Dr. Till Luckenbach
Adresse:
Permoserstr. 15
04318 Leipzig
Gebäude: 6.0
Raum: 229
Telefon: +49 341 235 1514
Dr. Till Luckenbach
Curriculum Vitae
Till Luckenbach, a molecular ecotoxicologist, is a senior researcher at the Department Bioanalytical Ecotoxicology. He works at the UFZ since 2006. Luckenbach studied biology at the University of Tübingen, where in 2002 he also received his doctorate. In 2002 he was a postdoc at the Max-Planck Institute for Developmental Biology in Tübingen, and, from 2002-2005, at Hopkins Marine Station of Stanford University in Pacific Grove, CA.
Funding for Till Luckenbach`s work was obtained from various sources, including the State of Baden-Württemberg (PhD fellowship), the German Academic Exchange Service (DAAD; PhD and postdoc fellowships, bi-national exchanges with Croatia (Dr. Tvrtko Smital, RBI) and Spain (Dr. Barata, CSIC)), the Deutsche Forschungsgemeinschaft (DFG; postdoc fellowship, early career grant), the Helmholtz Association (Helmholtz-Russia Joint Research Group with partners Irkutsk State University, Alfred-Wegener Institute, Bremerhaven, University of Leipzig) and the UFZ (joint project of five UFZ departments).
Till Luckenbach received the SETAC Best Publication Award 2006
Luckenbach`s research interest is in molecular mechanisms that control the uptake of chemicals from the outside and interactions of environmental contaminants with this system. One focus of his work is on molecular "pumps" located in the outer membrane of cells. These pumps are transporter proteins that prevent toxic chemicals from accumulating inside the cell. Action of these proteins confers resistance of cells against a broad range of toxic chemicals, which is called multixenobiotic resistance or MXR. These transporters are important determinants of toxicokinetics of many chemicals. Luckenbach develops tests to study these transporters and study interaction of environmental chemicals with this defensive mechanism. A problem arising from such interaction could be that function of the transporter proteins is impaired and they lose some of their protective power. Study systems include the zebrafish embryo, marine and freshwater invertebrates and cellular systems. Various chemical (such as chemical uptake) and biological aspects (such as joint actions of chemicals in a mixture) with regard to active transport mechanisms are addressed in collaborations within the Biotox department and with colleagues from other departments.
Some of these aspects are currently explored in a field-related project at Lake Baikal in Eastern Siberia. The lake is inhabited by a unique, species-rich endemic fauna and it is a question of high interest how this fauna is affected by the current rapid environmental changes regarding water chemistry and climate.
Publikationen
2023 (2)
- Lipaeva, P., Karkossa, I., Bedulina, D., Schubert, K., Luckenbach, T. (2023):
Cold-adapted amphipod species upon heat stress: Proteomic responses and their correlation with transcriptomic responses
Comp. Biochem. Physiol. D-Genomics Proteomics 45 , art. 101048
Volltext (DOI) - Lubyaga, Y., Yarinich, L., Drozdova, P., Pindyurin, A., Gurkov, A., Luckenbach, T., Timofeyev, M. (2023):
The ABCs of the amphipod P-glycoprotein: Heterologous production of the Abcb1 protein of a model species Eulimnogammarus verrucosus (Amphipoda: Gammaridae) from Lake Baikal
Comp. Biochem. Physiol. C-Toxicol. Pharmacol. 271 , art. 109677
Volltext (DOI)
