüher, M., Colbourne, J.K., Ebinghaus, R., Fantke, P., Hein, M., Köck, W., Kümmerer, K., Leipold, S., Li, X., Scheringer, M., Scholz, S., Schloter, M., Schweizer, P.-J., Tal, T., Tetko, I., Traidl-Hoffmann, C., Wick, L.Y., Fenner, K. (2023):
Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
Arch. Toxicol. 97 (5), 1267 - 1283 10.1007/s00204-023-03485-5
2021 (4)
- Kasmanas, J.C., Bartholomäus, A., Borim Corrêa, F., Tal, T., Jehmlich, N., Herberth, G., von Bergen, M., Stadler, P.F., de Carvalho, A.C.P.L.F., Nunes da Rocha, U. (2021):
HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes
Nucleic Acids Res. 49 (D1), D743 - D750 10.1093/nar/gkaa1031 - Tal, T., Vogs, C. (2021):
Invited perspective: PFAS bioconcentration and biotransformation in early life stage zebrafish and its implications for human health protection
Environ. Health Perspect. 129 (7), art. 071304 10.1289/EHP9625 - Volz, D.C., Cannon, J., Tal, T. (2021):
Introduction to leveraging non-mammalian models for developmental neurotoxicity testing
Neurotoxicol. Teratol. 87 , art. 107001 10.1016/j.ntt.2021.107001 - Weitekamp, C.A., Kvasnicka, A., Keely, S.P., Brinkmann, N.E., Howey, X.M., Gaballah, S., Phelps, D., Catron, T., Zurlinden, T., Wheaton, E., Tal, T. (2021):
Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish
Animal Microbiome 3 , art. 12 10.1186/s42523-020-00069-x
2020 (3)
- Bertotto, L.B., Catron, T.R., Tal, T. (2020):
Exploring interactions between xenobiotics, microbiota, and neurotoxicity in zebrafish
NeuroToxicology 76 , 235 - 244 10.1016/j.neuro.2019.11.008 - Gaballah, S., Swank, A., Sobus, J.R., Howey, X.M., Schmid, J., Catron, T., McCord, J., Hines, E., Strynar, M., Tal, T. (2020):
Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS
Environ. Health Perspect. 128 (4), art. 047005 10.1289/EHP5843 - Tal, T., Yaghoobi, B., Lein, P.J. (2020):
Translational toxicology in zebrafish
Curr. Opin. Toxicol. 23-24 , 56 - 66 10.1016/j.cotox.2020.05.004
2019 (1)
- Catron, T.R., Gaballah, S., Tal, T. (2019):
Using zebrafish to investigate interactions between xenobiotics and microbiota
Curr. Pharmacol. Rep. 5 , 468 - 480 10.1007/s40495-019-00203-7