Sylvia Hofmann, PhD


Address

Helmholtz Centre for
Environmental Research - UFZ
Department of Conservation Biology
Permoserstraße 15
04318 Leipzig, Germany

Tel: (0341) 235 4823 06
Fax: (0341) 235 2791
sylvia.hofmann@ufz.de

sh_ufz


Education

- Study of biology (main: zoology) at the Martin-Luther University of Halle-Wittenberg, Germany
- PhD (Dr. rer. nat) at the UFZ. Thesis: Population biology of the common lizard (Zootoca vivipara JACQUIN, 1787) in Saxony-Anhalt and Saxony: Distribution, Ecology, Behaviour and Population genetics
- Postgraduate study of toxikology and environmental conservation at the University of Leipzig
- Study of geoinformation systems at the Anhalt University of Applied Sciences



Research interests

  • phylogeography, evolution and systematics of High Asian herpetofauna
  • population genetics
  • impacts of land use changes on biodiversity
  • genetic epidemiology


Current projects

Predicting the local richness of pollinator species based on remotely sensed texture measures

Testing hypotheses of the uplift and environmental history of the Himalaya using high-elevation amphibians and reptiles


Publications

Hofmann S, Fritzsche P, Miehe G (in press) First record of Elaphe dione from high altitude in Western Sichuan reveals high intraspecific differentiation. Salamandra.

Mohapatra P, Schulz KD, Helfenberger N, Hofmann S, Dutta SK (2016) A contribution to the Indian Trinket Snake Coelognathus helena (DAUDIN, 1803), with the description of a new subspecies. Russian Journal of Herpetology 23 (2):115-144.

Hofmann S, Tillack F, Miehe G (2015) Genetic differentiation among species of the genus Thermophis Malnate (Serpentes, Colubridae) and comments on T. shangrila. Zootaxa 4028(1): 102–120. doi:http://dx.doi.org/10.11646/zootaxa.4028.1.4

Nutsua M, Fischer A, Nebel A, Hofmann S, Schreiber S, Krawczak M, Nothnagel M (2015) Family-based benchmarking of copy number variation detection software. PLoS One. 10(7):e0133465. doi: 10.1371/journal.pone.0133465. eCollection 2015.

Zimmermann A, Zissel G, Müller-Quernheim J, Hofmann S, Schreiber S, Fischer A (2015) Are bronchoalveolar lavages a good source for microbial profiling? Differences between throat and BAL microbiome. Journal of Medical Microbiology 64(8):94851. doi:10.1099/jmm.0.000112.

Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, Rybicki BA, Petrek M, Mrazek F, Pabst S,Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Mihailovic-Vucinic V, Jovanovic D, Sterclova M, Homolka J, the GenPhenReSa Consortium, Nöthen MM, Herms S, Gieger C, Strauch K, Winkelmann J, Boehm BO, Brand A, Büning C, Schürmann M, Ellinghaus E, Baurecht H, Lieb W, Nebel A, Müller-Quernheim J, Franke A, Schreiber S (2015) Identification of immune-relevant factors conferring sarcoidosis genetic risk. American Journal of Respiratory and Critical Care Medicine. 192(6):72736. doi: 10.1164/rccm.201503-0418OC.

Hofmann S, Kraus S, Dorge T, Nothnagel M, Fritzsche P, Miehe G (2014) Phylogeographic, demographic and population structure effects of Pleistocene climatic fluctuations in a high elevation snake species, Thermophis baileyi, on the Tibetan Plateau. Journal of Biogeography 41(11): 21622172. doi:10.1111/jbi.12358

Roitberg ES, Kuranova VN, Bulakhova NA, Orlova VF, Eplanova GV, Zinenko OI, Shamgunova RR, Hofmann S, Yakovlev VA (2013) Variation of Reproductive Traits and Female Body Size in the Most Widely-Ranging Terrestrial Reptile: Testing the Effects of Reproductive Mode, Lineage, and Climate. Evolutionary Biology 40, 420438. doi:10.1007/s11692-013-9247-2

Hofmann S, Fischer A, Nothnagel M, Jacobs G, Schmid B, Wittig M, Franke A, Gaede KI, Schürmann M, Petrek M, Mrazek F, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Rosenstiel P, Höhne K, Zissel G, Müller-Quernheim J, Schreiber S (2013). Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. European Respiratory Journal 41(4):888900. doi:10.1183/09031936.00033812

Hofmann S, Fritzsche P, Dorge T, Solhøy T, Miehe G. (2012) Microsatellites show evidence of sex-biased dispersal in Thermophis baileyi. Herpetologica 68(4):514522. doi: http://dx.doi.org/10.1655/HERPETOLOGICA-D-12-00017

Hofmann S (2012) Population genetic structure and geographic differentiation in the hot spring snake Thermophis baileyi (Serpentes, Colubridae): indications for glacial refuges in southern-central Tibet. Molecular Phylogenetics and Evolution 63(2):396406. doi:10.1016/j.ympev.2012.01.014.

Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S (2012). A Novel Sarcoidosis Risk Locus for Europeans on Chromosome 11q13.1. American Journal of Respiratory and Critical Care Medicine 186(9):87785. doi: 10.1164/rccm.201204-0708OC.

Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC, Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, van Diemen CC, Dubois PC, Edkins S, Fölster-Holst R, Fransen K, Glass DN, Heap GA, Hofmann S, Huizinga TW, Hunt S, Langford C, Lee J, Mansfield J, Marrosu MG, Mathew CG, Mein CA, Müller-Quernheim J, Nutland S, Onengut-Gumuscu S, Ouwehand W, Pearce K, Prescott NJ, Posthumus MD, Potter S, Rosati G, Sambrook J, Satsangi J, Schreiber S, Shtir C, Simmonds MJ, Sudman M, Thompson SD, Toes R, Trynka G, Vyse TJ, Walker NM, Weidinger S, Zhernakova A, Zoledziewska M; Type 1 Diabetes Genetics Consortium; UK Inflammatory Bowel Disease (IBD) Genetics Consortium; Wellcome Trust Case Control Consortium, Weersma RK, Gough SC, Sawcer S, Wijmenga C, Parkes M, Cucca F, Franke A, Deloukas P, Rich SS, Todd JA, van Heel DA. (2011). Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics 44(1):35. doi: 10.1038/ng.1037.

Hofmann S, Fischer A, Till A, Müller-Quernheim J, Häsler R, Franke A, Gäde KI, Schaarschmidt H; GenPhenReSa Consortium, Rosenstiel P, Nebel A, Schürmann M, Nothnagel M, Schreiber S (2011) A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1. European Respiratory Journal 38(5):112735. doi: 10.1183/09031936.00001711.

Keller A, Leidinger P, Bauer A, Elsharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager SU, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Haeusler SF, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel JD, Franke A, Meese E (2011) Toward the blood-borne miRNome of human diseases. Nature Methods 8(10):8413. doi:10.1038/nmeth.1682.

Hofmann S, Dorge T, Solhoy T, Miehe G (2010) Isolation and characterization of microsatellite markers in the Tibetan hot spring snake (Thermophis baileyi). Molecular Ecology Resources 10(6):10981105. doi: 10.1111/j.1755-0998.2010.02898.x.

Fischer A, Nothnagel M, Franke A, Saadati H R, Schürmann M, Müller-Quernheim J, Schreiber S, Hofmann S (2010) Association of inflammatory bowel disease risk loci with sarcoidosis, and its acute and chronic subphenotypes. European Respiratory Journal 37(3):6106. doi: 10.1183/09031936.00049410.

Fischer A, Müller-Quernheim J, Schürmann M, Schreiber S, Nothnagel M, Hofmann S (2010) A genome-wide linkage analysis in 181 German sarcoidosis families using clustered biallelic markers suggests new candidate genes. Chest 138(1):1517. doi: 10.1378/chest.09-2526.

Hofmann S, Franke A, Jacobs G, Fischer A, Müller-Quernheim J, Schürmann M, Gaede KI, Nothnagel M, Krawczak M, Rosenstiel P, Schreiber S (2008) Genome-wide association study identifies a new susceptibility gene for sarcoidosis. Nature Genetics 40:110306. doi: 10.1038/ng.198.

Franke A, Fischer A, Nothnagel M, Becker B, Grabe N, Till A, Müller Quernheim J, Wittig M, Hermann A, Balschun T, Hofmann S, Hampe J, Nürnberg P, Nikolaus S, Krawczak M, Schürmann M, Rosenstiel P, Nebel A, Schreiber S (2008) Combined analysis for sarcoidosis and Crohn disease discovers a common susceptibility locus on chromosome 10p12.2 in a genome-wide 100k SNP scan. Gastroenterology 135:1207–15. doi:10.1053/j.gastro.2008.07.017.

Müller-Quernheim J, Schürmann M, Hofmann S, Gaede KI, Fischer A, Prasse A, Zissel G, Schreiber S (2008) Genetics of Sarcoidosis. Review. Clinics in Chest Medicine 29:39114. doi: http://dx.doi.org/10.1016/j.ccm.2008.03.007.

Hofmann S (2008) Who is sitting next to me? Relatedness between next neighbours in common lizards. Amphibia-Reptilia 29:1924. doi:10.1163/156853808783431497.

Dorge T, Hofmann S, Wangdwei M, Lapager D, Solhøy T, Miehe G (2008) The ecological specialist, Thermophis baileyi (WALL, 1907) - new records, distribution and biogeographic conclusions. Herpetological Bulletin 101:812.

Hofmann S, Henle K (2006) Male reproductive success and intrasexual selection in the common lizard determined by DNA-microsatellites. Journal of Herpetology 40(1):16.

     doi: http://dx.doi.org/10.1670/58-05A.1.

Hofmann S (2002) A simple method to get blood from Zootoca vivipara. Salamandra 38:14548.

Weinandy R, Hofmann S, Gattermann R (2002) The estrus of female gerbils, Meriones unguiculatus is indicated by locomotor activity and influenced by male presence. Folia Zoologica 51:14556.

Weinandy R, Hofmann S, Gattermann R (2001) Mating behaviour during the estrous cycle in Mongolian gerbils (Meriones unguiculatus). Mammalian Biology 66:11620.