Analysis of the exposome in humans and aquatic organisms

Robert Bloch

Environmental factors including chemical contamination and life style may result in changes in the internal chemical environment in humans and other organisms. This internal chemical environment (called exposome) is increasingly realized as key factor for the development of diseases and ecological impacts. The exposome of an organism is understood as the cumulative internal exposure to chemicals. We contribute to unraveling the human exposome by developing multi- and non-target tools for the analysis of human blood and urine. A specific interest is on the analysis of mercapturic acids as a biomarker for electrophilic chemicals and the analytical support of epidemiological studies such as LiNA. The exposome in aquatic organisms including invertebrates and fish is addressed by effect-directed analysis and multi- and non-target screening of biota tissues.