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Title (Primary) Economic process evaluation and environmental life-cycle assessment of bio-aromatics production
Author Krömer, J.O.; Ferreira, R.G.; Petrides, D.; Kohlheb, N.;
Journal Frontiers in Bioengineering and Biotechnology
Year 2020
Department UBZ; SOMA;
Volume 8
Language englisch;
POF III (all) R61;
Supplements https://www.frontiersin.org/articles/10.3389/fbioe.2020.00403/full#supplementary-material
Keywords life-cycle assessment; process development; aromatics; fermentation; pHBA INTRODUCTION
Abstract The bio-based production of aromatics is experiencing a renaissance with systems and synthetic biology approaches promising to deliver bio-catalysts that will reach yields, rates, and titers comparable to already existing bulk bio-processes for the production of amino acids for instance. However, aromatic building blocks derived from petrochemical routes have a huge economic advantage, they are cheap, and very cheap in fact. In this article, we are trying to shed light on an important aspect of biocatalyst development that is frequently overlooked when working on strain development: economic and environmental impact of the production process. We estimate the production cost and environmental impact of a microbial fermentation process depending on culture pH, carbon source and process scale. As a model molecule we use para-hydroxybenzoic acid (pHBA), but the results are readily transferrable to other shikimate derived aromatics with similar carbon yields and production rates.
ID 23110
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=23110
Krömer, J.O., Ferreira, R.G., Petrides, D., Kohlheb, N. (2020):
Economic process evaluation and environmental life-cycle assessment of bio-aromatics production
Front. Bioeng. Biotechnol. 8 , art. 403