Federica Calabrese

Contact / Addess:


Phone +49 (0) 341 235 1005
Fax +49 (0) 341 235 450822

Helmholtz Centre for Environmental Research - UFZ
Permoserstrasse 15
04318 Leipzig


Curriculum Vitae

Since 2016 PhD student
Department of Isotope Biogeochemistry
ProVIS - Centre for Chemical Microscopy
Helmholtz Centre for Environmental Research –
UFZ, Leipzig
January – June 2015 Post Graduate Placement
Eli Lilly and Company Ltd (United Kingdom)
Research fellowship supported by "Noopolis" foundation and “Sapienza” University of Rome, Italy
June - December 2014 Research fellow
"Phage Display Technology for recognition of bacteria involved in sepsis"
University of Messina
October 2013 – June 2014 Research Assistant
“Micro & Nano biotechnology” laboratory at the University of Messina
Phage display for Biosensor applications
October 2013 M.Sc. in Biotechnology and applied Microbiology,
University of Messina, Italy
Internship for experimental thesis at "Fundamental and Applied Microbiology and Virology" Laboratory
March 2012 B. Sc. Biological science
University of Messina, Italy

Field of Expertise

  • Nano-scale Secondary Ion mass Spectrometry (nanoSIMS) for analysis of biological samples
  • Fluorescence microscopy
  • Microbiology
  • Stable isotope labeling

Research topic of my PhD project

   Single-cell chemical Imaging with NanoSIMS to study metabolic heterogeneity of bacterial     population during biodegradation processes

  • Imaging with NanoSIMS to study metabolic functions at single-cell level
  • Understand metabolic strategies of different microbial populations and the dynamics related to biodegradation of chemicals in the environment
  • Evaluate which factors (biotic and abiotic) control the microbial metabolic heterogeneity and how these influence the capacity of an ecosystem to biodegrade chemicals

Main Research Interests

  • Single cell approach on ecophysiology and metabolic networks of microbes in the environment
  • Study of physical and metabolic interactions between different microbes in experimental and natural set-up
  • Linking specific function (metabolic activity) with identity (FISH, CARD-FISH) of microorganisms in different environmental samples


  • Chen, S.-C., Musat, N., Lechtenfeld, O.J., Paschke, H., Schmidt, M., Said, N., Popp, D., Calabrese, F., Stryhanyuk, H., Jaekel, U., Zhu, Y.-G., Joye, S.B., Richnow, H.-H., Widdel, F., Musat, F., (2019):
    Anaerobic oxidation of ethane by archaea from a marine hydrocarbon seep
    Nature 568 (7750), 108 - 111
    full text (url)
  • Rotaru, A.-E., Calabrese, F., Stryhanyuk, H., Musat, F., Shrestha, P.M., Weber, H.S., Snoeyenbos-West, O.L.O., Hall, P.O.J., Richnow, H.H., Musat, N., Thamdrup, B., (2018):
    Conductive particles enable syntrophic acetate oxidation between Geobacter and Methanosarcina from coastal sediments
    mBio 9 (3), e00226-18
    full text (url)
  • Stryhanyuk, H., Calabrese, F., Kümmel, S., Musat, F., Richnow, H.-H., Musat, N., (2018):
    Calculation of single cell assimilation rates from SIP-nanoSIMS-derived isotope ratios: a comprehensive approach
    Front. Microbiol. 9 , art. 2342
    full text (url)

  • G. Lentini, E. Fazio, F. Calabrese, L.M. De Plano, M. Puliafico, D. Franco,M. S. Nicolò, S. Carnazza, S. Trusso, A. Allegra, F. Neri, C. Musolino and S. P. P. Guglielmino; PHAGE-AgNPs COMPLEX AS SERS PROBE FOR U937 CELL IDENTIFICATION; Biosensors and Bioelectronics, 74 (2015) 398–40.


  • Calabrese F. ; Carnazza S. ; De Plano L.M. ; Lentini G. ; Franco D. ; Guglielmino S.P.P., PHAGE-COATED PARAMAGNETIC BEADS AS SELECTIVE AND SPECIFIC CAPTURE SYSTEM FOR BIOSENSOR APPLICATIONS; Publisher: IEEE Conference Publications, AISEM Annual Conference, 2015 XVIII, vol., no., pp.1,4, 3-5 Feb. 2015.



M.Sc. thesis:

“Functionalization of magnetic beads with M13 Bacteriophage for biosensor application”