2022 (5)
- Halbach, K., Aulhorn, S., Lechtenfeld, O.J., Lecluse, M., Leippe, S., Reemtsma, T., Seiwert, B., Wagner, S., König, J., Luckenbach, T. (2022):
Zebrafish Oatp1d1 acts as a cellular efflux transporter of the anionic herbicide bromoxynil
Chem. Res. Toxicol. 35 (2), 315 - 325
Volltext (DOI) - Ortmann, J., Altenburger, R., Scholz, S., Luckenbach, T. (2022):
Photomotor response data analysis approach to assess chemical neurotoxicity with the zebrafish embryo
ALTEX-Altern. Anim. Exp. 39 (1), 82 - 94
Volltext (DOI) - Simonetti, S., Zupo, V., Gambi, M.C., Luckenbach, T., Corsi, I. (2022):
Unraveling cellular and molecular mechanisms of acid stress tolerance and resistance in marine species: New frontiers in the study of adaptation to ocean acidification
Mar. Pollut. Bull. 185, Part B , art. 114365
Volltext (DOI) - Švara, V., Michalski, S.G., Krauss, M., Schulze, T., Geuchen, S., Brack, W., Luckenbach, T. (2022):
Reduced genetic diversity of freshwater amphipods in rivers with increased levels of anthropogenic organic micropollutants [Dataset]
Dryad 10.5061/dryad.zw3r2288p - Švara, V., Michalski, S.G., Krauss, M., Schulze, T., Geuchen, S., Brack, W., Luckenbach, T. (2022):
Reduced genetic diversity of freshwater amphipods in rivers with increased levels of anthropogenic organic micropollutants
Evol. Appl. 15 (6), 976 - 991
Volltext (DOI)
2021 (6)
- Bedulina, D., Drozdova, P., Gurkov, A., von Bergen, M., Stadler, P.F., Luckenbach, T., Timofeyev, M., Kalkhof, S. (2021):
Proteomics reveals sex-specific heat shock response of Baikal amphipod Eulimnogammarus cyaneus
Sci. Total Environ. 763 , art. 143008
Volltext (DOI) - Bieczynski, F., Burkhardt-Medicke, K., Luquet, C.M., Scholz, S., Luckenbach, T. (2021):
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity
FEBS Lett. 595 (6), 828 - 843
Volltext (DOI) - Jakob, L., Vereshchagina, K.P., Tillmann, A., Rivarola-Duarte, L., Axenov-Gribanov, D.V., Bedulina, D.S., Gurkov, A.N., Drozdova, P., Timofeyev, M.A., Stadler, P.F., Luckenbach, T., Pörtner, H.-O., Sartoris, F.J., Lucassen, M. (2021):
Thermal reaction norms of key metabolic enzymes reflect divergent physiological and behavioral adaptations of closely related amphipod species
Sci. Rep. 11 , art. 4562
Volltext (DOI) - Lipaeva, P., Vereshchagina, K., Drozdova, P., Jakob, L., Kondrateva, E., Lucassen, M., Bedulina, D., Timofeyev, M., Stadler, P., Luckenbach, T. (2021):
Different ways to play it cool: Transcriptomic analysis sheds light on different activity patterns of three amphipod species under long-term cold exposure
Mol. Ecol. 30 (22), 5735 - 5751
Volltext (DOI) - Švara, V., Krauss, M., Michalski, S.G., Altenburger, R., Brack, W., Luckenbach, T. (2021):
Chemical pollution levels in a river explain site-specific sensitivities to micropollutants within a genetically homogeneous population of freshwater amphipods
Environ. Sci. Technol. 55 (9), 6087 - 6096
Volltext (DOI) - Vereshchagina, K., Kondrateva, E., Mutin, A., Jakob, L., Bedulina, D., Shchapova, E., Madyarova, E., Axenov-Gribanov, D., Luckenbach, T., Pörtner, H.-O., Lucassen, M., Timofeyev, M. (2021):
Low annual temperature likely prevents the Holarctic amphipod Gammarus lacustris from invading Lake Baikal
Sci. Rep. 11 , art. 10532
Volltext (DOI)
2020 (3)
- Halbach, K., Ulrich, N., Goss, K.-U., Seiwert, B., Wagner, S., Scholz, S., Luckenbach, T., Bauer, C., Schweiger, N., Reemtsma, T. (2020):
Yolk sac of zebrafish embryos as backpack for chemicals?
