Kollaborationen und Projekte 

Aktuelle Drittmittelprojekte

• NORMAN Association is a self-sustaining network of reference laboratories, research centres and related organisations for the monitoring and biomonitoring of emerging environmental substances.
  
  
• Joint Danube Survey 4 Our role is to assess water and sediment quality with effect-based tools.
  
  
• Kleingewässermonitoring Das Projekt Kleingewässermonitoring (KgM) liefert eine quantitative Einschätzung zum Einfluss von Pflanzenschutzmitteln aus diffusen Quellen der Landwirtschaft auf kleine und mittlere Fließgewässer.
  
  
• Effect-based Monitoring in Water Safety Planning in collaboration with the Global Water Research Coalition
  
  
• Xtract
  
  
• LVSPE Event
  
  
• Sentinel
  
  
• Microfate In the BMBF-funded project MICRO-FATE (Characterization of the fate and effects of microplastic particles between hotspots and remote regions in the Pacific Ocean) lead by Dr. Annika Jahnke, our contribution is to assess the mixture effect of pollutants extracted from plastic and its environments (seawater and sediments) with cell-based bioassays.
  
  
• Alternative methods for wastewater treatment The approach is outlined in “Application of bioanalytical tools to evaluate treatment efficacy of conventional and intensified treatment wetlands” and we presently collaborate with Nadine Sossalla of UBZ on the application of effect-based tools for improving the treatment efficacy of treatment wetlands.

Aktuelle Projekte innerhalb des UFZ

• Healthy Aquatic Ecosystem

• Exposome

Abgeschlossene Projekte

• SOLUTIONS wants to provide solutions for emerging pollutants in European water resources in close dialogue with stakeholders.
  
  
• LRI ECO36 The objective of this projects was to progress exposure assessment in in vitro bioassays used for high-throughput screening (HTS) in 384- and 1536-well plates and complex in vitro bioassays based on transwell and 3D cultures. The outcomes were experimentally validated models to predict the freely dissolved and cellular effect concentrations for existing in vitro toxicity data, including ToxCast and published data that were based on nominal effect concentrations only, which will then make them amenable for QIVIVE. The long-term benefit of the project will be routine analytical tools that will improve exposure assessment in HTS tests in the future and could revolutionise the application of HTS in risk assessment.
  
  
• IPIE In the project "Intelligence Led Assessment of Pharmaceuticals in the Environment” we lead the work package on ecotoxicity prediction methods. Our outputs are summarised in a review on "Recommendations for Improving Methods and Models for
  Aquatic Hazard Assessment of Ionizable Organic Chemicals”.
  
  
• NC3Rs CrackIT Challenge 27 The project" Using a Combination of Serum-mediated Passive Dosing and SPME Measurements for Controlling the Dose of Chemicals in in vitro Bioassays “ was lead by Dr. Luise Henneberger. The outcome is summarised in Henneberger L, Mühlenbrink M, König M, Schlichting R, Fischer FC, Escher BI (2019) Quantification of freely dissolved effect concentrations in in vitro cell-based bioassays.
  
  
• Unilever Building improved in-vitro exposure assessment capability: Towards the development and implementation of enhanced QIVIVE tools. The outcome is published in Experimental Validation of Mass Balance Models for in vitro Cell-based Bioassays. Environmental Science and Technology 2020 accepted
  
  
• Water quality of drinking water We collaborated with Veolia for bioanalxytical assessment of drinking water and drinking water treatment in France. The results are summarised in two publications "Bioanalytical assessment of adaptive stress responses in drinking water as a tool to differentiate between micropollutants and disinfection by-products” and "Application of in vitro bioassays for water quality monitoring in three drinking water treatment plants using different treatment processes including biological treatment, nanofiltration and ozonation coupled with disinfection"