Dr. Nils Klüver
His research is focused on the development of animal alternatives for risk assessment by using the zebrafish embryo. A particular focus of the work is on the optimization of assessment methods for sublethal endpoints, e.g. behavioral assays, heart beat and blood flow measurements and gene expression changes (toxicity pathways) to increase predictivity of the zebrafish embryo model for adult fish toxicity (acute and chronic). He has experience in linking toxicogenomic and behavioral responses of sublethal chemical exposures in the zebrafish embryo to specific modes of action and respective biomarkers. He is interested in toxicokinetic and toxicodynamic processes to relate observed effects to internal concentrations in the zebrafish embryo model. By performing gene knock downs he studies specific gene functions during embryo development in combination with chemical exposures.