Environ. Sci. Technol. 54 (16), 10159 - 10169
Volltext (DOI) - Protopopova, M.V., Pavlichenko, V.V., Luckenbach, T. (2020):
Changes of cellular stress response related hsp70 and abcb1 transcript and Hsp70 protein levels in Siberian freshwater amphipods upon exposure to cadmium chloride in the lethal concentration range
PeerJ 8 , e8635
Volltext (DOI) - Shatilina, Z., Drozdova, P., Bedulina, D., Rivarola-Duarte, L., Schreiber, S., Otto, C., Jühling, F., Aulhorn, S., Busch, W., Lubyaga, Y., Kondrateva, E., Pobezhimova, T., Jakob, L., Lucassen, M., Sartoris, F.J., Hackermüller, J., Pörtner, H.-O., Stadler, P.F., Luckenbach, T., Timofeyev, M. (2020):
Transcriptome-level effects of the model organic pollutant phenanthrene and its solvent acetone in three amphipod species
Comp. Biochem. Physiol. D-Genomics Proteomics 33 , art. 100630
Volltext (DOI)
2019 (5)
- Drozdova, P., Bedulina, D., Madyarova, E., Rivarola-Duarte, L., Schreiber, S., Stadler, P.F., Luckenbach, T., Timofeyev, M. (2019):
Description of strongly heat-inducible heat shock protein 70 transcripts from Baikal endemic amphipods
Sci. Rep. 9 , art. 8907
Volltext (DOI) - Drozdova, P., Rivarola-Duarte, L., Bedulina, D., Axenov-Gribanov, D., Schreiber, S., Gurkov, A., Shatilina, Z., Vereshchagina, K., Lubyaga, Y., Madyarova, E., Otto, C., Jühling, F., Busch, W., Jakob, L., Lucassen, M., Sartoris, F.J., Hackermüller, J., Hoffmann, S., Pörtner, H.-O., Luckenbach, T., Timofeyev, M., Stadler, P.F. (2019):
Comparison between transcriptomic responses to short-term stress exposures of a common Holarctic and endemic Lake Baikal amphipods
BMC Genomics 20 , art. 712
Volltext (DOI) - Gurkov, A., Rivarola-Duarte, L., Bedulina, D., Fernández Casas, I., Michael, H., Drozdova, P., Nazarova, A., Govorukhina, E.B., Timofeyev, M., Stadler, P.F., Luckenbach, T. (2019):
Indication of ongoing amphipod speciation in Lake Baikal by genetic structures within endemic species
BMC Evol. Biol. 19 , art. 138
Volltext (DOI) - Halbach, K., Wagner, S., Scholz, S., Luckenbach, T., Reemtsma, T. (2019):
Elemental imaging (LA-ICP-MS) of zebrafish embryos to study the toxicokinetics of the acetylcholinesterase inhibitor naled
Anal. Bioanal. Chem. 411 (3), 617 - 627
Volltext (DOI) - Švara, V., Norf, H., Luckenbach, T., Brack, W., Michalski, S.G. (2019):
Isolation and characterization of eleven novel microsatellite markers for fine-scale population genetic analyses of Gammarus pulex (Crustacea: Amphipoda)
Mol. Biol. Rep. 46 (6), 6609 - 6615
Volltext (DOI)
2018 (2)
- Oetken, M., Jungmann, D., Bundschuh, M., Heß, M., Höss, S., Klein, R., Luckenbach, T., Osterauer, R., Peschke, K., Sosat, R. (2018):
Aquatische Wirbellose – inwiefern können sie als Wirkungsindikatoren für eine Gewässerbelastung dienen? Aquatic invertebrates - How can they serve as output indicators of water pollution?
