Collaborations and Projects 

At UFZ we contribute to the IP Exposome and Healthy Aquatic Ecosystems.


iPiE

EU-Project Intelligence-led Assessment of Pharmaceuticals in the Environment (iPiE)

Active pharmaceutical ingredients (APIs) can be released to the natural environment during the manufacturing process, following use by patients or when unused medicines are disposed of in an incorrect manner. As APIs are biologically active compounds, concerns have been raised about the potential effects of APIs in the environment on human and environmental health. Over the past 25+ years, a substantial amount of work has been done to determine the occurrence, fate, effects and resulting risks of APIs in the environment and regulatory schemes have been developed requiring environmental risk assessments of all new APIs. However, for most APIs currently in use, only limited data are available on environmental risks, and for new APIs, the testing schemes may not always be optimal.
The aim of iPiE therefore is to develop frameworks that utilize information from toxicological studies, pharmacological mode of action and in silico models to support intelligence-based environmental testing of pharmaceuticals in development and to prioritise legacy pharmaceuticals (those authorized prior to 2006 enactment of Medicines Agency requirements) for targeted environmental risk assessment and/or environmental (bio) monitoring.

The Helmholtz Centre for Environmental Research (UFZ) is leading work package 4 on the development of methods for predicting environmental effects of APIs. A particular focus of UFZ’s activity is on the role of the speciation of organic acids and bases for ecotoxicity prediction models and the fish plasma model.

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EU project SOLUTIONS

We are partners of the EU project SOLUTIONS through a NHMRC-EU grant to the University of Queensland. Dr. Peta Neale is the postdoc working in SOLUTIONS on the application of bioanalytical tools for water quality monitoring, with a particular focus on bioassays indicative of adaptive stress response pathways (e.g. oxidative stress). We will also contribute to SOLUTIONS through extraction techniques for biota, mixture toxicity modeling and cumulative risk assessment (CRA) techniques.
 

LRI

Paving the way for QIVIVE: from nominal to free to cellular concentrations in in vitro assays

The project "Paving the way for QIVIVE: from nominal to free to cellular concentrations in in vitro assays” is running from 2017 to 2019 and funded by the CEFIC Long-range Research Initiative under the RFP LRI-ECO36 "Building improved in vitro exposure assessment capability”. The objective of this project is to progress exposure assessment in in vitro bioassays used for high-throughput screening (HTS). The expected outcomes are experimentally validated models to predict the freely dissolved and cellular effect concentrations for existing in vitro toxicity data, including ToxCast and published data that were based on nominal effect concentrations only, which will then make them amenable for QIVIVE. The long-term benefit of the project will be routine analytical tools that will improve exposure assessment in HTS tests in the future and could revolutionise the application of HTS in risk assessment. Project partners are Dr. Nynke Kramer from Utrecht University and Prof. Philipp Mayer from Technical University of Denmark.

For more information, see http://cefic-lri.org/projects/paving-the-way-for-qivive-from-nominal-to-free-to-cellular-concentrations-in-in-vitro-assays/

CHEMO-RISK - Chemometers for in situ risk assessment of mixtures of pollutants

In 2016, the European Research Council (ERC) selected the proposal "CHEMO-RISK - Chemometers for in situ risk assessment of mixtures of pollutants" submitted by Celltox researcher Annika Jahnke for funding as a Starting Grant. The project runs between 2017 and 2022. Recruitment of the new research team, consisting of three PhD students, a postdoctoral fellow and a technician, is ongoing. The CHEMO-RISK team will work on different aspects of a novel scientifically based risk assessment paradigm of environmental pollutants that brings together the assessment of exposure and effects of a broad range of chemicals in a single procedure and delivers information of potential relevance for ecosystem and human health. CHEMO-RISK aims at replacing the current paradigm in risk assessment of single "indicator" chemicals that disregards bioavailability and the combined effects of environmentally relevant mixtures of pollutants. The subprojects cover (i) thermodynamic assessment of bioaccumulation of mixtures of organic pollutants in lakes, (ii) studying internal exposure and effects within different organs and body fluids of seals, (iii) developing polymer-based surrogates to study human exposure to mixtures of environmental pollutants that avoid invasive sampling of blood, and (iv) chemical analysis of the resulting extracts using GC/high resolution-ORBITRAP-MS with the aim of identifying yet unknown problematic compounds.

MICRO-FATE

MICRO-FATE

In the context of the BMBF-funded project MICRO-FATE (Characterization of the fate and effects of microplastic particles between hotspots and remote regions in the Pacific Ocean), we work on the identification, quantification, characterization and possible effects of plastic debris in the Pacific Ocean. The research in MICRO-FATE includes the following topics: (i) On-site sampling of plastic material from surface waters, the water column and the sediment; (ii) Identification and quantification of the plastic material; (iii) Assessment of changing particle properties as a result of weathering and fragmentation; (iv) Investigating effects elicited by field-weathered plastic; (v) Characterizing the role of plastic-colonizing biofilms; (vi) Assessing the incorporation of microplastic in "marine snow" and large diatom aggregates; and (vii) Outreach in frame of “Science meets Society”. During the research cruise SO268/3 on the German research vessel SONNE in the Pacific Ocean between Vancouver and Singapore, we passed the so-called "Great Pacific Garbage Patch" to collect samples from surface water, the water column at different depths and the seabed. These will then be analysed back in the laboratory.