Gefahrst. Reinhalt. Luft 78 (4), 171 - 172 - Piotrowska, A., Syguda, A., Wyrwas, B., Chrzanowski, Ł., Luckenbach, T., Heipieper, H.J. (2018):
Effects of ammonium-based ionic liquids and 2,4-dichlorophenol on the phospholipid fatty acid composition of zebrafish embryos
PLOS One 13 (1), e0190779
Volltext (DOI)
2017 (6)
- Armitage, J.M., Erickson, R.J., Luckenbach, T., Ng, C.A., Prosser, R.S., Arnot, J.A., Schirmer, K., Nichols, J.W. (2017):
Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities
Environ. Toxicol. Chem. 36 (4), 882 - 897
Volltext (DOI) - Cunha, V., Burkhardt-Medicke, K., Wellner, P., Santos, M.M., Moradas-Ferreira, P., Luckenbach, T., Ferreira, M. (2017):
Effects of pharmaceuticals and personal care products (PPCPs) on multixenobiotic resistance (MXR) related efflux transporter activity in zebrafish (Danio rerio) embryos
Ecotox. Environ. Safe. 136 , 14 - 23
Volltext (DOI) - Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106
Volltext (DOI) - Jakob, L., Bedulina, D.S., Axenov-Gribanov, D.V., Ginzburg, M., Shatilina, Z.M., Lubyaga, Y.A., Madyarova, E.V., Gurkov, A.N., Timofeyev, M.A., Portner, H.-O., Sartoris, F.J., Altenburger, R., Luckenbach, T. (2017):
Uptake kinetics and subcellular compartmentalization explain lethal but not sublethal effects of cadmium in two closely related amphipod species
Environ. Sci. Technol. 51 (12), 7208 - 7218
Volltext (DOI) - Kurth, D., Lips, S., Massei, R., Krauss, M., Luckenbach, T., Schulze, T., Brack, W. (2017):
The impact of chemosensitisation on bioaccumulation and sediment toxicity
Chemosphere 186 , 652 - 659
Volltext (DOI) - Luckenbach, T. (2017):
What are the global boundaries of chemical pollution? Каковы глобальные границы химического загрязнения?
Russian-German Scientific Summer School „Scientific collaboration – contribution to sustainable development“, October 16-22, 2016, Sochi. The Noosphere [Noosfera] No 1/2017
V.I. Vernadsky Nongovernmental Ecological Foundation ; Helmholtz Association of the German Scientific Centers, Moskau, Berlin, p. 59 - 63
2016 (5)
- Axenov-Gribanov, D., Bedulina, D., Shatilina, Z., Jakob, L., Vereshchagina, K., Lubyaga, Y., Gurkov, A., Shchapova, E., Luckenbach, T., Lucassen, M., Sartoris, F.J., Pörtner, H.-O., Timofeyev, M. (2016):
Thermal preference ranges correlate with stable signals of universal stress markers in Lake Baikal endemic and Holarctic amphipods
PLOS One 11 (10), e0164226
Volltext (DOI) - Faria, M., Pavlichenko, V.V., Burkhardt-Medicke, K., Soares, A.M.V.M., Altenburger, R., Barata, C., Luckenbach, T. (2016):
Use of a combined effect model approach for discriminating between ABCB1- and ABCC1-type efflux activities in native bivalve gill tissue
Toxicol. Appl. Pharmacol. 297 , 56 - 67
Volltext (DOI) - Faria, M., Pavlichenko, V.V., Burkhardt-Medicke, K., Soares, A.M.V.M., Altenburger, R., Barata, C., Luckenbach, T. (2016):
Corrigendum to "Use of a combined effect model approach for discriminating between ABCB1- and ABCC1-type efflux activities in native bivalve gill tissue" [Toxicol. Appl. Pharmacol. (2016) 56–67]
Toxicol. Appl. Pharmacol. 303 , 110
Volltext (DOI) - Jakob, L., Axenov-Gribanov, D.V., Gurkov, A.N., Ginzburg, M., Bedulina, D.S., Timofeyev, M.A., Luckenbach, T., Lucassen, M., Sartoris, F.J., Pörtner, H.-O. (2016):
Lake Baikal amphipods under climate change: thermal constraints and ecological consequences
Ecosphere 7 (3), e01308
Volltext (DOI) - Keiter, S., Burkhardt-Medicke, K., Wellner, P., Kais, B., Färber, H., Skutlarek, D., Engwall, M., Braunbeck, T., Keiter, S.H., Luckenbach, T. (2016):
Does perfluorooctane sulfonate (PFOS) act as chemosensitizer in zebrafish embryos?
Sci. Total Environ. 548–549 , 317 - 324
Volltext (DOI)
2015 (5)
- Hachicho, N., Reithel, S., Miltner, A., Heipieper, H.J., Küster, E., Luckenbach, T. (2015):
Body mass parameters, lipid profiles and protein contents of zebrafish embryos and effects of 2,4-dinitrophenol exposure
PLOS One 10 (8), e0134755
Volltext (DOI) - Kurth, D., Brack, W., Luckenbach, T. (2015):
Is chemosensitisation by environmental pollutants ecotoxicologically relevant?
Aquat. Toxicol. 167 , 134 - 140
Volltext (DOI) - Luckenbach, T., Bedulina, D.S., Timofeyev, M. (2015):
Is the endemic fauna of Lake Baikal affected by global change?
In: Karthe, D., Chalov, S.R., Kasimov, N.S., Kappas, M. (eds.)
Water and environment in the Selenga-Baikal Basin : international research cooperation for an ecoregion of global relevance
Erdsicht : Einblicke in geographische und geoinformationstechnische Arbeitsweisen 23
Ibidem-Verlag, Stuttgart, p. 219 - 235 - Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
What determines chemical uptake by the zebrafish embryo model?
Toxicol. Lett. 238 (2, Suppl.), S54
Volltext (DOI) - Pavlichenko, V.V., Protopopova, M.V., Timofeyev, M., Luckenbach, T. (2015):
Identification of a putatively multixenobiotic resistance related Abcb1 transporter in amphipod species endemic to the highly pristine Lake Baikal
Environ. Sci. Pollut. Res. 22 (7), 5453 - 5468
Volltext (DOI)
2014 (5)
- Bedulina, D.S., Takhteev, V.V., Pogrebnyak, S.G., Govorukhina, E.B., Madyarova, E.V., Lubyaga, Y.A., Vereshchagina, K.P., Timofeyev, M.A., Luckenbach, T. (2014):
On Eulimnogammarus messerschmidtii, sp. n. (Amphipoda: Gammaridea) from Lake Baikal, Siberia, with redescription of E. cyanoides (Sowinsky) and remarks on taxonomy of the genus Eulimnogammarus
Zootaxa 3838 (5), 518 - 544
Volltext (DOI) - Campos, B., Altenburger, R., Gómez, C., Lacorte, S., Piña, B., Barata, C., Luckenbach, T. (2014):
First evidence for toxic defense based on the multixenobiotic resistance (MXR) mechanism in Daphnia magna
Aquat. Toxicol. 148 , 139 - 151
Volltext (DOI) - Luckenbach, T., Fischer, S., Sturm, A. (2014):
Current advances on ABC drug transporters in fish
Comp. Biochem. Physiol. C-Toxicol. Pharmacol. 165 , 28 - 52
Volltext (DOI) - Protopopova, M.V., Pavlichenko, V.V., Menzel, R., Putschew, A., Luckenbach, T., Steinberg, C.E.W. (2014):
Contrasting cellular stress responses of Baikalian and Palearctic amphipods upon exposure to humic substances: environmental implications
Environ. Sci. Pollut. Res. 21 (24), 14124 - 14137
Volltext (DOI) - Rivarola-Duarte, L., Otto, C., Jühling, F., Schreiber, S., Bedulina, D.S., Jakob, L., Gurkov, A., Axenov-Gribanov, D., Sahyoun, A.H., Lucassen, M., Hackermüller, J., Hoffmann, S., Sartoris, F., Pörtner, H.-O., Timofeyev, M., Luckenbach, T., Stadler, P.F. (2014):
A first glimpse at the genome of the Baikalian amphipod Eulimnogammarus verrucosus
J. Exp. Zool. Part B 322 (3), 177 - 189
Volltext (DOI)
2013 (4)
- Bedulina, D.S., Evgen'ev, M.B., Timofeyev, M.A., Protopopova, M.V., Garbuz, D.G., Pavlichenko, V.V., Luckenbach, T., Shatilina, Z.M., Axenov-Gribanov, D.V., Gurkov, A.N., Sokolova, I.M., Zatsepina, O.G. (2013):
Expression patterns and organization of the hsp70 genes correlate with thermotolerance in two congener endemic amphipod species (Eulimnogammarus cyaneus and E. verrucosus) from Lake Baikal
Mol. Ecol. 22 (5), 1416 - 1430
Volltext (DOI) - Fischer, S., Klüver, N., Burkhardt-Medicke, K., Pietsch, M., Schmidt, A.-M., Wellner, P., Schirmer, K., Luckenbach, T. (2013):
Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos
BMC Biol. 11 , art. 69
Volltext (DOI) - Madyarova, E.V., Lubyaga, J.A., Gurkov, A.N., Vereshchagina, K.P., Kondrateva, E.M., Shchapova, E.P., Timofeyev, M.A., Luckenbach, T., Bedulina, D.S. (2013):
A comparative analysis of hsp70 mRNA and HSP70 protein expression in two distant populations of the Baikal amphipod Eulimnogammarus verrucosus (Gerstf., 1858)
Journal of Stress Physiology & Biochemistry 9 (4), 345 - 351
Volltext (URL) - Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013):
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Regul. Toxicol. Pharmacol. 67 (3), 506 - 530
Volltext (DOI)
2012 (1)
- Navarro, A., Weißbach, S., Faria, M., Barata, C., Piña, B., Luckenbach, T. (2012):
Abcb and Abcc transporter homologs are expressed and active in larvae and adults of zebra mussel and induced by chemical stress
Aquat. Toxicol. 122–123 , 144 - 152
Volltext (DOI)
2011 (2)
- Faria, M., Navarro, A., Luckenbach, T., Piña, B., Barata, C. (2011):
Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants
Aquat. Toxicol. 101 (1), 78 - 87
Volltext (DOI) - Fischer, S., Loncar, J., Zaja, R., Schnell, S., Schirmer, K., Smital, T., Luckenbach, T. (2011):
Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss)
Aquat. Toxicol. 101 (2), 438 - 446
Volltext (DOI)
2010 (3)
- Brennan, C., Dosch, R., Haramis, A.-P., Luckenbach, T., Martínez-Morales, J.-R., Moro, E., Polok, B., Ramesch, T.M., Russell, C., Argenton, F., Strähle, U. (2010):
Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18-22, 2010
Zebrafish 7 (3), 305 - 310
Volltext (DOI) - Fischer, S., Pietsch, M., Schirmer, K., Luckenbach, T. (2010):
Identification of multi-drug resistance associated proteins MRP1 (ABCC1) and MRP3 (ABCC3) from rainbow trout (Oncorhynchus mykiss)
Mar. Environ. Res. 69 (Suppl. 1), S7 - S10
Volltext (DOI) - Zucchi, S., Corsi, I., Luckenbach, T., Bard, S.M., Regoli, F., Focardi, S. (2010):
Identification of five partial ABC genes in the liver of the Antarctic fish Trematomus bernacchii and sensitivity of ABCB1 and ABCC2 to Cd exposure
Environ. Pollut. 158 (8), 2746 - 2756
Volltext (DOI)
2008 (5)
- Epel, D., Luckenbach, T., Stevenson, C.N., MacManus-Spencer, L.A., Hamdoun, A., Smital, T. (2008):
Efflux transporters: newly appreciated roles in protection against pollutants
Environ. Sci. Technol. 42 (11), 3914 - 3920
Volltext (DOI) - Luckenbach, T., Ahnert, M., Fischer, S., Schirmer, K. (2008):
Zebrafish embryos are sensitized towards chemicals by efflux transporter inhibitors
Mar. Environ. Res. 66 (1), 81
Volltext (DOI) - Luckenbach, T., Altenburger, R., Epel, D. (2008):
Teasing apart activities of different types of ABC efflux pumps in bivalve gills using the concepts of independent action and concentration addition
Mar. Environ. Res. 66 (1), 75 - 76
Volltext (DOI) - Luckenbach, T., Epel, D. (2008):
ABCB- and ABCC-type transporters confer multixenobiotic resistance and form an environment-tissue barrier in bivalve gills
Am. J. Physiol.-Regul. Integr. Comp. Physiol. 294 , R1919 - R1929
Volltext (DOI) - Scholz, S., Fischer, S., Gündel, U., Küster, E., Luckenbach, T., Voelker, D. (2008):
The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
Environ. Sci. Pollut. Res. 15 (5), 394 - 404
Volltext (DOI)
2006 (3)
- Luckenbach, T., Epel, D. (2006):
The chemosensitizer problem: Unraveling how musks inhibit efflux transporters in mussels and use of this approach for predicting chemo sensitizing potential
Mar. Environ. Res. 62 (Suppl. 1), S69 - S70
Volltext (DOI) - Smital, T., Sauerborn, R., Zaja, R., Luckenbach, T., Hamdoun, A.M., Epel, D. (2006):
Multidrug resistance-associated proteins (MRPs) as an integral part of multixenobiotic resistance (MXR) in aquatic organisms
Mar. Environ. Res. 62 (Suppl. 1), S46 - S47
Volltext (DOI) - Stevenson, C.N., MacManus-Spencer, L.A., Luckenbach, T., Luthy, R.G., Epel, D. (2006):
New perspectives on perfluorochemical ecotoxicology: inhibition and induction of an efflux transporter in the marine mussel, Mytilus californianus
Environ. Sci. Technol. 40 (17), 5580 - 5585
Volltext (DOI)
2005 (2)
- Hallare, A.V., Schirling, M., Luckenbach, T., Köhler, H.-R., Triebskorn, R. (2005):
Combined effects of temperature and cadmium on developmental parameters and biomarker responses in zebrafish (Danio rerio) embryos
J. Therm. Biol. 30 (1), 7 - 17
Volltext (DOI) - Luckenbach, T., Epel, D. (2005):
Nitromusk and polycyclic musk compounds as long-term inhibitors of cellular xenobiotic defense systems mediated by multidrug transporters
Environ. Health Perspect. 113 (1), 17 - 24
Volltext (DOI)
2004 (2)
- Luckenbach, T., Corsi, I., Epel, D. (2004):
Fatal attraction: synthetic musk fragrances compromise multixenobiotic defense systems in mussels
Mar. Environ. Res. 58 (2-5), 215 - 219
Volltext (DOI) - Smital, T., Luckenbach, T., Sauerborn, R., Hamdoun, A.M., Vega, R.L., Epel, D. (2004):
Emerging contaminants-pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms
Mutat. Res.-Fundam. Mol. Mech. Mutagen. 552 (1-2), 101 - 117
Volltext (DOI)
2003 (2)
- Luckenbach, T., Ferling, H., Gernhofer, M., Köhler, H.-R., Negele, R.D., Pfefferle, E., Triebskorn, R. (2003):
Developmental and subcellular effects of chronic exposure to sub-lethal concentrations of ammonia, PAH and PCP mixtures in brown trout (Salmo trutta f. fario L.) early life stages
Aquat. Toxicol. 65 (1), 39 - 54
Volltext (DOI) - Luckenbach, T., Kilian, M., Triebskorn, R., Oberemm, A. (2003):
Assessment of the developmental success of brown trout (Salmo trutta f. fario L.) embryos in two differently polluted streams in Germany
Hydrobiologia 490 (1-3), 53 - 62
Volltext (DOI)
2001 (1)
- Luckenbach, T., Triebskorn, R., Müller, E., Oberemm, A. (2001):
Toxicity of waters from two streams to early life stages of brown trout (Salmo trutta f. fario L.), tested under semi-field conditions
Chemosphere 45 (4-5), 571 - 579
Volltext (DOI)
1999 (1)
- Luckenbach, T., Kilian, M., Triebskorn, R., Oberemm, A. (1999):
Fish early life stage tests as a tool to assess embryotoxic potentials in small streams
J. Aquat. Ecosys. Stress Recov. 8 (3-4), 355 - 370
Volltext (DOI)